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Items: 1 to 50 of 345

1.

Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection.

Baeza Garcia A, Siu E, Sun T, Exler V, Brito L, Hekele A, Otten G, Augustijn K, Janse CJ, Ulmer JB, Bernhagen J, Fikrig E, Geall A, Bucala R.

Nat Commun. 2018 Jul 13;9(1):2714. doi: 10.1038/s41467-018-05041-7.

2.

Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization.

Moss CE, Robson A, Fikrig E, Narasimhan S.

J Vis Exp. 2018 Jun 1;(136). doi: 10.3791/57758.

PMID:
29912204
3.

UBXN3B positively regulates STING-mediated antiviral immune responses.

Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P.

Nat Commun. 2018 Jun 13;9(1):2329. doi: 10.1038/s41467-018-04759-8.

4.

Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells.

Silver AC, Buckley SM, Hughes ME, Hastings AK, Nitabach MN, Fikrig E.

Heliyon. 2018 Mar 20;4(3):e00579. doi: 10.1016/j.heliyon.2018.e00579. eCollection 2018 Mar.

5.

Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism.

Heipertz EL, Harper J, Lopez CA, Fikrig E, Hughes ME, Walker WE.

J Immunol. 2018 Jul 1;201(1):193-201. doi: 10.4049/jimmunol.1701677. Epub 2018 May 14.

PMID:
29760192
6.

Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice.

Dragovic SM, Agunbiade TA, Freudzon M, Yang J, Hastings AK, Schleicher TR, Zhou X, Craft S, Chuang YM, Gonzalez F, Li Y, Hrebikova G, Tripathi A, Mlambo G, Almeras L, Ploss A, Dimopoulos G, Fikrig E.

Cell Host Microbe. 2018 Apr 11;23(4):523-535.e5. doi: 10.1016/j.chom.2018.03.008.

7.

Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus.

Beloor J, Maes N, Ullah I, Uchil P, Jackson A, Fikrig E, Lee SK, Kumar P.

Cell Host Microbe. 2018 Apr 11;23(4):549-556.e3. doi: 10.1016/j.chom.2018.03.001. Epub 2018 Mar 29.

PMID:
29606496
8.

Altered vector competence in an experimental mosquito-mouse transmission model of Zika infection.

Uraki R, Hastings AK, Gloria-Soria A, Powell JR, Fikrig E.

PLoS Negl Trop Dis. 2018 Mar 5;12(3):e0006350. doi: 10.1371/journal.pntd.0006350. eCollection 2018 Mar.

9.

Human Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species.

Krause PJ, Carroll M, Fedorova N, Brancato J, Dumouchel C, Akosa F, Narasimhan S, Fikrig E, Lane RS.

PLoS One. 2018 Feb 8;13(2):e0191725. doi: 10.1371/journal.pone.0191725. eCollection 2018.

10.

Type I interferons instigate fetal demise after Zika virus infection.

Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A.

Sci Immunol. 2018 Jan 5;3(19). pii: eaao1680. doi: 10.1126/sciimmunol.aao1680.

PMID:
29305462
11.

Advances in Serodiagnostic Testing for Lyme Disease Are at Hand.

Branda JA, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder J, Steere AC, Witkowski J, Wong SJ, Schutzer SE.

Clin Infect Dis. 2018 Mar 19;66(7):1133-1139. doi: 10.1093/cid/cix943.

PMID:
29228208
12.

Artificial Infection of Ticks with Borrelia burgdorferi Using a Microinjection Method and Their Detection In Vivo Using Quantitative PCR Targeting flaB RNA.

Smith AA, Yang X, Fikrig E, Pal U.

Methods Mol Biol. 2018;1690:105-114. doi: 10.1007/978-1-4939-7383-5_9.

PMID:
29032540
13.

Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization.

Narasimhan S, Schuijt TJ, Abraham NM, Rajeevan N, Coumou J, Graham M, Robson A, Wu MJ, Daffre S, Hovius JW, Fikrig E.

Nat Commun. 2017 Aug 4;8(1):184. doi: 10.1038/s41467-017-00208-0.

14.

Zika Virus and Sexual Transmission: A New Route of Transmission for Mosquito-borne Flaviviruses
.

Hastings AK, Fikrig E.

Yale J Biol Med. 2017 Jun 23;90(2):325-330. eCollection 2017 Jun. Review.

15.

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.

Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA.

Nature. 2017 Jun 29;546(7660):667-670. doi: 10.1038/nature22967. Epub 2017 Jun 21.

16.

Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets.

Murfin KE, Fikrig E.

Front Cell Infect Microbiol. 2017 Jun 6;7:222. doi: 10.3389/fcimb.2017.00222. eCollection 2017. No abstract available.

17.

An essential role of PI3K in the control of West Nile virus infection.

Wang L, Yang L, Fikrig E, Wang P.

Sci Rep. 2017 Jun 16;7(1):3724. doi: 10.1038/s41598-017-03912-5.

18.

Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice.

Uraki R, Jurado KA, Hwang J, Szigeti-Buck K, Horvath TL, Iwasaki A, Fikrig E.

J Infect Dis. 2017 Jun 1;215(11):1720-1724. doi: 10.1093/infdis/jix204.

19.

A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus.

Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Sutton E, Heisig M, Jacobs-Wagner C, Fikrig E.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00113-17. doi: 10.1128/AAC.00113-17. Print 2017 Jul.

20.

TAM Receptors Are Not Required for Zika Virus Infection in Mice.

Hastings AK, Yockey LJ, Jagger BW, Hwang J, Uraki R, Gaitsch HF, Parnell LA, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A.

Cell Rep. 2017 Apr 18;19(3):558-568. doi: 10.1016/j.celrep.2017.03.058.

21.

Anti-Biofilm Activity of a Self-Aggregating Peptide against Streptococcus mutans.

Ansari JM, Abraham NM, Massaro J, Murphy K, Smith-Carpenter J, Fikrig E.

Front Microbiol. 2017 Mar 24;8:488. doi: 10.3389/fmicb.2017.00488. eCollection 2017.

22.

Zika virus causes testicular atrophy.

Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E.

Sci Adv. 2017 Feb 22;3(2):e1602899. doi: 10.1126/sciadv.1602899. eCollection 2017 Feb.

23.

Infection-derived lipids elicit an immune deficiency circuit in arthropods.

Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH.

Nat Commun. 2017 Feb 14;8:14401. doi: 10.1038/ncomms14401.

24.

Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα.

Hu Y, O'Boyle K, Auer J, Raju S, You F, Wang P, Fikrig E, Sutton RE.

PLoS Pathog. 2017 Feb 2;13(2):e1006187. doi: 10.1371/journal.ppat.1006187. eCollection 2017 Feb.

25.

Pathogen-mediated manipulation of arthropod microbiota to promote infection.

Abraham NM, Liu L, Jutras BL, Yadav AK, Narasimhan S, Gopalakrishnan V, Ansari JM, Jefferson KK, Cava F, Jacobs-Wagner C, Fikrig E.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E781-E790. doi: 10.1073/pnas.1613422114. Epub 2017 Jan 17.

26.

Zika virus infection of Hofbauer cells.

Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S.

Am J Reprod Immunol. 2017 Feb;77(2). doi: 10.1111/aji.12613. Epub 2016 Dec 14. Review.

27.

TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice.

Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F.

J Immunol. 2016 Dec 1;197(11):4425-4435. Epub 2016 Oct 21.

28.

Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance.

Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F.

J Virol. 2016 Dec 16;91(1). pii: e01529-16. Print 2017 Jan 1.

29.

Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection.

Conway MJ, Londono-Renteria B, Troupin A, Watson AM, Klimstra WB, Fikrig E, Colpitts TM.

PLoS Negl Trop Dis. 2016 Sep 15;10(9):e0004941. doi: 10.1371/journal.pntd.0004941. eCollection 2016 Sep.

30.

Zika virus productively infects primary human placenta-specific macrophages.

Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, Fikrig E.

JCI Insight. 2016 Aug 18;1(13). pii: e88461.

31.

A novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection.

Troupin A, Londono-Renteria B, Conway MJ, Cloherty E, Jameson S, Higgs S, Vanlandingham DL, Fikrig E, Colpitts TM.

Biochim Biophys Acta. 2016 Sep;1860(9):1898-909. doi: 10.1016/j.bbagen.2016.05.033. Epub 2016 May 27.

32.

Genetics of War and Truce between Mosquitos and Emerging Viruses.

Hwang J, Jurado KA, Fikrig E.

Cell Host Microbe. 2016 May 11;19(5):583-7. doi: 10.1016/j.chom.2016.04.009.

33.

Variable Major Proteins as Targets for Specific Antibodies against Borrelia miyamotoi.

Wagemakers A, Koetsveld J, Narasimhan S, Wickel M, Deponte K, Bleijlevens B, Jahfari S, Sprong H, Karan LS, Sarksyan DS, van der Poll T, Bockenstedt LK, Bins AD, Platonov AE, Fikrig E, Hovius JW.

J Immunol. 2016 May 15;196(10):4185-95. doi: 10.4049/jimmunol.1600014. Epub 2016 Apr 13.

34.

Ixodes scapularis dystroglycan-like protein promotes Borrelia burgdorferi migration from the gut.

Coumou J, Narasimhan S, Trentelman JJ, Wagemakers A, Koetsveld J, Ersoz JI, Oei A, Fikrig E, Hovius JW.

J Mol Med (Berl). 2016 Mar;94(3):361-70. doi: 10.1007/s00109-015-1365-0. Epub 2015 Nov 23.

35.

Nlrp6 regulates intestinal antiviral innate immunity.

Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E.

Science. 2015 Nov 13;350(6262):826-30. doi: 10.1126/science.aab3145. Epub 2015 Oct 22.

36.

Dengue Virus Infection of Aedes aegypti Requires a Putative Cysteine Rich Venom Protein.

Londono-Renteria B, Troupin A, Conway MJ, Vesely D, Ledizet M, Roundy CM, Cloherty E, Jameson S, Vanlandingham D, Higgs S, Fikrig E, Colpitts TM.

PLoS Pathog. 2015 Oct 22;11(10):e1005202. doi: 10.1371/journal.ppat.1005202. eCollection 2015 Oct.

37.

Tick microbiome: the force within.

Narasimhan S, Fikrig E.

Trends Parasitol. 2015 Jul;31(7):315-23. doi: 10.1016/j.pt.2015.03.010. Epub 2015 Apr 27. Review.

38.

Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.

Walker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, Barakat L, Francis J, Fisher A, Kozal M, Zapata H, Shaw A, Lifton R, Sutton RE, Fikrig E.

J Virol. 2015 May;89(10):5502-14. doi: 10.1128/JVI.00118-15. Epub 2015 Mar 4.

39.

Frostbite protection in mice expressing an antifreeze glycoprotein.

Heisig M, Mattessich S, Rembisz A, Acar A, Shapiro M, Booth CJ, Neelakanta G, Fikrig E.

PLoS One. 2015 Feb 25;10(2):e0116562. doi: 10.1371/journal.pone.0116562. eCollection 2015.

40.

Vaccine development: how scientific collaboration and communication help prevent the spread of disease: an interview with Erol Fikrig, MD.

Fikrig E, Turchick A, Czochor J.

Yale J Biol Med. 2014 Dec 12;87(4):519-25. eCollection 2014 Dec. No abstract available.

41.

Antivirulence properties of an antifreeze protein.

Heisig M, Abraham NM, Liu L, Neelakanta G, Mattessich S, Sultana H, Shang Z, Ansari JM, Killiam C, Walker W, Cooley L, Flavell RA, Agaisse H, Fikrig E.

Cell Rep. 2014 Oct 23;9(2):417-24. doi: 10.1016/j.celrep.2014.09.034. Epub 2014 Oct 16. Erratum in: Cell Rep. 2014 Dec 24;9(6):2344.

42.

Role of the Vector in Arbovirus Transmission.

Conway MJ, Colpitts TM, Fikrig E.

Annu Rev Virol. 2014 Nov;1(1):71-88. doi: 10.1146/annurev-virology-031413-085513. Epub 2014 Jun 2.

PMID:
26958715
43.

Systems immunology reveals markers of susceptibility to West Nile virus infection.

Qian F, Goel G, Meng H, Wang X, You F, Devine L, Raddassi K, Garcia MN, Murray KO, Bolen CR, Gaujoux R, Shen-Orr SS, Hafler D, Fikrig E, Xavier R, Kleinstein SH, Montgomery RR.

Clin Vaccine Immunol. 2015 Jan;22(1):6-16. doi: 10.1128/CVI.00508-14. Epub 2014 Oct 29.

44.

A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission.

Narasimhan S, Coumou J, Schuijt TJ, Boder E, Hovius JW, Fikrig E.

PLoS Pathog. 2014 Aug 7;10(8):e1004278. doi: 10.1371/journal.ppat.1004278. eCollection 2014 Aug.

45.

Innexin AGAP001476 is critical for mediating anti-Plasmodium responses in Anopheles mosquitoes.

Li MW, Wang J, Zhao YO, Fikrig E.

J Biol Chem. 2014 Sep 5;289(36):24885-97. doi: 10.1074/jbc.M114.554519. Epub 2014 Jul 17.

46.

Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States.

Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, Lepore T, Dardick K, Mamula M, Rollend L, Steeves TK, Diuk-Wasser M, Usmani-Brown S, Williamson P, Sarksyan DS, Fikrig E, Fish D; Tick Borne Diseases Group.

Emerg Infect Dis. 2014 Jul;20(7):1183-90. doi: 10.3201/eid2007.131587.

47.

Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells.

Seidman D, Ojogun N, Walker NJ, Mastronunzio J, Kahlon A, Hebert KS, Karandashova S, Miller DP, Tegels BK, Marconi RT, Fikrig E, Borjesson DL, Carlyon JA.

Cell Microbiol. 2014 Aug;16(8):1133-45. doi: 10.1111/cmi.12286. Epub 2014 Apr 3.

48.

Immune markers associated with host susceptibility to infection with West Nile virus.

Qian F, Thakar J, Yuan X, Nolan M, Murray KO, Lee WT, Wong SJ, Meng H, Fikrig E, Kleinstein SH, Montgomery RR.

Viral Immunol. 2014 Mar;27(2):39-47. doi: 10.1089/vim.2013.0074.

49.

Innate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders.

Juthani-Mehta M, Guo X, Shaw AC, Towle V, Ning Y, Wang X, Allore HG, Fikrig E, Montgomery RR.

J Aging Sci. 2014 Jan 27;2. pii: 1000115.

50.

Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete.

Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, Deponte K, Fish D, Fikrig E.

Cell Host Microbe. 2014 Jan 15;15(1):58-71. doi: 10.1016/j.chom.2013.12.001.

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