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AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice.

Uraki R, Hastings AK, Brackney DE, Armstrong PM, Fikrig E.

NPJ Vaccines. 2019 Jul 8;4:23. doi: 10.1038/s41541-019-0120-x. eCollection 2019.


Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by LXR Agonist.

Hwang J, Wang Y, Fikrig E.

Antimicrob Agents Chemother. 2019 Jul 15. pii: AAC.01220-19. doi: 10.1128/AAC.01220-19. [Epub ahead of print]


Anopheles gambiae lacking AgTRIO inefficiently transmit Plasmodium berghei to mice.

Chuang YM, Freudzon M, Yang J, Dong Y, Dimopoulos G, Fikrig E.

Infect Immun. 2019 Jul 8. pii: IAI.00326-19. doi: 10.1128/IAI.00326-19. [Epub ahead of print]


Borrelia burgdorferi chemotaxis toward tick protein Salp12 contributes to acquisition.

Murfin KE, Kleinbard R, Aydin M, Salazar SA, Fikrig E.

Ticks Tick Borne Dis. 2019 Jun 8. pii: S1877-959X(19)30095-0. doi: 10.1016/j.ttbdis.2019.06.002. [Epub ahead of print]


Aedes aegypti NeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils.

Hastings AK, Uraki R, Gaitsch H, Dhaliwal K, Stanley S, Sproch H, Williamson E, MacNeil T, Marin-Lopez A, Hwang J, Wang Y, Grover JR, Fikrig E.

J Virol. 2019 Jun 14;93(13). pii: e00395-19. doi: 10.1128/JVI.00395-19. Print 2019 Jul 1.


ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp.

Wang D, Zhang Z, Cui S, Zhao Y, Craft S, Fikrig E, You F.

J Biol Chem. 2019 May 10;294(19):7787-7796. doi: 10.1074/jbc.RA118.006321. Epub 2019 Mar 21.


HIPK2 is necessary for type I interferon-mediated antiviral immunity.

Cao L, Yang G, Gao S, Jing C, Montgomery RR, Yin Y, Wang P, Fikrig E, You F.

Sci Signal. 2019 Mar 19;12(573). pii: eaau4604. doi: 10.1126/scisignal.aau4604.


Loss of the TAM Receptor Axl Ameliorates Severe Zika Virus Pathogenesis and Reduces Apoptosis in Microglia.

Hastings AK, Hastings K, Uraki R, Hwang J, Gaitsch H, Dhaliwal K, Williamson E, Fikrig E.

iScience. 2019 Mar 29;13:339-350. doi: 10.1016/j.isci.2019.03.003. Epub 2019 Mar 5.


Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice.

Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E.

Nat Microbiol. 2019 Jun;4(6):948-955. doi: 10.1038/s41564-019-0385-x. Epub 2019 Mar 11.


The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato.

Coumou J, Wagemakers A, Narasimhan S, Schuijt TJ, Ersoz JI, Oei A, de Boer OJ, Roelofs JJTH, Fikrig E, Hovius JW.

Sci Rep. 2019 Feb 5;9(1):1431. doi: 10.1038/s41598-018-37922-8.


Modeling Arboviral Infection in Mice Lacking the Interferon Alpha/Beta Receptor.

Marín-Lopez A, Calvo-Pinilla E, Moreno S, Utrilla-Trigo S, Nogales A, Brun A, Fikrig E, Ortego J.

Viruses. 2019 Jan 8;11(1). pii: E35. doi: 10.3390/v11010035. Review.


Rev-erb Agonist Inhibits Chikungunya and O'nyong'nyong Virus Replication.

Hwang J, Jiang A, Fikrig E.

Open Forum Infect Dis. 2018 Nov 20;5(12):ofy315. doi: 10.1093/ofid/ofy315. eCollection 2018 Dec.


Host-specific expression of Ixodes scapularis salivary genes.

Narasimhan S, Booth CJ, DePonte K, Wu MJ, Liang X, Mohanty S, Kantor F, Fikrig E.

Ticks Tick Borne Dis. 2019 Feb;10(2):386-397. doi: 10.1016/j.ttbdis.2018.12.001. Epub 2018 Dec 3.


A potent prolyl tRNA synthetase inhibitor antagonizes Chikungunya and Dengue viruses.

Hwang J, Jiang A, Fikrig E.

Antiviral Res. 2019 Jan;161:163-168. doi: 10.1016/j.antiviral.2018.11.017. Epub 2018 Dec 3.


Direct Diagnostic Tests for Lyme Disease.

Schutzer SE, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder JL, Steere AC, Witkowski J, Wong SJ, Branda JA.

Clin Infect Dis. 2019 Mar 5;68(6):1052-1057. doi: 10.1093/cid/ciy614.


Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance.

Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF.

Trends Immunol. 2018 Nov;39(11):862-873. doi: 10.1016/ Epub 2018 Oct 6. Review.


MiR-221 negatively regulates innate anti-viral response.

Du H, Cui S, Li Y, Yang G, Wang P, Fikrig E, You F.

PLoS One. 2018 Aug 8;13(8):e0200385. doi: 10.1371/journal.pone.0200385. eCollection 2018.


A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission.

Schleicher TR, Yang J, Freudzon M, Rembisz A, Craft S, Hamilton M, Graham M, Mlambo G, Tripathi AK, Li Y, Cresswell P, Sinnis P, Dimopoulos G, Fikrig E.

Nat Commun. 2018 Jul 25;9(1):2908. doi: 10.1038/s41467-018-05374-3.


Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection.

Baeza Garcia A, Siu E, Sun T, Exler V, Brito L, Hekele A, Otten G, Augustijn K, Janse CJ, Ulmer JB, Bernhagen J, Fikrig E, Geall A, Bucala R.

Nat Commun. 2018 Jul 13;9(1):2714. doi: 10.1038/s41467-018-05041-7.


Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization.

Moss CE, Robson A, Fikrig E, Narasimhan S.

J Vis Exp. 2018 Jun 1;(136). doi: 10.3791/57758.


UBXN3B positively regulates STING-mediated antiviral immune responses.

Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P.

Nat Commun. 2018 Jun 13;9(1):2329. doi: 10.1038/s41467-018-04759-8.


Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells.

Silver AC, Buckley SM, Hughes ME, Hastings AK, Nitabach MN, Fikrig E.

Heliyon. 2018 Mar 20;4(3):e00579. doi: 10.1016/j.heliyon.2018.e00579. eCollection 2018 Mar.


Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism.

Heipertz EL, Harper J, Lopez CA, Fikrig E, Hughes ME, Walker WE.

J Immunol. 2018 Jul 1;201(1):193-201. doi: 10.4049/jimmunol.1701677. Epub 2018 May 14.


Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice.

Dragovic SM, Agunbiade TA, Freudzon M, Yang J, Hastings AK, Schleicher TR, Zhou X, Craft S, Chuang YM, Gonzalez F, Li Y, Hrebikova G, Tripathi A, Mlambo G, Almeras L, Ploss A, Dimopoulos G, Fikrig E.

Cell Host Microbe. 2018 Apr 11;23(4):523-535.e5. doi: 10.1016/j.chom.2018.03.008.


Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus.

Beloor J, Maes N, Ullah I, Uchil P, Jackson A, Fikrig E, Lee SK, Kumar P.

Cell Host Microbe. 2018 Apr 11;23(4):549-556.e3. doi: 10.1016/j.chom.2018.03.001. Epub 2018 Mar 29.


Altered vector competence in an experimental mosquito-mouse transmission model of Zika infection.

Uraki R, Hastings AK, Gloria-Soria A, Powell JR, Fikrig E.

PLoS Negl Trop Dis. 2018 Mar 5;12(3):e0006350. doi: 10.1371/journal.pntd.0006350. eCollection 2018 Mar.


Human Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species.

Krause PJ, Carroll M, Fedorova N, Brancato J, Dumouchel C, Akosa F, Narasimhan S, Fikrig E, Lane RS.

PLoS One. 2018 Feb 8;13(2):e0191725. doi: 10.1371/journal.pone.0191725. eCollection 2018.


Type I interferons instigate fetal demise after Zika virus infection.

Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A.

Sci Immunol. 2018 Jan 5;3(19). pii: eaao1680. doi: 10.1126/sciimmunol.aao1680.


Advances in Serodiagnostic Testing for Lyme Disease Are at Hand.

Branda JA, Body BA, Boyle J, Branson BM, Dattwyler RJ, Fikrig E, Gerald NJ, Gomes-Solecki M, Kintrup M, Ledizet M, Levin AE, Lewinski M, Liotta LA, Marques A, Mead PS, Mongodin EF, Pillai S, Rao P, Robinson WH, Roth KM, Schriefer ME, Slezak T, Snyder J, Steere AC, Witkowski J, Wong SJ, Schutzer SE.

Clin Infect Dis. 2018 Mar 19;66(7):1133-1139. doi: 10.1093/cid/cix943.


Artificial Infection of Ticks with Borrelia burgdorferi Using a Microinjection Method and Their Detection In Vivo Using Quantitative PCR Targeting flaB RNA.

Smith AA, Yang X, Fikrig E, Pal U.

Methods Mol Biol. 2018;1690:105-114. doi: 10.1007/978-1-4939-7383-5_9.


Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization.

Narasimhan S, Schuijt TJ, Abraham NM, Rajeevan N, Coumou J, Graham M, Robson A, Wu MJ, Daffre S, Hovius JW, Fikrig E.

Nat Commun. 2017 Aug 4;8(1):184. doi: 10.1038/s41467-017-00208-0.


Zika Virus and Sexual Transmission: A New Route of Transmission for Mosquito-borne Flaviviruses

Hastings AK, Fikrig E.

Yale J Biol Med. 2017 Jun 23;90(2):325-330. eCollection 2017 Jun. Review.


Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.

Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA.

Nature. 2017 Jun 29;546(7660):667-670. doi: 10.1038/nature22967. Epub 2017 Jun 21.


Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets.

Murfin KE, Fikrig E.

Front Cell Infect Microbiol. 2017 Jun 6;7:222. doi: 10.3389/fcimb.2017.00222. eCollection 2017. No abstract available.


An essential role of PI3K in the control of West Nile virus infection.

Wang L, Yang L, Fikrig E, Wang P.

Sci Rep. 2017 Jun 16;7(1):3724. doi: 10.1038/s41598-017-03912-5.


Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice.

Uraki R, Jurado KA, Hwang J, Szigeti-Buck K, Horvath TL, Iwasaki A, Fikrig E.

J Infect Dis. 2017 Jun 1;215(11):1720-1724. doi: 10.1093/infdis/jix204.


A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus.

Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Sutton E, Heisig M, Jacobs-Wagner C, Fikrig E.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00113-17. doi: 10.1128/AAC.00113-17. Print 2017 Jul.


TAM Receptors Are Not Required for Zika Virus Infection in Mice.

Hastings AK, Yockey LJ, Jagger BW, Hwang J, Uraki R, Gaitsch HF, Parnell LA, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A.

Cell Rep. 2017 Apr 18;19(3):558-568. doi: 10.1016/j.celrep.2017.03.058.


Anti-Biofilm Activity of a Self-Aggregating Peptide against Streptococcus mutans.

Ansari JM, Abraham NM, Massaro J, Murphy K, Smith-Carpenter J, Fikrig E.

Front Microbiol. 2017 Mar 24;8:488. doi: 10.3389/fmicb.2017.00488. eCollection 2017.


Zika virus causes testicular atrophy.

Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E.

Sci Adv. 2017 Feb 22;3(2):e1602899. doi: 10.1126/sciadv.1602899. eCollection 2017 Feb.


Infection-derived lipids elicit an immune deficiency circuit in arthropods.

Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH.

Nat Commun. 2017 Feb 14;8:14401. doi: 10.1038/ncomms14401.


Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα.

Hu Y, O'Boyle K, Auer J, Raju S, You F, Wang P, Fikrig E, Sutton RE.

PLoS Pathog. 2017 Feb 2;13(2):e1006187. doi: 10.1371/journal.ppat.1006187. eCollection 2017 Feb.


Pathogen-mediated manipulation of arthropod microbiota to promote infection.

Abraham NM, Liu L, Jutras BL, Yadav AK, Narasimhan S, Gopalakrishnan V, Ansari JM, Jefferson KK, Cava F, Jacobs-Wagner C, Fikrig E.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E781-E790. doi: 10.1073/pnas.1613422114. Epub 2017 Jan 17.


Zika virus infection of Hofbauer cells.

Simoni MK, Jurado KA, Abrahams VM, Fikrig E, Guller S.

Am J Reprod Immunol. 2017 Feb;77(2). doi: 10.1111/aji.12613. Epub 2016 Dec 14. Review.


TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice.

Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F.

J Immunol. 2016 Dec 1;197(11):4425-4435. Epub 2016 Oct 21.


Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance.

Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F.

J Virol. 2016 Dec 16;91(1). pii: e01529-16. doi: 10.1128/JVI.01529-16. Print 2017 Jan 1.


Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection.

Conway MJ, Londono-Renteria B, Troupin A, Watson AM, Klimstra WB, Fikrig E, Colpitts TM.

PLoS Negl Trop Dis. 2016 Sep 15;10(9):e0004941. doi: 10.1371/journal.pntd.0004941. eCollection 2016 Sep.


Zika virus productively infects primary human placenta-specific macrophages.

Jurado KA, Simoni MK, Tang Z, Uraki R, Hwang J, Householder S, Wu M, Lindenbach BD, Abrahams VM, Guller S, Fikrig E.

JCI Insight. 2016 Aug 18;1(13). pii: e88461.


A novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection.

Troupin A, Londono-Renteria B, Conway MJ, Cloherty E, Jameson S, Higgs S, Vanlandingham DL, Fikrig E, Colpitts TM.

Biochim Biophys Acta. 2016 Sep;1860(9):1898-909. doi: 10.1016/j.bbagen.2016.05.033. Epub 2016 May 27.


Genetics of War and Truce between Mosquitos and Emerging Viruses.

Hwang J, Jurado KA, Fikrig E.

Cell Host Microbe. 2016 May 11;19(5):583-7. doi: 10.1016/j.chom.2016.04.009.

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