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Enolase From Aspergillus fumigatus Is a Moonlighting Protein That Binds the Human Plasma Complement Proteins Factor H, FHL-1, C4BP, and Plasminogen.

Dasari P, Koleci N, Shopova IA, Wartenberg D, Beyersdorf N, Dietrich S, Sahagún-Ruiz A, Figge MT, Skerka C, Brakhage AA, Zipfel PF.

Front Immunol. 2019 Nov 22;10:2573. doi: 10.3389/fimmu.2019.02573. eCollection 2019.


Regulation of the Germinal Center Reaction and Somatic Hypermutation Dynamics by Homologous Recombination.

Hirth G, Svensson CM, Böttcher K, Ullrich S, Figge MT, Jungnickel B.

J Immunol. 2019 Sep 15;203(6):1493-1501. doi: 10.4049/jimmunol.1900483. Epub 2019 Aug 9.


A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies.

Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS.

Biomaterials. 2019 Nov;220:119396. doi: 10.1016/j.biomaterials.2019.119396. Epub 2019 Aug 2.


The geographical region of origin determines the phagocytic vulnerability of Lichtheimia strains.

Hassan MIA, Cseresnyes Z, Al-Zaben N, Dahse HM, Vilela de Oliveira RJ, Walther G, Voigt K, Figge MT.

Environ Microbiol. 2019 Dec;21(12):4563-4581. doi: 10.1111/1462-2920.14752. Epub 2019 Aug 5.


Automated tracking of label-free cells with enhanced recognition of whole tracks.

Al-Zaben N, Medyukhina A, Dietrich S, Marolda A, Hünniger K, Kurzai O, Figge MT.

Sci Rep. 2019 Mar 1;9(1):3317. doi: 10.1038/s41598-019-39725-x.


Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation.

Kresinsky A, Schnöder TM, Jacobsen ID, Rauner M, Hofbauer LC, Ast V, König R, Hoffmann B, Svensson CM, Figge MT, Hilger I, Heidel FH, Böhmer FD, Müller JP.

Oncogene. 2019 Jun;38(24):4773-4787. doi: 10.1038/s41388-019-0757-y. Epub 2019 Feb 28.


Comparative Assessment of Aspergillosis by Virtual Infection Modeling in Murine and Human Lung.

Blickensdorf M, Timme S, Figge MT.

Front Immunol. 2019 Feb 5;10:142. doi: 10.3389/fimmu.2019.00142. eCollection 2019.


Coding of Experimental Conditions in Microfluidic Droplet Assays Using Colored Beads and Machine Learning Supported Image Analysis.

Svensson CM, Shvydkiv O, Dietrich S, Mahler L, Weber T, Choudhary M, Tovar M, Figge MT, Roth M.

Small. 2019 Jan;15(4):e1802384. doi: 10.1002/smll.201802384. Epub 2018 Dec 14.


Aspf2 From Aspergillus fumigatus Recruits Human Immune Regulators for Immune Evasion and Cell Damage.

Dasari P, Shopova IA, Stroe M, Wartenberg D, Martin-Dahse H, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF.

Front Immunol. 2018 Aug 3;9:1635. doi: 10.3389/fimmu.2018.01635. eCollection 2018.


Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice.

Schaarschmidt B, Vlaic S, Medyukhina A, Neugebauer S, Nietzsche S, Gonnert FA, Rödel J, Singer M, Kiehntopf M, Figge MT, Jacobsen ID, Bauer M, Press AT.

Theranostics. 2018 Jun 13;8(14):3766-3780. doi: 10.7150/thno.24333. eCollection 2018.


Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease.

Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amann K, Coldewey SM.

Front Immunol. 2018 Jun 25;9:1459. doi: 10.3389/fimmu.2018.01459. eCollection 2018.


Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers.

Allert S, Förster TM, Svensson CM, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, Mogavero S, Hube B.

MBio. 2018 Jun 5;9(3). pii: e00915-18. doi: 10.1128/mBio.00915-18.


Quantitative Simulations Predict Treatment Strategies Against Fungal Infections in Virtual Neutropenic Patients.

Timme S, Lehnert T, Prauße MTE, Hünniger K, Leonhardt I, Kurzai O, Figge MT.

Front Immunol. 2018 Apr 4;9:667. doi: 10.3389/fimmu.2018.00667. eCollection 2018.


Predictive Virtual Infection Modeling of Fungal Immune Evasion in Human Whole Blood.

Prauße MTE, Lehnert T, Timme S, Hünniger K, Leonhardt I, Kurzai O, Figge MT.

Front Immunol. 2018 Mar 21;9:560. doi: 10.3389/fimmu.2018.00560. eCollection 2018.


Quantitative bioimage analysis of cell characteristics.

Figge MT.

Cytometry A. 2018 Mar;93(3):278-280. doi: 10.1002/cyto.a.23349. No abstract available.


Dimensionality of Motion and Binding Valency Govern Receptor-Ligand Kinetics As Revealed by Agent-Based Modeling.

Lehnert T, Figge MT.

Front Immunol. 2017 Nov 30;8:1692. doi: 10.3389/fimmu.2017.01692. eCollection 2017.


Mast cells acquire MHCII from dendritic cells during skin inflammation.

Dudeck J, Medyukhina A, Fröbel J, Svensson CM, Kotrba J, Gerlach M, Gradtke AC, Schröder B, Speier S, Figge MT, Dudeck A.

J Exp Med. 2017 Dec 4;214(12):3791-3811. doi: 10.1084/jem.20160783. Epub 2017 Oct 30.


Untangling cell tracks: Quantifying cell migration by time lapse image data analysis.

Svensson CM, Medyukhina A, Belyaev I, Al-Zaben N, Figge MT.

Cytometry A. 2018 Mar;93(3):357-370. doi: 10.1002/cyto.a.23249. Epub 2017 Oct 4. Review.


Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells.

Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Coldewey SM, Cseresnyés Z, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF.

J Infect Dis. 2018 Jan 17;217(3):358-370. doi: 10.1093/infdis/jix305.


Hessian-based quantitative image analysis of host-pathogen confrontation assays.

Cseresnyes Z, Kraibooj K, Figge MT.

Cytometry A. 2018 Mar;93(3):346-356. doi: 10.1002/cyto.a.23201. Epub 2017 Sep 15.


Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data.

Svensson CM, Hoffmann B, Irmler IM, Straßburger M, Figge MT, Saluz HP.

Sci Rep. 2017 Mar 14;7:44434. doi: 10.1038/srep44434.


Migration and interaction tracking for quantitative analysis of phagocyte-pathogen confrontation assays.

Brandes S, Dietrich S, Hünniger K, Kurzai O, Figge MT.

Med Image Anal. 2017 Feb;36:172-183. doi: 10.1016/ Epub 2016 Nov 25.


Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy.

Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Gunzer M.

J Am Soc Nephrol. 2017 Feb;28(2):452-459. doi: 10.1681/ASN.2016020232. Epub 2016 Aug 3.


Deciphering the Counterplay of Aspergillus fumigatus Infection and Host Inflammation by Evolutionary Games on Graphs.

Pollmächer J, Timme S, Schuster S, Brakhage AA, Zipfel PF, Figge MT.

Sci Rep. 2016 Jun 13;6:27807. doi: 10.1038/srep27807.


FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.

Buhlmann D, Eberhardt HU, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C.

J Immunol. 2016 Jul 15;197(2):620-9. doi: 10.4049/jimmunol.1600053. Epub 2016 Jun 8.


Automated Classification of Circulating Tumor Cells and the Impact of Interobsever Variability on Classifier Training and Performance.

Svensson CM, Hübler R, Figge MT.

J Immunol Res. 2015;2015:573165. doi: 10.1155/2015/573165. Epub 2015 Oct 4.


Human neutrophils dump Candida glabrata after intracellular killing.

Essig F, Hünniger K, Dietrich S, Figge MT, Kurzai O.

Fungal Genet Biol. 2015 Nov;84:37-40. doi: 10.1016/j.fgb.2015.09.008. Epub 2015 Sep 16.


Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus.

Mattern DJ, Schoeler H, Weber J, Novohradská S, Kraibooj K, Dahse HM, Hillmann F, Valiante V, Figge MT, Brakhage AA.

Appl Microbiol Biotechnol. 2015 Dec;99(23):10151-61. doi: 10.1007/s00253-015-6898-1. Epub 2015 Aug 18.


Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions.

Lehnert T, Timme S, Pollmächer J, Hünniger K, Kurzai O, Figge MT.

Front Microbiol. 2015 Jun 19;6:608. doi: 10.3389/fmicb.2015.00608. eCollection 2015.


Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm.

Kraibooj K, Schoeler H, Svensson CM, Brakhage AA, Figge MT.

Front Microbiol. 2015 Jun 9;6:549. doi: 10.3389/fmicb.2015.00549. eCollection 2015.


Deciphering chemokine properties by a hybrid agent-based model of Aspergillus fumigatus infection in human alveoli.

Pollmächer J, Figge MT.

Front Microbiol. 2015 May 28;6:503. doi: 10.3389/fmicb.2015.00503. eCollection 2015.


Image-based systems biology.

Figge MT, Murphy RF.

Cytometry A. 2015 Jun;87(6):459-61. doi: 10.1002/cyto.a.22663. No abstract available.


Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes.

Duggan S, Essig F, Hünniger K, Mokhtari Z, Bauer L, Lehnert T, Brandes S, Häder A, Jacobsen ID, Martin R, Figge MT, Kurzai O.

Cell Microbiol. 2015 Sep;17(9):1259-76. doi: 10.1111/cmi.12443. Epub 2015 May 5.


Quantitative image analysis of cell colocalization in murine bone marrow.

Mokhtari Z, Mech F, Zehentmeier S, Hauser AE, Figge MT.

Cytometry A. 2015 Jun;87(6):503-12. doi: 10.1002/cyto.a.22641. Epub 2015 Feb 4.


Image-based systems biology of infection.

Medyukhina A, Timme S, Mokhtari Z, Figge MT.

Cytometry A. 2015 Jun;87(6):462-70. doi: 10.1002/cyto.a.22638. Epub 2015 Jan 29. Review.


A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a.

Hünniger K, Bieber K, Martin R, Lehnert T, Figge MT, Löffler J, Guo RF, Riedemann NC, Kurzai O.

J Immunol. 2015 Feb 1;194(3):1199-210. doi: 10.4049/jimmunol.1401845. Epub 2014 Dec 24.


Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils.

Brandes S, Mokhtari Z, Essig F, Hünniger K, Kurzai O, Figge MT.

Med Image Anal. 2015 Feb;20(1):34-51. doi: 10.1016/ Epub 2014 Nov 8.


Agent-based model of human alveoli predicts chemotactic signaling by epithelial cells during early Aspergillus fumigatus infection.

Pollmächer J, Figge MT.

PLoS One. 2014 Oct 31;9(10):e111630. doi: 10.1371/journal.pone.0111630. eCollection 2014.


Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis.

Kraibooj K, Park HR, Dahse HM, Skerka C, Voigt K, Figge MT.

Mycoses. 2014 Dec;57 Suppl 3:56-66. doi: 10.1111/myc.12237. Epub 2014 Sep 1.


18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis.

Irmler IM, Gebhardt P, Hoffmann B, Opfermann T, Figge MT, Saluz HP, Kamradt T.

Arthritis Res Ther. 2014 Jul 22;16(4):R155. doi: 10.1186/ar4670.


A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood.

Hünniger K, Lehnert T, Bieber K, Martin R, Figge MT, Kurzai O.

PLoS Comput Biol. 2014 Feb 20;10(2):e1003479. doi: 10.1371/journal.pcbi.1003479. eCollection 2014 Feb.


Automated characterization and parameter-free classification of cell tracks based on local migration behavior.

Mokhtari Z, Mech F, Zitzmann C, Hasenberg M, Gunzer M, Figge MT.

PLoS One. 2013 Dec 6;8(12):e80808. doi: 10.1371/journal.pone.0080808. eCollection 2013. Erratum in: PLoS One. 2014;9(12):e115158.


Real-time image processing for label-free enrichment of Actinobacteria cultivated in picolitre droplets.

Zang E, Brandes S, Tovar M, Martin K, Mech F, Horbert P, Henkel T, Figge MT, Roth M.

Lab Chip. 2013 Sep 21;13(18):3707-13. doi: 10.1039/c3lc50572c.


Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions.

Coelho FM, Natale D, Soriano SF, Hons M, Swoger J, Mayer J, Danuser R, Scandella E, Pieczyk M, Zerwes HG, Junt T, Sailer AW, Ludewig B, Sharpe J, Figge MT, Stein JV.

Blood. 2013 May 16;121(20):4101-9. doi: 10.1182/blood-2012-10-465336. Epub 2013 Apr 4.


Germinal center B cells govern their own fate via antibody feedback.

Zhang Y, Meyer-Hermann M, George LA, Figge MT, Khan M, Goodall M, Young SP, Reynolds A, Falciani F, Waisman A, Notley CA, Ehrenstein MR, Kosco-Vilbois M, Toellner KM.

J Exp Med. 2013 Mar 11;210(3):457-64. doi: 10.1084/jem.20120150. Epub 2013 Feb 18.


Quality control of mitochondria during aging: is there a good and a bad side of mitochondrial dynamics?

Figge MT, Osiewacz HD, Reichert AS.

Bioessays. 2013 Apr;35(4):314-22. doi: 10.1002/bies.201200125. Epub 2013 Jan 29.


Systems biology of microbial infection.

Guthke R, Linde J, Mech F, Figge MT.

Front Microbiol. 2012 Sep 12;3:328. doi: 10.3389/fmicb.2012.00328. eCollection 2012. No abstract available.


Deceleration of fusion-fission cycles improves mitochondrial quality control during aging.

Figge MT, Reichert AS, Meyer-Hermann M, Osiewacz HD.

PLoS Comput Biol. 2012;8(6):e1002576. doi: 10.1371/journal.pcbi.1002576. Epub 2012 Jun 28.


Agent-based modeling approach of immune defense against spores of opportunistic human pathogenic fungi.

Tokarski C, Hummert S, Mech F, Figge MT, Germerodt S, Schroeter A, Schuster S.

Front Microbiol. 2012 Apr 26;3:129. doi: 10.3389/fmicb.2012.00129. eCollection 2012.


Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus.

Mech F, Thywissen A, Guthke R, Brakhage AA, Figge MT.

PLoS One. 2011 May 5;6(5):e19591. doi: 10.1371/journal.pone.0019591.

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