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Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration.

Bargehr J, Ong LP, Colzani M, Davaapil H, Hofsteen P, Bhandari S, Gambardella L, Le Novère N, Iyer D, Sampaziotis F, Weinberger F, Bertero A, Leonard A, Bernard WG, Martinson A, Figg N, Regnier M, Bennett MR, Murry CE, Sinha S.

Nat Biotechnol. 2019 Aug;37(8):895-906. doi: 10.1038/s41587-019-0197-9. Epub 2019 Aug 2.


Glucagon-Like Peptide-1-Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion.

Giblett JP, Axell RG, White PA, Aetesam-Ur-Rahman M, Clarke SJ, Figg N, Bennett MR, West NEJ, Hoole SP.

JACC Basic Transl Sci. 2019 Apr 29;4(2):222-233. doi: 10.1016/j.jacbts.2018.12.002. eCollection 2019 Apr.


The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.

Burzynski LC, Humphry M, Pyrillou K, Wiggins KA, Chan JNE, Figg N, Kitt LL, Summers C, Tatham KC, Martin PB, Bennett MR, Clarke MCH.

Immunity. 2019 Apr 16;50(4):1033-1042.e6. doi: 10.1016/j.immuni.2019.03.003. Epub 2019 Mar 26.


Bayesian Inference-Based Estimation of Normal Aortic, Aneurysmal and Atherosclerotic Tissue Mechanical Properties: From Material Testing, Modeling and Histology.

Wang S, Tokgoz A, Huang Y, Zhang Y, Feng J, Sastry P, Sun C, Figg N, Lu Q, Sutcliffe MPF, Teng Z, Gillard JH.

IEEE Trans Biomed Eng. 2019 Aug;66(8):2269-2278. doi: 10.1109/TBME.2018.2886681. Epub 2019 Jan 25.


GLP-1 Is a Coronary Artery Vasodilator in Humans.

Clarke SJ, Giblett JP, Yang LL, Hubsch A, Zhao T, Aetesam-Ur-Rahman M, West NEJ, O'Sullivan M, Figg N, Bennett M, Wewer Albrechtsen NJ, Deacon CF, Cheriyan J, Hoole SP.

J Am Heart Assoc. 2018 Nov 20;7(22):e010321. doi: 10.1161/JAHA.118.010321.


Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness.

Maskari RA, Hardege I, Cleary S, Figg N, Li Y, Siew K, Khir A, Yu Y, Liu P, Wilkinson I, O'Shaughnessy K, Yasmin.

Eur J Hum Genet. 2018 Nov;26(11):1648-1657. doi: 10.1038/s41431-018-0226-z. Epub 2018 Aug 8.


The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness.

Yasmin, Maskari RA, McEniery CM, Cleary SE, Li Y, Siew K, Figg NL, Khir AW, Cockcroft JR, Wilkinson IB, O'Shaughnessy KM.

Sci Rep. 2018 Jun 4;8(1):8550. doi: 10.1038/s41598-018-25851-5.


Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice.

Foote K, Reinhold J, Yu EPK, Figg NL, Finigan A, Murphy MP, Bennett MR.

Aging Cell. 2018 Aug;17(4):e12773. doi: 10.1111/acel.12773. Epub 2018 May 9.


Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis.

Shah A, Gray K, Figg N, Finigan A, Starks L, Bennett M.

Circulation. 2018 Oct 2;138(14):1446-1462. doi: 10.1161/CIRCULATIONAHA.117.033249.


FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13).

Yu H, Fellows A, Foote K, Yang Z, Figg N, Littlewood T, Bennett M.

Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):555-565. doi: 10.1161/ATVBAHA.117.310502. Epub 2018 Jan 11.


Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels.

Hardege I, Long L, Al Maskari R, Figg N, O'Shaughnessy KM.

Clin Sci (Lond). 2018 Jan 16;132(1):145-156. doi: 10.1042/CS20171285. Print 2018 Jan 16.


Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness.

Yu EPK, Reinhold J, Yu H, Starks L, Uryga AK, Foote K, Finigan A, Figg N, Pung YF, Logan A, Murphy MP, Bennett M.

Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):2322-2332. doi: 10.1161/ATVBAHA.117.310042. Epub 2017 Sep 28. Erratum in: Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):e135.


Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.

Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z.

Nat Med. 2017 May;23(5):601-610. doi: 10.1038/nm.4315. Epub 2017 Apr 17.


Vascular Imaging With 18F-Fluorodeoxyglucose Positron Emission Tomography Is Influenced by Hypoxia.

Joshi FR, Manavaki R, Fryer TD, Figg NL, Sluimer JC, Aigbirhio FI, Davenport AP, Kirkpatrick PJ, Warburton EA, Rudd JH.

J Am Coll Cardiol. 2017 Apr 11;69(14):1873-1874. doi: 10.1016/j.jacc.2017.01.050. No abstract available.


Detection of Atherosclerotic Inflammation by 68Ga-DOTATATE PET Compared to [18F]FDG PET Imaging.

Tarkin JM, Joshi FR, Evans NR, Chowdhury MM, Figg NL, Shah AV, Starks LT, Martin-Garrido A, Manavaki R, Yu E, Kuc RE, Grassi L, Kreuzhuber R, Kostadima MA, Frontini M, Kirkpatrick PJ, Coughlin PA, Gopalan D, Fryer TD, Buscombe JR, Groves AM, Ouwehand WH, Bennett MR, Warburton EA, Davenport AP, Rudd JH.

J Am Coll Cardiol. 2017 Apr 11;69(14):1774-1791. doi: 10.1016/j.jacc.2017.01.060.


The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.

Pung YF, Chilian WM, Bennett MR, Figg N, Kamarulzaman MH.

Am J Physiol Heart Circ Physiol. 2017 Mar 1;312(3):H541-H545. doi: 10.1152/ajpheart.00653.2016. Epub 2016 Dec 16.


A missense TGFB2 variant p.(Arg320Cys) causes a paradoxical and striking increase in aortic TGFB1/2 expression.

Al Maskari R, Yasmin, Cleary S, Figg N, Mehta S, Rassl D, Wilkinson I, O'Shaughnessy KM.

Eur J Hum Genet. 2016 Jan;25(1):157-160. doi: 10.1038/ejhg.2016.143. Epub 2016 Oct 26.


Quantification of Apoptosis in Mouse Atherosclerotic Lesions.

Figg NL, Bennett MR.

Methods Mol Biol. 2015;1339:191-9. doi: 10.1007/978-1-4939-2929-0_13.


Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability.

Wang J, Uryga AK, Reinhold J, Figg N, Baker L, Finigan A, Gray K, Kumar S, Clarke M, Bennett M.

Circulation. 2015 Nov 17;132(20):1909-19. doi: 10.1161/CIRCULATIONAHA.115.016457. Epub 2015 Sep 28.


Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells.

Hardege I, Xu S, Gordon RD, Thompson AJ, Figg N, Stowasser M, Murrell-Lagnado R, O'Shaughnessy KM.

Mol Endocrinol. 2015 Oct;29(10):1522-30. doi: 10.1210/me.2015-1195. Epub 2015 Sep 4.


Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.

Schumacher FR, Siew K, Zhang J, Johnson C, Wood N, Cleary SE, Al Maskari RS, Ferryman JT, Hardege I, Yasmin, Figg NL, Enchev R, Knebel A, O'Shaughnessy KM, Kurz T.

EMBO Mol Med. 2015 Oct;7(10):1285-306. doi: 10.15252/emmm.201505444.


LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal.

Shaikh LH, Zhou J, Teo AE, Garg S, Neogi SG, Figg N, Yeo GS, Yu H, Maguire JJ, Zhao W, Bennett MR, Azizan EA, Davenport AP, McKenzie G, Brown MJ.

J Clin Endocrinol Metab. 2015 Jun;100(6):E836-44. doi: 10.1210/jc.2015-1734. Epub 2015 Apr 27.


Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B.

Vujic A, Robinson EL, Ito M, Haider S, Ackers-Johnson M, See K, Methner C, Figg N, Brien P, Roderick HL, Skepper J, A Ferguson-Smith, Foo RS.

J Mol Cell Cardiol. 2015 May;82:174-83. doi: 10.1016/j.yjmcc.2015.03.007. Epub 2015 Mar 14.


DACH1, a zona glomerulosa selective gene in the human adrenal, activates transforming growth factor-β signaling and suppresses aldosterone secretion.

Zhou J, Shaikh LH, Neogi SG, McFarlane I, Zhao W, Figg N, Brighton CA, Maniero C, Teo AE, Azizan EA, Brown MJ.

Hypertension. 2015 May;65(5):1103-10. doi: 10.1161/HYP.0000000000000025. Epub 2015 Mar 16.


Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation.

Patel MN, Bernard WG, Milev NB, Cawthorn WP, Figg N, Hart D, Prieur X, Virtue S, Hegyi K, Bonnafous S, Bailly-Maitre B, Chu Y, Griffin JL, Mallat Z, Considine RV, Tran A, Gual P, Takeuchi O, Akira S, Vidal-Puig A, Bennett MR, Sethi JK.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):506-11. doi: 10.1073/pnas.1414536112. Epub 2014 Dec 24.


Effects of DNA damage in smooth muscle cells in atherosclerosis.

Gray K, Kumar S, Figg N, Harrison J, Baker L, Mercer J, Littlewood T, Bennett M.

Circ Res. 2015 Feb 27;116(5):816-26. doi: 10.1161/CIRCRESAHA.116.304921. Epub 2014 Dec 18.


Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis.

Tucka J, Yu H, Gray K, Figg N, Maguire J, Lam B, Bennett M, Littlewood T.

Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2421-8. doi: 10.1161/ATVBAHA.114.304284. Epub 2014 Sep 18.


Deletion of chromosome 9p21 noncoding cardiovascular risk interval in mice alters Smad2 signaling and promotes vascular aneurysm.

Loinard C, Basatemur G, Masters L, Baker L, Harrison J, Figg N, Vilar J, Sage AP, Mallat Z.

Circ Cardiovasc Genet. 2014 Dec;7(6):799-805. doi: 10.1161/CIRCGENETICS.114.000696. Epub 2014 Aug 30.


Response to letter regarding article, "Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans".

Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JJ, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR.

Circulation. 2014 Mar 25;129(12):e408. doi: 10.1161/CIRCULATIONAHA.113.008032. No abstract available.


Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans.

Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JC, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR.

Circulation. 2013 Aug 13;128(7):702-12. doi: 10.1161/CIRCULATIONAHA.113.002271. Epub 2013 Jul 10.


Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis.

Gorenne I, Kumar S, Gray K, Figg N, Yu H, Mercer J, Bennett M.

Circulation. 2013 Jan 22;127(3):386-96. doi: 10.1161/CIRCULATIONAHA.112.124404. Epub 2012 Dec 7.


The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE(-/-) mice.

Mercer JR, Gray K, Figg N, Kumar S, Bennett MR.

Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2461-7. doi: 10.1161/ATVBAHA.112.251322. Epub 2012 Aug 2. Erratum in: Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):e148.


Poor maternal nutrition programmes a pro-atherosclerotic phenotype in ApoE-/- mice.

Blackmore HL, Piekarz AV, Fernandez-Twinn DS, Mercer JR, Figg N, Bennett M, Ozanne SE.

Clin Sci (Lond). 2012 Aug 1;123(4):251-7. doi: 10.1042/CS20110487.


Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1.

Siggens L, Figg N, Bennett M, Foo R.

FASEB J. 2012 May;26(5):2117-24. doi: 10.1096/fj.11-197525. Epub 2012 Feb 1.


The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis.

Gaspar-Pereira S, Fullard N, Townsend PA, Banks PS, Ellis EL, Fox C, Maxwell AG, Murphy LB, Kirk A, Bauer R, Caamaño JH, Figg N, Foo RS, Mann J, Mann DA, Oakley F.

Am J Pathol. 2012 Mar;180(3):929-39. doi: 10.1016/j.ajpath.2011.11.007. Epub 2011 Dec 30.


The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice.

Mercer JR, Yu E, Figg N, Cheng KK, Prime TA, Griffin JL, Masoodi M, Vidal-Puig A, Murphy MP, Bennett MR.

Free Radic Biol Med. 2012 Mar 1;52(5):841-9. doi: 10.1016/j.freeradbiomed.2011.11.026. Epub 2011 Dec 14.


Smooth muscle cell apoptosis promotes vessel remodeling and repair via activation of cell migration, proliferation, and collagen synthesis.

Yu H, Clarke MC, Figg N, Littlewood TD, Bennett MR.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2402-9. doi: 10.1161/ATVBAHA.111.235622.


Bone marrow-derived smooth muscle-like cells are infrequent in advanced primary atherosclerotic plaques but promote atherosclerosis.

Yu H, Stoneman V, Clarke M, Figg N, Xin HB, Kotlikoff M, Littlewood T, Bennett M.

Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1291-9. doi: 10.1161/ATVBAHA.110.218578. Epub 2011 Mar 3.


The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4.

Glover M, Mercier Zuber A, Figg N, O'Shaughnessy KM.

Can J Physiol Pharmacol. 2010 Oct;88(10):986-95. doi: 10.1139/y10-080.


DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome.

Mercer JR, Cheng KK, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal-Puig A, Logan A, Murphy MP, Bennett M.

Circ Res. 2010 Oct 15;107(8):1021-31. doi: 10.1161/CIRCRESAHA.110.218966. Epub 2010 Aug 12. Erratum in: Circ Res. 2011 Jan 7;108(1):e2.


High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.

Choy MK, Movassagh M, Siggens L, Vujic A, Goddard M, Sánchez A, Perkins N, Figg N, Bennett M, Carroll J, Foo R.

Genome Med. 2010 Jun 14;2(6):37. doi: 10.1186/gm158.


Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging.

Ragnauth CD, Warren DT, Liu Y, McNair R, Tajsic T, Figg N, Shroff R, Skepper J, Shanahan CM.

Circulation. 2010 May 25;121(20):2200-10. doi: 10.1161/CIRCULATIONAHA.109.902056. Epub 2010 May 10.


Evaluation of translocator protein quantification as a tool for characterising macrophage burden in human carotid atherosclerosis.

Bird JL, Izquierdo-Garcia D, Davies JR, Rudd JH, Probst KC, Figg N, Clark JC, Weissberg PL, Davenport AP, Warburton EA.

Atherosclerosis. 2010 Jun;210(2):388-91. doi: 10.1016/j.atherosclerosis.2009.11.047. Epub 2009 Dec 4.


Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification.

Shroff RC, McNair R, Skepper JN, Figg N, Schurgers LJ, Deanfield J, Rees L, Shanahan CM.

J Am Soc Nephrol. 2010 Jan;21(1):103-12. doi: 10.1681/ASN.2009060640. Epub 2009 Dec 3.


Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes.

Harzheim D, Talasila A, Movassagh M, Foo RS, Figg N, Bootman MD, Roderick HL.

Channels (Austin). 2010 Jan-Feb;4(1):67-71. Epub 2010 Jan 17.


Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: effects of hyperlipidemia-mediated inhibition of phagocytosis.

Clarke MC, Talib S, Figg NL, Bennett MR.

Circ Res. 2010 Feb 5;106(2):363-72. doi: 10.1161/CIRCRESAHA.109.208389. Epub 2009 Nov 19.


FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.

Davies JR, Izquierdo-Garcia D, Rudd JH, Figg N, Richards HK, Bird JL, Aigbirhio FI, Davenport AP, Weissberg PL, Fryer TD, Warburton EA.

Int J Cardiovasc Imaging. 2010 Jan;26(1):41-8. doi: 10.1007/s10554-009-9506-6. Epub 2009 Sep 22.


Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis.

Shroff RC, McNair R, Figg N, Skepper JN, Schurgers L, Gupta A, Hiorns M, Donald AE, Deanfield J, Rees L, Shanahan CM.

Circulation. 2008 Oct 21;118(17):1748-57. doi: 10.1161/CIRCULATIONAHA.108.783738. Epub 2008 Oct 6.


Statins use a novel Nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells.

Mahmoudi M, Gorenne I, Mercer J, Figg N, Littlewood T, Bennett M.

Circ Res. 2008 Sep 26;103(7):717-25. doi: 10.1161/CIRCRESAHA.108.182899. Epub 2008 Aug 21.


Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration.

Clarke MC, Littlewood TD, Figg N, Maguire JJ, Davenport AP, Goddard M, Bennett MR.

Circ Res. 2008 Jun 20;102(12):1529-38. doi: 10.1161/CIRCRESAHA.108.175976. Epub 2008 May 22.


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