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Interplay between substrate recognition, 5' end tRNA processing and methylation activity of human mitochondrial RNase P.

Karasik A, Fierke CA, Koutmos M.

RNA. 2019 Aug 27. pii: rna.069310.118. doi: 10.1261/rna.069310.118. [Epub ahead of print]


Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer.

Nissim S, Leshchiner I, Mancias JD, Greenblatt MB, Maertens O, Cassa CA, Rosenfeld JA, Cox AG, Hedgepeth J, Wucherpfennig JI, Kim AJ, Henderson JE, Gonyo P, Brandt A, Lorimer E, Unger B, Prokop JW, Heidel JR, Wang XX, Ukaegbu CI, Jennings BC, Paulo JA, Gableske S, Fierke CA, Getz G, Sunyaev SR, Wade Harper J, Cichowski K, Kimmelman AC, Houvras Y, Syngal S, Williams C, Goessling W.

Nat Genet. 2019 Sep;51(9):1308-1314. doi: 10.1038/s41588-019-0475-y. Epub 2019 Aug 12.


The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases.

García-Torres D, Fierke CA.

J Biol Chem. 2019 Aug 2;294(31):11793-11804. doi: 10.1074/jbc.RA119.007438. Epub 2019 Jun 13.


A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation.

Sahoo BR, Genjo T, Nakayama TW, Stoddard AK, Ando T, Yasuhara K, Fierke CA, Ramamoorthy A.

Chem Sci. 2019 Feb 27;10(14):3976-3986. doi: 10.1039/c8sc05771k. eCollection 2019 Apr 14.


Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.

Sahoo BR, Genjo T, Bekier M, Cox SJ, Stoddard AK, Ivanova M, Yasuhara K, Fierke CA, Wang Y, Ramamoorthy A.

Chem Commun (Camb). 2018 Nov 13;54(91):12883-12886. doi: 10.1039/c8cc07921h.


Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.

Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL 3rd, Fierke CA, Mapp AK.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8960-8965. doi: 10.1073/pnas.1806202115. Epub 2018 Aug 20.


SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent.

Jennings BC, Lawton AJ, Rizk Z, Fierke CA.

Biochemistry. 2018 Jul 24;57(29):4289-4298. doi: 10.1021/acs.biochem.8b00567. Epub 2018 Jul 10.


Inner-Sphere Coordination of Divalent Metal Ion with Nucleobase in Catalytic RNA.

Liu X, Chen Y, Fierke CA.

J Am Chem Soc. 2017 Dec 6;139(48):17457-17463. doi: 10.1021/jacs.7b08755. Epub 2017 Nov 22.


HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides.

Castañeda CA, Wolfson NA, Leng KR, Kuo YM, Andrews AJ, Fierke CA.

J Biol Chem. 2017 Dec 29;292(52):21568-21577. doi: 10.1074/jbc.M117.811026. Epub 2017 Nov 6.


HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking.

Lopez JE, Haynes SE, Majmudar JD, Martin BR, Fierke CA.

J Am Chem Soc. 2017 Nov 15;139(45):16222-16227. doi: 10.1021/jacs.7b07603. Epub 2017 Nov 1.


Ion Mobility-Mass Spectrometry Reveals Evidence of Specific Complex Formation between Human Histone Deacetylase 8 and Poly-r(C)-binding Protein 1.

Niu S, Kim BC, Fierke CA, Ruotolo BT.

Int J Mass Spectrom. 2017 Sep;420:9-15. doi: 10.1016/j.ijms.2016.12.017. Epub 2016 Dec 15.


Active Site Metal Identity Alters Histone Deacetylase 8 Substrate Selectivity: A Potential Novel Regulatory Mechanism.

Castaneda CA, Lopez JE, Joseph CG, Scholle MD, Mrksich M, Fierke CA.

Biochemistry. 2017 Oct 24;56(42):5663-5670. doi: 10.1021/acs.biochem.7b00851. Epub 2017 Oct 12.


Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P.

Klemm BP, Karasik A, Kaitany KJ, Shanmuganathan A, Henley MJ, Thelen AZ, Dewar AJL, Jackson ND, Koutmos M, Fierke CA.

RNA. 2017 Dec;23(12):1860-1873. doi: 10.1261/rna.061457.117. Epub 2017 Sep 5.



Thompson RB, Fierke CA.

Methods Enzymol. 2017;589:xvii-xviii. doi: 10.1016/S0076-6879(17)30107-6. No abstract available.


Measuring and Imaging Metal Ions With Fluorescence-Based Biosensors: Speciation, Selectivity, Kinetics, and Other Issues.

Thompson RB, Fierke CA.

Methods Enzymol. 2017;589:281-299. doi: 10.1016/bs.mie.2017.01.003. Epub 2017 Mar 9.


Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues.

Temple KJ, Wright EN, Fierke CA, Gibbs RA.

Org Lett. 2016 Dec 2;18(23):6038-6041. Epub 2016 Nov 14.


Fluorescence-Based Real-Time Activity Assays to Identify RNase P Inhibitors.

Chen Y, Liu X, Wu N, Fierke CA.

Methods Mol Biol. 2017;1520:201-225. doi: 10.1007/978-1-4939-6634-9_12.


Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.

Temple KJ, Wright EN, Fierke CA, Gibbs RA.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3503-7. doi: 10.1016/j.bmcl.2016.06.035. Epub 2016 Jun 15.


Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.

Temple KJ, Wright EN, Fierke CA, Gibbs RA.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3499-502. doi: 10.1016/j.bmcl.2016.06.034. Epub 2016 Jun 16.


The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases.

Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL.

J Biol Chem. 2016 May 13;291(20):10948. doi: 10.1074/jbc.A115.696831. No abstract available.


The Diversity of Ribonuclease P: Protein and RNA Catalysts with Analogous Biological Functions.

Klemm BP, Wu N, Chen Y, Liu X, Kaitany KJ, Howard MJ, Fierke CA.

Biomolecules. 2016 May 13;6(2). pii: E27. doi: 10.3390/biom6020027. Review.


Differential substrate recognition by isozymes of plant protein-only Ribonuclease P.

Howard MJ, Karasik A, Klemm BP, Mei C, Shanmuganathan A, Fierke CA, Koutmos M.

RNA. 2016 May;22(5):782-92. doi: 10.1261/rna.055541.115. Epub 2016 Mar 10.


Structure-Based Identification of HDAC8 Non-histone Substrates.

Alam N, Zimmerman L, Wolfson NA, Joseph CG, Fierke CA, Schueler-Furman O.

Structure. 2016 Mar 1;24(3):458-68. doi: 10.1016/j.str.2016.02.002.


Metal-dependent Deacetylases: Cancer and Epigenetic Regulators.

López JE, Sullivan ED, Fierke CA.

ACS Chem Biol. 2016 Mar 18;11(3):706-16. doi: 10.1021/acschembio.5b01067. Review.


The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases.

Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL.

J Biol Chem. 2016 Mar 18;291(12):6534-45. doi: 10.1074/jbc.M115.696831. Epub 2016 Jan 26. Erratum in: J Biol Chem. 2016 May 13;291(20):10948.


General Base-General Acid Catalysis in Human Histone Deacetylase 8.

Gantt SM, Decroos C, Lee MS, Gullett LE, Bowman CM, Christianson DW, Fierke CA.

Biochemistry. 2016 Feb 9;55(5):820-32. doi: 10.1021/acs.biochem.5b01327. Epub 2016 Jan 25.


Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase.

Jennings BC, Danowitz AM, Wang YC, Gibbs RA, Distefano MD, Fierke CA.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1333-6. doi: 10.1016/j.bmcl.2015.12.079. Epub 2015 Dec 22.


Nuclear Protein-Only Ribonuclease P2 Structure and Biochemical Characterization Provide Insight into the Conserved Properties of tRNA 5' End Processing Enzymes.

Karasik A, Shanmuganathan A, Howard MJ, Fierke CA, Koutmos M.

J Mol Biol. 2016 Jan 16;428(1):26-40. doi: 10.1016/j.jmb.2015.11.025. Epub 2015 Dec 3.


Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives.

Pithadia A, Brender JR, Fierke CA, Ramamoorthy A.

J Diabetes Res. 2016;2016:2046327. doi: 10.1155/2016/2046327. Epub 2015 Nov 15. Review.


Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.

Pithadia AS, Bhunia A, Sribalan R, Padmini V, Fierke CA, Ramamoorthy A.

Chem Commun (Camb). 2016 Jan 18;52(5):942-5. doi: 10.1039/c5cc07792c.


Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.

Daniel KB, Sullivan ED, Chen Y, Chan JC, Jennings PA, Fierke CA, Cohen SM.

J Med Chem. 2015 Jun 11;58(11):4812-21. doi: 10.1021/acs.jmedchem.5b00539. Epub 2015 Jun 2.


Mechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease P.

Howard MJ, Klemm BP, Fierke CA.

J Biol Chem. 2015 May 22;290(21):13454-64. doi: 10.1074/jbc.M115.644831. Epub 2015 Mar 27.


Self-assembly of a nine-residue amyloid-forming peptide fragment of SARS corona virus E-protein: mechanism of self aggregation and amyloid-inhibition of hIAPP.

Ghosh A, Pithadia AS, Bhat J, Bera S, Midya A, Fierke CA, Ramamoorthy A, Bhunia A.

Biochemistry. 2015 Apr 7;54(13):2249-2261. doi: 10.1021/acs.biochem.5b00061. Epub 2015 Mar 24.


The evolution of RNase P.

Engelke DR, Fierke CA.

RNA. 2015 Apr;21(4):517-8. doi: 10.1261/rna.050732.115. No abstract available.


Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding.

Mustoe AM, Liu X, Lin PJ, Al-Hashimi HM, Fierke CA, Brooks CL 3rd.

J Am Chem Soc. 2015 Mar 18;137(10):3592-9. doi: 10.1021/ja5130308. Epub 2015 Mar 9.


Kinetics and thermodynamics of metal-binding to histone deacetylase 8.

Kim B, Pithadia AS, Fierke CA.

Protein Sci. 2015 Mar;24(3):354-65. doi: 10.1002/pro.2623. Epub 2015 Jan 13.


A real-time fluorescence polarization activity assay to screen for inhibitors of bacterial ribonuclease P.

Liu X, Chen Y, Fierke CA.

Nucleic Acids Res. 2014 Nov 10;42(20):e159. doi: 10.1093/nar/gku850. Epub 2014 Sep 23.


An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.

Olson DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T, Natoli T, Lu X, Paulk J, McCarren P, Wagner FF, Barker D, Howe E, Lazzaro F, Gale JP, Zhang YL, Subramanian A, Fierke CA, Carr SA, Holson EB.

ACS Chem Biol. 2014 Oct 17;9(10):2210-6. doi: 10.1021/cb500492r. Epub 2014 Aug 11.


Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand.

Wang N, Lodge JM, Fierke CA, Mapp AK.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12061-6. doi: 10.1073/pnas.1406033111. Epub 2014 Jul 21.


In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy.

Patel HR, Pithadia AS, Brender JR, Fierke CA, Ramamoorthy A.

J Phys Chem Lett. 2014 Jun 5;5(11):1864-70. doi: 10.1021/jz5001775. Epub 2014 May 15.


An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity.

Wolfson NA, Pitcairn CA, Sullivan ED, Joseph CG, Fierke CA.

Anal Biochem. 2014 Jul 1;456:61-9. doi: 10.1016/j.ab.2014.03.012. Epub 2014 Mar 25.


Fluorescence lifetime imaging of physiological free Cu(II) levels in live cells with a Cu(II)-selective carbonic anhydrase-based biosensor.

McCranor BJ, Szmacinski H, Zeng HH, Stoddard AK, Hurst T, Fierke CA, Lakowicz JR, Thompson RB.

Metallomics. 2014 May;6(5):1034-42. doi: 10.1039/c3mt00305a.


Fibroblasts from long-lived rodent species exclude cadmium.

Dostál L, Kohler WM, Penner-Hahn JE, Miller RA, Fierke CA.

J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):10-9. doi: 10.1093/gerona/glu001. Epub 2014 Feb 12.


Ligand concentration regulates the pathways of coupled protein folding and binding.

Daniels KG, Tonthat NK, McClure DR, Chang YC, Liu X, Schumacher MA, Fierke CA, Schmidler SC, Oas TG.

J Am Chem Soc. 2014 Jan 22;136(3):822-5. doi: 10.1021/ja4086726. Epub 2014 Jan 9.


Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface.

Parisien M, Wang X, Perdrizet G 2nd, Lamphear C, Fierke CA, Maheshwari KC, Wilde MJ, Sosnick TR, Pan T.

Cell Rep. 2013 May 30;3(5):1703-13. doi: 10.1016/j.celrep.2013.04.010. Epub 2013 May 9.


RNase P enzymes: divergent scaffolds for a conserved biological reaction.

Howard MJ, Liu X, Lim WH, Klemm BP, Fierke CA, Koutmos M, Engelke DR.

RNA Biol. 2013 Jun;10(6):909-14. doi: 10.4161/rna.24513. Epub 2013 Apr 1.


The BaeSR regulon is involved in defense against zinc toxicity in E. coli.

Wang D, Fierke CA.

Metallomics. 2013 Apr;5(4):372-83. doi: 10.1039/c3mt20217h.


Long wavelength fluorescence ratiometric zinc biosensor.

Zeng HH, Matveeva EG, Stoddard AK, Fierke CA, Thompson RB.

J Fluoresc. 2013 May;23(3):375-9. doi: 10.1007/s10895-013-1161-6. Epub 2013 Jan 24.


HDAC8 substrates: Histones and beyond.

Wolfson NA, Pitcairn CA, Fierke CA.

Biopolymers. 2013 Feb;99(2):112-26. doi: 10.1002/bip.22135. Review.


Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions.

Zverina EA, Lamphear CL, Wright EN, Fierke CA.

Curr Opin Chem Biol. 2012 Dec;16(5-6):544-52. doi: 10.1016/j.cbpa.2012.10.015. Epub 2012 Nov 8. Review.

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