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Protein kinase Cι: A versatile oncogene in the lung.

Fields AP, Ali SA, Justilien V, Murray NR.

Mol Cell Oncol. 2018 May 10;5(5):e1190886. doi: 10.1080/23723556.2016.1190886. eCollection 2018.


Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC.

Justilien V, Lewis KC, Murray NR, Fields AP.

Small GTPases. 2017 Jun 28:1-7. doi: 10.1080/21541248.2017.1335274. [Epub ahead of print]


Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.

Justilien V, Ali SA, Jamieson L, Yin N, Cox AD, Der CJ, Murray NR, Fields AP.

Cancer Cell. 2017 Feb 13;31(2):256-269. doi: 10.1016/j.ccell.2016.12.010. Epub 2017 Jan 19.


A proof-of-concept trial of protein kinase C iota inhibition with auranofin for the paclitaxel-induced acute pain syndrome.

Jatoi A, Grudem ME, Dockter TJ, Block MS, Villasboas JC, Tan A, Deering E, Kasi PM, Mansfield AS, Botero JP, Okuno SH, Smith DR, Fields AP.

Support Care Cancer. 2017 Mar;25(3):833-838. doi: 10.1007/s00520-016-3467-9. Epub 2016 Nov 12.


Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS.

Elife. 2016 Sep 23;5. pii: e19760. doi: 10.7554/eLife.19760.


SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse.

Murray NR, Justilien V, Fields AP.

Cancer Cell. 2016 Oct 10;30(4):505-507. doi: 10.1016/j.ccell.2016.09.012.


PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis.

Wang Y, Justilien V, Brennan KI, Jamieson L, Murray NR, Fields AP.

Oncogene. 2017 Jan 26;36(4):534-545. doi: 10.1038/onc.2016.224. Epub 2016 Jun 20.


Oncogenic PKCι decides tumor-initiating cell fate.

Fields AP, Ali SA, Murray NR.

Cell Cycle. 2016 Sep 16;15(18):2383-4. doi: 10.1080/15384101.2016.1194624. Epub 2016 Jun 17. No abstract available.


Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC.

Fields AP, Ali SA, Justilien V, Murray NR.

Small GTPases. 2017 Jan 2;8(1):58-64. doi: 10.1080/21541248.2016.1194953. Epub 2016 May 31.


Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model.

Riabov V, Yin S, Song B, Avdic A, Schledzewski K, Ovsiy I, Gratchev A, Llopis Verdiell M, Sticht C, Schmuttermaier C, Schönhaber H, Weiss C, Fields AP, Simon-Keller K, Pfister F, Berlit S, Marx A, Arnold B, Goerdt S, Kzhyshkowska J.

Oncotarget. 2016 May 24;7(21):31097-110. doi: 10.18632/oncotarget.8857.


Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma.

Ali SA, Justilien V, Jamieson L, Murray NR, Fields AP.

Cancer Cell. 2016 Mar 14;29(3):367-378. doi: 10.1016/j.ccell.2016.02.012.


The chromosome 3q26 OncCassette: A multigenic driver of human cancer.

Fields AP, Justilien V, Murray NR.

Adv Biol Regul. 2016 Jan;60:47-63. doi: 10.1016/j.jbior.2015.10.009. Epub 2015 Dec 23.


A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation.

Fields AP, Rodriguez EH, Jovanovic M, Stern-Ginossar N, Haas BJ, Mertins P, Raychowdhury R, Hacohen N, Carr SA, Ingolia NT, Regev A, Weissman JS.

Mol Cell. 2015 Dec 3;60(5):816-827. doi: 10.1016/j.molcel.2015.11.013.


A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion.

Butler AM, Scotti Buzhardt ML, Erdogan E, Li S, Inman KS, Fields AP, Murray NR.

Oncotarget. 2015 Jun 20;6(17):15297-310.


Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens.

Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman JS, Carr SA, Hacohen N, Regev A.

Science. 2015 Mar 6;347(6226):1259038. doi: 10.1126/science.1259038. Epub 2015 Feb 12.


Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.

Liou GY, Döppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P.

Nat Commun. 2015 Feb 20;6:6200. doi: 10.1038/ncomms7200.


Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells.

Justilien V, Fields AP.

Clin Cancer Res. 2015 Feb 1;21(3):505-13. doi: 10.1158/1078-0432.CCR-14-0507. Review.


A mixed-methods feasibility trial of protein kinase C iota inhibition with auranofin in asymptomatic ovarian cancer patients.

Jatoi A, Radecki Breitkopf C, Foster NR, Block MS, Grudem M, Wahner Hendrickson A, Carlson RE, Barrette B, Karlin N, Fields AP.

Oncology. 2015;88(4):208-13. doi: 10.1159/000369257. Epub 2014 Dec 6.


The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma.

Justilien V, Walsh MP, Ali SA, Thompson EA, Murray NR, Fields AP.

Cancer Cell. 2014 Feb 10;25(2):139-51. doi: 10.1016/j.ccr.2014.01.008.


Utility and applications of orthotopic models of human non-small cell lung cancer (NSCLC) for the evaluation of novel and emerging cancer therapeutics.

Justilien V, Fields AP.

Curr Protoc Pharmacol. 2013 Oct 8;62:Unit 14.27.. doi: 10.1002/0471141755.ph1427s62.


Atypical protein kinase Cι as a human oncogene and therapeutic target.

Parker PJ, Justilien V, Riou P, Linch M, Fields AP.

Biochem Pharmacol. 2014 Mar 1;88(1):1-11. doi: 10.1016/j.bcp.2013.10.023. Epub 2013 Nov 11. Review.


PKCι maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis.

Wang Y, Hill KS, Fields AP.

Mol Cancer Res. 2013 Dec;11(12):1624-35. doi: 10.1158/1541-7786.MCR-13-0371-T. Epub 2013 Oct 30.


Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism.

Butler AM, Scotti Buzhardt ML, Li S, Smith KE, Fields AP, Murray NR.

PLoS One. 2013 Aug 28;8(8):e72061. doi: 10.1371/journal.pone.0072061. eCollection 2013.


Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer.

Mansfield AS, Fields AP, Jatoi A, Qi Y, Adjei AA, Erlichman C, Molina JR.

Anticancer Drugs. 2013 Nov;24(10):1079-83. doi: 10.1097/CAD.0000000000000009.


Euler buckling and nonlinear kinking of double-stranded DNA.

Fields AP, Meyer EA, Cohen AE.

Nucleic Acids Res. 2013 Nov;41(21):9881-90. doi: 10.1093/nar/gkt739. Epub 2013 Aug 16.


Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis.

Hill KS, Erdogan E, Khoor A, Walsh MP, Leitges M, Murray NR, Fields AP.

Oncogene. 2014 Apr 17;33(16):2134-44. doi: 10.1038/onc.2013.147. Epub 2013 Apr 22.


Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2.

Greer YE, Fields AP, Brown AM, Rubin JS.

J Biol Chem. 2013 Mar 29;288(13):9438-46. doi: 10.1074/jbc.M112.448282. Epub 2013 Feb 8.


Optimal tracking of a Brownian particle.

Fields AP, Cohen AE.

Opt Express. 2012 Sep 24;20(20):22585-601. doi: 10.1364/OE.20.022585.


Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression.

Stallings-Mann ML, Waldmann J, Zhang Y, Miller E, Gauthier ML, Visscher DW, Downey GP, Radisky ES, Fields AP, Radisky DC.

Sci Transl Med. 2012 Jul 11;4(142):142ra95. doi: 10.1126/scitranslmed.3004062.


Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations.

Kalari KR, Rossell D, Necela BM, Asmann YW, Nair A, Baheti S, Kachergus JM, Younkin CS, Baker T, Carr JM, Tang X, Walsh MP, Chai HS, Sun Z, Hart SN, Leontovich AA, Hossain A, Kocher JP, Perez EA, Reisman DN, Fields AP, Thompson EA.

Front Oncol. 2012 Feb 10;2:12. doi: 10.3389/fonc.2012.00012. eCollection 2012.


Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.

Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP.

PLoS One. 2012;7(4):e35040. doi: 10.1371/journal.pone.0035040. Epub 2012 Apr 24.


Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.

Batra J, Robinson J, Soares AS, Fields AP, Radisky DC, Radisky ES.

J Biol Chem. 2012 May 4;287(19):15935-46. doi: 10.1074/jbc.M112.341156. Epub 2012 Mar 16.


Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia.

Scotti ML, Smith KE, Butler AM, Calcagno SR, Crawford HC, Leitges M, Fields AP, Murray NR.

PLoS One. 2012;7(2):e30509. doi: 10.1371/journal.pone.0030509. Epub 2012 Feb 16.


Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma.

Kikuchi K, Soundararajan A, Zarzabal LA, Weems CR, Nelon LD, Hampton ST, Michalek JE, Rubin BP, Fields AP, Keller C.

Oncogene. 2013 Jan 17;32(3):286-95. doi: 10.1038/onc.2012.46. Epub 2012 Feb 20.


Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι.

Sajan MP, Nimal S, Mastorides S, Acevedo-Duncan M, Kahn CR, Fields AP, Braun U, Leitges M, Farese RV.

Metabolism. 2012 Apr;61(4):459-69. doi: 10.1016/j.metabol.2011.12.008. Epub 2012 Jan 5.


Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer.

Deng X, Cao Y, Liu Y, Li F, Sambandam K, Rajaraman S, Perkins AS, Fields AP, Hellmich MR, Townsend CM Jr, Thompson EA, Ko TC.

Mol Carcinog. 2013 Apr;52(4):255-264. doi: 10.1002/mc.21852. Epub 2011 Dec 7.


Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1).

O'Neill AK, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall RA, Newton AC.

J Biol Chem. 2011 Dec 16;286(50):43559-68. doi: 10.1074/jbc.M111.294603. Epub 2011 Oct 25.


Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.

Regala RP, Justilien V, Walsh MP, Weems C, Khoor A, Murray NR, Fields AP.

PLoS One. 2011;6(10):e26439. doi: 10.1371/journal.pone.0026439. Epub 2011 Oct 17.


Ultrasensitive measurements of microbial rhodopsin photocycles using photochromic FRET.

Bayraktar H, Fields AP, Kralj JM, Spudich JL, Rothschild KJ, Cohen AE.

Photochem Photobiol. 2012 Jan-Feb;88(1):90-7. doi: 10.1111/j.1751-1097.2011.01011.x. Epub 2011 Nov 17.


Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis.

Calcagno SR, Li S, Shahid MW, Wallace MB, Leitges M, Fields AP, Murray NR.

Inflamm Bowel Dis. 2011 Aug;17(8):1685-97. doi: 10.1002/ibd.21547. Epub 2010 Nov 15.


The cat that caught the canary: what to do with single-molecule trapping.

Cohen AE, Fields AP.

ACS Nano. 2011 Jul 26;5(7):5296-9. doi: 10.1021/nn202313g. Epub 2011 Jun 28.


Electrokinetic trapping at the one nanometer limit.

Fields AP, Cohen AE.

Proc Natl Acad Sci U S A. 2011 May 31;108(22):8937-42. doi: 10.1073/pnas.1103554108. Epub 2011 May 11.


Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.

Justilien V, Jameison L, Der CJ, Rossman KL, Fields AP.

J Biol Chem. 2011 Mar 11;286(10):8149-57. doi: 10.1074/jbc.M110.196113. Epub 2010 Dec 28.


Protein kinase Cι expression and oncogenic signaling mechanisms in cancer.

Murray NR, Kalari KR, Fields AP.

J Cell Physiol. 2011 Apr;226(4):879-87. doi: 10.1002/jcp.22463. Review.


Splice variants of SmgGDS control small GTPase prenylation and membrane localization.

Berg TJ, Gastonguay AJ, Lorimer EL, Kuhnmuench JR, Li R, Fields AP, Williams CL.

J Biol Chem. 2010 Nov 12;285(46):35255-66. doi: 10.1074/jbc.M110.129916. Epub 2010 Aug 13.


Anti-Brownian traps for studies on single molecules.

Fields AP, Cohen AE.

Methods Enzymol. 2010;475:149-74. doi: 10.1016/S0076-6879(10)75007-2.


Convex lens-induced confinement for imaging single molecules.

Leslie SR, Fields AP, Cohen AE.

Anal Chem. 2010 Jul 15;82(14):6224-9. doi: 10.1021/ac101041s.


Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis.

Scotti ML, Bamlet WR, Smyrk TC, Fields AP, Murray NR.

Cancer Res. 2010 Mar 1;70(5):2064-74. doi: 10.1158/0008-5472.CAN-09-2684. Epub 2010 Feb 23.


The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer.

Fields AP, Justilien V.

Adv Enzyme Regul. 2010;50(1):190-200. doi: 10.1016/j.advenzreg.2009.10.010. Epub 2009 Nov 6. Review. No abstract available.


Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis.

Regala RP, Davis RK, Kunz A, Khoor A, Leitges M, Fields AP.

Cancer Res. 2009 Oct 1;69(19):7603-11. doi: 10.1158/0008-5472.CAN-09-2066. Epub 2009 Sep 8.

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