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Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin.

Lord SR, Collins JM, Cheng WC, Haider S, Wigfield S, Gaude E, Fielding BA, Pinnick KE, Harjes U, Segaran A, Jha P, Hoefler G, Pollak MN, Thompson AM, Roy PG, English R, Adams RF, Frezza C, Buffa FM, Karpe F, Harris AL.

Br J Cancer. 2019 Dec 10. doi: 10.1038/s41416-019-0665-5. [Epub ahead of print]


Taxing confectionery, biscuits, and cakes to control obesity.

Moore JB, Fielding BA.

BMJ. 2019 Sep 4;366:l5298. doi: 10.1136/bmj.l5298. No abstract available.


Fasting hepatic de novo lipogenesis is not reliably assessed using circulating fatty acid markers.

Rosqvist F, McNeil CA, Pramfalk C, Parry SA, Low WS, Cornfield T, Fielding BA, Hodson L.

Am J Clin Nutr. 2019 Feb 1;109(2):260-268. doi: 10.1093/ajcn/nqy304.


Starchy Carbohydrates in a Healthy Diet: The Role of the Humble Potato.

Robertson TM, Alzaabi AZ, Robertson MD, Fielding BA.

Nutrients. 2018 Nov 14;10(11). pii: E1764. doi: 10.3390/nu10111764. Review.


Evaluation of the nutrient content of yogurts: a comprehensive survey of yogurt products in the major UK supermarkets.

Moore JB, Horti A, Fielding BA.

BMJ Open. 2018 Sep 18;8(8):e021387. doi: 10.1136/bmjopen-2017-021387.


Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells.

Sibbons CM, Irvine NA, Pérez-Mojica JE, Calder PC, Lillycrop KA, Fielding BA, Burdge GC.

Front Immunol. 2018 Mar 5;9:432. doi: 10.3389/fimmu.2018.00432. eCollection 2018.


Ω-3 index as a prognosis tool in cardiovascular disease.

Fielding BA.

Curr Opin Clin Nutr Metab Care. 2017 Sep;20(5):360-365. doi: 10.1097/MCO.0000000000000404. Review.


Role of the Enterocyte in Fructose-Induced Hypertriglyceridaemia.

Steenson S, Umpleby AM, Lovegrove JA, Jackson KG, Fielding BA.

Nutrients. 2017 Apr 1;9(4). pii: E349. doi: 10.3390/nu9040349. Review.


Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and apoC-III.

Ooi EM, Chan DC, Hodson L, Adiels M, Boren J, Karpe F, Fielding BA, Watts GF, Barrett PH.

Eur J Clin Invest. 2016 Aug;46(8):730-6. doi: 10.1111/eci.12657.


Sugar and metabolic health: is there still a debate?

Moore JB, Fielding BA.

Curr Opin Clin Nutr Metab Care. 2016 Jul;19(4):303-9. doi: 10.1097/MCO.0000000000000289. Review.


Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women.

Hodson L, Banerjee R, Rial B, Arlt W, Adiels M, Boren J, Marinou K, Fisher C, Mostad IL, Stratton IM, Barrett PH, Chan DC, Watts GF, Harnden K, Karpe F, Fielding BA.

J Am Heart Assoc. 2015 Oct 2;4(10):e002258. doi: 10.1161/JAHA.115.002258.


LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.

Loh NY, Neville MJ, Marinou K, Hardcastle SA, Fielding BA, Duncan EL, McCarthy MI, Tobias JH, Gregson CL, Karpe F, Christodoulides C.

Cell Metab. 2015 Feb 3;21(2):262-273. doi: 10.1016/j.cmet.2015.01.009.


The role of dietary sugars and de novo lipogenesis in non-alcoholic fatty liver disease.

Moore JB, Gunn PJ, Fielding BA.

Nutrients. 2014 Dec 10;6(12):5679-703. doi: 10.3390/nu6125679. Review.


Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome.

Bucci M, Karmi AC, Iozzo P, Fielding BA, Viljanen A, Badeau RM, Borra R, Saunavaara V, Pham T, Hannukainen JC, Kalliokoski K, Haaparanta-Solin M, Viljanen T, Parkkola R, Frayn KN, Nuutila P.

Diabetologia. 2015 Jan;58(1):158-64. doi: 10.1007/s00125-014-3402-x. Epub 2014 Oct 21.


Lower resting and total energy expenditure in postmenopausal compared with premenopausal women matched for abdominal obesity.

Hodson L, Harnden K, Banerjee R, Real B, Marinou K, Karpe F, Fielding BA.

J Nutr Sci. 2014 Feb 13;3:e3. doi: 10.1017/jns.2013.38. eCollection 2014.


Fatty acid-binding protein 4, a point of convergence for angiogenic and metabolic signaling pathways in endothelial cells.

Harjes U, Bridges E, McIntyre A, Fielding BA, Harris AL.

J Biol Chem. 2014 Aug 15;289(33):23168-76. doi: 10.1074/jbc.M114.576512. Epub 2014 Jun 17.


Structural and functional properties of deep abdominal subcutaneous adipose tissue explain its association with insulin resistance and cardiovascular risk in men.

Marinou K, Hodson L, Vasan SK, Fielding BA, Banerjee R, Brismar K, Koutsilieris M, Clark A, Neville MJ, Karpe F.

Diabetes Care. 2014;37(3):821-9. doi: 10.2337/dc13-1353. Epub 2013 Nov 1.


Adipose dipeptidyl peptidase-4 and obesity: correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro.

Sell H, Blüher M, Klöting N, Schlich R, Willems M, Ruppe F, Knoefel WT, Dietrich A, Fielding BA, Arner P, Frayn KN, Eckel J.

Diabetes Care. 2013 Dec;36(12):4083-90. doi: 10.2337/dc13-0496. Epub 2013 Oct 15.


Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects.

Egli L, Lecoultre V, Theytaz F, Campos V, Hodson L, Schneiter P, Mittendorfer B, Patterson BW, Fielding BA, Gerber PA, Giusti V, Berneis K, Tappy L.

Diabetes. 2013 Jul;62(7):2259-65. doi: 10.2337/db12-1651. Epub 2013 May 14.


Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies.

Hodson L, Neville M, Chong MF, Rogers I, Huda SS, Freeman DJ, Frayn KN, Fielding BA.

Nutr Metab Cardiovasc Dis. 2013 Nov;23(11):1128-33. doi: 10.1016/j.numecd.2012.11.003. Epub 2012 Dec 8.


Stearoyl-CoA desaturase: rogue or innocent bystander?

Hodson L, Fielding BA.

Prog Lipid Res. 2013 Jan;52(1):15-42. doi: 10.1016/j.plipres.2012.08.002. Epub 2012 Sep 21. Review.


Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans.

Sevastianova K, Santos A, Kotronen A, Hakkarainen A, Makkonen J, Silander K, Peltonen M, Romeo S, Lundbom J, Lundbom N, Olkkonen VM, Gylling H, Fielding BA, Rissanen A, Yki-Järvinen H.

Am J Clin Nutr. 2012 Oct;96(4):727-34. Epub 2012 Sep 5.


Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans.

Pinnick KE, Neville MJ, Fielding BA, Frayn KN, Karpe F, Hodson L.

Diabetes. 2012 Jun;61(6):1399-403. doi: 10.2337/db11-1810. Epub 2012 Apr 9.


Failure to increase postprandial blood flow in subcutaneous adipose tissue is associated with tissue resistance to adrenergic stimulation.

Ardilouze JL, Sotorník R, Dennis LA, Fielding BA, Frayn KN, Karpe F.

Diabetes Metab. 2012 Feb;38(1):27-33. doi: 10.1016/j.diabet.2011.06.005. Epub 2011 Aug 23.


Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men.

Marinou K, Adiels M, Hodson L, Frayn KN, Karpe F, Fielding BA.

Br J Nutr. 2011 Mar;105(6):857-65. doi: 10.1017/S0007114510004472. Epub 2011 Jan 21.


Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?

McQuaid SE, Hodson L, Neville MJ, Dennis AL, Cheeseman J, Humphreys SM, Ruge T, Gilbert M, Fielding BA, Frayn KN, Karpe F.

Diabetes. 2011 Jan;60(1):47-55. doi: 10.2337/db10-0867. Epub 2010 Oct 13.


Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids.

McQuaid SE, Humphreys SM, Hodson L, Fielding BA, Karpe F, Frayn KN.

Diabetes. 2010 Oct;59(10):2465-73. doi: 10.2337/db10-0678. Epub 2010 Aug 3.


Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?

Hodson L, McQuaid SE, Humphreys SM, Milne R, Fielding BA, Frayn KN, Karpe F.

Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E584-92. doi: 10.1152/ajpendo.00272.2010. Epub 2010 Jul 13.


Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.

Westerbacka J, Kotronen A, Fielding BA, Wahren J, Hodson L, Perttilä J, Seppänen-Laakso T, Suortti T, Arola J, Hultcrantz R, Castillo S, Olkkonen VM, Frayn KN, Orešič M, Yki-Järvinen H.

Gastroenterology. 2010 Dec;139(6):1961-1971.e1. doi: 10.1053/j.gastro.2010.06.064. Epub 2010 Jun 27.


Increased brain fatty acid uptake in metabolic syndrome.

Karmi A, Iozzo P, Viljanen A, Hirvonen J, Fielding BA, Virtanen K, Oikonen V, Kemppainen J, Viljanen T, Guiducci L, Haaparanta-Solin M, Någren K, Solin O, Nuutila P.

Diabetes. 2010 Sep;59(9):2171-7. doi: 10.2337/db09-0138. Epub 2010 Jun 21.


Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load.

Tran C, Jacot-Descombes D, Lecoultre V, Fielding BA, Carrel G, Lê KA, Schneiter P, Bortolotti M, Frayn KN, Tappy L.

Br J Nutr. 2010 Oct;104(8):1139-47. doi: 10.1017/S000711451000190X. Epub 2010 Jun 14.


Optimization of N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density lipoproteins.

Adiels M, Larsson T, Sutton P, Taskinen MR, Borén J, Fielding BA.

Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):586-92. doi: 10.1002/rcm.4422.


Liver fat and lipid oxidation in humans.

Kotronen A, Seppälä-Lindroos A, Vehkavaara S, Bergholm R, Frayn KN, Fielding BA, Yki-Järvinen H.

Liver Int. 2009 Oct;29(9):1439-46. doi: 10.1111/j.1478-3231.2009.02076.x. Epub 2009 Jul 7.


Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage.

Ruge T, Hodson L, Cheeseman J, Dennis AL, Fielding BA, Humphreys SM, Frayn KN, Karpe F.

J Clin Endocrinol Metab. 2009 May;94(5):1781-8. doi: 10.1210/jc.2008-2090. Epub 2009 Feb 17.


Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate.

Hodson L, McQuaid SE, Karpe F, Frayn KN, Fielding BA.

Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E64-71. doi: 10.1152/ajpendo.90730.2008. Epub 2008 Oct 21.


Fatty acid metabolism in patients with PPARgamma mutations.

Tan GD, Savage DB, Fielding BA, Collins J, Hodson L, Humphreys SM, O'Rahilly S, Chatterjee K, Frayn KN, Karpe F.

J Clin Endocrinol Metab. 2008 Nov;93(11):4462-70. doi: 10.1210/jc.2007-2356. Epub 2008 Aug 19.


Adipose tissue fatty acid metabolism in insulin-resistant men.

Bickerton AS, Roberts R, Fielding BA, Tornqvist H, Blaak EE, Wagenmakers AJ, Gilbert M, Humphreys SM, Karpe F, Frayn KN.

Diabetologia. 2008 Aug;51(8):1466-74. doi: 10.1007/s00125-008-1040-x. Epub 2008 May 27. Erratum in: Diabetologia. 2008 Oct;51(10):1936.


Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake.

Hodson L, Skeaff CM, Fielding BA.

Prog Lipid Res. 2008 Sep;47(5):348-80. doi: 10.1016/j.plipres.2008.03.003. Epub 2008 Apr 4. Review.


Reduced oxidation of dietary fat after a short term high-carbohydrate diet.

Roberts R, Bickerton AS, Fielding BA, Blaak EE, Wagenmakers AJ, Chong MF, Gilbert M, Karpe F, Frayn KN.

Am J Clin Nutr. 2008 Apr;87(4):824-31.


Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding.

Chong MF, Hodson L, Bickerton AS, Roberts R, Neville M, Karpe F, Frayn KN, Fielding BA.

Am J Clin Nutr. 2008 Apr;87(4):817-23.


Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition.

Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA.

Obesity (Silver Spring). 2008 Mar;16(3):522-30. doi: 10.1038/oby.2007.110. Epub 2008 Jan 17.


Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

Risérus U, Sprecher D, Johnson T, Olson E, Hirschberg S, Liu A, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum JC, Basu S, Cheeseman J, Fielding BA, Humphreys SM, Danoff T, Moore NR, Murgatroyd P, O'Rahilly S, Sutton P, Willson T, Hassall D, Frayn KN, Karpe F.

Diabetes. 2008 Feb;57(2):332-9. Epub 2007 Nov 16.


The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state.

Hodson L, Bickerton AS, McQuaid SE, Roberts R, Karpe F, Frayn KN, Fielding BA.

Diabetes. 2007 Oct;56(10):2433-41. Epub 2007 Jun 29.


Mechanisms for the acute effect of fructose on postprandial lipemia.

Chong MF, Fielding BA, Frayn KN.

Am J Clin Nutr. 2007 Jun;85(6):1511-20.


Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation.

Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN.

Biochem Soc Trans. 2007 Jun;35(Pt 3):472-6. Review.


Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis.

Chong MF, Fielding BA, Frayn KN.

Proc Nutr Soc. 2007 Feb;66(1):52-9. Review.


Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period.

Bickerton AS, Roberts R, Fielding BA, Hodson L, Blaak EE, Wagenmakers AJ, Gilbert M, Karpe F, Frayn KN.

Diabetes. 2007 Jan;56(1):168-76.


The in vivo effects of the Pro12Ala PPARgamma2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank.

Tan GD, Neville MJ, Liverani E, Humphreys SM, Currie JM, Dennis L, Fielding BA, Karpe F.

Diabetologia. 2006 Jan;49(1):158-68. Epub 2005 Dec 17.


Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro.

Moffitt JH, Fielding BA, Evershed R, Berstan R, Currie JM, Clark A.

Diabetologia. 2005 Sep;48(9):1819-29. Epub 2005 Aug 11.


Adipose tissue fatty acid metabolism and cardiovascular disease.

Frayn KN, Fielding BA, Karpe F.

Curr Opin Lipidol. 2005 Aug;16(4):409-15. Review.


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