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SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes.

Saura A, Iribarren PA, Rojas-Barros D, Bart JM, López-Farfán D, Andrés-León E, Vidal-Cobo I, Boehm C, Alvarez VE, Field MC, Navarro M.

EMBO Rep. 2019 Dec 5;20(12):e48029. doi: 10.15252/embr.201948029. Epub 2019 Nov 6.


Evolution of late steps in exocytosis: conservation, specialization.

Boehm C, Field MC.

Wellcome Open Res. 2019 Jul 26;4:112. doi: 10.12688/wellcomeopenres.15142.1. eCollection 2019.


Metabolic quirks and the colourful history of the Euglena gracilis secondary plastid.

Novák Vanclová AMG, Zoltner M, Kelly S, Soukal P, Záhonová K, Füssy Z, Ebenezer TE, Lacová Dobáková E, Eliáš M, Lukeš J, Field MC, Hampl V.

New Phytol. 2019 Oct 3. doi: 10.1111/nph.16237. [Epub ahead of print]


Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex.

Faria J, Glover L, Hutchinson S, Boehm C, Field MC, Horn D.

Nat Commun. 2019 Jul 9;10(1):3023. doi: 10.1038/s41467-019-10823-8.


The kinetochore and the origin of eukaryotic chromosome segregation.

Field MC.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12596-12598. doi: 10.1073/pnas.1908067116. Epub 2019 Jun 7. No abstract available.


Pore timing: the evolutionary origins of the nucleus and nuclear pore complex.

Field MC, Rout MP.

F1000Res. 2019 Apr 3;8. pii: F1000 Faculty Rev-369. doi: 10.12688/f1000research.16402.1. eCollection 2019. Review.


Transcriptome, proteome and draft genome of Euglena gracilis.

Ebenezer TE, Zoltner M, Burrell A, Nenarokova A, Novák Vanclová AMG, Prasad B, Soukal P, Santana-Molina C, O'Neill E, Nankissoor NN, Vadakedath N, Daiker V, Obado S, Silva-Pereira S, Jackson AP, Devos DP, Lukeš J, Lebert M, Vaughan S, Hampl V, Carrington M, Ginger ML, Dacks JB, Kelly S, Field MC.

BMC Biol. 2019 Feb 7;17(1):11. doi: 10.1186/s12915-019-0626-8.


Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Field MC, Horn D, Fairlamb AH, Ferguson MAJ, Gray DW, Read KD, De Rycker M, Torrie LS, Wyatt PG, Wyllie S, Gilbert IH.

Nat Rev Microbiol. 2018 Nov;16(11):714. doi: 10.1038/s41579-018-0085-1.


Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.

Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, Freund Y, Alley MRK, Field MC, Wyllie S, Horn D.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9616-9621. doi: 10.1073/pnas.1807915115. Epub 2018 Sep 5.


Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA.

Zoltner M, Krienitz N, Field MC, Kramer S.

PLoS Negl Trop Dis. 2018 Jul 24;12(7):e0006679. doi: 10.1371/journal.pntd.0006679. eCollection 2018 Jul.


Evolution of protein trafficking in kinetoplastid parasites: Complexity and pathogenesis.

Venkatesh D, Zhang N, Zoltner M, Del Pino RC, Field MC.

Traffic. 2018 Nov;19(11):803-812. doi: 10.1111/tra.12601. Epub 2018 Jul 24. Review.


Evolutionary origins and specialisation of membrane transport.

Dacks JB, Field MC.

Curr Opin Cell Biol. 2018 Aug;53:70-76. doi: 10.1016/ Epub 2018 Jun 19. Review.


Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

Steketee PC, Vincent IM, Achcar F, Giordani F, Kim DH, Creek DJ, Freund Y, Jacobs R, Rattigan K, Horn D, Field MC, MacLeod A, Barrett MP.

PLoS Negl Trop Dis. 2018 May 14;12(5):e0006450. doi: 10.1371/journal.pntd.0006450. eCollection 2018 May.


Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins.

Herman EK, Ali M, Field MC, Dacks JB.

Traffic. 2018 Jul;19(7):546-563. doi: 10.1111/tra.12570. Epub 2018 Apr 25.


Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes.

Holden JM, Koreny L, Obado S, Ratushny AV, Chen WM, Bart JM, Navarro M, Chait BT, Aitchison JD, Rout MP, Field MC.

Mol Biol Cell. 2018 May 1;29(9):1100-1110. doi: 10.1091/mbc.E17-06-0430.


Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Zhang N, Zoltner M, Leung KF, Scullion P, Hutchinson S, Del Pino RC, Vincent IM, Zhang YK, Freund YR, Alley MRK, Jacobs RT, Read KD, Barrett MP, Horn D, Field MC.

PLoS Pathog. 2018 Feb 9;14(2):e1006850. doi: 10.1371/journal.ppat.1006850. eCollection 2018 Feb.


Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Field MC, Horn D, Fairlamb AH, Ferguson MAJ, Gray DW, Read KD, De Rycker M, Torrie LS, Wyatt PG, Wyllie S, Gilbert IH.

Nat Rev Microbiol. 2017 Jul;15(7):447. doi: 10.1038/nrmicro.2017.69. Epub 2017 Jun 5. No abstract available.


The Evolution of Organellar Coat Complexes and Organization of the Eukaryotic Cell.

Rout MP, Field MC.

Annu Rev Biochem. 2017 Jun 20;86:637-657. doi: 10.1146/annurev-biochem-061516-044643. Epub 2017 May 3. Review.


Comparative interactomics provides evidence for functional specialization of the nuclear pore complex.

Obado SO, Field MC, Rout MP.

Nucleus. 2017 Jul 4;8(4):340-352. doi: 10.1080/19491034.2017.1313936. Epub 2017 May 2.


Euglena gracilis Genome and Transcriptome: Organelles, Nuclear Genome Assembly Strategies and Initial Features.

Ebenezer TE, Carrington M, Lebert M, Kelly S, Field MC.

Adv Exp Med Biol. 2017;979:125-140. doi: 10.1007/978-3-319-54910-1_7. Review.


A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei.

Peña-Diaz P, Vancová M, Resl C, Field MC, Lukeš J.

PLoS Pathog. 2017 Apr 7;13(4):e1006310. doi: 10.1371/journal.ppat.1006310. eCollection 2017 Apr.


Evolution of the endomembrane systems of trypanosomatids - conservation and specialisation.

Venkatesh D, Boehm C, Barlow LD, Nankissoor NN, O'Reilly A, Kelly S, Dacks JB, Field MC.

J Cell Sci. 2017 Apr 15;130(8):1421-1434. doi: 10.1242/jcs.197640. Epub 2017 Apr 6.


Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity.

Rout MP, Obado SO, Schenkman S, Field MC.

PLoS Pathog. 2017 Mar 2;13(3):e1006170. doi: 10.1371/journal.ppat.1006170. eCollection 2017 Mar. Review. No abstract available.


Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Field MC, Horn D, Fairlamb AH, Ferguson MA, Gray DW, Read KD, De Rycker M, Torrie LS, Wyatt PG, Wyllie S, Gilbert IH.

Nat Rev Microbiol. 2017 Feb 27;15(4):217-231. doi: 10.1038/nrmicro.2016.193. [Epub ahead of print] Review. Erratum in: Nat Rev Microbiol. 2017 Jul;15(7):447. Nat Rev Microbiol. 2018 Nov;16(11):714.


Lineage-specific proteins essential for endocytosis in trypanosomes.

Manna PT, Obado SO, Boehm C, Gadelha C, Sali A, Chait BT, Rout MP, Field MC.

J Cell Sci. 2017 Apr 15;130(8):1379-1392. doi: 10.1242/jcs.191478. Epub 2017 Feb 23.


The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis.

Boehm CM, Obado S, Gadelha C, Kaupisch A, Manna PT, Gould GW, Munson M, Chait BT, Rout MP, Field MC.

PLoS Pathog. 2017 Jan 23;13(1):e1006063. doi: 10.1371/journal.ppat.1006063. eCollection 2017 Jan.


Making the pathogen: Evolution and adaptation in parasitic protists.

Ginger M, Field MC.

Mol Biochem Parasitol. 2016 Sep - Oct;209(1-2):1-2. doi: 10.1016/j.molbiopara.2016.11.002. No abstract available.


Exploiting the Achilles' heel of membrane trafficking in trypanosomes.

Zoltner M, Horn D, de Koning HP, Field MC.

Curr Opin Microbiol. 2016 Dec;34:97-103. doi: 10.1016/j.mib.2016.08.005. Epub 2016 Sep 9. Review.


The changing view of eukaryogenesis - fossils, cells, lineages and how they all come together.

Dacks JB, Field MC, Buick R, Eme L, Gribaldo S, Roger AJ, Brochier-Armanet C, Devos DP.

J Cell Sci. 2016 Oct 15;129(20):3695-3703. Epub 2016 Sep 26. Review.


Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.

Maishman L, Obado SO, Alsford S, Bart JM, Chen WM, Ratushny AV, Navarro M, Horn D, Aitchison JD, Chait BT, Rout MP, Field MC.

Nucleic Acids Res. 2016 Dec 15;44(22):10554-10570. Epub 2016 Sep 12.


Conservation and divergence within the clathrin interactome of Trypanosoma cruzi.

Kalb LC, Frederico YC, Boehm C, Moreira CM, Soares MJ, Field MC.

Sci Rep. 2016 Aug 9;6:31212. doi: 10.1038/srep31212.


Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology.

Klinger CM, Ramirez-Macias I, Herman EK, Turkewitz AP, Field MC, Dacks JB.

Mol Biochem Parasitol. 2016 Sep - Oct;209(1-2):88-103. doi: 10.1016/j.molbiopara.2016.07.003. Epub 2016 Jul 19. Review.


Ancient Eukaryotic Origin and Evolutionary Plasticity of Nuclear Lamina.

Koreny L, Field MC.

Genome Biol Evol. 2016 Sep 19;8(9):2663-71. doi: 10.1093/gbe/evw087.


High-Efficiency Isolation of Nuclear Envelope Protein Complexes from Trypanosomes.

Obado SO, Field MC, Chait BT, Rout MP.

Methods Mol Biol. 2016;1411:67-80. doi: 10.1007/978-1-4939-3530-7_3.


Phosphoinositides, kinases and adaptors coordinating endocytosis in Trypanosoma brucei.

Manna PT, Field MC.

Commun Integr Biol. 2016 Jan 19;8(6):e1082691. doi: 10.1080/19420889.2015.1082691. eCollection 2015 Nov-Dec.


Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania.

Flegontov P, Butenko A, Firsov S, Kraeva N, Eliáš M, Field MC, Filatov D, Flegontova O, Gerasimov ES, Hlaváčová J, Ishemgulova A, Jackson AP, Kelly S, Kostygov AY, Logacheva MD, Maslov DA, Opperdoes FR, O'Reilly A, Sádlová J, Ševčíková T, Venkatesh D, Vlček Č, Volf P, Votýpka J, Záhonová K, Yurchenko V, Lukeš J.

Sci Rep. 2016 Mar 29;6:23704. doi: 10.1038/srep23704.


Interactome Mapping Reveals the Evolutionary History of the Nuclear Pore Complex.

Obado SO, Brillantes M, Uryu K, Zhang W, Ketaren NE, Chait BT, Field MC, Rout MP.

PLoS Biol. 2016 Feb 18;14(2):e1002365. doi: 10.1371/journal.pbio.1002365. eCollection 2016 Feb.


Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism.

Jackson AP, Otto TD, Aslett M, Armstrong SD, Bringaud F, Schlacht A, Hartley C, Sanders M, Wastling JM, Dacks JB, Acosta-Serrano A, Field MC, Ginger ML, Berriman M.

Curr Biol. 2016 Jan 25;26(2):161-172. doi: 10.1016/j.cub.2015.11.055. Epub 2015 Dec 24. Review.


Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex.

Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M.

Nat Struct Mol Biol. 2016 Jan;23(1):59-66. doi: 10.1038/nsmb.3146. Epub 2015 Dec 14.


Correction: Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes.

Zoltner M, Leung KF, Alsford S, Horn D, Field MC.

PLoS Pathog. 2015 Nov 23;11(11):e1005291. doi: 10.1371/journal.ppat.1005291. eCollection 2015 Nov. No abstract available.


Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes.

Zoltner M, Leung KF, Alsford S, Horn D, Field MC.

PLoS Pathog. 2015 Oct 22;11(10):e1005236. doi: 10.1371/journal.ppat.1005236. eCollection 2015 Oct. Erratum in: PLoS Pathog. 2015 Nov;11(11):e1005291. PLoS Pathog. 2016 Feb;12(2):e1005432.


An extensive endoplasmic reticulum-localised glycoprotein family in trypanosomatids.

Allison H, O'Reilly AJ, Sternberg J, Field MC.

Microb Cell. 2014 Oct 1;1(10):325-345.


Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei.

McCulloch R, Field MC.

Trends Parasitol. 2015 Aug;31(8):346-9. doi: 10.1016/ Epub 2015 May 18.


Architecture of a Host-Parasite Interface: Complex Targeting Mechanisms Revealed Through Proteomics.

Gadelha C, Zhang W, Chamberlain JW, Chait BT, Wickstead B, Field MC.

Mol Cell Proteomics. 2015 Jul;14(7):1911-26. doi: 10.1074/mcp.M114.047647. Epub 2015 Apr 30.


Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei.

Bart JM, Cordon-Obras C, Vidal I, Reed J, Perez-Pastrana E, Cuevas L, Field MC, Carrington M, Navarro M.

Cell Microbiol. 2015 Oct;17(10):1523-35. doi: 10.1111/cmi.12454. Epub 2015 Jun 26.


ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis.

Manna PT, Gadelha C, Puttick AE, Field MC.

J Cell Sci. 2015 Jun 1;128(11):2130-42. doi: 10.1242/jcs.167726. Epub 2015 Apr 23.


Touching from a distance.

Holden JM, Koreny L, Kelly S, Chait BT, Rout MP, Field MC, Obado SO.

Nucleus. 2014 Jul-Aug;5(4):304-10. doi: 10.4161/nucl.32228.


Evolutionary cell biology: two origins, one objective.

Lynch M, Field MC, Goodson HV, Malik HS, Pereira-Leal JB, Roos DS, Turkewitz AP, Sazer S.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):16990-4. doi: 10.1073/pnas.1415861111. Epub 2014 Nov 17.


Missing pieces of an ancient puzzle: evolution of the eukaryotic membrane-trafficking system.

Schlacht A, Herman EK, Klute MJ, Field MC, Dacks JB.

Cold Spring Harb Perspect Biol. 2014 Oct 1;6(10):a016048. doi: 10.1101/cshperspect.a016048. Review.


Life and times: synthesis, trafficking, and evolution of VSG.

Manna PT, Boehm C, Leung KF, Natesan SK, Field MC.

Trends Parasitol. 2014 May;30(5):251-8. doi: 10.1016/ Epub 2014 Apr 12. Review.

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