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Items: 1 to 50 of 293

1.

Laboratory Screening Protocol to Identify Novel Oleaginous Yeasts.

Sitepu IR, Garay AL, Cajka T, Fiehn O, Boundy-Mills KL.

Methods Mol Biol. 2019;1995:33-50. doi: 10.1007/978-1-4939-9484-7_2.

PMID:
31148120
2.

A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium.

Barupal DK, Zhang Y, Shen T, Fan S, Roberts BS, Fitzgerald P, Wancewicz B, Valdiviez L, Wohlgemuth G, Byram G, Choy YY, Haffner B, Showalter MR, Vaniya A, Bloszies CS, Folz JS, Kind T, Flenniken AM, McKerlie C, Nutter LMJ, Lloyd KC, Fiehn O.

Metabolites. 2019 May 22;9(5). pii: E101. doi: 10.3390/metabo9050101.

3.

Alternative outlets for sustaining photosynthetic electron transport during dark-to-light transitions.

Saroussi S, Karns DAJ, Thomas DC, Bloszies C, Fiehn O, Posewitz MC, Grossman AR.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11518-11527. doi: 10.1073/pnas.1903185116. Epub 2019 May 17.

4.

Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway.

Xia Y, Ye B, Ding J, Yu Y, Alptekin A, Thangaraju M, Prasad PD, Ding ZC, Park EJ, Choi JH, Gao B, Fiehn O, Yan C, Dong Z, Zha Y, Ding HF.

Cancer Res. 2019 May 14. pii: canres.3541.2018. doi: 10.1158/0008-5472.CAN-18-3541. [Epub ahead of print]

PMID:
31088832
5.

Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease.

Jia Q, Han Y, Huang P, Woodward NC, Gukasyan J, Kettunen J, Ala-Korpela M, Anufrieva O, Wang Q, Perola M, Raitakari O, Lehtimäki T, Viikari J, Järvelin MR, Boehnke M, Laakso M, Mohlke KL, Fiehn O, Wang Z, Tang WHW, Hazen SL, Hartiala JA, Allayee H.

J Am Heart Assoc. 2019 May 21;8(10):e011922. doi: 10.1161/JAHA.119.011922.

6.

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.

Eckert MA, Coscia F, Chryplewicz A, Chang JW, Hernandez KM, Pan S, Tienda SM, Nahotko DA, Li G, Blaženović I, Lastra RR, Curtis M, Yamada SD, Perets R, McGregor SM, Andrade J, Fiehn O, Moellering RE, Mann M, Lengyel E.

Nature. 2019 May;569(7758):723-728. doi: 10.1038/s41586-019-1173-8. Epub 2019 May 1.

PMID:
31043742
7.

Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma.

Gao B, Lue HW, Podolak J, Fan S, Zhang Y, Serawat A, Alumkal JJ, Fiehn O, Thomas GV.

Metabolites. 2019 Apr 26;9(5). pii: E82. doi: 10.3390/metabo9050082.

8.

Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation.

Showalter MR, Wancewicz B, Fiehn O, Archard JA, Clayton S, Wagner J, Deng P, Halmai J, Fink KD, Bauer G, Fury B, Perotti NH, Apperson M, Butters J, Belafsky P, Farwell G, Kuhn M, Nolta JA, Anderson JD.

Biochem Biophys Res Commun. 2019 May 14;512(4):729-735. doi: 10.1016/j.bbrc.2019.03.119. Epub 2019 Mar 26.

9.

Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare.

Karunanithi PS, Dhanota P, Addison JB, Tong S, Fiehn O, Zerbe P.

BMC Plant Biol. 2019 Mar 25;19(1):114. doi: 10.1186/s12870-019-1702-5.

10.

Impact of post-collection freezing delay on the reliability of serum metabolomics in samples reflecting the California mid-term pregnancy biobank.

La Frano MR, Carmichael SL, Ma C, Hardley M, Shen T, Wong R, Rosales L, Borkowski K, Pedersen TL, Shaw GM, Stevenson DK, Fiehn O, Newman JW.

Metabolomics. 2018 Nov 15;14(11):151. doi: 10.1007/s11306-018-1450-9.

PMID:
30830400
11.

Chronic, Intermittent Microdoses of the Psychedelic N, N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents.

Cameron LP, Benson CJ, DeFelice BC, Fiehn O, Olson DE.

ACS Chem Neurosci. 2019 Mar 4. doi: 10.1021/acschemneuro.8b00692. [Epub ahead of print]

PMID:
30829033
12.

Systematic Error Removal Using Random Forest for Normalizing Large-Scale Untargeted Lipidomics Data.

Fan S, Kind T, Cajka T, Hazen SL, Tang WHW, Kaddurah-Daouk R, Irvin MR, Arnett DK, Barupal DK, Fiehn O.

Anal Chem. 2019 Mar 5;91(5):3590-3596. doi: 10.1021/acs.analchem.8b05592. Epub 2019 Feb 19.

PMID:
30758187
13.

17-α estradiol ameliorates age-associated sarcopenia and improves late-life physical function in male mice but not in females or castrated males.

Garratt M, Leander D, Pifer K, Bower B, Herrera JJ, Day SM, Fiehn O, Brooks SV, Miller RA.

Aging Cell. 2019 Apr;18(2):e12920. doi: 10.1111/acel.12920. Epub 2019 Feb 10.

14.

Metabolomics Analyses of 14 Classical Neurotransmitters by GC-TOF with LC-MS Illustrates Secretion of 9 Cell-Cell Signaling Molecules from Sympathoadrenal Chromaffin Cells in the Presence of Lithium.

Hook V, Kind T, Podvin S, Palazoglu M, Tran C, Toneff T, Samra S, Lietz C, Fiehn O.

ACS Chem Neurosci. 2019 Mar 20;10(3):1369-1379. doi: 10.1021/acschemneuro.8b00432. Epub 2019 Jan 23.

PMID:
30698015
15.

The metabolite repair enzyme Nit1 is a dual-targeted amidase that disposes of damaged glutathione in Arabidopsis.

Niehaus TD, Patterson JA, Alexander DC, Folz JS, Pyc M, MacTavish BS, Bruner SD, Mullen RT, Fiehn O, Hanson AD.

Biochem J. 2019 Feb 19;476(4):683-697. doi: 10.1042/BCJ20180931.

PMID:
30692244
16.

Rapid LC-MS/MS quantification of cancer related acetylated polyamines in human biofluids.

DeFelice BC, Fiehn O.

Talanta. 2019 May 1;196:415-419. doi: 10.1016/j.talanta.2018.12.074. Epub 2018 Dec 26.

PMID:
30683386
17.

Tissue-Specific Transcriptome Analysis Reveals Candidate Genes for Terpenoid and Phenylpropanoid Metabolism in the Medicinal Plant Ferula assafoetida.

Amini H, Naghavi MR, Shen T, Wang Y, Nasiri J, Khan IA, Fiehn O, Zerbe P, Maloof JN.

G3 (Bethesda). 2019 Mar 7;9(3):807-816. doi: 10.1534/g3.118.200852.

18.

Structure Annotation of All Mass Spectra in Untargeted Metabolomics.

Blaženović I, Kind T, Sa MR, Ji J, Vaniya A, Wancewicz B, Roberts BS, Torbašinović H, Lee T, Mehta SS, Showalter MR, Song H, Kwok J, Jahn D, Kim J, Fiehn O.

Anal Chem. 2019 Feb 5;91(3):2155-2162. doi: 10.1021/acs.analchem.8b04698. Epub 2019 Jan 16.

PMID:
30608141
19.

Effects of Gut Bacteria Depletion and High-Na+ and Low-K+ Intake on Circulating Levels of Biogenic Amines.

Blaženović I, Oh YT, Li F, Ji J, Nguyen AK, Wancewicz B, Bender JM, Fiehn O, Youn JH.

Mol Nutr Food Res. 2019 Feb;63(4):e1801184. doi: 10.1002/mnfr.201801184. Epub 2018 Dec 12.

PMID:
30513547
20.

Generation and quality control of lipidomics data for the alzheimer's disease neuroimaging initiative cohort.

Barupal DK, Fan S, Wancewicz B, Cajka T, Sa M, Showalter MR, Baillie R, Tenenbaum JD, Louie G; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Metabolomics Consortium, Kaddurah-Daouk R, Fiehn O.

Sci Data. 2018 Nov 20;5:180263. doi: 10.1038/sdata.2018.263.

21.

Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice.

Hendrikx T, Duan Y, Wang Y, Oh JH, Alexander LM, Huang W, Stärkel P, Ho SB, Gao B, Fiehn O, Emond P, Sokol H, van Pijkeren JP, Schnabl B.

Gut. 2018 Nov 17. pii: gutjnl-2018-317232. doi: 10.1136/gutjnl-2018-317232. [Epub ahead of print]

PMID:
30448775
22.

Skeletal muscle interstitial fluid metabolomics at rest and associated with an exercise bout: application in rats and humans.

Zhang J, Bhattacharyya S, Hickner RC, Light AR, Lambert CJ, Gale BK, Fiehn O, Adams SH.

Am J Physiol Endocrinol Metab. 2019 Jan 1;316(1):E43-E53. doi: 10.1152/ajpendo.00156.2018. Epub 2018 Nov 6.

PMID:
30398905
23.

Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.

Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11091-E11100. doi: 10.1073/pnas.1813956115. Epub 2018 Nov 5.

24.

Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia.

Sundberg JP, Shen T, Fiehn O, Rice RH, Silva KA, Kennedy VE, Gott NE, Dionne LA, Bechtold LS, Murray SA, Kuiper R, Pratt CH.

PLoS One. 2018 Oct 29;13(10):e0205775. doi: 10.1371/journal.pone.0205775. eCollection 2018.

25.

Distinctive Patterns of Flavonoid Biosynthesis in Roots and Nodules of Datisca glomerata and Medicago spp. Revealed by Metabolomic and Gene Expression Profiles.

Gifford I, Battenberg K, Vaniya A, Wilson A, Tian L, Fiehn O, Berry AM.

Front Plant Sci. 2018 Oct 10;9:1463. doi: 10.3389/fpls.2018.01463. eCollection 2018.

26.

Effects of Centella asiatica extract on antioxidant status and liver metabolome of rotenone-treated rats using GC-MS.

Intararuchikul T, Teerapattarakan N, Rodsiri R, Tantisira M, Wohlgemuth G, Fiehn O, Tansawat R.

Biomed Chromatogr. 2019 Feb;33(2):e4395. doi: 10.1002/bmc.4395. Epub 2018 Oct 17.

PMID:
30242859
27.

Umbilical cord blood metabolomics reveal distinct signatures of dyslipidemia prior to bronchopulmonary dysplasia and pulmonary hypertension.

La Frano MR, Fahrmann JF, Grapov D, Pedersen TL, Newman JW, Fiehn O, Underwood MA, Mestan K, Steinhorn RH, Wedgwood S.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L870-L881. doi: 10.1152/ajplung.00283.2017. Epub 2018 Aug 16.

PMID:
30113229
28.

NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells.

Becker-Kettern J, Paczia N, Conrotte JF, Zhu C, Fiehn O, Jung PP, Steinmetz LM, Linster CL.

FEBS J. 2018 Sep;285(18):3376-3401. doi: 10.1111/febs.14631. Epub 2018 Aug 27.

PMID:
30098110
29.

Increasing Compound Identification Rates in Untargeted Lipidomics Research with Liquid Chromatography Drift Time-Ion Mobility Mass Spectrometry.

Blaženović I, Shen T, Mehta SS, Kind T, Ji J, Piparo M, Cacciola F, Mondello L, Fiehn O.

Anal Chem. 2018 Sep 18;90(18):10758-10764. doi: 10.1021/acs.analchem.8b01527. Epub 2018 Aug 29.

PMID:
30096227
30.

Sex-associated differences in baseline urinary metabolites of healthy adults.

Fan S, Yeon A, Shahid M, Anger JT, Eilber KS, Fiehn O, Kim J.

Sci Rep. 2018 Aug 8;8(1):11883. doi: 10.1038/s41598-018-29592-3.

31.

Salvage of the 5-deoxyribose byproduct of radical SAM enzymes.

Beaudoin GAW, Li Q, Folz J, Fiehn O, Goodsell JL, Angerhofer A, Bruner SD, Hanson AD.

Nat Commun. 2018 Aug 6;9(1):3105. doi: 10.1038/s41467-018-05589-4.

32.

Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart.

Warren JS, Tracy CM, Miller MR, Makaju A, Szulik MW, Oka SI, Yuzyuk TN, Cox JE, Kumar A, Lozier BK, Wang L, Llana JG, Sabry AD, Cawley KM, Barton DW, Han YH, Boudina S, Fiehn O, Tucker HO, Zaitsev AV, Franklin S.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7871-E7880. doi: 10.1073/pnas.1800680115. Epub 2018 Jul 30.

33.

The Iceman's Last Meal Consisted of Fat, Wild Meat, and Cereals.

Maixner F, Turaev D, Cazenave-Gassiot A, Janko M, Krause-Kyora B, Hoopmann MR, Kusebauch U, Sartain M, Guerriero G, O'Sullivan N, Teasdale M, Cipollini G, Paladin A, Mattiangeli V, Samadelli M, Tecchiati U, Putzer A, Palazoglu M, Meissen J, Lösch S, Rausch P, Baines JF, Kim BJ, An HJ, Gostner P, Egarter-Vigl E, Malfertheiner P, Keller A, Stark RW, Wenk M, Bishop D, Bradley DG, Fiehn O, Engstrand L, Moritz RL, Doble P, Franke A, Nebel A, Oeggl K, Rattei T, Grimm R, Zink A.

Curr Biol. 2018 Jul 23;28(14):2348-2355.e9. doi: 10.1016/j.cub.2018.05.067. Epub 2018 Jul 12.

34.

Gut microbial and metabolomic profiles after fecal microbiota transplantation in pediatric ulcerative colitis patients.

Nusbaum DJ, Sun F, Ren J, Zhu Z, Ramsy N, Pervolarakis N, Kunde S, England W, Gao B, Fiehn O, Michail S, Whiteson K.

FEMS Microbiol Ecol. 2018 Sep 1;94(9). doi: 10.1093/femsec/fiy133.

PMID:
30010747
35.

Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.

Nagy-Szakal D, Barupal DK, Lee B, Che X, Williams BL, Kahn EJR, Ukaigwe JE, Bateman L, Klimas NG, Komaroff AL, Levine S, Montoya JG, Peterson DL, Levin B, Hornig M, Fiehn O, Lipkin WI.

Sci Rep. 2018 Jul 3;8(1):10056. doi: 10.1038/s41598-018-28477-9.

36.

Reference samples guide variable selection for correlation of wine sensory and volatile profiling data.

Sherman E, Harbertson JF, Greenwood DR, Villas-Bôas SG, Fiehn O, Heymann H.

Food Chem. 2018 Nov 30;267:344-354. doi: 10.1016/j.foodchem.2017.10.073. Epub 2017 Oct 12.

PMID:
29934177
37.

Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative).

Kirwan JA, Brennan L, Broadhurst D, Fiehn O, Cascante M, Dunn WB, Schmidt MA, Velagapudi V.

Clin Chem. 2018 Aug;64(8):1158-1182. doi: 10.1373/clinchem.2018.287045. Epub 2018 Jun 19. Review.

PMID:
29921725
38.

Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics.

Blaženović I, Kind T, Ji J, Fiehn O.

Metabolites. 2018 May 10;8(2). pii: E31. doi: 10.3390/metabo8020031. Review.

39.

Tracking Polymicrobial Metabolism in Cystic Fibrosis Airways: Pseudomonas aeruginosa Metabolism and Physiology Are Influenced by Rothia mucilaginosa-Derived Metabolites.

Gao B, Gallagher T, Zhang Y, Elbadawi-Sidhu M, Lai Z, Fiehn O, Whiteson KL.

mSphere. 2018 Apr 25;3(2). pii: e00151-18. doi: 10.1128/mSphere.00151-18. Print 2018 Apr 25.

40.

Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry.

Hook V, Lietz CB, Podvin S, Cajka T, Fiehn O.

J Am Soc Mass Spectrom. 2018 May;29(5):807-816. doi: 10.1007/s13361-018-1914-1. Epub 2018 Apr 17.

41.

Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function.

Niehaus TD, Elbadawi-Sidhu M, Huang L, Prunetti L, Gregory JF 3rd, de Crécy-Lagard V, Fiehn O, Hanson AD.

Biosci Rep. 2018 May 8;38(3). pii: BSR20180223. doi: 10.1042/BSR20180223. Print 2018 Jun 29.

42.

Identification of a metabolic disposal route for the oncometabolite S-(2-succino)cysteine in Bacillus subtilis.

Niehaus TD, Folz J, McCarty DR, Cooper AJL, Moraga Amador D, Fiehn O, Hanson AD.

J Biol Chem. 2018 May 25;293(21):8255-8263. doi: 10.1074/jbc.RA118.002925. Epub 2018 Apr 6.

43.

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.

Li XS, Wang Z, Cajka T, Buffa JA, Nemet I, Hurd AG, Gu X, Skye SM, Roberts AB, Wu Y, Li L, Shahen CJ, Wagner MA, Hartiala JA, Kerby RL, Romano KA, Han Y, Obeid S, Lüscher TF, Allayee H, Rey FE, DiDonato JA, Fiehn O, Tang WHW, Hazen SL.

JCI Insight. 2018 Mar 22;3(6). pii: 99096. doi: 10.1172/jci.insight.99096.

44.

Integrating bioinformatics approaches for a comprehensive interpretation of metabolomics datasets.

Barupal DK, Fan S, Fiehn O.

Curr Opin Biotechnol. 2018 Dec;54:1-9. doi: 10.1016/j.copbio.2018.01.010. Epub 2018 Feb 6. Review.

PMID:
29413745
45.

Obesogenic diets alter metabolism in mice.

Showalter MR, Nonnecke EB, Linderholm AL, Cajka T, Sa MR, Lönnerdal B, Kenyon NJ, Fiehn O.

PLoS One. 2018 Jan 11;13(1):e0190632. doi: 10.1371/journal.pone.0190632. eCollection 2018.

46.

Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics.

Shahin MH, Gong Y, Frye RF, Rotroff DM, Beitelshees AL, Baillie RA, Chapman AB, Gums JG, Turner ST, Boerwinkle E, Motsinger-Reif A, Fiehn O, Cooper-DeHoff RM, Han X, Kaddurah-Daouk R, Johnson JA.

J Am Heart Assoc. 2017 Dec 29;7(1). pii: e006656. doi: 10.1161/JAHA.117.006656.

47.

Strategies for dereplication of natural compounds using high-resolution tandem mass spectrometry.

Kind T, Fiehn O.

Phytochem Lett. 2017 Sep;21:313-319. doi: 10.1016/j.phytol.2016.11.006. Epub 2016 Nov 17.

48.

Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics.

Lai Z, Tsugawa H, Wohlgemuth G, Mehta S, Mueller M, Zheng Y, Ogiwara A, Meissen J, Showalter M, Takeuchi K, Kind T, Beal P, Arita M, Fiehn O.

Nat Methods. 2018 Jan;15(1):53-56. doi: 10.1038/nmeth.4512. Epub 2017 Nov 27.

49.

Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia.

Fong LY, Jing R, Smalley KJ, Taccioli C, Fahrmann J, Barupal DK, Alder H, Farber JL, Fiehn O, Croce CM.

Oncotarget. 2017 Jun 9;8(47):81910-81925. doi: 10.18632/oncotarget.18434. eCollection 2017 Oct 10.

50.

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