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Items: 1 to 50 of 333

1.

Karamomycins A-C: 2-Naphthalen-2-yl-thiazoles from Nonomuraea endophytica.

Shaaban KA, Shaaban M, Rahman H, Grün-Wollny I, Kämpfer P, Kelter G, Fiebig HH, Laatsch H.

J Nat Prod. 2019 Apr 26;82(4):870-877. doi: 10.1021/acs.jnatprod.8b00928. Epub 2019 Mar 25.

PMID:
30907593
2.

Studies on the constituents of Helleborus purpurascens: analysis and biological activity of the aqueous and organic extracts.

Franz MH, Birzoi R, Maftei CV, Maftei E, Kelter G, Fiebig HH, Neda I.

Amino Acids. 2018 Jan;50(1):163-188. doi: 10.1007/s00726-017-2502-6. Epub 2017 Oct 12.

PMID:
29027024
3.

Lung Cancer: EGFR Inhibitors with Low Nanomolar Activity against a Therapy-Resistant L858R/T790M/C797S Mutant.

Günther M, Juchum M, Kelter G, Fiebig H, Laufer S.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10890-4. doi: 10.1002/anie.201603736. Epub 2016 Jul 28.

PMID:
27466205
4.

Marine Bacteria, XLVII - Psychrotolerant Bacteria from Extreme Antarctic Habitats as Producers of Rare Bis- and Trisindole Alkaloids.

Nair V, Schuhmann I, Anke H, Kelter G, Fiebig HH, Helmke E, Laatsch H.

Planta Med. 2016 Jun;82(9-10):910-8. doi: 10.1055/s-0042-108204. Epub 2016 Jun 10.

PMID:
27286331
5.

Bacaryolanes A-C, Rare Bacterial Caryolanes from a Mangrove Endophyte.

Ding L, Goerls H, Dornblut K, Lin W, Maier A, Fiebig HH, Hertweck C.

J Nat Prod. 2015 Dec 24;78(12):2963-7. doi: 10.1021/acs.jnatprod.5b00674. Epub 2015 Nov 27.

6.

Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor.

Forest A, Amatulli M, Ludwig DL, Damoci CB, Wang Y, Burns CA, Donoho GP, Zanella N, Fiebig HH, Prewett MC, Surguladze D, DeLigio JT, Houghton PJ, Smith MA, Novosiadly R.

Mol Cancer Res. 2015 Dec;13(12):1615-26. doi: 10.1158/1541-7786.MCR-15-0279. Epub 2015 Aug 11.

7.

N-heterocyclic carbenes (NHC) with 1,2,4-oxadiazole-substituents related to natural products: synthesis, structure and potential antitumor activity of some corresponding gold(I) and silver(I) complexes.

Maftei CV, Fodor E, Jones PG, Freytag M, Franz MH, Kelter G, Fiebig HH, Tamm M, Neda I.

Eur J Med Chem. 2015 Aug 28;101:431-41. doi: 10.1016/j.ejmech.2015.06.053. Epub 2015 Jul 2.

PMID:
26185007
8.

Allergen Microarray Indicates Pooideae Sensitization in Brazilian Grass Pollen Allergic Patients.

Moreira PF, Gangl K, Vieira Fde A, Ynoue LH, Linhart B, Flicker S, Fiebig H, Swoboda I, Focke-Tejkl M, Taketomi EA, Valenta R, Niederberger V.

PLoS One. 2015 Jun 11;10(6):e0128402. doi: 10.1371/journal.pone.0128402. eCollection 2015.

9.

Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells.

Hampson P, Wang K, Ersvær E, McCormack E, Schüler J, Fiebig HH, Gjertsen BT, Bruserud Ø, Lord JM.

Oncoscience. 2014 Aug 6;1(8):529-39. eCollection 2014.

10.

Annotation of human cancers with EGFR signaling-associated protein complexes using proximity ligation assays.

Smith MA, Hall R, Fisher K, Haake SM, Khalil F, Schabath MB, Vuaroqueaux V, Fiebig HH, Altiok S, Chen YA, Haura EB.

Sci Signal. 2015 Jan 13;8(359):ra4. doi: 10.1126/scisignal.2005906.

11.

Altersolanol A: a selective cytotoxic anthraquinone from a Phomopsis sp.

Mishra PD, Verekar SA, Deshmukh SK, Joshi KS, Fiebig HH, Kelter G.

Lett Appl Microbiol. 2015 Apr;60(4):387-91. doi: 10.1111/lam.12384. Epub 2015 Feb 8.

12.

Synthesis, cytotoxic, and antitumor activities of 2-pyridylhydrazones derived from 3-benzoylpyridazines.

Easmon J, Pürstinger G, Heinisch G, Fiebig HH, Roth T, Hofmann J.

Arch Pharm (Weinheim). 2014 Aug;347(8):599-608. doi: 10.1002/ardp.201400137. Epub 2014 Jun 11.

PMID:
24917378
13.

Anticancer activity of new depsipeptide compound isolated from an endophytic fungus.

Verekar SA, Mishra PD, Sreekumar ES, Deshmukh SK, Fiebig HH, Kelter G, Maier A.

J Antibiot (Tokyo). 2014 Oct;67(10):697-701. doi: 10.1038/ja.2014.58. Epub 2014 May 14.

PMID:
24824817
14.

Total synthesis and cytotoxicity of the marine natural product malevamide D and a photoreactive analog.

Telle W, Kelter G, Fiebig HH, Jones PG, Lindel T.

Beilstein J Org Chem. 2014 Feb 3;10:316-22. doi: 10.3762/bjoc.10.29. eCollection 2014.

15.

Pharmacogenomics of cantharidin in tumor cells.

Kadioglu O, Kermani NS, Kelter G, Schumacher U, Fiebig HH, Greten HJ, Efferth T.

Biochem Pharmacol. 2014 Feb 1;87(3):399-409. doi: 10.1016/j.bcp.2013.10.025. Epub 2013 Nov 11.

PMID:
24231507
16.

Intratibial injection of human multiple myeloma cells in NOD/SCID IL-2Rγ(null) mice mimics human myeloma and serves as a valuable tool for the development of anticancer strategies.

Schueler J, Wider D, Klingner K, Siegers GM, May AM, Wäsch R, Fiebig HH, Engelhardt M.

PLoS One. 2013 Nov 6;8(11):e79939. doi: 10.1371/journal.pone.0079939. eCollection 2013.

17.

Synthesis and characterization of novel bioactive 1,2,4-oxadiazole natural product analogs bearing the N-phenylmaleimide and N-phenylsuccinimide moieties.

Maftei CV, Fodor E, Jones PG, Franz MH, Kelter G, Fiebig H, Neda I.

Beilstein J Org Chem. 2013 Oct 25;9:2202-15. doi: 10.3762/bjoc.9.259. eCollection 2013.

18.

Pachydictyols B and C: new diterpenes from Dictyota dichotoma Hudson.

Abou-El-Wafa GS, Shaaban M, Shaaban KA, El-Naggar ME, Maier A, Fiebig HH, Laatsch H.

Mar Drugs. 2013 Aug 22;11(9):3109-23. doi: 10.3390/md11093109.

19.

Doubly prenylated tryptamines: cytotoxicity, antimicrobial activity and cyclisation to the marine natural product flustramine A.

Adla SK, Sasse F, Kelter G, Fiebig HH, Lindel T.

Org Biomol Chem. 2013 Sep 28;11(36):6119-30. doi: 10.1039/c3ob40896e.

PMID:
23925418
20.

Validation of tumour models for use in anticancer nanomedicine evaluation: the EPR effect and cathepsin B-mediated drug release rate.

Duncan R, Sat-Klopsch YN, Burger AM, Bibby MC, Fiebig HH, Sausville EA.

Cancer Chemother Pharmacol. 2013 Aug;72(2):417-27.

21.

Synthesis and antiproliferative activity of 2,5-bis(3'-indolyl)pyrroles, analogues of the marine alkaloid nortopsentin.

Carbone A, Parrino B, Barraja P, Spanò V, Cirrincione G, Diana P, Maier A, Kelter G, Fiebig HH.

Mar Drugs. 2013 Mar 1;11(3):643-54. doi: 10.3390/md11030643.

22.

Establishment of recombinant major allergens Bet v 1 and Phl p 5a as Ph. Eur. reference standards and validation of ELISA methods for their measurement. Results from feasibility studies.

Vieths S, Barber D, Chapman M, Costanzo A, Daas A, Fiebig H, Hanschmann KM, Hrabina M, Kaul S, Ledesma A, Moingeon P, Reese G, Schörner C, van Ree R, Weber B, Buchheit KH.

Pharmeur Bio Sci Notes. 2012 Apr;2012:118-34.

PMID:
23327896
23.

Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs.

Baechler SA, Fehr M, Habermeyer M, Hofmann A, Merz KH, Fiebig HH, Marko D, Eisenbrand G.

Bioorg Med Chem. 2013 Feb 1;21(3):814-23. doi: 10.1016/j.bmc.2012.11.011. Epub 2012 Nov 26.

PMID:
23266176
24.

Kandenols A-E, eudesmenes from an endophytic Streptomyces sp. of the mangrove tree Kandelia candel.

Ding L, Maier A, Fiebig HH, Lin WH, Peschel G, Hertweck C.

J Nat Prod. 2012 Dec 28;75(12):2223-7. doi: 10.1021/np300387n. Epub 2012 Dec 12.

PMID:
23234344
25.

Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.

Ding L, Ndejouong Ble S, Maier A, Fiebig HH, Hertweck C.

J Nat Prod. 2012 Oct 26;75(10):1729-34. doi: 10.1021/np300329m. Epub 2012 Sep 26.

PMID:
23013356
26.

Hypoallergenic mutants of the Timothy grass pollen allergen Phl p 5 generated by proline mutations.

Wald M, Kahlert H, Reese G, Krontal N, Zafred D, Keller W, Cromwell O, Fiebig H, Nandy A.

Int Arch Allergy Immunol. 2012;159(2):130-42. doi: 10.1159/000336651. Epub 2012 May 30.

PMID:
22653364
27.

Characterization of colon cancer cells: a functional approach characterizing CD133 as a potential stem cell marker.

Schneider M, Huber J, Hadaschik B, Siegers GM, Fiebig HH, Schüler J.

BMC Cancer. 2012 Mar 20;12:96. doi: 10.1186/1471-2407-12-96.

28.

Inactivated orf virus (Parapoxvirus ovis) induces antitumoral activity in transplantable tumor models.

Fiebig HH, Siegling A, Volk HD, Friebe A, Knolle P, Limmer A, Weber O.

Anticancer Res. 2011 Dec;31(12):4185-90.

PMID:
22199278
29.

Predictive gene signatures for bevacizumab and cetuximab as well as cytotoxic agents.

Fiebig HH, Vuaroqueaux V, Korrat A, Foucault F, Beckers T.

Int J Clin Pharmacol Ther. 2012 Jan;50(1):70-1. No abstract available.

30.

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.

Beckers T, Sellmer A, Eichhorn E, Pongratz H, Schächtele C, Totzke F, Kelter G, Krumbach R, Fiebig HH, Böhmer FD, Mahboobi S.

Bioorg Med Chem. 2012 Jan 1;20(1):125-36. doi: 10.1016/j.bmc.2011.11.023. Epub 2011 Nov 20.

PMID:
22169601
31.

Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model.

Wehr C, Müller F, Schüler J, Tomann T, Nitschke C, Seismann H, Spillner E, Klingner K, Schneider-Merck T, Binder M, Fiebig HH, Mertelsmann R, Trepel M.

Int J Cancer. 2012 Jul 15;131(2):E10-20. doi: 10.1002/ijc.26464. Epub 2011 Nov 19.

32.

Mechanistic studies on two dinuclear organogold(III) compounds showing appreciable antiproliferative properties and a high redox stability.

Gabbiani C, Casini A, Kelter G, Cocco F, Cinellu MA, Fiebig HH, Messori L.

Metallomics. 2011 Dec;3(12):1318-23. doi: 10.1039/c1mt00113b. Epub 2011 Sep 2.

PMID:
21887452
33.

Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus.

Ueberschaar N, Ndejouong Ble S, Ding L, Maier A, Fiebig HH, Hertweck C.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5839-41. doi: 10.1016/j.bmcl.2011.07.108. Epub 2011 Aug 4.

PMID:
21868221
34.

Clinical experience with recombinant molecules for allergy vaccination.

Cromwell O, Niederberger V, Horak F, Fiebig H.

Curr Top Microbiol Immunol. 2011;352:27-42. doi: 10.1007/82_2011_129. Review.

PMID:
21562972
35.

Molecular editing and assessment of the cytotoxic properties of iejimalide and progeny.

Gagnepain J, Moulin E, Nevado C, Waser M, Maier A, Kelter G, Fiebig HH, Fürstner A.

Chemistry. 2011 Jun 14;17(25):6973-84. doi: 10.1002/chem.201100180. Epub 2011 May 9.

PMID:
21557355
36.

A family of multicyclic indolosesquiterpenes from a bacterial endophyte.

Ding L, Maier A, Fiebig HH, Lin WH, Hertweck C.

Org Biomol Chem. 2011 Jun 7;9(11):4029-31. doi: 10.1039/c1ob05283g. Epub 2011 Apr 28.

PMID:
21528153
37.

The preclinical and clinical activity of aviscumine: a potential anticancer drug.

Zwierzina H, Bergmann L, Fiebig H, Aamdal S, Schöffski P, Witthohn K, Lentzen H.

Eur J Cancer. 2011 Jul;47(10):1450-7. doi: 10.1016/j.ejca.2011.02.022. Epub 2011 Apr 12. Review.

PMID:
21482461
38.

Divergolides A-D from a mangrove endophyte reveal an unparalleled plasticity in ansa-macrolide biosynthesis.

Ding L, Maier A, Fiebig HH, Görls H, Lin WH, Peschel G, Hertweck C.

Angew Chem Int Ed Engl. 2011 Feb 11;50(7):1630-4. doi: 10.1002/anie.201006165. Epub 2011 Jan 11. No abstract available.

PMID:
21308920
39.

Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum.

Rashan LJ, Franke K, Khine MM, Kelter G, Fiebig HH, Neumann J, Wessjohann LA.

J Ethnopharmacol. 2011 Apr 12;134(3):781-8. doi: 10.1016/j.jep.2011.01.038. Epub 2011 Feb 1.

PMID:
21291990
40.

Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: activation of MET as one mechanism for drug resistance.

Krumbach R, Schüler J, Hofmann M, Giesemann T, Fiebig HH, Beckers T.

Eur J Cancer. 2011 May;47(8):1231-43. doi: 10.1016/j.ejca.2010.12.019. Epub 2011 Jan 25.

PMID:
21273060
41.

Mode of action of epoxyphomalins A and B and characterization of related metabolites from the marine-derived fungus Paraconiothyrium sp.

Mohamed IE, Kehraus S, Krick A, König GM, Kelter G, Maier A, Fiebig HH, Kalesse M, Malek NP, Gross H.

J Nat Prod. 2010 Dec 27;73(12):2053-6. doi: 10.1021/np100310k. Epub 2010 Nov 29.

PMID:
21114274
42.

Glucopiericidin C: a cytotoxic piericidin glucoside antibiotic produced by a marine Streptomyces isolate.

Shaaban KA, Helmke E, Kelter G, Fiebig HH, Laatsch H.

J Antibiot (Tokyo). 2011 Feb;64(2):205-9. doi: 10.1038/ja.2010.125. Epub 2010 Nov 17. No abstract available.

PMID:
21081953
43.

[Au2(phen(2Me))2(μ-O)2](PF6)2, a Novel Dinuclear Gold(III) Complex Showing Excellent Antiproliferative Properties.

Cinellu MA, Maiore L, Manassero M, Casini A, Arca M, Fiebig HH, Kelter G, Michelucci E, Pieraccini G, Gabbiani C, Messori L.

ACS Med Chem Lett. 2010 Jul 2;1(7):336-9. doi: 10.1021/ml100097f. eCollection 2010 Oct 14.

44.

Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.

Ding L, Münch J, Goerls H, Maier A, Fiebig HH, Lin WH, Hertweck C.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6685-7. doi: 10.1016/j.bmcl.2010.09.010. Epub 2010 Sep 9.

PMID:
20880706
45.

Hygrobafilomycin, a cytotoxic and antifungal macrolide bearing a unique monoalkylmaleic anhydride moiety, from Streptomyces varsoviensis.

Tchize Ndejouong Ble S, Sattler I, Maier A, Kelter G, Menzel KD, Fiebig HH, Hertweck C.

J Antibiot (Tokyo). 2010 Jul;63(7):359-63. doi: 10.1038/ja.2010.52. Epub 2010 Jun 16.

PMID:
20551984
46.

Antiarol cinnamate and africanoside, a cinnamoyl triterpene and a hydroperoxy-cardenolide from the stem bark of Antiaris africana.

Vouffo B, Dongo E, Facey P, Thorn A, Sheldrick G, Maier A, Fiebig HH, Laatsch H.

Planta Med. 2010 Oct;76(15):1717-23. doi: 10.1055/s-0030-1249958. Epub 2010 Jun 8.

PMID:
20533166
47.

Synthesis and antitumor activity of 2,5-bis(3'-indolyl)-furans and 3,5-bis(3'-indolyl)-isoxazoles, nortopsentin analogues.

Diana P, Carbone A, Barraja P, Kelter G, Fiebig HH, Cirrincione G.

Bioorg Med Chem. 2010 Jun 15;18(12):4524-9. doi: 10.1016/j.bmc.2010.04.061. Epub 2010 Apr 28.

PMID:
20472437
48.

Telomerase activity and telomere length in human tumor cells with acquired resistance to anticancer agents.

Smith V, Dai F, Spitz M, Peters GJ, Fiebig HH, Hussain A, Burger AM.

J Chemother. 2009 Nov;21(5):542-9.

PMID:
19933046
49.

Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete.

Hawas UW, Shaaban M, Shaaban KA, Speitling M, Maier A, Kelter G, Fiebig HH, Meiners M, Helmke E, Laatsch H.

J Nat Prod. 2009 Dec;72(12):2120-4. doi: 10.1021/np900160g.

PMID:
19921834
50.

Epoxyphomalin A and B, prenylated polyketides with potent cytotoxicity from the marine-derived fungus Phoma sp.

Mohamed IE, Gross H, Pontius A, Kehraus S, Krick A, Kelter G, Maier A, Fiebig HH, König GM.

Org Lett. 2009 Nov 5;11(21):5014-7. doi: 10.1021/ol901996g.

PMID:
19813715

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