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Levels of Human Immunodeficiency Virus DNA Are Determined Before ART Initiation and Linked to CD8 T-Cell Activation and Memory Expansion.

Martin GE, Pace M, Shearer FM, Zilber E, Hurst J, Meyerowitz J, Thornhill JP, Lwanga J, Brown H, Robinson N, Hopkins E, Olejniczak N, Nwokolo N, Fox J, Fidler S, Willberg CB, Frater J.

J Infect Dis. 2019 Nov 28. pii: jiz563. doi: 10.1093/infdis/jiz563. [Epub ahead of print]


Highlights of the 10th International AIDS Society (IAS) Conference on HIV Science, 21-25 July 2019, Mexico City, Mexico.

Psomas CK, Waters L, Barber T, Fidler S, Macartney M, Alagaratnam J, Perera B, Kinloch S.

J Virus Erad. 2019 Nov 4;5(4):245-252. No abstract available.


Vedolizumab use and the associations between α4β7 expression and HIV reservoir in the gut during treated primary HIV infection.

Thornhill JP, Lynch KD, Skelton JK, Dorner M, Khan M, Martin GE, Hoare J, Peake S, Frater J, Fidler S.

AIDS. 2019 Nov 15;33(14):2268-2271. doi: 10.1097/QAD.0000000000002344. No abstract available.


Responses to Quadrivalent Influenza Vaccine Reveal Distinct Circulating CD4+CXCR5+ T Cell Subsets in Men Living with HIV.

Cole ME, Saeed Z, Shaw AT, Guo Y, Höschler K, Winston A, Cooke GS, Fidler S, Taylor GP, Pollock KM.

Sci Rep. 2019 Oct 30;9(1):15650. doi: 10.1038/s41598-019-51961-9.


Clinical outcomes post transition to adult services in young adults with perinatally acquired HIV infection: mortality, retention in care, and viral suppression.

Foster C, Ayers S, Mcdonald S, Frize G, Chhabra S, Pasvol TJ, Fidler S.

AIDS. 2019 Oct 16. doi: 10.1097/QAD.0000000000002410. [Epub ahead of print]


Compromised CD4:CD8 ratio recovery in people living with HIV aged over 50 years: an observational study.

Francis-Morris A, Mackie NE, Eliahoo J, Ramzan F, Fidler S, Pollock KM.

HIV Med. 2019 Oct 16. doi: 10.1111/hiv.12800. [Epub ahead of print]


Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers.

Phetsouphanh C, Aldridge D, Marchi E, Munier CML, Meyerowitz J, Murray L, Van Vuuren C, Goedhals D, Fidler S, Kelleher A, Klenerman P, Frater J.

Front Immunol. 2019 Aug 8;10:1844. doi: 10.3389/fimmu.2019.01844. eCollection 2019.


Effect of Universal Testing and Treatment on HIV Incidence - HPTN 071 (PopART).

Hayes RJ, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Yang B, Phiri M, Schaap A, Eshleman SH, Piwowar-Manning E, Kosloff B, James A, Skalland T, Wilson E, Emel L, Macleod D, Dunbar R, Simwinga M, Makola N, Bond V, Hoddinott G, Moore A, Griffith S, Deshmane Sista N, Vermund SH, El-Sadr W, Burns DN, Hargreaves JR, Hauck K, Fraser C, Shanaube K, Bock P, Beyers N, Ayles H, Fidler S; HPTN 071 (PopART) Study Team.

N Engl J Med. 2019 Jul 18;381(3):207-218. doi: 10.1056/NEJMoa1814556.


Mapping the drivers of within-host pathogen evolution using massive data sets.

Palmer DS, Turner I, Fidler S, Frater J, Goedhals D, Goulder P, Huang KG, Oxenius A, Phillips R, Shapiro R, Vuuren CV, McLean AR, McVean G.

Nat Commun. 2019 Jul 9;10(1):3017. doi: 10.1038/s41467-019-10724-w.


CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype.

Thornhill JP, Pace M, Martin GE, Hoare J, Peake S, Herrera C, Phetsouphanh C, Meyerowitz J, Hopkins E, Brown H, Dunn P, Olejniczak N, Willberg C, Klenerman P, Goldin R, Fox J, Fidler S, Frater J; CHERUB investigators.

Mucosal Immunol. 2019 Sep;12(5):1212-1219. doi: 10.1038/s41385-019-0180-2. Epub 2019 Jun 25.


Identifying Clinical Terms in Medical Text Using Ontology-Guided Machine Learning.

Arbabi A, Adams DR, Fidler S, Brudno M.

JMIR Med Inform. 2019 May 10;7(2):e12596. doi: 10.2196/12596.


Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection.

Zilber E, Martin GE, Willberg CB, Fox J, Nwokolo N, Fidler S, Frater J; CHERUB Investigators.

AIDS. 2019 Jun 1;33(7):1253-1256. doi: 10.1097/QAD.0000000000002165.


Renal dysfunction by baseline CD4 cell count in a cohort of adults starting antiretroviral treatment regardless of CD4 count in the HIV Prevention Trials Network 071 [HPTN 071; Population Effect of Antiretroviral Therapy to Reduce HIV Transmission (PopART)] study in South Africa.

Bock P, Nel K, Fatti G, Sloot R, Ford N, Voget J, Gunst C, Grobbelaar N, Louis F, Floyd S, Hayes R, Ayles H, Beyers N, Fidler S; HPTN 071 (PopART) Team.

HIV Med. 2019 Jul;20(6):392-403. doi: 10.1111/hiv.12729. Epub 2019 Apr 8.


Work and home productivity of people living with HIV in Zambia and South Africa.

Thomas R, Friebel R, Barker K, Mwenge L, Kanema S, Vanqa N, Harper A, Bell-Mandla N, Smith PC, Floyd S, Bock P, Ayles H, Fidler S, Hayes R, Hauck K; HPTN 071 (PopART) Study Team.

AIDS. 2019 May 1;33(6):1063-1071. doi: 10.1097/QAD.0000000000002160.


Better Virological Outcomes amongst People Living with HIV Initiating Early Antiretroviral Treatment (CD4 counts ≥ 500 cells/µL) in the HPTN 071 (PopART) Trial in South Africa.

Fatti G, Grimwood A, Nachega JB, Nelson JA, LaSorda K, Zyl GV, Grobbelaar N, Ayles H, Hayes R, Beyers N, Fidler S, Bock P; HPTN 071 (PopART) study team.

Clin Infect Dis. 2019 Mar 16. pii: ciz214. doi: 10.1093/cid/ciz214. [Epub ahead of print]


Case series of infertility amongst young women with perinatally acquired HIV: data from a London cohort.

Teh J, Pasvol T, Ayres S, Foster C, Fidler S.

J Virus Erad. 2019 Jan 1;5(1):44-46.


Reasons for delayed antiretroviral therapy (ART) initiation in the era of early ART initiation guidelines: a retrospective service evaluation.

Lee MJ, Venturelli S, McKenna W, Teh J, Negedu O, Florman KE, Musbahi E, Bailey AC, Mackie NE, Fox J, Fidler S.

Int J STD AIDS. 2019 Mar;30(4):415-418. doi: 10.1177/0956462418814985. Epub 2019 Jan 8.


Community based distribution of oral HIV self-testing kits in Zambia: a cluster-randomised trial nested in four HPTN 071 (PopART) intervention communities.

Mulubwa C, Hensen B, Phiri MM, Shanaube K, Schaap AJ, Floyd S, Phiri CR, Bwalya C, Bond V, Simwinga M, Mwenge L, Fidler S, Hayes R, Mwinga A, Ayles H; HPTN 071 (PopART) Study Team.

Lancet HIV. 2019 Feb;6(2):e81-e92. doi: 10.1016/S2352-3018(18)30258-3. Epub 2018 Dec 21.


Highlights from the 22nd International AIDS Conference (AIDS 2018), 22-27 July 2018, Amsterdam, the Netherlands.

Psomas CK, Fidler S, Macartney M, Jeffreys R, Reilly L, Collins S, Moreno S, Routy JP, Pasternak A, Kinloch-de Loës S.

J Virus Erad. 2018 Oct 1;4(4):238-247.


Understanding the Time Needed to Link to Care and Start ART in Seven HPTN 071 (PopART) Study Communities in Zambia and South Africa.

Seeley J, Bond V, Yang B, Floyd S, MacLeod D, Viljoen L, Phiri M, Simuyaba M, Hoddinott G, Shanaube K, Bwalya C, de Villiers L, Jennings K, Mwanza M, Schaap A, Dunbar R, Sabapathy K, Ayles H, Bock P, Hayes R, Fidler S; HPTN 071 (PopART) study team.

AIDS Behav. 2019 Apr;23(4):929-946. doi: 10.1007/s10461-018-2335-7.


Virological remission after antiretroviral therapy interruption in female African HIV seroconverters.

Gossez M, Martin GE, Pace M, Ramjee G, Premraj A, Kaleebu P, Rees H, Inshaw J, Stöhr W, Meyerowitz J, Hopkins E, Jones M, Hurst J, Porter K, Babiker A, Fidler S, Frater J; SPARTAC Trial Investigators.

AIDS. 2019 Feb 1;33(2):185-197. doi: 10.1097/QAD.0000000000002044.


Towards 90-90: Findings after two years of the HPTN 071 (PopART) cluster-randomized trial of a universal testing-and-treatment intervention in Zambia.

Floyd S, Ayles H, Schaap A, Shanaube K, MacLeod D, Phiri M, Griffith S, Bock P, Beyers N, Fidler S, Hayes R; HPTN 071 (PopART) Study Team.

PLoS One. 2018 Aug 10;13(8):e0197904. doi: 10.1371/journal.pone.0197904. eCollection 2018.


CD4:CD8 ratio in children with perinatally acquired HIV-1 infection.

Seers T, Vassallo P, Pollock K, Thornhill JP, Fidler S, Foster C.

HIV Med. 2018 Oct;19(9):668-672. doi: 10.1111/hiv.12642. Epub 2018 Aug 6.


The cascade of care following community-based detection of HIV in sub-Saharan Africa - A systematic review with 90-90-90 targets in sight.

Sabapathy K, Hensen B, Varsaneux O, Floyd S, Fidler S, Hayes R.

PLoS One. 2018 Jul 27;13(7):e0200737. doi: 10.1371/journal.pone.0200737. eCollection 2018.


Careful consideration when responding to new data: dolutegravir and pregnancy.

Foster C, Fidler S, Lyall E, Taylor G.

J Virus Erad. 2018 Jul 1;4(3):208.


Spinning plates: livelihood mobility, household responsibility and anti-retroviral treatment in an urban Zambian community during the HPTN 071 (PopART) study.

Bond V, Ngwenya F, Thomas A, Simuyaba M, Hoddinott G, Fidler S, Hayes R, Ayles H, Seeley J; HPTN 071 (PopART) study team.

J Int AIDS Soc. 2018 Jul;21 Suppl 4:e25117. doi: 10.1002/jia2.25117.


A study on the dynamics of temporary HIV treatment to assess the controversial outcomes of clinical trials: An in-silico approach.

Mancini E, Quax R, De Luca A, Fidler S, Stohr W, Sloot PMA.

PLoS One. 2018 Jul 18;13(7):e0200892. doi: 10.1371/journal.pone.0200892. eCollection 2018.


CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA.

Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Meyerowitz J, Gossez M, Brown H, Olejniczak N, Lwanga J, Ramjee G, Kaleebu P, Porter K, Willberg CB, Klenerman P, Nwokolo N, Fox J, Fidler S, Frater J.

Front Immunol. 2018 May 4;9:928. doi: 10.3389/fimmu.2018.00928. eCollection 2018.


Attrition when providing antiretroviral treatment at CD4 counts >500cells/μL at three government clinics included in the HPTN 071 (PopART) trial in South Africa.

Bock P, Fatti G, Ford N, Jennings K, Kruger J, Gunst C, Louis F, Grobbelaar N, Shanaube K, Floyd S, Grimwood A, Hayes R, Ayles H, Fidler S, Beyers N; HPTN 071 (PopART) trial team.

PLoS One. 2018 Apr 19;13(4):e0195127. doi: 10.1371/journal.pone.0195127. eCollection 2018.


Sexually Transmitted Bedfellows: Exquisite Association Between HIV and Herpes Simplex Virus Type 2 in 21 Communities in Southern Africa in the HIV Prevention Trials Network 071 (PopART) Study.

Bradley J, Floyd S, Piwowar-Manning E, Laeyendecker O, Young A, Bell-Mandla N, Bwalya J, Bock P, Fidler S, Ayles H, Hayes RJ; HPTN 071 (PopART) Study Team.

J Infect Dis. 2018 Jul 2;218(3):443-452. doi: 10.1093/infdis/jiy178.


Correlation and agreement between eplet mismatches calculated using serological, low-intermediate and high resolution molecular human leukocyte antigen typing methods.

Fidler S, D'Orsogna L, Irish AB, Lewis JR, Wong G, Lim WH.

Oncotarget. 2018 Feb 1;9(17):13116-13124. doi: 10.18632/oncotarget.24349. eCollection 2018 Mar 2.


Novel therapies/hopes for HIV cure in perinatally acquired HIV-positive adolescents.

Pasvol TJ, Foster C, Fidler S.

Curr Opin HIV AIDS. 2018 May;13(3):281-287. doi: 10.1097/COH.0000000000000455. Review.


Cross-sectional study of CD4: CD8 ratio recovery in young adults with perinatally acquired HIV-1 infection.

Pollock KM, Pintilie H, Foster C, Fidler S.

Medicine (Baltimore). 2018 Feb;97(8):e9798. doi: 10.1097/MD.0000000000009798.


A heterogeneous human immunodeficiency virus-like particle (VLP) formulation produced by a novel vector system.

Pankrac J, Klein K, McKay PF, King DFL, Bain K, Knapp J, Biru T, Wijewardhana CN, Pawa R, Canaday DH, Gao Y, Fidler S, Shattock RJ, Arts EJ, Mann JFS.

NPJ Vaccines. 2018 Jan 19;3:2. doi: 10.1038/s41541-017-0040-6. eCollection 2018.


Predictors of timely linkage-to-ART within universal test and treat in the HPTN 071 (PopART) trial in Zambia and South Africa: findings from a nested case-control study.

Sabapathy K, Mubekapi-Musadaidzwa C, Mulubwa C, Schaap A, Hoddinott G, Stangl A, Floyd S, Ayles H, Fidler S, Hayes R; HPTN 071 (PopART) study team.

J Int AIDS Soc. 2017 Dec;20(4). doi: 10.1002/jia2.25037.


Optimizing HIV transition services for young adults.

Foster C, Fidler S.

Curr Opin Infect Dis. 2018 Feb;31(1):33-38. doi: 10.1097/QCO.0000000000000424. Review.


Hospital-based routine HIV testing in high-income countries: a systematic literature review.

Elgalib A, Fidler S, Sabapathy K.

HIV Med. 2018 Mar;19(3):195-205. doi: 10.1111/hiv.12568. Epub 2017 Nov 23.


A pilot evaluation of whole blood finger-prick sampling for point-of-care HIV viral load measurement: the UNICORN study.

Fidler S, Lewis H, Meyerowitz J, Kuldanek K, Thornhill J, Muir D, Bonnissent A, Timson G, Frater J.

Sci Rep. 2017 Oct 20;7(1):13658. doi: 10.1038/s41598-017-13287-2.


Bone mineral density optimisation in adults with perinatally acquired HIV infection in routine care.

Pasvol TJ, Fyles F, Foster C, Fidler S.

J Virus Erad. 2017 Oct 1;3(4):262. No abstract available.


Incidence of Tuberculosis Among HIV-Positive Individuals Initiating Antiretroviral Treatment at Higher CD4 Counts in the HPTN 071 (PopART) Trial in South Africa.

Bock P, Jennings K, Vermaak R, Cox H, Meintjes G, Fatti G, Kruger J, De Azevedo V, Maschilla L, Louis F, Gunst C, Grobbelaar N, Dunbar R, Limbada M, Floyd S, Grimwood A, Ayles H, Hayes R, Fidler S, Beyers N.

J Acquir Immune Defic Syndr. 2018 Jan 1;77(1):93-101. doi: 10.1097/QAI.0000000000001560.


Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial.

Thomas R, Burger R, Harper A, Kanema S, Mwenge L, Vanqa N, Bell-Mandla N, Smith PC, Floyd S, Bock P, Ayles H, Beyers N, Donnell D, Fidler S, Hayes R, Hauck K; HPTN 071 (PopART) Study Team.

Lancet Glob Health. 2017 Nov;5(11):e1133-e1141. doi: 10.1016/S2214-109X(17)30367-4. Epub 2017 Sep 27.


Understanding low sensitivity of community-based HIV rapid testing: experiences from the HPTN 071 (PopART) trial in Zambia and South Africa.

Bock P, Phiri C, Piwowar-Manning E, Kosloff B, Mandla N, Young A, James A, Schaap A, Scheepers M, Donnell D, Griffith S, El-Sadr W, Shanaube K, Beyers N, Hayes R, Fidler S, Ayles H; HPTN 071 (PopART) Study Team.

J Int AIDS Soc. 2017 Aug 29;20(Suppl 6):21780. doi: 10.7448/IAS.20.7.21780.


A qualitative study exploring the social and environmental context of recently acquired HIV infection among men who have sex with men in South-East England.

Gourlay A, Fox J, Gafos M, Fidler S, Nwokolo N, Clarke A, Gilson R, Orkin C, Collins S, Porter K, Hart G.

BMJ Open. 2017 Aug 28;7(8):e016494. doi: 10.1136/bmjopen-2017-016494. Erratum in: BMJ Open. 2017 Dec 22;7(12 ):e016494corr1.


The impact of immunoglobulin in acute HIV infection on the HIV reservoir: a randomized controlled trial.

Tiraboschi J, Ray S, Patel K, Teague A, Pace M, Phalora P, Robinson N, Hopkins E, Meyerowitz J, Wang Y, Cason J, Kaye S, Sanderson J, Klenerman P, Fidler S, Frater J, Fox J.

HIV Med. 2017 Nov;18(10):777-781. doi: 10.1111/hiv.12524. Epub 2017 Jul 18.


Clinical and public health implications of acute and early HIV detection and treatment: a scoping review.

Rutstein SE, Ananworanich J, Fidler S, Johnson C, Sanders EJ, Sued O, Saez-Cirion A, Pilcher CD, Fraser C, Cohen MS, Vitoria M, Doherty M, Tucker JD.

J Int AIDS Soc. 2017 Jun 28;20(1):21579. doi: 10.7448/IAS.20.1.21579. Review.


Community intervention improves knowledge of HIV status of adolescents in Zambia: findings from HPTN 071-PopART for youth study.

Shanaube K, Schaap A, Chaila MJ, Floyd S, Mackworth-Young C, Hoddinott G, Hayes R, Fidler S, Ayles H; HPTN 071 (PopART) Study Team.

AIDS. 2017 Jul 1;31 Suppl 3:S221-S232. doi: 10.1097/QAD.0000000000001530.


Hepatocellular Carcinoma in Perinatally Acquired HIV and HBV Coinfection: A Case Report.

Seers T, Sarker D, Ross P, Heaton N, Suddle A, Lyall H, Tudor-Williams G, Fidler S, Foster C.

Pediatr Infect Dis J. 2017 Dec;36(12):1156-1158. doi: 10.1097/INF.0000000000001662.


Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection.

Foster C, Pace M, Kaye S, Hopkins E, Jones M, Robinson N, Mant C, Cason J, Fidler S, Frater J; CHERUB Investigators.

AIDS. 2017 Aug 24;31(13):1847-1851. doi: 10.1097/QAD.0000000000001565.


A Phase 1 Human Immunodeficiency Virus Vaccine Trial for Cross-Profiling the Kinetics of Serum and Mucosal Antibody Responses to CN54gp140 Modulated by Two Homologous Prime-Boost Vaccine Regimens.

Kratochvil S, McKay PF, Kopycinski JT, Bishop C, Hayes PJ, Muir L, Pinder CL, Cizmeci D, King D, Aldon Y, Wines BD, Hogarth PM, Chung AW, Kent SJ, Held K, Geldmacher C, Dally L, Santos NS, Cole T, Gilmour J, Fidler S, Shattock RJ.

Front Immunol. 2017 May 24;8:595. doi: 10.3389/fimmu.2017.00595. eCollection 2017.


3D Object Proposals Using Stereo Imagery for Accurate Object Class Detection.

Chen X, Kundu K, Zhu Y, Ma H, Fidler S, Urtasun R.

IEEE Trans Pattern Anal Mach Intell. 2018 May;40(5):1259-1272. doi: 10.1109/TPAMI.2017.2706685. Epub 2017 May 19.


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