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Editor's Note: Inhibition of Platelet-derived Growth Factor-mediated Proliferation of Osteosarcoma Cells by the Novel Tyrosine Kinase Inhibitor STI571.

McGary EC, Weber K, Mills L, Doucet M, Lewis V, Lev DC, Fidler IJ, Bar-Eli M.

Clin Cancer Res. 2019 May 15;25(10):3196. doi: 10.1158/1078-0432.CCR-19-1101. No abstract available.


Commentary on "Tumor Heterogeneity and the Biology of Cancer Invasion and Metastasis".

Fidler IJ.

Cancer Res. 2016 Jun 15;76(12):3441-2. doi: 10.1158/0008-5472.CAN-16-1330. No abstract available.


Treatment of experimental human breast cancer and lung cancer brain metastases in mice by macitentan, a dual antagonist of endothelin receptors, combined with paclitaxel.

Lee HJ, Hanibuchi M, Kim SJ, Yu H, Kim MS, He J, Langley RR, Lehembre F, Regenass U, Fidler IJ.

Neuro Oncol. 2016 Apr;18(4):486-96. doi: 10.1093/neuonc/now037.


The challenge of targeting metastasis.

Fidler IJ, Kripke ML.

Cancer Metastasis Rev. 2015 Dec;34(4):635-41. doi: 10.1007/s10555-015-9586-9. Review.


The Biology of Brain Metastasis: Challenges for Therapy.

Fidler IJ.

Cancer J. 2015 Jul-Aug;21(4):284-93. doi: 10.1097/PPO.0000000000000126. Review.


In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs.

Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC Jr, Bennett JM, Benz EJ Jr, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ Jr, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA.

Mayo Clin Proc. 2015 Aug;90(8):996-1000. doi: 10.1016/j.mayocp.2015.06.001. Epub 2015 Jul 23. No abstract available.


Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice.

Kim SJ, Lee HJ, Kim MS, Choi HJ, He J, Wu Q, Aldape K, Weinberg JS, Yung WK, Conrad CA, Langley RR, Lehembre F, Regenass U, Fidler IJ.

Clin Cancer Res. 2015 Oct 15;21(20):4630-41. doi: 10.1158/1078-0432.CCR-14-3195. Epub 2015 Jun 23.


Modulation of the cancer cell transcriptome by culture media formulations and cell density.

Kim SW, Kim SJ, Langley RR, Fidler IJ.

Int J Oncol. 2015 May;46(5):2067-75. doi: 10.3892/ijo.2015.2930. Epub 2015 Mar 17.


Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.

Shoshan E, Mobley AK, Braeuer RR, Kamiya T, Huang L, Vasquez ME, Salameh A, Lee HJ, Kim SJ, Ivan C, Velazquez-Torres G, Nip KM, Zhu K, Brooks D, Jones SJ, Birol I, Mosqueda M, Wen YY, Eterovic AK, Sood AK, Hwu P, Gershenwald JE, Robertson AG, Calin GA, Markel G, Fidler IJ, Bar-Eli M.

Nat Cell Biol. 2015 Mar;17(3):311-21. doi: 10.1038/ncb3110. Epub 2015 Feb 16.


Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain.

Chen J, Lee HJ, Wu X, Huo L, Kim SJ, Xu L, Wang Y, He J, Bollu LR, Gao G, Su F, Briggs J, Liu X, Melman T, Asara JM, Fidler IJ, Cantley LC, Locasale JW, Weihua Z.

Cancer Res. 2015 Feb 1;75(3):554-65. doi: 10.1158/0008-5472.CAN-14-2268. Epub 2014 Dec 15.


The molecular biology of lung cancer brain metastasis: an overview of current comprehensions and future perspectives.

Hanibuchi M, Kim SJ, Fidler IJ, Nishioka Y.

J Med Invest. 2014;61(3-4):241-53. Review.


Hematogenous metastasis of ovarian cancer: rethinking mode of spread.

Pradeep S, Kim SW, Wu SY, Nishimura M, Chaluvally-Raghavan P, Miyake T, Pecot CV, Kim SJ, Choi HJ, Bischoff FZ, Mayer JA, Huang L, Nick AM, Hall CS, Rodriguez-Aguayo C, Zand B, Dalton HJ, Arumugam T, Lee HJ, Han HD, Cho MS, Rupaimoole R, Mangala LS, Sehgal V, Oh SC, Liu J, Lee JS, Coleman RL, Ram P, Lopez-Berestein G, Fidler IJ, Sood AK.

Cancer Cell. 2014 Jul 14;26(1):77-91. doi: 10.1016/j.ccr.2014.05.002.


Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells.

Kim SW, Choi HJ, Lee HJ, He J, Wu Q, Langley RR, Fidler IJ, Kim SJ.

Neuro Oncol. 2014 Dec;16(12):1585-98. doi: 10.1093/neuonc/nou128. Epub 2014 Jul 9.


Exogenous expression of human SGLT1 exhibits aggregations in sodium dodecyl sulfate polyacrylamide gel electrophoresis.

Huang WC, Hsu SC, Huang SJ, Chen YJ, Hsiao YC, Zhang W, Fidler IJ, Hung MC.

Am J Transl Res. 2013 May 24;5(4):441-9. Print 2013.


The biology of brain metastasis.

Langley RR, Fidler IJ.

Clin Chem. 2013 Jan;59(1):180-9. doi: 10.1373/clinchem.2012.193342. Epub 2012 Oct 31. Review.


Porous silicon nanocarriers for dual targeting tumor associated endothelial cells and macrophages in stroma of orthotopic human pancreatic cancers.

Yokoi K, Godin B, Oborn CJ, Alexander JF, Liu X, Fidler IJ, Ferrari M.

Cancer Lett. 2013 Jul 1;334(2):319-27. doi: 10.1016/j.canlet.2012.09.001. Epub 2012 Sep 18.


Biological heterogeneity of cancer: implication to therapy.

Fidler IJ.

Hum Vaccin Immunother. 2012 Aug;8(8):1141-2. doi: 10.4161/hv.19643. Epub 2012 Aug 1. Review.


Antivascular therapy for multidrug-resistant ovarian tumors by macitentan, a dual endothelin receptor antagonist.

Kim SJ, Kim JS, Kim SW, Yun SJ, He J, Brantley E, Fan D, Strickner P, Lehembre F, Regenass U, Fidler IJ.

Transl Oncol. 2012 Feb;5(1):39-47. Epub 2012 Feb 1.


Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis.

Park ES, Kim SJ, Kim SW, Yoon SL, Leem SH, Kim SB, Kim SM, Park YY, Cheong JH, Woo HG, Mills GB, Fidler IJ, Lee JS.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17456-61. doi: 10.1073/pnas.1114210108. Epub 2011 Oct 10.


Selection of brain metastasis-initiating breast cancer cells determined by growth on hard agar.

Guo L, Fan D, Zhang F, Price JE, Lee JS, Marchetti D, Fidler IJ, Langley RR.

Am J Pathol. 2011 May;178(5):2357-66. doi: 10.1016/j.ajpath.2011.01.047.


Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer.

Yokoi K, Hawke D, Oborn CJ, Jang JY, Nishioka Y, Fan D, Kim SW, Kim SJ, Fidler IJ.

Transl Oncol. 2011 Apr 1;4(2):83-91.


Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.

Kim SJ, Kim JS, Park ES, Lee JS, Lin Q, Langley RR, Maya M, He J, Kim SW, Weihua Z, Balasubramanian K, Fan D, Mills GB, Hung MC, Fidler IJ.

Neoplasia. 2011 Mar;13(3):286-98.


The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organs.

Langley RR, Fidler IJ.

Int J Cancer. 2011 Jun 1;128(11):2527-35. doi: 10.1002/ijc.26031. Epub 2011 Mar 25. Review.


Formation of solid tumors by a single multinucleated cancer cell.

Weihua Z, Lin Q, Ramoth AJ, Fan D, Fidler IJ.

Cancer. 2011 Sep 1;117(17):4092-9. doi: 10.1002/cncr.26021. Epub 2011 Mar 1.


Consistent interactions between tumor cell IL-6 and macrophage TNF-α enhance the growth of human prostate cancer cells in the bone of nude mouse.

Kim SW, Kim JS, Papadopoulos J, Choi HJ, He J, Maya M, Langley RR, Fan D, Fidler IJ, Kim SJ.

Int Immunopharmacol. 2011 Jul;11(7):862-72. doi: 10.1016/j.intimp.2011.01.004. Epub 2011 Jan 18.


The role of the organ microenvironment in brain metastasis.

Fidler IJ.

Semin Cancer Biol. 2011 Apr;21(2):107-12. doi: 10.1016/j.semcancer.2010.12.009. Epub 2010 Dec 16. Review.


Nitric oxide-mediated tumoricidal activity of murine microglial cells.

Brantley EC, Guo L, Zhang C, Lin Q, Yokoi K, Langley RR, Kruzel E, Maya M, Kim SW, Kim SJ, Fan D, Fidler IJ.

Transl Oncol. 2010 Dec 1;3(6):380-8.


The biology of cancer metastasis.

Fidler IJ.

Semin Cancer Biol. 2011 Apr;21(2):71. doi: 10.1016/j.semcancer.2010.12.004. Epub 2010 Dec 9. No abstract available.


In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in mice.

Tanaka T, Godin B, Bhavane R, Nieves-Alicea R, Gu J, Liu X, Chiappini C, Fakhoury JR, Amra S, Ewing A, Li Q, Fidler IJ, Ferrari M.

Int J Pharm. 2010 Dec 15;402(1-2):190-7. doi: 10.1016/j.ijpharm.2010.09.015. Epub 2010 Sep 29.


Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels.

Lin Q, Balasubramanian K, Fan D, Kim SJ, Guo L, Wang H, Bar-Eli M, Aldape KD, Fidler IJ.

Neoplasia. 2010 Sep;12(9):748-54.


Finding the tumor copycat. Therapy fails, patients don't.

Ellis LM, Fidler IJ.

Nat Med. 2010 Sep;16(9):974-5. doi: 10.1038/nm0910-974. No abstract available.


The brain microenvironment and cancer metastasis.

Fidler IJ, Balasubramanian K, Lin Q, Kim SW, Kim SJ.

Mol Cells. 2010 Aug;30(2):93-8. doi: 10.1007/s10059-010-0133-9. Epub 2010 Aug 19.


AACR centennial series: the biology of cancer metastasis: historical perspective.

Talmadge JE, Fidler IJ.

Cancer Res. 2010 Jul 15;70(14):5649-69. doi: 10.1158/0008-5472.CAN-10-1040. Epub 2010 Jul 7. Review.


ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.

Kuo HP, Lee DF, Chen CT, Liu M, Chou CK, Lee HJ, Du Y, Xie X, Wei Y, Xia W, Weihua Z, Yang JY, Yen CJ, Huang TH, Tan M, Xing G, Zhao Y, Lin CH, Tsai SF, Fidler IJ, Hung MC.

Sci Signal. 2010 Feb 9;3(108):ra9. doi: 10.1126/scisignal.2000590.


Constitutive expression of the alpha4 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma.

Rebhun RB, Cheng H, Gershenwald JE, Fan D, Fidler IJ, Langley RR.

Neoplasia. 2010 Feb;12(2):173-82.


Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis.

Langley RR, Fan D, Guo L, Zhang C, Lin Q, Brantley EC, McCarty JH, Fidler IJ.

Int J Oncol. 2009 Oct;35(4):665-72.


Circulating monocytes expressing CD31: implications for acute and chronic angiogenesis.

Kim SJ, Kim JS, Papadopoulos J, Wook Kim S, Maya M, Zhang F, He J, Fan D, Langley R, Fidler IJ.

Am J Pathol. 2009 May;174(5):1972-80. doi: 10.2353/ajpath.2009.080819. Epub 2009 Apr 6.


Transforming growth factor-beta2 is a molecular determinant for site-specific melanoma metastasis in the brain.

Zhang C, Zhang F, Tsan R, Fidler IJ.

Cancer Res. 2009 Feb 1;69(3):828-35. doi: 10.1158/0008-5472.CAN-08-2588. Epub 2009 Jan 13.


Neoadjuvant platelet derived growth factor receptor inhibitor therapy combined with docetaxel and androgen ablation for high risk localized prostate cancer.

Mathew P, Pisters LL, Wood CG, Papadopoulos JN, Williams DL, Thall PF, Wen S, Horne E, Oborn CJ, Langley R, Fidler IJ, Pettaway CA.

J Urol. 2009 Jan;181(1):81-7; discussion 87. doi: 10.1016/j.juro.2008.09.006. Epub 2008 Nov 13.


Dynamic change in phosphorylated platelet-derived growth factor receptor in peripheral blood leukocytes following docetaxel therapy predicts progression-free and overall survival in prostate cancer.

Mathew P, Thall PF, Wen S, Bucana C, Jones D, Horne E, Oh WK, Morris MJ, Lee YC, Logothetis CJ, Lin SH, Fidler IJ.

Br J Cancer. 2008 Nov 4;99(9):1426-32. doi: 10.1038/sj.bjc.6604706. Epub 2008 Oct 7.


Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.

Giordano RJ, Lahdenranta J, Zhen L, Chukwueke U, Petrache I, Langley RR, Fidler IJ, Pasqualini R, Tuder RM, Arap W.

J Biol Chem. 2008 Oct 24;283(43):29447-60. doi: 10.1074/jbc.M804595200. Epub 2008 Aug 21.


The "seed and soil" hypothesis revisited.

Fidler IJ, Poste G.

Lancet Oncol. 2008 Aug;9(8):808. doi: 10.1016/S1470-2045(08)70201-8. No abstract available.


Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model.

Sasaki T, Nakamura T, Rebhun RB, Cheng H, Hale KS, Tsan RZ, Fidler IJ, Langley RR.

Am J Pathol. 2008 Jul;173(1):205-16. doi: 10.2353/ajpath.2008.071147.


Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors.

Kuwai T, Nakamura T, Sasaki T, Kim SJ, Fan D, Villares GJ, Zigler M, Wang H, Bar-Eli M, Kerbel RS, Fidler IJ.

Neoplasia. 2008 May;10(5):489-500.


Survival of cancer cells is maintained by EGFR independent of its kinase activity.

Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH, Fidler IJ, Hung MC.

Cancer Cell. 2008 May;13(5):385-93. doi: 10.1016/j.ccr.2008.03.015.


Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy.

Kuwai T, Nakamura T, Sasaki T, Kitadai Y, Kim JS, Langley RR, Fan D, Wang X, Do KA, Kim SJ, Fidler IJ.

Clin Exp Metastasis. 2008;25(4):477-89. doi: 10.1007/s10585-008-9153-7. Epub 2008 Mar 7.


Impact of sentinel lymphadenectomy on survival in a murine model of melanoma.

Rebhun RB, Lazar AJ, Fidler IJ, Gershenwald JE.

Clin Exp Metastasis. 2008;25(3):191-9. doi: 10.1007/s10585-008-9141-y. Epub 2008 Feb 9.


Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors.

Kuwai T, Nakamura T, Kim SJ, Sasaki T, Kitadai Y, Langley RR, Fan D, Hamilton SR, Fidler IJ.

Am J Pathol. 2008 Feb;172(2):358-66. doi: 10.2353/ajpath.2008.070625. Epub 2008 Jan 17.


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