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Items: 25


A novel use of random priming-based single-strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples.

Saunderson EA, Baker AM, Williams M, Curtius K, Jones JL, Graham TA, Ficz G.

NAR Genom Bioinform. 2020 Mar;2(1):lqz017. doi: 10.1093/nargab/lqz017. Epub 2019 Dec 16.


Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1 regulated transcription.

Edelmann J, Holzmann K, Tausch E, Saunderson EA, Jebaraj BMC, Steinbrecher D, Dolnik A, Blätte TJ, Landau DA, Saub J, Estenfelder S, Ibach S, Cymbalista F, Leblond V, Delmer A, Bahlo J, Robrecht S, Fischer K, Goede V, Bullinger L, Wu CJ, Mertens D, Ficz G, Gribben JG, Hallek M, Döhner H, Stilgenbauer S.

Haematologica. 2019 Aug 29. pii: haematol.2019.217307. doi: 10.3324/haematol.2019.217307. [Epub ahead of print]


Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors.

Saunderson EA, Stepper P, Gomm JJ, Hoa L, Morgan A, Allen MD, Jones JL, Gribben JG, Jurkowski TP, Ficz G.

Nat Commun. 2017 Nov 13;8(1):1450. doi: 10.1038/s41467-017-01078-2.


Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.

Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q, Wakelam MJ, Beyer A, Reik W, Partridge L.

Genome Biol. 2017 Mar 28;18(1):56. doi: 10.1186/s13059-017-1187-1.


The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice.

Langie SA, Cameron KM, Ficz G, Oxley D, Tomaszewski B, Gorniak JP, Maas LM, Godschalk RW, van Schooten FJ, Reik W, von Zglinicki T, Mathers JC.

Genes (Basel). 2017 Feb 17;8(2). pii: E75. doi: 10.3390/genes8020075.


Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.

Hore TA, von Meyenn F, Ravichandran M, Bachman M, Ficz G, Oxley D, Santos F, Balasubramanian S, Jurkowski TP, Reik W.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12202-12207. Epub 2016 Oct 11.


The Influence of Hydroxylation on Maintaining CpG Methylation Patterns: A Hidden Markov Model Approach.

Giehr P, Kyriakopoulos C, Ficz G, Wolf V, Walter J.

PLoS Comput Biol. 2016 May 25;12(5):e1004905. doi: 10.1371/journal.pcbi.1004905. eCollection 2016 May.


Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human.

Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F, Clarke J, Mansfield W, Reik W, Bertone P, Smith A.

Cell. 2015 Jul 16;162(2):452-453. doi: 10.1016/j.cell.2015.06.052. Epub 2015 Jul 16. No abstract available.


Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES).

Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, Woodward G, Lyttleton O, Evans DM, Reik W, Paul YL, Ficz G, Ozanne SE, Wipat A, Flanagan K, Lister A, Heijmans BT, Ring SM, Davey Smith G.

Int J Epidemiol. 2015 Aug;44(4):1181-90. doi: 10.1093/ije/dyv072. Epub 2015 May 19. No abstract available.


New insights into mechanisms that regulate DNA methylation patterning.

Ficz G.

J Exp Biol. 2015 Jan 1;218(Pt 1):14-20. doi: 10.1242/jeb.107961. Review.


Genome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation.

Peat JR, Dean W, Clark SJ, Krueger F, Smallwood SA, Ficz G, Kim JK, Marioni JC, Hore TA, Reik W.

Cell Rep. 2014 Dec 24;9(6):1990-2000. doi: 10.1016/j.celrep.2014.11.034. Epub 2014 Dec 12.


Resetting transcription factor control circuitry toward ground-state pluripotency in human.

Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F, Clarke J, Mansfield W, Reik W, Bertone P, Smith A.

Cell. 2014 Sep 11;158(6):1254-1269. doi: 10.1016/j.cell.2014.08.029. Erratum in: Cell. 2015 Jul 16;162(2):152-3. Cell. 2015 Jul 16;162(2):452-453.


Loss of 5-hydroxymethylcytosine in cancer: cause or consequence?

Ficz G, Gribben JG.

Genomics. 2014 Nov;104(5):352-7. doi: 10.1016/j.ygeno.2014.08.017. Epub 2014 Aug 30. Review.


A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation.

Iurlaro M, Ficz G, Oxley D, Raiber EA, Bachman M, Booth MJ, Andrews S, Balasubramanian S, Reik W.

Genome Biol. 2013;14(10):R119.


Breaking the resolution limit in light microscopy.

Heintzmann R, Ficz G.

Methods Cell Biol. 2013;114:525-44. doi: 10.1016/B978-0-12-407761-4.00022-1.


FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency.

Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D, Paul YL, Walter J, Cook SJ, Andrews S, Branco MR, Reik W.

Cell Stem Cell. 2013 Sep 5;13(3):351-9. doi: 10.1016/j.stem.2013.06.004. Epub 2013 Jul 11.


Reprogramming by cell fusion: boosted by Tets.

Ficz G, Reik W.

Mol Cell. 2013 Mar 28;49(6):1017-8. doi: 10.1016/j.molcel.2013.03.014.


Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase.

Raiber EA, Beraldi D, Ficz G, Burgess HE, Branco MR, Murat P, Oxley D, Booth MJ, Reik W, Balasubramanian S.

Genome Biol. 2012 Aug 17;13(8):R69. doi: 10.1186/gb-2012-13-8-r69.


Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.

Booth MJ, Branco MR, Ficz G, Oxley D, Krueger F, Reik W, Balasubramanian S.

Science. 2012 May 18;336(6083):934-7. doi: 10.1126/science.1220671. Epub 2012 Apr 26.


Uncovering the role of 5-hydroxymethylcytosine in the epigenome.

Branco MR, Ficz G, Reik W.

Nat Rev Genet. 2011 Nov 15;13(1):7-13. doi: 10.1038/nrg3080. Review.


Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.

Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, Marques CJ, Andrews S, Reik W.

Nature. 2011 May 19;473(7347):398-402. doi: 10.1038/nature10008. Epub 2011 Apr 3.


Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.

Farthing CR, Ficz G, Ng RK, Chan CF, Andrews S, Dean W, Hemberger M, Reik W.

PLoS Genet. 2008 Jun 27;4(6):e1000116. doi: 10.1371/journal.pgen.1000116.


Breaking the resolution limit in light microscopy.

Heintzmann R, Ficz G.

Methods Cell Biol. 2007;81:561-80. Review. No abstract available.


Breaking the resolution limit in light microscopy.

Heintzmann R, Ficz G.

Brief Funct Genomic Proteomic. 2006 Dec;5(4):289-301. Review.


Polycomb group protein complexes exchange rapidly in living Drosophila.

Ficz G, Heintzmann R, Arndt-Jovin DJ.

Development. 2005 Sep;132(17):3963-76. Epub 2005 Aug 3. Erratum in: Development. 2005 Sep;132(17):4016.

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