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Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2.

Hamann F, Schmitt A, Favretto F, Hofele R, Neumann P, Xiang S, Urlaub H, Zweckstetter M, Ficner R.

Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2948-2956. doi: 10.1073/pnas.1907960117. Epub 2020 Jan 23.


Crystal structures of the c-di-AMP-synthesizing enzyme CdaA.

Heidemann JL, Neumann P, Dickmanns A, Ficner R.

J Biol Chem. 2019 Jul 5;294(27):10463-10470. doi: 10.1074/jbc.RA119.009246. Epub 2019 May 22.


Structural basis for RNA translocation by DEAH-box ATPases.

Hamann F, Enders M, Ficner R.

Nucleic Acids Res. 2019 May 7;47(8):4349-4362. doi: 10.1093/nar/gkz150.


Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.

Bonnin E, Cabochette P, Filosa A, Jühlen R, Komatsuzaki S, Hezwani M, Dickmanns A, Martinelli V, Vermeersch M, Supply L, Martins N, Pirenne L, Ravenscroft G, Lombard M, Port S, Spillner C, Janssens S, Roets E, Van Dorpe J, Lammens M, Kehlenbach RH, Ficner R, Laing NG, Hoffmann K, Vanhollebeke B, Fahrenkrog B.

PLoS Genet. 2018 Dec 13;14(12):e1007845. doi: 10.1371/journal.pgen.1007845. eCollection 2018 Dec.


Validating Resolution Revolution.

Neumann P, Dickmanns A, Ficner R.

Structure. 2018 Dec 4;26(12):1678. doi: 10.1016/j.str.2018.10.028. No abstract available.


Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria.

Commichau FM, Heidemann JL, Ficner R, Stülke J.

J Bacteriol. 2018 Dec 7;201(1). pii: e00462-18. doi: 10.1128/JB.00462-18. Print 2019 Jan 1. Review.


Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1.

Johannsson S, Neumann P, Ficner R.

Biomolecules. 2018 Aug 24;8(3). pii: E81. doi: 10.3390/biom8030081.


Crystal structure of the spliceosomal DEAH-box ATPase Prp2.

Schmitt A, Hamann F, Neumann P, Ficner R.

Acta Crystallogr D Struct Biol. 2018 Jul 1;74(Pt 7):643-654. doi: 10.1107/S2059798318006356. Epub 2018 Jun 8.


Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine.

Johannsson S, Neumann P, Wulf A, Welp LM, Gerber HD, Krull M, Diederichsen U, Urlaub H, Ficner R.

Sci Rep. 2018 Jun 11;8(1):8880. doi: 10.1038/s41598-018-27118-5.


Validating Resolution Revolution.

Neumann P, Dickmanns A, Ficner R.

Structure. 2018 May 1;26(5):785-795.e4. doi: 10.1016/j.str.2018.03.004. Epub 2018 Mar 29. Erratum in: Structure. 2018 Dec 4;26(12):1678.


Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis.

Dickmanns A, Zschiedrich CP, Arens J, Parfentev I, Gundlach J, Hofele R, Neumann P, Urlaub H, Görke B, Ficner R, Stülke J.

J Biol Chem. 2018 Apr 20;293(16):5781-5792. doi: 10.1074/jbc.RA117.001289. Epub 2018 Mar 7.


Sem1 links proteasome stability and specificity to multicellular development.

Kolog Gulko M, Heinrich G, Gross C, Popova B, Valerius O, Neumann P, Ficner R, Braus GH.

PLoS Genet. 2018 Feb 5;14(2):e1007141. doi: 10.1371/journal.pgen.1007141. eCollection 2018 Feb.


Activity-Dependent Phosphorylation by CaMKIIδ Alters the Ca2+ Affinity of the Multi-C2-Domain Protein Otoferlin.

Meese S, Cepeda AP, Gahlen F, Adams CM, Ficner R, Ricci AJ, Heller S, Reisinger E, Herget M.

Front Synaptic Neurosci. 2017 Oct 4;9:13. doi: 10.3389/fnsyn.2017.00013. eCollection 2017.


Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism.

Gonzalez GM, Durica-Mitic S, Hardwick SW, Moncrieffe MC, Resch M, Neumann P, Ficner R, Görke B, Luisi BF.

Nucleic Acids Res. 2017 Oct 13;45(18):10845-10860. doi: 10.1093/nar/gkx732.


Studying structure and function of spliceosomal helicases.

Ficner R, Dickmanns A, Neumann P.

Methods. 2017 Aug 1;125:63-69. doi: 10.1016/j.ymeth.2017.06.028. Epub 2017 Jun 29. Review.


Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by steric shielding and substrate fixation.

Newie J, Neumann P, Werner M, Mata RA, Ficner R, Feussner I.

Sci Rep. 2017 May 18;7(1):2069. doi: 10.1038/s41598-017-02153-w.


Structural insights into the mechanism of the DEAH-box RNA helicase Prp43.

Tauchert MJ, Fourmann JB, Lührmann R, Ficner R.

Elife. 2017 Jan 16;6. pii: e21510. doi: 10.7554/eLife.21510.


Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2.

Fourmann JB, Tauchert MJ, Ficner R, Fabrizio P, Lührmann R.

Nucleic Acids Res. 2017 Apr 20;45(7):4068-4080. doi: 10.1093/nar/gkw1225.


The pathway to GTPase activation of elongation factor SelB on the ribosome.

Fischer N, Neumann P, Bock LV, Maracci C, Wang Z, Paleskava A, Konevega AL, Schröder GF, Grubmüller H, Ficner R, Rodnina MV, Stark H.

Nature. 2016 Dec 1;540(7631):80-85. doi: 10.1038/nature20560. Epub 2016 Nov 14.


A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity.

Boesler C, Rigo N, Anokhina MM, Tauchert MJ, Agafonov DE, Kastner B, Urlaub H, Ficner R, Will CL, Lührmann R.

Nat Commun. 2016 Jul 5;7:11997. doi: 10.1038/ncomms11997.


Impact of the crystallization condition on importin-β conformation.

Tauchert MJ, Hémonnot C, Neumann P, Köster S, Ficner R, Dickmanns A.

Acta Crystallogr D Struct Biol. 2016 Jun;72(Pt 6):705-17. doi: 10.1107/S2059798316004940. Epub 2016 May 25.


Structural analysis of the spliceosomal RNA helicase Prp28 from the thermophilic eukaryote Chaetomium thermophilum.

Tauchert MJ, Ficner R.

Acta Crystallogr F Struct Biol Commun. 2016 May;72(Pt 5):409-16. doi: 10.1107/S2053230X16006038. Epub 2016 Apr 22.


Combretastatin A-4 derived 5-(1-methyl-4-phenyl-imidazol-5-yl)indoles with superior cytotoxic and anti-vascular effects on chemoresistant cancer cells and tumors.

Mahal K, Biersack B, Schruefer S, Resch M, Ficner R, Schobert R, Mueller T.

Eur J Med Chem. 2016 Aug 8;118:9-20. doi: 10.1016/j.ejmech.2016.04.045. Epub 2016 Apr 19.


The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction.

Fourmann JB, Dybkov O, Agafonov DE, Tauchert MJ, Urlaub H, Ficner R, Fabrizio P, Lührmann R.

Elife. 2016 Apr 26;5. pii: e15564. doi: 10.7554/eLife.15564.


Crystal Structure of Alcohol Oxidase from Pichia pastoris.

Koch C, Neumann P, Valerius O, Feussner I, Ficner R.

PLoS One. 2016 Feb 23;11(2):e0149846. doi: 10.1371/journal.pone.0149846. eCollection 2016.


Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum.

Tauchert MJ, Fourmann JB, Christian H, Lührmann R, Ficner R.

Acta Crystallogr F Struct Biol Commun. 2016 Feb;72(Pt 2):112-20. doi: 10.1107/S2053230X15024498. Epub 2016 Jan 22.


Crystal structure of a lipoxygenase from Cyanothece sp. may reveal novel features for substrate acquisition.

Newie J, Andreou A, Neumann P, Einsle O, Feussner I, Ficner R.

J Lipid Res. 2016 Feb;57(2):276-87. doi: 10.1194/jlr.M064980. Epub 2015 Dec 14.


Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex.

Monecke T, Dickmanns A, Weiss MS, Port SA, Kehlenbach RH, Ficner R.

Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1481-7. doi: 10.1107/S2053230X15021524. Epub 2015 Nov 18.


Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export.

Port SA, Monecke T, Dickmanns A, Spillner C, Hofele R, Urlaub H, Ficner R, Kehlenbach RH.

Cell Rep. 2015 Oct 27;13(4):690-702. doi: 10.1016/j.celrep.2015.09.042. Epub 2015 Oct 17.


Tuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot Spot.

Wechsler C, Meyer D, Loschonsky S, Funk LM, Neumann P, Ficner R, Brodhun F, Müller M, Tittmann K.

Chembiochem. 2015 Dec;16(18):2580-4. doi: 10.1002/cbic.201500529. Epub 2015 Nov 18.


Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T.

EMBO J. 2015 Nov 3;34(21):2686-702. doi: 10.15252/embj.201591885. Epub 2015 Oct 7.


Structural Basis of Targeting the Exportin CRM1 in Cancer.

Dickmanns A, Monecke T, Ficner R.

Cells. 2015 Sep 21;4(3):538-68. doi: 10.3390/cells4030538. Review.


Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.

Kuhle B, Eulig NK, Ficner R.

Nucleic Acids Res. 2015 Nov 16;43(20):9994-10014. doi: 10.1093/nar/gkv930. Epub 2015 Sep 17.


Role of JNK and NF-κB in mediating the effect of combretastatin A-4 and brimamin on endothelial and carcinoma cells.

Mahal K, Ahmad A, Sethi S, Resch M, Ficner R, Sarkar FH, Schobert R, Biersack B.

Cell Oncol (Dordr). 2015 Dec;38(6):463-78. doi: 10.1007/s13402-015-0243-7. Epub 2015 Sep 10.


MD simulations and FRET reveal an environment-sensitive conformational plasticity of importin-β.

Halder K, Dölker N, Van Q, Gregor I, Dickmanns A, Baade I, Kehlenbach RH, Ficner R, Enderlein J, Grubmüller H, Neumann H.

Biophys J. 2015 Jul 21;109(2):277-86. doi: 10.1016/j.bpj.2015.06.014.


A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria.

Melin J, Kilisch M, Neumann P, Lytovchenko O, Gomkale R, Schendzielorz A, Schmidt B, Liepold T, Ficner R, Jahn O, Rehling P, Schulz C.

Biochim Biophys Acta. 2015 Aug;1853(8):1850-9. doi: 10.1016/j.bbamcr.2015.04.021. Epub 2015 May 7.


A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.

Commichau FM, Dickmanns A, Gundlach J, Ficner R, Stülke J.

Mol Microbiol. 2015 Jul;97(2):189-204. doi: 10.1111/mmi.13026. Epub 2015 May 9. Review.


Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM.

Fischer N, Neumann P, Konevega AL, Bock LV, Ficner R, Rodnina MV, Stark H.

Nature. 2015 Apr 23;520(7548):567-70. doi: 10.1038/nature14275. Epub 2015 Feb 23.


Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes.

Rosenberg J, Dickmanns A, Neumann P, Gunka K, Arens J, Kaever V, Stülke J, Ficner R, Commichau FM.

J Biol Chem. 2015 Mar 6;290(10):6596-606. doi: 10.1074/jbc.M114.630418. Epub 2015 Jan 20.


Identification, characterization, and structure analysis of the cyclic di-AMP-binding PII-like signal transduction protein DarA.

Gundlach J, Dickmanns A, Schröder-Tittmann K, Neumann P, Kaesler J, Kampf J, Herzberg C, Hammer E, Schwede F, Kaever V, Tittmann K, Stülke J, Ficner R.

J Biol Chem. 2015 Jan 30;290(5):3069-80. doi: 10.1074/jbc.M114.619619. Epub 2014 Nov 28.


Structural insight into the recognition of amino-acylated initiator tRNA by eIF5B in the 80S initiation complex.

Kuhle B, Ficner R.

BMC Struct Biol. 2014 Sep 17;14:20. doi: 10.1186/s12900-014-0020-2.


A monovalent cation acts as structural and catalytic cofactor in translational GTPases.

Kuhle B, Ficner R.

EMBO J. 2014 Nov 3;33(21):2547-63. doi: 10.15252/embj.201488517. Epub 2014 Sep 15.


Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28.

Möhlmann S, Mathew R, Neumann P, Schmitt A, Lührmann R, Ficner R.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1622-30. doi: 10.1107/S1399004714006439. Epub 2014 May 24.


Allosteric control of the exportin CRM1 unraveled by crystal structure analysis.

Monecke T, Dickmanns A, Ficner R.

FEBS J. 2014 Sep;281(18):4179-94. doi: 10.1111/febs.12842. Epub 2014 Jun 6. Review.


Translation initiation factor eIF3b contains a nine-bladed β-propeller and interacts with the 40S ribosomal subunit.

Liu Y, Neumann P, Kuhle B, Monecke T, Schell S, Chari A, Ficner R.

Structure. 2014 Jun 10;22(6):923-30. doi: 10.1016/j.str.2014.03.010. Epub 2014 Apr 24.


Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification.

Neumann P, Lakomek K, Naumann PT, Erwin WM, Lauhon CT, Ficner R.

Nucleic Acids Res. 2014 Jun;42(10):6673-85. doi: 10.1093/nar/gku249. Epub 2014 Apr 5.


eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.

Kuhle B, Ficner R.

EMBO J. 2014 May 16;33(10):1177-91. doi: 10.1002/embj.201387344. Epub 2014 Mar 31.


Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels.

Mahal K, Resch M, Ficner R, Schobert R, Biersack B, Mueller T.

ChemMedChem. 2014 Apr;9(4):847-54. doi: 10.1002/cmdc.201300531. Epub 2014 Feb 23.


RNA synthesis and purification for structural studies.

Ahmed YL, Ficner R.

RNA Biol. 2014;11(5):427-32. Epub 2014 Feb 10. Review.


Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP.

Monecke T, Buschmann J, Neumann P, Wahle E, Ficner R.

PLoS One. 2014 Mar 6;9(3):e90915. doi: 10.1371/journal.pone.0090915. eCollection 2014.

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