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Items: 1 to 50 of 90

1.

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity.

Chai S, Wan X, Ramirez-Navarro A, Tesar PJ, Kaufman ES, Ficker E, George AL Jr, Deschênes I.

J Clin Invest. 2018 Mar 1;128(3):1043-1056. doi: 10.1172/JCI94996. Epub 2018 Feb 12.

2.

Voltage-gated sodium channels assemble and gate as dimers.

Clatot J, Hoshi M, Wan X, Liu H, Jain A, Shinlapawittayatorn K, Marionneau C, Ficker E, Ha T, Deschênes I.

Nat Commun. 2017 Dec 12;8(1):2077. doi: 10.1038/s41467-017-02262-0.

3.

KChIP2 is a core transcriptional regulator of cardiac excitability.

Nassal DM, Wan X, Liu H, Maleski D, Ramirez-Navarro A, Moravec CS, Ficker E, Laurita KR, Deschênes I.

Elife. 2017 Mar 6;6. pii: e17304. doi: 10.7554/eLife.17304.

4.

Brugada syndrome disease phenotype explained in apparently benign sodium channel mutations.

Hoshi M, Du XX, Shinlapawittayatorn K, Liu H, Chai S, Wan X, Ficker E, Deschênes I.

Circ Cardiovasc Genet. 2014 Apr;7(2):123-31. doi: 10.1161/CIRCGENETICS.113.000292. Epub 2014 Feb 26.

5.

Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis.

Khan S, Abu Jawdeh BG, Goel M, Schilling WP, Parker MD, Puchowicz MA, Yadav SP, Harris RC, El-Meanawy A, Hoshi M, Shinlapawittayatorn K, Deschênes I, Ficker E, Schelling JR.

J Clin Invest. 2014 Mar;124(3):1057-68. doi: 10.1172/JCI71863. Epub 2014 Feb 17.

6.

The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT.

Mechakra A, Vincent Y, Chevalier P, Millat G, Ficker E, Jastrzebski M, Poulin H, Pouliot V, Chahine M, Christé G.

Gene. 2014 Feb 25;536(2):348-56. doi: 10.1016/j.gene.2013.11.072. Epub 2013 Dec 12.

PMID:
24334129
7.

Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane.

Apaja PM, Foo B, Okiyoneda T, Valinsky WC, Barriere H, Atanasiu R, Ficker E, Lukacs GL, Shrier A.

Mol Biol Cell. 2013 Dec;24(24):3787-804. doi: 10.1091/mbc.E13-07-0417. Epub 2013 Oct 23.

8.

Ionic bases for electrical remodeling of the canine cardiac ventricle.

Jeyaraj D, Wan X, Ficker E, Stelzer JE, Deschenes I, Liu H, Wilson LD, Decker KF, Said TH, Jain MK, Rudy Y, Rosenbaum DS.

Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H410-9. doi: 10.1152/ajpheart.00213.2013. Epub 2013 May 24.

9.

Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells.

Jehle J, Ficker E, Wan X, Deschenes I, Kisselbach J, Wiedmann F, Staudacher I, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D.

Br J Pharmacol. 2013 Mar;168(5):1215-29. doi: 10.1111/bph.12002.

10.

A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo.

Petty A, Myshkin E, Qin H, Guo H, Miao H, Tochtrop GP, Hsieh JT, Page P, Liu L, Lindner DJ, Acharya C, MacKerell AD Jr, Ficker E, Song J, Wang B.

PLoS One. 2012;7(8):e42120. doi: 10.1371/journal.pone.0042120. Epub 2012 Aug 15.

11.

The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart.

Werdich AA, Brzezinski A, Jeyaraj D, Khaled Sabeh M, Ficker E, Wan X, McDermott BM Jr, Macrae CA, Rosenbaum DS.

Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):154-65. doi: 10.1016/j.pbiomolbio.2012.07.006. Epub 2012 Jul 23.

12.

Circadian rhythms govern cardiac repolarization and arrhythmogenesis.

Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK.

Nature. 2012 Feb 22;483(7387):96-9. doi: 10.1038/nature10852.

13.

Molecular determinants of pentamidine-induced hERG trafficking inhibition.

Dennis AT, Wang L, Wan H, Nassal D, Deschenes I, Ficker E.

Mol Pharmacol. 2012 Feb;81(2):198-209. doi: 10.1124/mol.111.075135. Epub 2011 Nov 1.

14.

Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival.

Abu Jawdeh BG, Khan S, Deschênes I, Hoshi M, Goel M, Lock JT, Shinlapawittayatorn K, Babcock G, Lakhe-Reddy S, DeCaro G, Yadav SP, Mohan ML, Naga Prasad SV, Schilling WP, Ficker E, Schelling JR.

J Biol Chem. 2011 Dec 9;286(49):42435-45. doi: 10.1074/jbc.M110.212845. Epub 2011 Oct 21.

15.

Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway.

Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M.

J Biol Chem. 2011 Nov 11;286(45):39091-9. doi: 10.1074/jbc.M111.292060. Epub 2011 Sep 9.

16.

A novel strategy using cardiac sodium channel polymorphic fragments to rescue trafficking-deficient SCN5A mutations.

Shinlapawittayatorn K, Dudash LA, Du XX, Heller L, Poelzing S, Ficker E, Deschênes I.

Circ Cardiovasc Genet. 2011 Oct;4(5):500-9. doi: 10.1161/CIRCGENETICS.111.960633. Epub 2011 Aug 12.

17.

Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG.

Dennis AT, Nassal D, Deschenes I, Thomas D, Ficker E.

J Biol Chem. 2011 Sep 30;286(39):34413-25. doi: 10.1074/jbc.M111.254367. Epub 2011 Aug 9.

18.

Carvedilol targets human K2P 3.1 (TASK1) K+ leak channels.

Staudacher K, Staudacher I, Ficker E, Seyler C, Gierten J, Kisselbach J, Rahm AK, Trappe K, Schweizer PA, Becker R, Katus HA, Thomas D.

Br J Pharmacol. 2011 Jul;163(5):1099-110. doi: 10.1111/j.1476-5381.2011.01319.x.

19.

hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine.

Staudacher I, Wang L, Wan X, Obers S, Wenzel W, Tristram F, Koschny R, Staudacher K, Kisselbach J, Koelsch P, Schweizer PA, Katus HA, Ficker E, Thomas D.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Feb;383(2):119-39. doi: 10.1007/s00210-010-0583-9. Epub 2010 Dec 1.

PMID:
21120454
20.

A common SCN5A polymorphism modulates the biophysical defects of SCN5A mutations.

Shinlapawittayatorn K, Du XX, Liu H, Ficker E, Kaufman ES, Deschênes I.

Heart Rhythm. 2011 Mar;8(3):455-62. doi: 10.1016/j.hrthm.2010.11.034. Epub 2010 Nov 23.

21.

Oxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT syndrome.

Wan X, Dennis AT, Obejero-Paz C, Overholt JL, Heredia-Moya J, Kirk KL, Ficker E.

J Biol Chem. 2011 Jan 28;286(4):2843-52. doi: 10.1074/jbc.M110.125526. Epub 2010 Nov 20.

22.

Exercise training accelerates the removal from plasma of LDL-like nanoemulsion in moderately hypercholesterolemic subjects.

Ficker ES, Maranhão RC, Chacra AP, Neves VC, Negrão CE, Martins VC, Vinagre CG.

Atherosclerosis. 2010 Sep;212(1):230-6. doi: 10.1016/j.atherosclerosis.2010.04.030. Epub 2010 May 6.

PMID:
20627247
23.

Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine.

Obers S, Staudacher I, Ficker E, Dennis A, Koschny R, Erdal H, Bloehs R, Kisselbach J, Karle CA, Schweizer PA, Katus HA, Thomas D.

Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):385-400. doi: 10.1007/s00210-010-0496-7. Epub 2010 Mar 13.

PMID:
20229012
24.

Metabolism of a lipid nanoemulsion resembling low-density lipoprotein in patients with grade iii obesity.

Dantas SA, Ficker ES, Vinagre CG, Ianni BM, Maranhão RC, Mady C.

Clinics (Sao Paulo). 2010;65(1):23-7. doi: 10.1590/S1807-59322010000100005.

25.

Gap junction heterogeneity as mechanism for electrophysiologically distinct properties across the ventricular wall.

Strom M, Wan X, Poelzing S, Ficker E, Rosenbaum DS.

Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H787-94. doi: 10.1152/ajpheart.00887.2009. Epub 2009 Dec 24.

26.

The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone.

Gierten J, Ficker E, Bloehs R, Schweizer PA, Zitron E, Scholz E, Karle C, Katus HA, Thomas D.

Naunyn Schmiedebergs Arch Pharmacol. 2010 Mar;381(3):261-70. doi: 10.1007/s00210-009-0454-4. Epub 2009 Sep 24.

PMID:
19777211
27.

Characterization of novel KCNH2 mutations in type 2 long QT syndrome manifesting as seizures.

Keller DI, Grenier J, Christé G, Dubouloz F, Osswald S, Brink M, Ficker E, Chahine M.

Can J Cardiol. 2009 Aug;25(8):455-62.

28.

Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS.

Nanduri J, Bergson P, Wang N, Ficker E, Prabhakar NR.

Biochem Biophys Res Commun. 2009 Oct 16;388(2):212-6. doi: 10.1016/j.bbrc.2009.07.149. Epub 2009 Aug 3.

29.

Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.

Wang L, Dennis AT, Trieu P, Charron F, Ethier N, Hebert TE, Wan X, Ficker E.

Mol Pharmacol. 2009 Apr;75(4):927-37. doi: 10.1124/mol.108.053793. Epub 2009 Jan 12.

30.

A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope.

Christé G, Thériault O, Chahine M, Millat G, Rodriguez-Lafrasse C, Rousson R, Deschênes I, Ficker E, Chevalier P.

Heart Rhythm. 2008 Nov;5(11):1577-86. doi: 10.1016/j.hrthm.2008.08.031. Epub 2008 Aug 31.

31.

In utero onset of long QT syndrome with atrioventricular block and spontaneous or lidocaine-induced ventricular tachycardia: compound effects of hERG pore region mutation and SCN5A N-terminus variant.

Lin MT, Wu MH, Chang CC, Chiu SN, Thériault O, Huang H, Christé G, Ficker E, Chahine M.

Heart Rhythm. 2008 Nov;5(11):1567-74. doi: 10.1016/j.hrthm.2008.08.010. Epub 2008 Aug 17.

32.

Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein.

Nanduri J, Wang N, Bergson P, Yuan G, Ficker E, Prabhakar NR.

Biochem Biophys Res Commun. 2008 Aug 22;373(2):309-14. doi: 10.1016/j.bbrc.2008.06.028. Epub 2008 Jun 18.

PMID:
18570888
33.

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.

Gierten J, Ficker E, Bloehs R, Schlömer K, Kathöfer S, Scholz E, Zitron E, Kiesecker C, Bauer A, Becker R, Katus HA, Karle CA, Thomas D.

Br J Pharmacol. 2008 Aug;154(8):1680-90. doi: 10.1038/bjp.2008.213. Epub 2008 Jun 2.

34.

Doxazosin induces apoptosis of cells expressing hERG K+ channels.

Thomas D, Bloehs R, Koschny R, Ficker E, Sykora J, Kiehn J, Schlömer K, Gierten J, Kathöfer S, Zitron E, Scholz EP, Kiesecker C, Katus HA, Karle CA.

Eur J Pharmacol. 2008 Jan 28;579(1-3):98-103. Epub 2007 Dec 4.

35.

hERG channel trafficking: novel targets in drug-induced long QT syndrome.

Dennis A, Wang L, Wan X, Ficker E.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1060-3. Review.

PMID:
17956279
36.

Enhanced removal from the plasma of LDL-like nanoemulsion cholesteryl ester in trained men compared with sedentary healthy men.

Vinagre CG, Ficker ES, Finazzo C, Alves MJ, de Angelis K, Irigoyen MC, Negrão CE, Maranhão RC.

J Appl Physiol (1985). 2007 Oct;103(4):1166-71. Epub 2007 Jul 12.

37.

Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking.

Wang L, Wible BA, Wan X, Ficker E.

J Pharmacol Exp Ther. 2007 Feb;320(2):525-34. Epub 2006 Nov 9.

PMID:
17095614
38.

Antimony-based antileishmanial compounds prolong the cardiac action potential by an increase in cardiac calcium currents.

Kuryshev YA, Wang L, Wible BA, Wan X, Ficker E.

Mol Pharmacol. 2006 Apr;69(4):1216-25. Epub 2006 Jan 17.

PMID:
16418337
39.

Plasma kinetics of a cholesterol-rich microemulsion (LDE) in patients with Hodgkin's and non-Hodgkin's lymphoma and a preliminary study on the toxicity of etoposide associated with LDE.

Pinheiro KV, Hungria VT, Ficker ES, Valduga CJ, Mesquita CH, Maranhão RC.

Cancer Chemother Pharmacol. 2006 May;57(5):624-30. Epub 2005 Aug 25.

PMID:
16133527
40.

HERG channel trafficking.

Ficker E, Dennis A, Kuryshev Y, Wible BA, Brown AM.

Novartis Found Symp. 2005;266:57-69; discussion 70-4, 95-9. Review.

PMID:
16050262
41.

HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk.

Wible BA, Hawryluk P, Ficker E, Kuryshev YA, Kirsch G, Brown AM.

J Pharmacol Toxicol Methods. 2005 Jul-Aug;52(1):136-45.

PMID:
15950494
42.

Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X).

Thomas D, Hammerling BC, Wimmer AB, Wu K, Ficker E, Kuryshev YA, Scherer D, Kiehn J, Katus HA, Schoels W, Karle CA.

Cardiovasc Res. 2004 Dec 1;64(3):467-76.

PMID:
15537500
43.

Pentamidine-induced long QT syndrome and block of hERG trafficking.

Kuryshev YA, Ficker E, Wang L, Hawryluk P, Dennis AT, Wible BA, Brown AM, Kang J, Chen XL, Sawamura K, Reynolds W, Rampe D.

J Pharmacol Exp Ther. 2005 Jan;312(1):316-23. Epub 2004 Aug 31.

PMID:
15340016
44.

Mechanisms of arsenic-induced prolongation of cardiac repolarization.

Ficker E, Kuryshev YA, Dennis AT, Obejero-Paz C, Wang L, Hawryluk P, Wible BA, Brown AM.

Mol Pharmacol. 2004 Jul;66(1):33-44.

PMID:
15213294
45.

Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.

Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker EK, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathöfer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J.

Br J Pharmacol. 2004 Jun;142(3):485-94. Epub 2004 May 17.

46.

Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin.

Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA.

Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):462-72. Epub 2004 Apr 20.

PMID:
15098086
47.

Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG.

Ficker E, Dennis AT, Wang L, Brown AM.

Circ Res. 2003 Jun 27;92(12):e87-100. Epub 2003 May 29.

PMID:
12775586
48.

Is restoration of intracellular trafficking clinically feasible in the long QT syndrome?: The example of HERG mutations.

Kaufman ES, Ficker E.

J Cardiovasc Electrophysiol. 2003 Mar;14(3):320-2. Review. No abstract available.

PMID:
12716119
49.

Dopamine modulates synaptic transmission in the nucleus of the solitary tract.

Kline DD, Takacs KN, Ficker E, Kunze DL.

J Neurophysiol. 2002 Nov;88(5):2736-44.

50.

The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia.

Scherer CR, Lerche C, Decher N, Dennis AT, Maier P, Ficker E, Busch AE, Wollnik B, Steinmeyer K.

Br J Pharmacol. 2002 Nov;137(6):892-900.

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