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Science. 1998 May 15;280(5366):1091-4.

COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility.

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School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.


The coi1 mutation defines an Arabidopsis gene required for response to jasmonates, which regulate defense against insects and pathogens, wound healing, and pollen fertility. The wild-type allele, COI1, was mapped to a 90-kilobase genomic fragment and located by complementation of coi1-1 mutants. The predicted amino acid sequence of the COI1 protein contains 16 leucine-rich repeats and an F-box motif. It has similarity to the F-box proteins Arabidopsis TIR1, human Skp2, and yeast Grr1, which appear to function by targeting repressor proteins for removal by ubiquitination.

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