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Dual-targeting triplebody 33-16-123 (SPM-2) mediates effective redirected lysis of primary blasts from patients with a broad range of AML subtypes in combination with natural killer cells.

Braciak TA, Roskopf CC, Wildenhain S, Fenn NC, Schiller CB, Schubert IA, Jacob U, Honegger A, Krupka C, Subklewe M, Spiekermann K, Hopfner KP, Fey GH, Aigner M, Krause S, Mackensen A, Oduncu FS.

Oncoimmunology. 2018 Jul 30;7(9):e1472195. doi: 10.1080/2162402X.2018.1472195. eCollection 2018.


CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells.

Schiller CB, Braciak TA, Fenn NC, Seidel UJ, Roskopf CC, Wildenhain S, Honegger A, Schubert IA, Schele A, Lämmermann K, Fey GH, Jacob U, Lang P, Hopfner KP, Oduncu FS.

Oncotarget. 2016 Dec 13;7(50):83392-83408. doi: 10.18632/oncotarget.13110.


Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells.

Roskopf CC, Braciak TA, Fenn NC, Kobold S, Fey GH, Hopfner KP, Oduncu FS.

Oncotarget. 2016 Apr 19;7(16):22579-89. doi: 10.18632/oncotarget.8022.


Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody.

Chatzopoulou EI, Roskopf CC, Sekhavati F, Braciak TA, Fenn NC, Hopfner KP, Oduncu FS, Fey GH, Rädler JO.

Analyst. 2016 Apr 7;141(7):2284-95. doi: 10.1039/c5an02585k.


T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell.

Roskopf CC, Schiller CB, Braciak TA, Kobold S, Schubert IA, Fey GH, Hopfner KP, Oduncu FS.

Oncotarget. 2014 Aug 15;5(15):6466-83.


NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2.

Braciak TA, Wildenhain S, Roskopf CC, Schubert IA, Fey GH, Jacob U, Hopfner KP, Oduncu FS.

J Transl Med. 2013 Nov 16;11:289. doi: 10.1186/1479-5876-11-289.


A dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic cells.

Schubert I, Saul D, Nowecki S, Mackensen A, Fey GH, Oduncu FS.

MAbs. 2014 Jan-Feb;6(1):286-96.


A recombinant triplebody with specificity for CD19 and HLA-DR mediates preferential binding to antigen double-positive cells by dual-targeting.

Schubert I, Kellner C, Stein C, Kügler M, Schwenkert M, Saul D, Stockmeyer B, Berens C, Oduncu FS, Mackensen A, Fey GH.

MAbs. 2012 Jan-Feb;4(1):45-56. doi: 10.4161/mabs.4.1.18498.


Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC.

Repp R, Kellner C, Muskulus A, Staudinger M, Nodehi SM, Glorius P, Akramiene D, Dechant M, Fey GH, van Berkel PH, van de Winkel JG, Parren PW, Valerius T, Gramatzki M, Peipp M.

J Immunol Methods. 2011 Oct 28;373(1-2):67-78. doi: 10.1016/j.jim.2011.08.003. Epub 2011 Aug 9.


Heterodimeric bispecific antibody-derivatives against CD19 and CD16 induce effective antibody-dependent cellular cytotoxicity against B-lymphoid tumor cells.

Kellner C, Bruenke J, Horner H, Schubert J, Schwenkert M, Mentz K, Barbin K, Stein C, Peipp M, Stockmeyer B, Fey GH.

Cancer Lett. 2011 Apr 28;303(2):128-39. doi: 10.1016/j.canlet.2011.01.020. Epub 2011 Feb 19.


Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo.

de Bruyn M, Rybczynska AA, Wei Y, Schwenkert M, Fey GH, Dierckx RA, van Waarde A, Helfrich W, Bremer E.

Mol Cancer. 2010 Nov 23;9:301. doi: 10.1186/1476-4598-9-301.


A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting.

Schubert I, Kellner C, Stein C, Kügler M, Schwenkert M, Saul D, Mentz K, Singer H, Stockmeyer B, Hillen W, Mackensen A, Fey GH.

MAbs. 2011 Jan-Feb;3(1):21-30. Epub 2011 Jan 1.


A recombinant trispecific single-chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting.

Kügler M, Stein C, Kellner C, Mentz K, Saul D, Schwenkert M, Schubert I, Singer H, Oduncu F, Stockmeyer B, Mackensen A, Fey GH.

Br J Haematol. 2010 Sep;150(5):574-86. doi: 10.1111/j.1365-2141.2010.08300.x. Epub 2010 Jul 16.


Effective elimination of acute myeloid leukemic cells by recombinant bispecific antibody derivatives directed against CD33 and CD16.

Singer H, Kellner C, Lanig H, Aigner M, Stockmeyer B, Oduncu F, Schwemmlein M, Stein C, Mentz K, Mackensen A, Fey GH.

J Immunother. 2010 Jul-Aug;33(6):599-608. doi: 10.1097/CJI.0b013e3181dda225.


Novel conjugates of single-chain Fv antibody fragments specific for stem cell antigen CD123 mediate potent death of acute myeloid leukaemia cells.

Stein C, Kellner C, Kügler M, Reiff N, Mentz K, Schwenkert M, Stockmeyer B, Mackensen A, Fey GH.

Br J Haematol. 2010 Mar;148(6):879-89. doi: 10.1111/j.1365-2141.2009.08033.x. Epub 2010 Jan 8.


A recombinant bispecific single-chain fragment variable specific for HLA class II and Fc alpha RI (CD89) recruits polymorphonuclear neutrophils for efficient lysis of malignant B lymphoid cells.

Guettinger Y, Barbin K, Peipp M, Bruenke J, Dechant M, Horner H, Thierschmidt D, Valerius T, Repp R, Fey GH, Stockmeyer B.

J Immunol. 2010 Feb 1;184(3):1210-7. doi: 10.4049/jimmunol.0902033. Epub 2009 Dec 30.


Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework.

Kügler M, Stein C, Schwenkert M, Saul D, Vockentanz L, Huber T, Wetzel SK, Scholz O, Plückthun A, Honegger A, Fey GH.

Protein Eng Des Sel. 2009 Mar;22(3):135-47. doi: 10.1093/protein/gzn079. Epub 2009 Feb 1.


A novel CD19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells.

Kellner C, Bruenke J, Stieglmaier J, Schwemmlein M, Schwenkert M, Singer H, Mentz K, Peipp M, Lang P, Oduncu F, Stockmeyer B, Fey GH.

J Immunother. 2008 Nov-Dec;31(9):871-84. doi: 10.1097/CJI.0b013e318186c8b4.


T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.

Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Haridas V, Habiro K, Yang YG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Manjunath N, Shultz LD, Lee SK, Shankar P.

Cell. 2008 Aug 22;134(4):577-86. doi: 10.1016/j.cell.2008.06.034. Epub 2008 Aug 7.


A single chain immunotoxin, targeting the melanoma-associated chondroitin sulfate proteoglycan, is a potent inducer of apoptosis in cultured human melanoma cells.

Schwenkert M, Birkholz K, Schwemmlein M, Kellner C, Kügler M, Peipp M, Nettelbeck DM, Schuler-Thurner B, Schaft N, Dörrie J, Ferrone S, Kämpgen E, Fey GH.

Melanoma Res. 2008 Apr;18(2):73-84. doi: 10.1097/CMR.0b013e3282f7c8f9.


Superior activity of fusion protein scFvRit:sFasL over cotreatment with rituximab and Fas agonists.

Bremer E, ten Cate B, Samplonius DF, Mueller N, Wajant H, Stel AJ, Chamuleau M, van de Loosdrecht AA, Stieglmaier J, Fey GH, Helfrich W.

Cancer Res. 2008 Jan 15;68(2):597-604. doi: 10.1158/0008-5472.CAN-07-5171.


Selective induction of apoptosis in leukemic B-lymphoid cells by a CD19-specific TRAIL fusion protein.

Stieglmaier J, Bremer E, Kellner C, Liebig TM, ten Cate B, Peipp M, Schulze-Koops H, Pfeiffer M, Bühring HJ, Greil J, Oduncu F, Emmerich B, Fey GH, Helfrich W.

Cancer Immunol Immunother. 2008 Feb;57(2):233-46. Epub 2007 Jul 31.


A CD19-specific single-chain immunotoxin mediates potent apoptosis of B-lineage leukemic cells.

Schwemmlein M, Stieglmaier J, Kellner C, Peipp M, Saul D, Oduncu F, Emmerich B, Stockmeyer B, Lang P, Beck JD, Fey GH.

Leukemia. 2007 Jul;21(7):1405-12. Epub 2007 May 10.


A CD33-specific single-chain immunotoxin mediates potent apoptosis of cultured human myeloid leukaemia cells.

Schwemmlein M, Peipp M, Barbin K, Saul D, Stockmeyer B, Repp R, Birkmann J, Oduncu F, Emmerich B, Fey GH.

Br J Haematol. 2006 Apr;133(2):141-51.


Influence of variable N-glycosylation on the cytolytic potential of chimeric CD19 antibodies.

Barbin K, Stieglmaier J, Saul D, Stieglmaier K, Stockmeyer B, Pfeiffer M, Lang P, Fey GH.

J Immunother. 2006 Mar-Apr;29(2):122-33.


Effective lysis of lymphoma cells with a stabilised bispecific single-chain Fv antibody against CD19 and FcgammaRIII (CD16).

Bruenke J, Barbin K, Kunert S, Lang P, Pfeiffer M, Stieglmaier K, Niethammer D, Stockmeyer B, Peipp M, Repp R, Valerius T, Fey GH.

Br J Haematol. 2005 Jul;130(2):218-28.


Target cell-restricted apoptosis induction of acute leukemic T cells by a recombinant tumor necrosis factor-related apoptosis-inducing ligand fusion protein with specificity for human CD7.

Bremer E, Samplonius DF, Peipp M, van Genne L, Kroesen BJ, Fey GH, Gramatzki M, de Leij LF, Helfrich W.

Cancer Res. 2005 Apr 15;65(8):3380-8.


Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.

Hofmann H, Geier M, Marzi A, Krumbiegel M, Peipp M, Fey GH, Gramberg T, Pöhlmann S.

Biochem Biophys Res Commun. 2004 Jul 9;319(4):1216-21.


A recombinant bispecific single-chain Fv antibody against HLA class II and FcgammaRIII (CD16) triggers effective lysis of lymphoma cells.

Bruenke J, Fischer B, Barbin K, Schreiter K, Wachter Y, Mahr K, Titgemeyer F, Niederweis M, Peipp M, Zunino SJ, Repp R, Valerius T, Fey GH.

Br J Haematol. 2004 Apr;125(2):167-79.


Efficient eukaryotic expression of fluorescent scFv fusion proteins directed against CD antigens for FACS applications.

Peipp M, Saul D, Barbin K, Bruenke J, Zunino SJ, Niederweis M, Fey GH.

J Immunol Methods. 2004 Feb 15;285(2):265-80.


Chimeric CD19 antibody mediates cytotoxic activity against leukemic blasts with effector cells from pediatric patients who received T-cell-depleted allografts.

Lang P, Barbin K, Feuchtinger T, Greil J, Peipp M, Zunino SJ, Pfeiffer M, Handgretinger R, Niethammer D, Fey GH.

Blood. 2004 May 15;103(10):3982-5. Epub 2004 Feb 5.


A recombinant CD7-specific single-chain immunotoxin is a potent inducer of apoptosis in acute leukemic T cells.

Peipp M, Küpers H, Saul D, Schlierf B, Greil J, Zunino SJ, Gramatzki M, Fey GH.

Cancer Res. 2002 May 15;62(10):2848-55.


Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL.

Reichel M, Gillert E, Angermüller S, Hensel JP, Heidel F, Lode M, Leis T, Biondi A, Haas OA, Strehl S, Panzer-Grümayer ER, Griesinger F, Beck JD, Greil J, Fey GH, Uckun FM, Marschalek R.

Oncogene. 2001 May 24;20(23):2900-7.


An improved procedure for the generation of recombinant single-chain Fv antibody fragments reacting with human CD13 on intact cells.

Peipp M, Simon N, Loichinger A, Baum W, Mahr K, Zunino SJ, Fey GH.

J Immunol Methods. 2001 May 1;251(1-2):161-76.


Rapid isolation of chromosomal breakpoints from patients with t(4;11) acute lymphoblastic leukemia: implications for basic and clinical research.

Reichel M, Gillert E, Breitenlohner I, Angermüller S, Fey GH, Marschalek R, Repp R, Greil J, Beck JD.

Leukemia. 2001 Feb;15(2):286-8. No abstract available.


Rab11b is essential for recycling of transferrin to the plasma membrane.

Schlierf B, Fey GH, Hauber J, Hocke GM, Rosorius O.

Exp Cell Res. 2000 Aug 25;259(1):257-65.


ENL, the MLL fusion partner in t(11;19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t(10;11)+.

García-Cuéllar MP, Schreiner SA, Birke M, Hamacher M, Fey GH, Slany RK.

Oncogene. 2000 Mar 30;19(14):1744-51.


Regulation of CD95 expression and CD95-mediated cell death by interferon-gamma in acute lymphoblastic leukemia with chromosomal translocation t(4;11).

Dörrie J, Schuh W, Keil A, Bongards E, Greil J, Fey GH, Zunino SJ.

Leukemia. 1999 Oct;13(10):1539-47.


The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator.

Schreiner SA, García-Cuéllar MP, Fey GH, Slany RK.

Leukemia. 1999 Oct;13(10):1525-33.


A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells.

Gillert E, Leis T, Repp R, Reichel M, Hösch A, Breitenlohner I, Angermüller S, Borkhardt A, Harbott J, Lampert F, Griesinger F, Greil J, Fey GH, Marschalek R.

Oncogene. 1999 Aug 19;18(33):4663-71.


Modulation of hepatic acute phase gene expression by epidermal growth factor and Src protein tyrosine kinases in murine and human hepatic cells.

Wang Y, Ripperger J, Fey GH, Samols D, Kordula T, Wetzler M, Van Etten RA, Baumann H.

Hepatology. 1999 Sep;30(3):682-97.


Rapid isolation of chromosomal breakpoints from patients with t(4;11) acute lymphoblastic leukemia: implications for basic and clinical research.

Reichel M, Gillert E, Breitenlohner I, Repp R, Greil J, Beck JD, Fey GH, Marschalek R.

Cancer Res. 1999 Jul 15;59(14):3357-62.


A novel set of hepatic mRNAs preferentially expressed during an acute inflammation in rat represents mostly intracellular proteins.

Olivier E, Soury E, Risler JL, Smih F, Schneider K, Lochner K, Jouzeau JY, Fey GH, Salier JP.

Genomics. 1999 May 1;57(3):352-64.


Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation.

Reichel M, Gillert E, Nilson I, Siegler G, Greil J, Fey GH, Marschalek R.

Oncogene. 1998 Dec 10;17(23):3035-44.


The structure of the human ALL-1/MLL/HRX gene.

Marschalek R, Nilson I, Löchner K, Greim R, Siegler G, Greil J, Beck JD, Fey GH.

Leuk Lymphoma. 1997 Nov;27(5-6):417-28. Review.


A 32-kDa proteolytic fragment of transcription factor Stat3 is capable of specific DNA binding.

Dreier B, Fritz S, Volkert G, Brachvogel B, Lottspeich F, Fey GH.

J Biol Chem. 1997 Aug 29;272(35):22118-24.


Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia.

Nilson I, Reichel M, Ennas MG, Greim R, Knörr C, Siegler G, Greil J, Fey GH, Marschalek R.

Br J Haematol. 1997 Jul;98(1):157-69.


The human ALL-1/MLL/HRX antigen is predominantly localized in the nucleus of resting and proliferating peripheral blood mononuclear cells.

Ennas MG, Sorio C, Greim R, Nieddu M, Scarpa A, Orlandini S, Croce CM, Fey GH, Marschalek R.

Cancer Res. 1997 May 15;57(10):2035-41.

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