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Items: 1 to 50 of 64

1.

Alternative Biosynthetic Starter Units Enhance the Structural Diversity of Cyanobacterial Lipopeptides.

Mareš J, Hájek J, Urajová P, Kust A, Jokela J, Saurav K, Galica T, Čapková K, Mattila A, Haapaniemi E, Permi P, Mysterud I, Skulberg OM, Karlsen J, Fewer DP, Sivonen K, Tønnesen HH, Hrouzek P.

Appl Environ Microbiol. 2019 Feb 6;85(4). pii: e02675-18. doi: 10.1128/AEM.02675-18. Print 2019 Feb 15.

PMID:
30504214
2.

N-Prenylation of Tryptophan by an Aromatic Prenyltransferase from the Cyanobactin Biosynthetic Pathway.

Dalponte L, Parajuli A, Younger E, Mattila A, Jokela J, Wahlsten M, Leikoski N, Sivonen K, Jarmusch SA, Houssen WE, Fewer DP.

Biochemistry. 2018 Dec 18;57(50):6860-6867. doi: 10.1021/acs.biochem.8b00879. Epub 2018 Dec 3.

PMID:
30452235
3.

Sphaerocyclamide, a prenylated cyanobactin from the cyanobacterium Sphaerospermopsis sp. LEGE 00249.

Martins J, Leikoski N, Wahlsten M, Azevedo J, Antunes J, Jokela J, Sivonen K, Vasconcelos V, Fewer DP, Leão PN.

Sci Rep. 2018 Sep 28;8(1):14537. doi: 10.1038/s41598-018-32618-5.

4.

Discovery of a Pederin Family Compound in a Nonsymbiotic Bloom-Forming Cyanobacterium.

Kust A, Mareš J, Jokela J, Urajová P, Hájek J, Saurav K, Voráčová K, Fewer DP, Haapaniemi E, Permi P, Řeháková K, Sivonen K, Hrouzek P.

ACS Chem Biol. 2018 May 18;13(5):1123-1129. doi: 10.1021/acschembio.7b01048. Epub 2018 May 2.

PMID:
29570981
5.

Strains of the toxic and bloom-forming Nodularia spumigena (cyanobacteria) can degrade methylphosphonate and release methane.

Teikari JE, Fewer DP, Shrestha R, Hou S, Leikoski N, Mäkelä M, Simojoki A, Hess WR, Sivonen K.

ISME J. 2018 Jun;12(6):1619-1630. doi: 10.1038/s41396-018-0056-6. Epub 2018 Feb 14.

6.

The swinholide biosynthetic gene cluster from a terrestrial cyanobacterium Nostoc sp. UHCC 0450.

Humisto A, Jokela J, Liu L, Wahlsten M, Wang H, Permi P, Machado JP, Antunes A, Fewer DP, Sivonen K.

Appl Environ Microbiol. 2017 Nov 17. pii: AEM.02321-17. doi: 10.1128/AEM.02321-17. [Epub ahead of print]

7.

Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543.

Jokela J, Heinilä LMP, Shishido TK, Wahlsten M, Fewer DP, Fiore MF, Wang H, Haapaniemi E, Permi P, Sivonen K.

Front Microbiol. 2017 Oct 9;8:1963. doi: 10.3389/fmicb.2017.01963. eCollection 2017.

8.

Simultaneous Production of Anabaenopeptins and Namalides by the Cyanobacterium Nostoc sp. CENA543.

Shishido TK, Jokela J, Fewer DP, Wahlsten M, Fiore MF, Sivonen K.

ACS Chem Biol. 2017 Nov 17;12(11):2746-2755. doi: 10.1021/acschembio.7b00570. Epub 2017 Sep 29.

PMID:
28933529
9.

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants.

Alexandru-Crivac CN, Umeobika C, Leikoski N, Jokela J, Rickaby KA, Grilo AM, Sjö P, Plowright AT, Idress M, Siebs E, Nneoyi-Egbe A, Wahlsten M, Sivonen K, Jaspars M, Trembleau L, Fewer DP, Houssen WE.

Chem Commun (Camb). 2017 Sep 26;53(77):10656-10659. doi: 10.1039/c7cc05913b.

PMID:
28905052
10.

Rearranged Biosynthetic Gene Cluster and Synthesis of Hassallidin E in Planktothrix serta PCC 8927.

Pancrace C, Jokela J, Sassoon N, Ganneau C, Desnos-Ollivier M, Wahlsten M, Humisto A, Calteau A, Bay S, Fewer DP, Sivonen K, Gugger M.

ACS Chem Biol. 2017 Jul 21;12(7):1796-1804. doi: 10.1021/acschembio.7b00093. Epub 2017 May 17.

PMID:
28489343
11.

Phylogenomic Analysis of the Microviridin Biosynthetic Pathway Coupled with Targeted Chemo-Enzymatic Synthesis Yields Potent Protease Inhibitors.

Ahmed MN, Reyna-González E, Schmid B, Wiebach V, Süssmuth RD, Dittmann E, Fewer DP.

ACS Chem Biol. 2017 Jun 16;12(6):1538-1546. doi: 10.1021/acschembio.7b00124. Epub 2017 Apr 26.

PMID:
28406289
12.

Genetic Organization of Anabaenopeptin and Spumigin Biosynthetic Gene Clusters in the Cyanobacterium Sphaerospermopsis torques-reginae ITEP-024.

Lima ST, Alvarenga DO, Etchegaray A, Fewer DP, Jokela J, Varani AM, Sanz M, Dörr FA, Pinto E, Sivonen K, Fiore MF.

ACS Chem Biol. 2017 Mar 17;12(3):769-778. doi: 10.1021/acschembio.6b00948. Epub 2017 Jan 26.

PMID:
28085246
13.

Corrigendum: A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway.

Parajuli A, Kwak DH, Dalponte L, Leikoski N, Galica T, Umeobika U, Trembleau L, Bent A, Sivonen K, Wahlsten M, Wang H, Rizzi E, De Bellis G, Naismith J, Jaspars M, Liu X, Houssen W, Fewer DP.

Angew Chem Int Ed Engl. 2017 Jan 9;56(2):433. doi: 10.1002/anie.201609949. No abstract available.

PMID:
28045232
14.

The cyclochlorotine mycotoxin is produced by the nonribosomal peptide synthetase CctN in Talaromyces islandicus ('Penicillium islandicum').

Schafhauser T, Kirchner N, Kulik A, Huijbers MM, Flor L, Caradec T, Fewer DP, Gross H, Jacques P, Jahn L, Jokela J, Leclère V, Ludwig-Müller J, Sivonen K, van Berkel WJ, Weber T, Wohlleben W, van Pée KH.

Environ Microbiol. 2016 Nov;18(11):3728-3741. doi: 10.1111/1462-2920.13294. Epub 2016 Jun 27.

PMID:
26954535
15.

A liquid chromatography-mass spectrometric method for the detection of cyclic β-amino fatty acid lipopeptides.

Urajová P, Hájek J, Wahlsten M, Jokela J, Galica T, Fewer DP, Kust A, Zapomělová-Kozlíková E, Delawská K, Sivonen K, Kopecký J, Hrouzek P.

J Chromatogr A. 2016 Mar 18;1438:76-83. doi: 10.1016/j.chroma.2016.02.013. Epub 2016 Feb 15.

PMID:
26893022
16.

A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway.

Parajuli A, Kwak DH, Dalponte L, Leikoski N, Galica T, Umeobika U, Trembleau L, Bent A, Sivonen K, Wahlsten M, Wang H, Rizzi E, De Bellis G, Naismith J, Jaspars M, Liu X, Houssen W, Fewer DP.

Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3596-9. doi: 10.1002/anie.201509920. Epub 2016 Feb 5. Erratum in: Angew Chem Int Ed Engl. 2017 Jan 9;56(2):433.

17.

Genomic insights into the distribution, genetic diversity and evolution of polyketide synthases and nonribosomal peptide synthetases.

Wang H, Sivonen K, Fewer DP.

Curr Opin Genet Dev. 2015 Dec;35:79-85. doi: 10.1016/j.gde.2015.10.004. Epub 2015 Nov 21. Review.

PMID:
26605685
18.

Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria.

Shishido TK, Jokela J, Kolehmainen CT, Fewer DP, Wahlsten M, Wang H, Rouhiainen L, Rizzi E, De Bellis G, Permi P, Sivonen K.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13669-74. doi: 10.1073/pnas.1510432112. Epub 2015 Oct 16.

19.

Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria.

Dittmann E, Gugger M, Sivonen K, Fewer DP.

Trends Microbiol. 2015 Oct;23(10):642-652. doi: 10.1016/j.tim.2015.07.008. Review.

PMID:
26433696
20.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

21.

Draft genome sequence of Talaromyces islandicus ("Penicillium islandicum") WF-38-12, a neglected mold with significant biotechnological potential.

Schafhauser T, Wibberg D, Rückert C, Winkler A, Flor L, van Pée KH, Fewer DP, Sivonen K, Jahn L, Ludwig-Müller J, Caradec T, Jacques P, Huijbers MM, van Berkel WJ, Weber T, Wohlleben W, Kalinowski J.

J Biotechnol. 2015 Oct 10;211:101-2. doi: 10.1016/j.jbiotec.2015.07.004. Epub 2015 Jul 18.

PMID:
26197417
22.

Antifungal compounds from cyanobacteria.

Shishido TK, Humisto A, Jokela J, Liu L, Wahlsten M, Tamrakar A, Fewer DP, Permi P, Andreote AP, Fiore MF, Sivonen K.

Mar Drugs. 2015 Apr 13;13(4):2124-40. doi: 10.3390/md13042124.

23.

Identification of geosmin and 2-methylisoborneol in cyanobacteria and molecular detection methods for the producers of these compounds.

Suurnäkki S, Gomez-Saez GV, Rantala-Ylinen A, Jokela J, Fewer DP, Sivonen K.

Water Res. 2015 Jan 1;68:56-66.

PMID:
25462716
24.

Pseudoaeruginosins, nonribosomal peptides in Nodularia spumigena.

Liu L, Budnjo A, Jokela J, Haug BE, Fewer DP, Wahlsten M, Rouhiainen L, Permi P, Fossen T, Sivonen K.

ACS Chem Biol. 2015 Mar 20;10(3):725-33. doi: 10.1021/cb5004306. Epub 2014 Dec 5.

PMID:
25419633
25.

Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria.

Calteau A, Fewer DP, Latifi A, Coursin T, Laurent T, Jokela J, Kerfeld CA, Sivonen K, Piel J, Gugger M.

BMC Genomics. 2014 Nov 18;15:977. doi: 10.1186/1471-2164-15-977.

26.

4-Methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides.

Liu L, Jokela J, Herfindal L, Wahlsten M, Sinkkonen J, Permi P, Fewer DP, Døskeland SO, Sivonen K.

ACS Chem Biol. 2014 Nov 21;9(11):2646-55. doi: 10.1021/cb500436p. Epub 2014 Sep 25.

PMID:
25203327
27.

Reply to Sasso et al.: Distribution and phylogeny of nonribosomal peptide and polyketide biosynthetic pathways in eukaryotes.

Wang H, Fewer DP, Holm L, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3947. doi: 10.1073/pnas.1413343111. Epub 2014 Sep 2. No abstract available.

28.

Nostosins, Trypsin Inhibitors Isolated from the Terrestrial Cyanobacterium Nostoc sp. Strain FSN.

Liu L, Jokela J, Wahlsten M, Nowruzi B, Permi P, Zhang YZ, Xhaard H, Fewer DP, Sivonen K.

J Nat Prod. 2014 Aug 22;77(8):1784-90. doi: 10.1021/np500106w.

PMID:
25069058
29.

Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes.

Wang H, Fewer DP, Holm L, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9259-64. doi: 10.1073/pnas.1401734111. Epub 2014 Jun 9.

30.

Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway.

Vestola J, Shishido TK, Jokela J, Fewer DP, Aitio O, Permi P, Wahlsten M, Wang H, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1909-17. doi: 10.1073/pnas.1320913111. Epub 2014 Apr 17.

31.

New structural variants of aeruginosin produced by the toxic bloom forming cyanobacterium Nodularia spumigena.

Fewer DP, Jokela J, Paukku E, Österholm J, Wahlsten M, Permi P, Aitio O, Rouhiainen L, Gomez-Saez GV, Sivonen K.

PLoS One. 2013 Sep 6;8(9):e73618. doi: 10.1371/journal.pone.0073618. eCollection 2013.

32.

Genome mining expands the chemical diversity of the cyanobactin family to include highly modified linear peptides.

Leikoski N, Liu L, Jokela J, Wahlsten M, Gugger M, Calteau A, Permi P, Kerfeld CA, Sivonen K, Fewer DP.

Chem Biol. 2013 Aug 22;20(8):1033-43. doi: 10.1016/j.chembiol.2013.06.015. Epub 2013 Aug 1.

33.

The genetic basis for O-acetylation of the microcystin toxin in cyanobacteria.

Fewer DP, Wahlsten M, Österholm J, Jokela J, Rouhiainen L, Kaasalainen U, Rikkinen J, Sivonen K.

Chem Biol. 2013 Jul 25;20(7):861-9. doi: 10.1016/j.chembiol.2013.04.020.

34.

Convergent evolution of [D-Leucine(1)] microcystin-LR in taxonomically disparate cyanobacteria.

Shishido TK, Kaasalainen U, Fewer DP, Rouhiainen L, Jokela J, Wahlsten M, Fiore MF, Yunes JS, Rikkinen J, Sivonen K.

BMC Evol Biol. 2013 Apr 19;13:86. doi: 10.1186/1471-2148-13-86.

35.

Insights into the physiology and ecology of the brackish-water-adapted Cyanobacterium Nodularia spumigena CCY9414 based on a genome-transcriptome analysis.

Voss B, Bolhuis H, Fewer DP, Kopf M, Möke F, Haas F, El-Shehawy R, Hayes P, Bergman B, Sivonen K, Dittmann E, Scanlan DJ, Hagemann M, Stal LJ, Hess WR.

PLoS One. 2013;8(3):e60224. doi: 10.1371/journal.pone.0060224. Epub 2013 Mar 28.

36.

Lichen species identity and diversity of cyanobacterial toxins in symbiosis.

Kaasalainen U, Fewer DP, Jokela J, Wahlsten M, Sivonen K, Rikkinen J.

New Phytol. 2013 May;198(3):647-51. doi: 10.1111/nph.12215. Epub 2013 Mar 6. No abstract available.

37.

Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.

Shih PM, Wu D, Latifi A, Axen SD, Fewer DP, Talla E, Calteau A, Cai F, Tandeau de Marsac N, Rippka R, Herdman M, Sivonen K, Coursin T, Laurent T, Goodwin L, Nolan M, Davenport KW, Han CS, Rubin EM, Eisen JA, Woyke T, Gugger M, Kerfeld CA.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1053-8. doi: 10.1073/pnas.1217107110. Epub 2012 Dec 31.

38.

Genome-derived insights into the biology of the hepatotoxic bloom-forming cyanobacterium Anabaena sp. strain 90.

Wang H, Sivonen K, Rouhiainen L, Fewer DP, Lyra C, Rantala-Ylinen A, Vestola J, Jokela J, Rantasärkkä K, Li Z, Liu B.

BMC Genomics. 2012 Nov 13;13:613. doi: 10.1186/1471-2164-13-613.

39.

Cyanobacterial toxins: biosynthetic routes and evolutionary roots.

Dittmann E, Fewer DP, Neilan BA.

FEMS Microbiol Rev. 2013 Jan;37(1):23-43. doi: 10.1111/j.1574-6976.2012.12000.x. Epub 2012 Oct 10. Review.

40.

Analysis of an inactive cyanobactin biosynthetic gene cluster leads to discovery of new natural products from strains of the genus Microcystis.

Leikoski N, Fewer DP, Jokela J, Alakoski P, Wahlsten M, Sivonen K.

PLoS One. 2012;7(8):e43002. doi: 10.1371/journal.pone.0043002. Epub 2012 Aug 27.

41.

Cyanobacteria produce a high variety of hepatotoxic peptides in lichen symbiosis.

Kaasalainen U, Fewer DP, Jokela J, Wahlsten M, Sivonen K, Rikkinen J.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5886-91. doi: 10.1073/pnas.1200279109. Epub 2012 Mar 26.

42.

Galega orientalis is more diverse than Galega officinalis in Caucasus--whole-genome AFLP analysis and phylogenetics of symbiosis-related genes.

Osterman J, Chizhevskaja EP, Andronov EE, Fewer DP, Terefework Z, Roumiantseva ML, Onichtchouk OP, Dresler-Nurmi A, Simarov BV, Dzyubenko NI, Lindström K.

Mol Ecol. 2011 Nov;20(22):4808-21. doi: 10.1111/j.1365-294X.2011.05291.x. Epub 2011 Oct 10.

PMID:
21980996
43.

Nostophycin biosynthesis is directed by a hybrid polyketide synthase-nonribosomal peptide synthetase in the toxic cyanobacterium Nostoc sp. strain 152.

Fewer DP, Osterholm J, Rouhiainen L, Jokela J, Wahlsten M, Sivonen K.

Appl Environ Microbiol. 2011 Nov;77(22):8034-40. doi: 10.1128/AEM.05993-11. Epub 2011 Sep 23.

44.

Genome mining demonstrates the widespread occurrence of gene clusters encoding bacteriocins in cyanobacteria.

Wang H, Fewer DP, Sivonen K.

PLoS One. 2011;6(7):e22384. doi: 10.1371/journal.pone.0022384. Epub 2011 Jul 20.

45.

Non-autonomous transposable elements associated with inactivation of microcystin gene clusters in strains of the genus Anabaena isolated from the Baltic Sea.

Fewer DP, Halinen K, Sipari H, Bernardová K, Mänttäri M, Eronen E, Sivonen K.

Environ Microbiol Rep. 2011 Apr;3(2):189-94. doi: 10.1111/j.1758-2229.2010.00207.x. Epub 2010 Aug 19.

PMID:
23761251
46.

Deinobacterium chartae gen. nov., sp. nov., an extremely radiation-resistant, biofilm-forming bacterium isolated from a Finnish paper mill.

Ekman JV, Raulio M, Busse HJ, Fewer DP, Salkinoja-Salonen M.

Int J Syst Evol Microbiol. 2011 Mar;61(Pt 3):540-8. doi: 10.1099/ijs.0.017970-0. Epub 2010 Apr 9.

PMID:
20382794
47.

Molecular evidence for a diverse green algal community growing in the hair of sloths and a specific association with Trichophilus welckeri (Chlorophyta, Ulvophyceae).

Suutari M, Majaneva M, Fewer DP, Voirin B, Aiello A, Friedl T, Chiarello AG, Blomster J.

BMC Evol Biol. 2010 Mar 30;10:86. doi: 10.1186/1471-2148-10-86.

48.

Two alternative starter modules for the non-ribosomal biosynthesis of specific anabaenopeptin variants in Anabaena (Cyanobacteria).

Rouhiainen L, Jokela J, Fewer DP, Urmann M, Sivonen K.

Chem Biol. 2010 Mar 26;17(3):265-73. doi: 10.1016/j.chembiol.2010.01.017.

49.

Cyanobactins-ribosomal cyclic peptides produced by cyanobacteria.

Sivonen K, Leikoski N, Fewer DP, Jokela J.

Appl Microbiol Biotechnol. 2010 May;86(5):1213-25. doi: 10.1007/s00253-010-2482-x. Epub 2010 Feb 27. Review.

50.

Highly diverse cyanobactins in strains of the genus Anabaena.

Leikoski N, Fewer DP, Jokela J, Wahlsten M, Rouhiainen L, Sivonen K.

Appl Environ Microbiol. 2010 Feb;76(3):701-9. doi: 10.1128/AEM.01061-09. Epub 2009 Dec 11.

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