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Items: 1 to 50 of 94

1.

Pseudomonas Quinolone Signal molecule PQS behaves like a B Class inhibitor at the IQ site of mitochondrial complex I.

Rieger B, Thierbach S, Ommer M, Dienhart FSV, Fetzner S, Busch KB.

FASEB Bioadv. 2020 Feb 19;2(3):188-202. doi: 10.1096/fba.2019-00084. eCollection 2020 Mar.

2.

Definition of an α/β-hydrolase fold subfamily comprising Pseudomonas quinolone signal cleaving dioxygenases.

Wullich SC, Arranz San Martín A, Fetzner S.

Appl Environ Microbiol. 2020 Feb 21. pii: AEM.00279-20. doi: 10.1128/AEM.00279-20. [Epub ahead of print]

PMID:
32086305
3.

Efficient modification of the Pseudomonas aeruginosa toxin 2-heptyl-1-hydroxyquinolin-4-one by three Bacillus glycosyltransferases with broad substrate ranges.

Thierbach S, Sartor P, Yücel O, Fetzner S.

J Biotechnol. 2020 Jan 20;308:74-81. doi: 10.1016/j.jbiotec.2019.11.015. Epub 2019 Nov 28.

PMID:
31786106
4.

Interference with Pseudomonas aeruginosa Quorum Sensing and Virulence by the Mycobacterial Pseudomonas Quinolone Signal Dioxygenase AqdC in Combination with the N-Acylhomoserine Lactone Lactonase QsdA.

Birmes FS, Säring R, Hauke MC, Ritzmann NH, Drees SL, Daniel J, Treffon J, Liebau E, Kahl BC, Fetzner S.

Infect Immun. 2019 Sep 19;87(10). pii: e00278-19. doi: 10.1128/IAI.00278-19. Print 2019 Oct.

5.

Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqdC, a mycobacterial dioxygenase of the α/β-hydrolase fold family.

Wullich SC, Kobus S, Wienhold M, Hennecke U, Smits SHJ, Fetzner S.

J Struct Biol. 2019 Sep 1;207(3):287-294. doi: 10.1016/j.jsb.2019.06.006. Epub 2019 Jun 19.

PMID:
31228546
6.

Bromination of alkyl quinolones by Microbulbifer sp. HZ11, a marine Gammaproteobacterium, modulates their antibacterial activity.

Ritzmann NH, Mährlein A, Ernst S, Hennecke U, Drees SL, Fetzner S.

Environ Microbiol. 2019 Jul;21(7):2595-2609. doi: 10.1111/1462-2920.14654. Epub 2019 Jun 6.

PMID:
31087606
7.

Synthesis and biological activity of methylated derivatives of the Pseudomonas metabolites HHQ, HQNO and PQS.

Thierbach S, Wienhold M, Fetzner S, Hennecke U.

Beilstein J Org Chem. 2019 Jan 21;15:187-193. doi: 10.3762/bjoc.15.18. eCollection 2019.

8.

PqsL uses reduced flavin to produce 2-hydroxylaminobenzoylacetate, a preferred PqsBC substrate in alkyl quinolone biosynthesis in Pseudomonas aeruginosa.

Drees SL, Ernst S, Belviso BD, Jagmann N, Hennecke U, Fetzner S.

J Biol Chem. 2018 Jun 15;293(24):9345-9357. doi: 10.1074/jbc.RA117.000789. Epub 2018 Apr 18.

9.

Chemical Modification and Detoxification of the Pseudomonas aeruginosa Toxin 2-Heptyl-4-hydroxyquinoline N-Oxide by Environmental and Pathogenic Bacteria.

Thierbach S, Birmes FS, Letzel MC, Hennecke U, Fetzner S.

ACS Chem Biol. 2017 Sep 15;12(9):2305-2312. doi: 10.1021/acschembio.7b00345. Epub 2017 Jul 27.

PMID:
28708374
10.

Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance.

Maura D, Drees SL, Bandyopadhaya A, Kitao T, Negri M, Starkey M, Lesic B, Milot S, Déziel E, Zahler R, Pucci M, Felici A, Fetzner S, Lépine F, Rahme LG.

ACS Chem Biol. 2017 May 19;12(5):1435-1443. doi: 10.1021/acschembio.6b01139. Epub 2017 Apr 12.

PMID:
28379691
11.

Mycobacterium abscessus subsp. abscessus Is Capable of Degrading Pseudomonas aeruginosa Quinolone Signals.

Birmes FS, Wolf T, Kohl TA, Rüger K, Bange F, Kalinowski J, Fetzner S.

Front Microbiol. 2017 Mar 2;8:339. doi: 10.3389/fmicb.2017.00339. eCollection 2017.

12.

Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS) Promotes Biofilm Formation of Pseudomonas aeruginosa by Increasing Iron Availability.

Tettmann B, Niewerth C, Kirschhöfer F, Neidig A, Dötsch A, Brenner-Weiss G, Fetzner S, Overhage J.

Front Microbiol. 2016 Dec 9;7:1978. doi: 10.3389/fmicb.2016.01978. eCollection 2016.

13.

Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds.

Zender M, Witzgall F, Drees SL, Weidel E, Maurer CK, Fetzner S, Blankenfeldt W, Empting M, Hartmann RW.

ACS Chem Biol. 2016 Jun 17;11(6):1755-63. doi: 10.1021/acschembio.6b00156. Epub 2016 Apr 28.

PMID:
27082157
14.

Quercetin 2,4-Dioxygenase Activates Dioxygen in a Side-On O2-Ni Complex.

Jeoung JH, Nianios D, Fetzner S, Dobbek H.

Angew Chem Int Ed Engl. 2016 Mar 1;55(10):3281-4. doi: 10.1002/anie.201510741. Epub 2016 Feb 5.

PMID:
26846734
15.

PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal: CRYSTAL STRUCTURE, INHIBITION, AND REACTION MECHANISM.

Drees SL, Li C, Prasetya F, Saleem M, Dreveny I, Williams P, Hennecke U, Emsley J, Fetzner S.

J Biol Chem. 2016 Mar 25;291(13):6610-24. doi: 10.1074/jbc.M115.708453. Epub 2016 Jan 25.

16.

Rhodococcus erythropolis BG43 Genes Mediating Pseudomonas aeruginosa Quinolone Signal Degradation and Virulence Factor Attenuation.

Müller C, Birmes FS, Rückert C, Kalinowski J, Fetzner S.

Appl Environ Microbiol. 2015 Nov;81(22):7720-9. doi: 10.1128/AEM.02145-15. Epub 2015 Aug 28.

17.

Complete genome sequence of Rhodococcus erythropolis BG43 (DSM 46869), a degrader of Pseudomonas aeruginosa quorum sensing signal molecules.

Rückert C, Birmes FS, Müller C, Niewerth H, Winkler A, Fetzner S, Kalinowski J.

J Biotechnol. 2015 Oct 10;211:99-100. doi: 10.1016/j.jbiotec.2015.07.014. Epub 2015 Jul 22.

PMID:
26210289
18.

PqsE of Pseudomonas aeruginosa Acts as Pathway-Specific Thioesterase in the Biosynthesis of Alkylquinolone Signaling Molecules.

Drees SL, Fetzner S.

Chem Biol. 2015 May 21;22(5):611-8. doi: 10.1016/j.chembiol.2015.04.012. Epub 2015 May 7.

19.

Nickel quercetinase, a "promiscuous" metalloenzyme: metal incorporation and metal ligand substitution studies.

Nianios D, Thierbach S, Steimer L, Lulchev P, Klostermeier D, Fetzner S.

BMC Biochem. 2015 Apr 23;16:10. doi: 10.1186/s12858-015-0039-4.

20.

Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule.

Soh EY, Chhabra SR, Halliday N, Heeb S, Müller C, Birmes FS, Fetzner S, Cámara M, Chan KG, Williams P.

Environ Microbiol. 2015 Nov;17(11):4352-65. doi: 10.1111/1462-2920.12857. Epub 2015 Apr 28.

PMID:
25809238
21.

Conversion of the Pseudomonas aeruginosa Quinolone Signal and Related Alkylhydroxyquinolines by Rhodococcus sp. Strain BG43.

Müller C, Birmes FS, Niewerth H, Fetzner S.

Appl Environ Microbiol. 2014 Dec;80(23):7266-74. doi: 10.1128/AEM.02342-14. Epub 2014 Sep 19.

22.

Quorum quenching enzymes.

Fetzner S.

J Biotechnol. 2015 May 10;201:2-14. doi: 10.1016/j.jbiotec.2014.09.001. Epub 2014 Sep 16. Review.

PMID:
25220028
23.

Crystal structure analysis of EstA from Arthrobacter sp. Rue61a--an insight into catalytic promiscuity.

Wagner UG, DiMaio F, Kolkenbrock S, Fetzner S.

FEBS Lett. 2014 Apr 2;588(7):1154-60. doi: 10.1016/j.febslet.2014.02.045. Epub 2014 Mar 5.

24.

Substrate-assisted O2 activation in a cofactor-independent dioxygenase.

Thierbach S, Bui N, Zapp J, Chhabra SR, Kappl R, Fetzner S.

Chem Biol. 2014 Feb 20;21(2):217-25. doi: 10.1016/j.chembiol.2013.11.013. Epub 2014 Jan 2.

25.

Old molecules, new biochemistry.

Fetzner S, Drees SL.

Chem Biol. 2013 Dec 19;20(12):1438-40. doi: 10.1016/j.chembiol.2013.12.001.

26.
27.

Complete genome sequence and metabolic potential of the quinaldine-degrading bacterium Arthrobacter sp. Rue61a.

Niewerth H, Schuldes J, Parschat K, Kiefer P, Vorholt JA, Daniel R, Fetzner S.

BMC Genomics. 2012 Oct 6;13:534. doi: 10.1186/1471-2164-13-534.

28.

A Pseudomonas putida bioreporter for the detection of enzymes active on 2-alkyl-4(1H)-quinolone signalling molecules.

Müller C, Fetzner S.

Appl Microbiol Biotechnol. 2013 Jan;97(2):751-60. doi: 10.1007/s00253-012-4236-4. Epub 2012 Jun 28.

PMID:
22740050
29.

Hydrolase-like properties of a cofactor-independent dioxygenase.

Thierbach S, Büldt-Karentzopoulos K, Dreiling A, Hennecke U, König S, Fetzner S.

Chembiochem. 2012 May 29;13(8):1125-7. doi: 10.1002/cbic.201200152. Epub 2012 Apr 30.

PMID:
22549932
30.

Ring-cleaving dioxygenases with a cupin fold.

Fetzner S.

Appl Environ Microbiol. 2012 Apr;78(8):2505-14. doi: 10.1128/AEM.07651-11. Epub 2012 Jan 27. Review.

31.

Synthesis and biotransformation of 2-alkyl-4(1H)-quinolones by recombinant Pseudomonas putida KT2440.

Niewerth H, Bergander K, Chhabra SR, Williams P, Fetzner S.

Appl Microbiol Biotechnol. 2011 Sep;91(5):1399-408. doi: 10.1007/s00253-011-3378-0. Epub 2011 Jun 14.

PMID:
21670979
32.

A novel replicative enzyme encoded by the linear Arthrobacter plasmid pAL1.

Kolkenbrock S, Naumann B, Hippler M, Fetzner S.

J Bacteriol. 2010 Oct;192(19):4935-43. doi: 10.1128/JB.00614-10. Epub 2010 Jul 30.

33.

Cofactor-independent oxidases and oxygenases.

Fetzner S, Steiner RA.

Appl Microbiol Biotechnol. 2010 Apr;86(3):791-804. doi: 10.1007/s00253-010-2455-0. Epub 2010 Feb 16. Review.

PMID:
20157809
34.

Identification and in vitro deoxynucleotidylation of the terminal protein of the linear plasmid pAL1 of Arthrobacter nitroguajacolicus Rü61a.

Kolkenbrock S, Fetzner S.

FEMS Microbiol Lett. 2010 Mar;304(2):169-76. doi: 10.1111/j.1574-6968.2010.01900.x. Epub 2010 Jan 12.

35.

Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the alpha/beta-hydrolase fold.

Steiner RA, Janssen HJ, Roversi P, Oakley AJ, Fetzner S.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):657-62. doi: 10.1073/pnas.0909033107. Epub 2009 Dec 22.

36.

Dioxygenase-mediated quenching of quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

Pustelny C, Albers A, Büldt-Karentzopoulos K, Parschat K, Chhabra SR, Cámara M, Williams P, Fetzner S.

Chem Biol. 2009 Dec 24;16(12):1259-67. doi: 10.1016/j.chembiol.2009.11.013.

37.

Quercetinase QueD of Streptomyces sp. FLA, a monocupin dioxygenase with a preference for nickel and cobalt.

Merkens H, Kappl R, Jakob RP, Schmid FX, Fetzner S.

Biochemistry. 2008 Nov 18;47(46):12185-96. doi: 10.1021/bi801398x. Epub 2008 Oct 25.

PMID:
18950192
38.

Transcriptional analysis of the queD gene coding for quercetinase of Streptomyces sp. FLA.

Merkens H, Fetzner S.

FEMS Microbiol Lett. 2008 Oct;287(1):100-7. doi: 10.1111/j.1574-6968.2008.01296.x. Epub 2008 Aug 2.

39.

Thermodynamic analysis of denaturant-induced unfolding of HodC69S protein supports a three-state mechanism.

Boehm K, Guddorf J, Albers A, Kamiyama T, Fetzner S, Hinz HJ.

Biochemistry. 2008 Jul 8;47(27):7116-26. doi: 10.1021/bi800554v. Epub 2008 Jun 13.

PMID:
18549245
40.

Cofactor-independent oxygenases go it alone.

Fetzner S.

Nat Chem Biol. 2007 Jul;3(7):374-5. No abstract available.

PMID:
17576423
41.
42.

Crystallization and diffraction data of 1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase: a cofactor-free oxygenase of the alpha/beta-hydrolase family.

Qi R, Fetzner S, Oakley AJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt 5):378-81. Epub 2007 Apr 6.

43.
44.

Stability, unfolding, and structural changes of cofactor-free 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase.

Beermann B, Guddorf J, Boehm K, Albers A, Kolkenbrock S, Fetzner S, Hinz HJ.

Biochemistry. 2007 Apr 10;46(14):4241-9. Epub 2007 Mar 20.

PMID:
17371045
45.
47.

Spectroscopic and biochemical studies on protein variants of quinaldine 4-oxidase: Role of E736 in catalysis and effects of serine ligands on the FeSI and FeSII clusters.

Kappl R, Sielker S, Ranguelova K, Wegner J, Parschat K, Hüttermann J, Fetzner S.

Biochemistry. 2006 Dec 12;45(49):14853-68.

PMID:
17144679
48.

N-acetylanthranilate amidase from Arthrobacter nitroguajacolicus Rü61a, an alpha/beta-hydrolase-fold protein active towards aryl-acylamides and -esters, and properties of its cysteine-deficient variant.

Kolkenbrock S, Parschat K, Beermann B, Hinz HJ, Fetzner S.

J Bacteriol. 2006 Dec;188(24):8430-40. Epub 2006 Oct 13. Erratum in: J Bacteriol. 2007 May;189(10):3933.

49.

On the purification and preliminary crystallographic analysis of isoquinoline 1-oxidoreductase from Brevundimonas diminuta 7.

Boer DR, Müller A, Fetzner S, Lowe DJ, Romão MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jan 1;61(Pt 1):137-40. Epub 2004 Dec 24.

50.

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