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Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells.

Fettiplace R, Nam JH.

Hear Res. 2019 May;376:11-21. doi: 10.1016/j.heares.2018.11.002. Epub 2018 Nov 16. Review.


Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea.

Beurg M, Cui R, Goldring AC, Ebrahim S, Fettiplace R, Kachar B.

Nat Commun. 2018 Jun 5;9(1):2185. doi: 10.1038/s41467-018-04589-8.


Spatiotemporal changes in the distribution of LHFPL5 in mice cochlear hair bundles during development and in the absence of PCDH15.

Mahendrasingam S, Fettiplace R, Alagramam KN, Cross E, Furness DN.

PLoS One. 2017 Oct 25;12(10):e0185285. doi: 10.1371/journal.pone.0185285. eCollection 2017.


PIEZO2 as the anomalous mechanotransducer channel in auditory hair cells.

Beurg M, Fettiplace R.

J Physiol. 2017 Dec 1;595(23):7039-7048. doi: 10.1113/JP274996. Epub 2017 Oct 26. Review.


Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.

Fettiplace R.

Compr Physiol. 2017 Sep 12;7(4):1197-1227. doi: 10.1002/cphy.c160049. Review.


CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.

Giese APJ, Tang YQ, Sinha GP, Bowl MR, Goldring AC, Parker A, Freeman MJ, Brown SDM, Riazuddin S, Fettiplace R, Schafer WR, Frolenkov GI, Ahmed ZM.

Nat Commun. 2017 Jun 29;8(1):43. doi: 10.1038/s41467-017-00061-1.


Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.

Wu Z, Grillet N, Zhao B, Cunningham C, Harkins-Perry S, Coste B, Ranade S, Zebarjadi N, Beurg M, Fettiplace R, Patapoutian A, Mueller U.

Nat Neurosci. 2017 Jan;20(1):24-33. doi: 10.1038/nn.4449. Epub 2016 Nov 28.


Evaluation of Nestin Expression in the Developing and Adult Mouse Inner Ear.

Chow CL, Trivedi P, Pyle MP, Matulle JT, Fettiplace R, Gubbels SP.

Stem Cells Dev. 2016 Oct 1;25(19):1419-32. doi: 10.1089/scd.2016.0176. Epub 2016 Sep 7.


Is TMC1 the Hair Cell Mechanotransducer Channel?

Fettiplace R.

Biophys J. 2016 Jul 12;111(1):3-9. doi: 10.1016/j.bpj.2016.05.032. Review.


Development and localization of reverse-polarity mechanotransducer channels in cochlear hair cells.

Beurg M, Goldring AC, Ricci AJ, Fettiplace R.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6767-72. doi: 10.1073/pnas.1601067113. Epub 2016 May 9.


The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells.

Beurg M, Goldring AC, Fettiplace R.

J Gen Physiol. 2015 Sep;146(3):233-43. doi: 10.1085/jgp.201511458.


Subunit determination of the conductance of hair-cell mechanotransducer channels.

Beurg M, Xiong W, Zhao B, Müller U, Fettiplace R.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1589-94. doi: 10.1073/pnas.1420906112. Epub 2014 Dec 30.


The physiology of mechanoelectrical transduction channels in hearing.

Fettiplace R, Kim KX.

Physiol Rev. 2014 Jul;94(3):951-86. doi: 10.1152/physrev.00038.2013. Review.


Conductance and block of hair-cell mechanotransducer channels in transmembrane channel-like protein mutants.

Beurg M, Kim KX, Fettiplace R.

J Gen Physiol. 2014 Jul;144(1):55-69. doi: 10.1085/jgp.201411173.


The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels.

Kim KX, Beurg M, Hackney CM, Furness DN, Mahendrasingam S, Fettiplace R.

J Gen Physiol. 2013 Nov;142(5):493-505. doi: 10.1085/jgp.201311068. Epub 2013 Oct 14.


Data-to-text summarisation of patient records: using computer-generated summaries to access patient histories.

Scott D, Hallett C, Fettiplace R.

Patient Educ Couns. 2013 Aug;92(2):153-9. doi: 10.1016/j.pec.2013.04.019. Epub 2013 Jun 5.


A prestin motor in chicken auditory hair cells: active force generation in a nonmammalian species.

Beurg M, Tan X, Fettiplace R.

Neuron. 2013 Jul 10;79(1):69-81. doi: 10.1016/j.neuron.2013.05.018. Epub 2013 Jun 6.


Electrical tuning and transduction in short hair cells of the chicken auditory papilla.

Tan X, Beurg M, Hackney C, Mahendrasingam S, Fettiplace R.

J Neurophysiol. 2013 Apr;109(8):2007-20. doi: 10.1152/jn.01028.2012. Epub 2013 Jan 30.


Optimal electrical properties of outer hair cells ensure cochlear amplification.

Nam JH, Fettiplace R.

PLoS One. 2012;7(11):e50572. doi: 10.1371/journal.pone.0050572. Epub 2012 Nov 27.


The resting transducer current drives spontaneous activity in prehearing mammalian cochlear inner hair cells.

Johnson SL, Kennedy HJ, Holley MC, Fettiplace R, Marcotti W.

J Neurosci. 2012 Aug 1;32(31):10479-83. doi: 10.1523/JNEUROSCI.0803-12.2012.


The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells.

Chen Q, Mahendrasingam S, Tickle JA, Hackney CM, Furness DN, Fettiplace R.

Eur J Neurosci. 2012 Aug;36(3):2302-10. doi: 10.1111/j.1460-9568.2012.08159.x. Epub 2012 Jun 6.


Prestin-driven cochlear amplification is not limited by the outer hair cell membrane time constant.

Johnson SL, Beurg M, Marcotti W, Fettiplace R.

Neuron. 2011 Jun 23;70(6):1143-54. doi: 10.1016/j.neuron.2011.04.024.


Force transmission in the organ of Corti micromachine.

Nam JH, Fettiplace R.

Biophys J. 2010 Jun 16;98(12):2813-21. doi: 10.1016/j.bpj.2010.03.052.


The remarkable cochlear amplifier.

Ashmore J, Avan P, Brownell WE, Dallos P, Dierkes K, Fettiplace R, Grosh K, Hackney CM, Hudspeth AJ, Jülicher F, Lindner B, Martin P, Meaud J, Petit C, Santos-Sacchi J, Sacchi JR, Canlon B.

Hear Res. 2010 Jul;266(1-2):1-17. doi: 10.1016/j.heares.2010.05.001. Erratum in: Hear Res. 2011 Oct;280(1-2):245. Sacchi, J R Santos [corrected to Santos-Sacchi, J].


The ultrastructural distribution of prestin in outer hair cells: a post-embedding immunogold investigation of low-frequency and high-frequency regions of the rat cochlea.

Mahendrasingam S, Beurg M, Fettiplace R, Hackney CM.

Eur J Neurosci. 2010 May;31(9):1595-605. doi: 10.1111/j.1460-9568.2010.07182.x.


Calcium balance and mechanotransduction in rat cochlear hair cells.

Beurg M, Nam JH, Chen Q, Fettiplace R.

J Neurophysiol. 2010 Jul;104(1):18-34. doi: 10.1152/jn.00019.2010. Epub 2010 Apr 28.


WITHDRAWN: The origin of the cochlear amplifier.

Hackney CM, Fettiplace R.

Hear Res. 2010 Jan 30. [Epub ahead of print]


WITHDRAWN: The origin of the cochlear amplifier.

Fettiplace R, Hackney C.

Hear Res. 2009 Oct 7. [Epub ahead of print]


Defining features of the hair cell mechanoelectrical transducer channel.

Fettiplace R.

Pflugers Arch. 2009 Oct;458(6):1115-23. doi: 10.1007/s00424-009-0683-x. Epub 2009 May 28. Review.


Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging.

Beurg M, Fettiplace R, Nam JH, Ricci AJ.

Nat Neurosci. 2009 May;12(5):553-8. doi: 10.1038/nn.2295. Epub 2009 Mar 29.


Theoretical conditions for high-frequency hair bundle oscillations in auditory hair cells.

Nam JH, Fettiplace R.

Biophys J. 2008 Nov 15;95(10):4948-62. doi: 10.1529/biophysj.108.138560. Epub 2008 Aug 1.


The dimensions and composition of stereociliary rootlets in mammalian cochlear hair cells: comparison between high- and low-frequency cells and evidence for a connection to the lateral membrane.

Furness DN, Mahendrasingam S, Ohashi M, Fettiplace R, Hackney CM.

J Neurosci. 2008 Jun 18;28(25):6342-53. doi: 10.1523/JNEUROSCI.1154-08.2008.


The actions of calcium on hair bundle mechanics in mammalian cochlear hair cells.

Beurg M, Nam JH, Crawford A, Fettiplace R.

Biophys J. 2008 Apr 1;94(7):2639-53. doi: 10.1529/biophysj.107.123257. Epub 2008 Jan 4.


A large-conductance calcium-selective mechanotransducer channel in mammalian cochlear hair cells.

Beurg M, Evans MG, Hackney CM, Fettiplace R.

J Neurosci. 2006 Oct 25;26(43):10992-1000.


Active hair bundle movements in auditory hair cells.

Fettiplace R.

J Physiol. 2006 Oct 1;576(Pt 1):29-36. Epub 2006 Aug 3. Review.


Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms.

Kennedy HJ, Evans MG, Crawford AC, Fettiplace R.

J Neurosci. 2006 Mar 8;26(10):2757-66.


The sensory and motor roles of auditory hair cells.

Fettiplace R, Hackney CM.

Nat Rev Neurosci. 2006 Jan;7(1):19-29. Review.


The concentrations of calcium buffering proteins in mammalian cochlear hair cells.

Hackney CM, Mahendrasingam S, Penn A, Fettiplace R.

J Neurosci. 2005 Aug 24;25(34):7867-75.


The transduction channel filter in auditory hair cells.

Ricci AJ, Kennedy HJ, Crawford AC, Fettiplace R.

J Neurosci. 2005 Aug 24;25(34):7831-9.


Force generation by mammalian hair bundles supports a role in cochlear amplification.

Kennedy HJ, Crawford AC, Fettiplace R.

Nature. 2005 Feb 24;433(7028):880-3. Epub 2005 Feb 6.


Tonotopic variation in the conductance of the hair cell mechanotransducer channel.

Ricci AJ, Crawford AC, Fettiplace R.

Neuron. 2003 Dec 4;40(5):983-90.


Adaptation in auditory hair cells.

Fettiplace R, Ricci AJ.

Curr Opin Neurobiol. 2003 Aug;13(4):446-51. Review.


Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cells.

Kennedy HJ, Evans MG, Crawford AC, Fettiplace R.

Nat Neurosci. 2003 Aug;6(8):832-6.


The distribution of calcium buffering proteins in the turtle cochlea.

Hackney CM, Mahendrasingam S, Jones EM, Fettiplace R.

J Neurosci. 2003 Jun 1;23(11):4577-89.


Quality, mainstream services with proactive and targeted outreach: a model of contraceptive service provision for young people.

Baraitser P, Fettiplace R, Dolan F, Massil H, Cowley S.

J Fam Plann Reprod Health Care. 2002 Apr;28(2):90-4.


Mechanisms of active hair bundle motion in auditory hair cells.

Ricci AJ, Crawford AC, Fettiplace R.

J Neurosci. 2002 Jan 1;22(1):44-52.


Clues to the cochlear amplifier from the turtle ear.

Fettiplace R, Ricci AJ, Hackney CM.

Trends Neurosci. 2001 Mar;24(3):169-75. Review.


Active hair bundle motion linked to fast transducer adaptation in auditory hair cells.

Ricci AJ, Crawford AC, Fettiplace R.

J Neurosci. 2000 Oct 1;20(19):7131-42.


Tonotopic variations of calcium signalling in turtle auditory hair cells.

Ricci AJ, Gray-Keller M, Fettiplace R.

J Physiol. 2000 Apr 15;524 Pt 2:423-36.

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