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Items: 1 to 50 of 148

1.

Thrombin and the Coag-Inflammatory Nexus in Neurotrauma, ALS, and Other Neurodegenerative Disorders.

Festoff BW, Citron BA.

Front Neurol. 2019 Feb 5;10:59. doi: 10.3389/fneur.2019.00059. eCollection 2019. Review.

2.

Proximate Mediators of Microvascular Dysfunction at the Blood-Brain Barrier: Neuroinflammatory Pathways to Neurodegeneration.

Festoff BW, Sajja RK, Cucullo L.

Biomed Res Int. 2017;2017:1549194. doi: 10.1155/2017/1549194. Epub 2017 Aug 14. Review.

3.

HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease.

Festoff BW, Sajja RK, van Dreden P, Cucullo L.

J Neuroinflammation. 2016 Aug 24;13(1):194. doi: 10.1186/s12974-016-0670-z.

4.

Membrane lipid peroxidation in neurodegeneration: Role of thrombin and proteinase-activated receptor-1.

Citron BA, Ameenuddin S, Uchida K, Suo WZ, SantaCruz K, Festoff BW.

Brain Res. 2016 Jul 15;1643:10-7. doi: 10.1016/j.brainres.2016.04.071. Epub 2016 Apr 30.

PMID:
27138068
5.

Mitochondrial lysates induce inflammation and Alzheimer's disease-relevant changes in microglial and neuronal cells.

Wilkins HM, Carl SM, Weber SG, Ramanujan SA, Festoff BW, Linseman DA, Swerdlow RH.

J Alzheimers Dis. 2015;45(1):305-18. doi: 10.3233/JAD-142334.

6.

Bioenergetic dysfunction and inflammation in Alzheimer's disease: a possible connection.

Wilkins HM, Carl SM, Greenlief AC, Festoff BW, Swerdlow RH.

Front Aging Neurosci. 2014 Nov 10;6:311. doi: 10.3389/fnagi.2014.00311. eCollection 2014. Review.

7.

Designing drugs that encourage spinal cord injury healing.

Festoff BW.

Expert Opin Drug Discov. 2014 Oct;9(10):1151-65. doi: 10.1517/17460441.2014.941350. Epub 2014 Jul 25. Review.

PMID:
25063571
8.

Novel mutation in VCP gene causes atypical amyotrophic lateral sclerosis.

González-Pérez P, Cirulli ET, Drory VE, Dabby R, Nisipeanu P, Carasso RL, Sadeh M, Fox A, Festoff BW, Sapp PC, McKenna-Yasek D, Goldstein DB, Brown RH Jr, Blumen SC.

Neurology. 2012 Nov 27;79(22):2201-8. doi: 10.1212/WNL.0b013e318275963b. Epub 2012 Nov 14.

9.

Soluble thrombomodulin levels in plasma of multiple sclerosis patients and their implication.

Festoff BW, Li C, Woodhams B, Lynch S.

J Neurol Sci. 2012 Dec 15;323(1-2):61-5. doi: 10.1016/j.jns.2012.08.008. Epub 2012 Sep 8.

PMID:
22967748
10.

Neuroprotective effects of caspase-3 inhibition on functional recovery and tissue sparing after acute spinal cord injury.

Citron BA, Arnold PM, Haynes NG, Ameenuddin S, Farooque M, Santacruz K, Festoff BW.

Spine (Phila Pa 1976). 2008 Oct 1;33(21):2269-77. doi: 10.1097/BRS.0b013e3181831f7e.

PMID:
18827691
11.

Longitudinal magnetic resonance imaging of spinal cord injury in mouse: changes in signal patterns associated with the inflammatory response.

Bilgen M, Al-Hafez B, Alrefae T, He YY, Smirnova IV, Aldur MM, Festoff BW.

Magn Reson Imaging. 2007 Jun;25(5):657-64. Epub 2006 Nov 21.

PMID:
17540277
12.

GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment.

Suo Z, Cox AA, Bartelli N, Rasul I, Festoff BW, Premont RT, Arendash GW.

Neurobiol Aging. 2007 Dec;28(12):1873-88. Epub 2006 Oct 2.

PMID:
17011668
13.

Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury.

Festoff BW, Ameenuddin S, Arnold PM, Wong A, Santacruz KS, Citron BA.

J Neurochem. 2006 Jun;97(5):1314-26. Epub 2006 Apr 21.

14.

Magnetic resonance imaging of mouse spinal cord.

Bilgen M, Al-Hafez B, Berman NE, Festoff BW.

Magn Reson Med. 2005 Nov;54(5):1226-31.

15.

Gender-related differences in recovery of locomotor function after spinal cord injury in mice.

Farooque M, Suo Z, Arnold PM, Wulser MJ, Chou CT, Vancura RW, Fowler S, Festoff BW.

Spinal Cord. 2006 Mar;44(3):182-7.

PMID:
16130019
17.

Neuroprotective effects of recombinant thrombomodulin in controlled contusion spinal cord injury implicates thrombin signaling.

Festoff BW, Ameenuddin S, Santacruz K, Morser J, Suo Z, Arnold PM, Stricker KE, Citron BA.

J Neurotrauma. 2004 Jul;21(7):907-22.

PMID:
15307903
18.
20.

Thrombin: a potential proinflammatory mediator in neurotrauma and neurodegenerative disorders.

Suo Z, Citron BA, Festoff BW.

Curr Drug Targets Inflamm Allergy. 2004 Mar;3(1):105-14. Review.

PMID:
15032647
21.
22.

Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling.

Suo Z, Wu M, Citron BA, Palazzo RE, Festoff BW.

J Biol Chem. 2003 Sep 26;278(39):37681-9. Epub 2003 Jun 23.

23.

Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation.

Suo Z, Wu M, Citron BA, Gao C, Festoff BW.

J Biol Chem. 2003 Aug 15;278(33):31177-83. Epub 2003 May 29.

24.

Injury-induced "switch" from GTP-regulated to novel GTP-independent isoform of tissue transglutaminase in the rat spinal cord.

Festoff BW, SantaCruz K, Arnold PM, Sebastian CT, Davies PJ, Citron BA.

J Neurochem. 2002 May;81(4):708-18.

25.

Participation of protease-activated receptor-1 in thrombin-induced microglial activation.

Suo Z, Wu M, Ameenuddin S, Anderson HE, Zoloty JE, Citron BA, Andrade-Gordon P, Festoff BW.

J Neurochem. 2002 Feb;80(4):655-66.

26.

Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration.

Citron BA, Suo Z, SantaCruz K, Davies PJ, Qin F, Festoff BW.

Neurochem Int. 2002 Jan;40(1):69-78.

PMID:
11738473
29.

Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injury.

Citron BA, Smirnova IV, Arnold PM, Festoff BW.

J Neurotrauma. 2000 Dec;17(12):1191-203.

PMID:
11186232
30.

Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlates with apoptotic cell death.

Citron BA, Arnold PM, Sebastian C, Qin F, Malladi S, Ameenuddin S, Landis ME, Festoff BW.

Exp Neurol. 2000 Dec;166(2):213-26.

PMID:
11085887
31.

Intron-exon swapping of transglutaminase mRNA and neuronal Tau aggregation in Alzheimer's disease.

Citron BA, SantaCruz KS, Davies PJ, Festoff BW.

J Biol Chem. 2001 Feb 2;276(5):3295-301. Epub 2000 Sep 29.

32.

Motor neuron cell death in wobbler mutant mice follows overexpression of the G-protein-coupled, protease-activated receptor for thrombin.

Festoff BW, D'Andrea MR, Citron BA, Salcedo RM, Smirnova IV, Andrade-Gordon P.

Mol Med. 2000 May;6(5):410-29.

33.

Selective developmental regulation of gene expression for insulin-like growth factor-binding proteins in mouse spinal cord.

Arnold PM, Ma JY, Citron BA, Zoubine MN, Festoff BW.

Spine (Phila Pa 1976). 2000 Jul 15;25(14):1765-70.

PMID:
10888943
34.

Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle.

Akaaboune M, Allinquant B, Farza H, Roy K, Magoul R, Fiszman M, Festoff BW, Hantaï D.

Mol Cell Neurosci. 2000 Apr;15(4):355-67.

PMID:
10845772
35.

Regulation of the dual function tissue transglutaminase/Galpha(h) during murine neuromuscular development: gene and enzyme isoform expression.

Citron BA, Gregory EJ, Steigerwalt DS, Qin F, Festoff BW.

Neurochem Int. 2000 Oct;37(4):337-49.

PMID:
10825574
36.

Insulin-like growth factor binding proteins in cerebrospinal fluid during human development and aging.

Arnold PM, Ma JY, Citron BA, Festoff BW.

Biochem Biophys Res Commun. 1999 Nov 2;264(3):652-6.

PMID:
10543987
37.

Serpin=serine protease-like complexes within neurofilament conglomerates of motoneurons in amyotrophic lateral sclerosis.

Chou SM, Taniguchi A, Wang HS, Festoff BW.

J Neurol Sci. 1998 Oct;160 Suppl 1:S73-9.

PMID:
9851654
38.
39.
40.

Developmental regulation of the serpin, protease nexin I, localization during activity-dependent polyneuronal synapse elimination in mouse skeletal muscle.

Akaaboune M, Hantaï D, Smirnova I, Lachkar S, Kapsimali M, Verdière-Sahuqué M, Festoff BW.

J Comp Neurol. 1998 Aug 10;397(4):572-9.

PMID:
9699917
41.
42.

Apoptosis in cellular compartments of rat spinal cord after severe contusion injury.

Yong C, Arnold PM, Zoubine MN, Citron BA, Watanabe I, Berman NE, Festoff BW.

J Neurotrauma. 1998 Jul;15(7):459-72.

PMID:
9674550
43.

Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons.

Smirnova IV, Zhang SX, Citron BA, Arnold PM, Festoff BW.

J Neurobiol. 1998 Jul;36(1):64-80.

PMID:
9658339
44.

Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons.

Smirnova IV, Vamos S, Wiegmann T, Citron BA, Arnold PM, Festoff BW.

J Mol Neurosci. 1998 Feb;10(1):31-44.

PMID:
9589368
45.

Characterization of apoptosis in a motor neuron cell line.

Smirnova IV, Citron BA, Arnold PM, Zhang SX, Festoff BW.

Spine (Phila Pa 1976). 1998 Jan 15;23(2):151-8.

PMID:
9474719
46.

Thrombin and its precursor in human cerebrospinal fluid.

Smirnova IV, Salazar A, Arnold PM, Glatt S, Handler M, Festoff BW.

Thromb Haemost. 1997 Dec;78(6):1473-9.

PMID:
9423797
47.

Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group.

Lai EC, Felice KJ, Festoff BW, Gawel MJ, Gelinas DF, Kratz R, Murphy MF, Natter HM, Norris FH, Rudnicki SA.

Neurology. 1997 Dec;49(6):1621-30.

PMID:
9409357
48.

Quantitative PCR analysis reveals novel expression of prothrombin mRNA and regulation of its levels in developing mouse muscle.

Citron BA, Smirnova IV, Zoubine MN, Festoff BW.

Thromb Res. 1997 Aug 1;87(3):303-13.

PMID:
9263397
49.

Apoptotic, injury-induced cell death in cultured mouse murine motor neurons.

Citron BA, Zhang SX, Smirnova IV, Festoff BW.

Neurosci Lett. 1997 Jul 11;230(1):25-8.

PMID:
9259455
50.

Identity of neurotrophic molecules released from astroglia by vasoactive intestinal peptide.

Brenneman DE, Phillips TM, Festoff BW, Gozes I.

Ann N Y Acad Sci. 1997 Apr 24;814:167-73. Review.

PMID:
9160969

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