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Items: 1 to 50 of 66

1.

Novel Insights on the Toxicity of Phycotoxins on the Gut through the Targeting of Enteric Glial Cells.

Reale O, Huguet A, Fessard V.

Mar Drugs. 2019 Jul 23;17(7). pii: E429. doi: 10.3390/md17070429.

2.

Three-dimensional HepaRG spheroids as a liver model to study human genotoxicity in vitro with the single cell gel electrophoresis assay.

Mandon M, Huet S, Dubreil E, Fessard V, Le Hégarat L.

Sci Rep. 2019 Jul 22;9(1):10548. doi: 10.1038/s41598-019-47114-7.

3.

Pinnatoxins' Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health.

Delcourt N, Lagrange E, Abadie E, Fessard V, Frémy JM, Vernoux JP, Peyrat MB, Maignien T, Arnich N, Molgó J, Mattei C.

Mar Drugs. 2019 Jul 20;17(7). pii: E425. doi: 10.3390/md17070425. Review.

4.

Simultaneous Detection of 14 Microcystin Congeners from Tissue Samples Using UPLC- ESI-MS/MS and Two Different Deuterated Synthetic Microcystins as Internal Standards.

Altaner S, Puddick J, Fessard V, Feurstein D, Zemskov I, Wittmann V, Dietrich DR.

Toxins (Basel). 2019 Jul 2;11(7). pii: E388. doi: 10.3390/toxins11070388.

5.

Combined effects of okadaic acid and pectenotoxin-2, 13-desmethylspirolide C or yessotoxin in human intestinal Caco-2 cells.

Alarcan J, Barbé S, Kopp B, Hessel-Pras S, Braeuning A, Lampen A, Le Hégarat L, Fessard V.

Chemosphere. 2019 Aug;228:139-148. doi: 10.1016/j.chemosphere.2019.04.018. Epub 2019 Apr 5.

PMID:
31029959
6.

Aluminum in liver cells - the element species matters.

Sieg H, Ellermann AL, Maria Kunz B, Jalili P, Burel A, Hogeveen K, Böhmert L, Chevance S, Braeuning A, Gauffre F, Fessard V, Lampen A.

Nanotoxicology. 2019 Sep;13(7):909-922. doi: 10.1080/17435390.2019.1593542. Epub 2019 Apr 2.

PMID:
30938204
7.

Identification of key pathways involved in the toxic response of the cyanobacterial toxin cylindrospermopsin in human hepatic HepaRG cells.

Huguet A, Lanceleur R, Quenault H, Le Hégarat L, Fessard V.

Toxicol In Vitro. 2019 Aug;58:69-77. doi: 10.1016/j.tiv.2019.03.023. Epub 2019 Mar 21.

PMID:
30905859
8.

Metabolism of the lipophilic phycotoxin 13-Desmethylspirolide C using human and rat in vitro liver models.

Alarcan J, Dubreil E, Huguet A, Aráoz R, Brée F, Bouaita B, Hurtaud-Pessel D, Braeuning A, Hessel-Pras S, Lampen A, Le Hégarat L, Fessard V.

Toxicol Lett. 2019 Jun 1;307:17-25. doi: 10.1016/j.toxlet.2019.02.012. Epub 2019 Feb 27.

PMID:
30825503
9.

Uptake and molecular impact of aluminum-containing nanomaterials on human intestinal caco-2 cells.

Sieg H, Braeuning C, Kunz BM, Daher H, Kästner C, Krause BC, Meyer T, Jalili P, Hogeveen K, Böhmert L, Lichtenstein D, Burel A, Chevance S, Jungnickel H, Tentschert J, Laux P, Braeuning A, Gauffre F, Fessard V, Meijer J, Estrela-Lopis I, Thünemann AF, Luch A, Lampen A.

Nanotoxicology. 2018 Nov;12(9):992-1013. doi: 10.1080/17435390.2018.1504999. Epub 2018 Oct 14.

PMID:
30317887
10.

Genotoxicity and mutagenicity assessment of food contaminant mixtures present in the French diet.

Kopp B, Vignard J, Mirey G, Fessard V, Zalko D, Le Hgarat L, Audebert M.

Environ Mol Mutagen. 2018 Oct;59(8):742-754. doi: 10.1002/em.22214. Epub 2018 Sep 19.

PMID:
30230031
11.

Assessment of the in vitro genotoxicity of TiO2 nanoparticles in a regulatory context.

Charles S, Jomini S, Fessard V, Bigorgne-Vizade E, Rousselle C, Michel C.

Nanotoxicology. 2018 May;12(4):357-374. doi: 10.1080/17435390.2018.1451567. Epub 2018 Mar 19. Review.

PMID:
29553842
12.

Mixtures of Lipophilic Phycotoxins: Exposure Data and Toxicological Assessment.

Alarcan J, Biré R, Le Hégarat L, Fessard V.

Mar Drugs. 2018 Jan 31;16(2). pii: E46. doi: 10.3390/md16020046. Review.

13.

Nanomaterials: certain aspects of application, risk assessment and risk communication.

Laux P, Tentschert J, Riebeling C, Braeuning A, Creutzenberg O, Epp A, Fessard V, Haas KH, Haase A, Hund-Rinke K, Jakubowski N, Kearns P, Lampen A, Rauscher H, Schoonjans R, Störmer A, Thielmann A, Mühle U, Luch A.

Arch Toxicol. 2018 Jan;92(1):121-141. doi: 10.1007/s00204-017-2144-1. Epub 2017 Dec 22. Review.

14.

Genotoxic effects of food contact recycled paperboard extracts on two human hepatic cell lines.

Souton E, Severin I, Le Hegarat L, Hogeveen K, Aljawish A, Fessard V, Marie-Christine C.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jan;35(1):159-170. doi: 10.1080/19440049.2017.1397774. Epub 2017 Nov 15.

PMID:
29076405
15.

Impact of an Artificial Digestion Procedure on Aluminum-Containing Nanomaterials.

Sieg H, Kästner C, Krause B, Meyer T, Burel A, Böhmert L, Lichtenstein D, Jungnickel H, Tentschert J, Laux P, Braeuning A, Estrela-Lopis I, Gauffre F, Fessard V, Meijer J, Luch A, Thünemann AF, Lampen A.

Langmuir. 2017 Oct 10;33(40):10726-10735. doi: 10.1021/acs.langmuir.7b02729. Epub 2017 Sep 26.

16.

Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus.

Pisapia F, Sibat M, Herrenknecht C, Lhaute K, Gaiani G, Ferron PJ, Fessard V, Fraga S, Nascimento SM, Litaker RW, Holland WC, Roullier C, Hess P.

Mar Drugs. 2017 Jul 11;15(7). pii: E220. doi: 10.3390/md15070220.

17.

Metabolism of the Marine Phycotoxin PTX-2 and Its Effects on Hepatic Xenobiotic Metabolism: Activation of Nuclear Receptors and Modulation of the Phase I Cytochrome P450.

Alarcan J, Dubreil E, Huguet A, Hurtaud-Pessel D, Hessel-Pras S, Lampen A, Fessard V, Le Hegarat L.

Toxins (Basel). 2017 Jul 5;9(7). pii: E212. doi: 10.3390/toxins9070212.

18.

High throughput toxicity screening and intracellular detection of nanomaterials.

Collins AR, Annangi B, Rubio L, Marcos R, Dorn M, Merker C, Estrela-Lopis I, Cimpan MR, Ibrahim M, Cimpan E, Ostermann M, Sauter A, Yamani NE, Shaposhnikov S, Chevillard S, Paget V, Grall R, Delic J, de-Cerio FG, Suarez-Merino B, Fessard V, Hogeveen KN, Fjellsbø LM, Pran ER, Brzicova T, Topinka J, Silva MJ, Leite PE, Ribeiro AR, Granjeiro JM, Grafström R, Prina-Mello A, Dusinska M.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Jan;9(1). doi: 10.1002/wnan.1413. Epub 2016 Jun 7. Review.

19.

Modulation of CYP3A4 activity alters the cytotoxicity of lipophilic phycotoxins in human hepatic HepaRG cells.

Ferron PJ, Hogeveen K, De Sousa G, Rahmani R, Dubreil E, Fessard V, Le Hegarat L.

Toxicol In Vitro. 2016 Jun;33:136-46. doi: 10.1016/j.tiv.2016.02.021. Epub 2016 Mar 5.

PMID:
26956883
20.

Combined Effects of Lipophilic Phycotoxins (Okadaic Acid, Azapsiracid-1 and Yessotoxin) on Human Intestinal Cells Models.

Ferron PJ, Dumazeau K, Beaulieu JF, Le Hégarat L, Fessard V.

Toxins (Basel). 2016 Feb 19;8(2):50. doi: 10.3390/toxins8020050.

21.

In vitro metabolism of the cyanotoxin cylindrospermopsin in HepaRG cells and liver tissue fractions.

Kittler K, Hurtaud-Pessel D, Maul R, Kolrep F, Fessard V.

Toxicon. 2016 Feb;110:47-50. doi: 10.1016/j.toxicon.2015.11.007. Epub 2015 Dec 2.

PMID:
26610396
22.

Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 1: oral route.

Tarantini A, Huet S, Jarry G, Lanceleur R, Poul M, Tavares A, Vital N, Louro H, João Silva M, Fessard V.

Environ Mol Mutagen. 2015 Mar;56(2):218-27. doi: 10.1002/em.21935. Epub 2014 Dec 15.

PMID:
25504566
23.

Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 2: intratracheal instillation and intravenous injection.

Guichard Y, Maire MA, Sébillaud S, Fontana C, Langlais C, Micillino JC, Darne C, Roszak J, Stępnik M, Fessard V, Binet S, Gaté L.

Environ Mol Mutagen. 2015 Mar;56(2):228-44. doi: 10.1002/em.21928. Epub 2014 Nov 28.

PMID:
25451515
24.

Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line.

Tarantini A, Lanceleur R, Mourot A, Lavault MT, Casterou G, Jarry G, Hogeveen K, Fessard V.

Toxicol In Vitro. 2015 Mar;29(2):398-407. doi: 10.1016/j.tiv.2014.10.023. Epub 2014 Nov 13.

PMID:
25448807
25.

Comparative analysis of the cytotoxic effects of okadaic acid-group toxins on human intestinal cell lines.

Ferron PJ, Hogeveen K, Fessard V, Le Hégarat L.

Mar Drugs. 2014 Aug 21;12(8):4616-34. doi: 10.3390/md12084616.

26.

Low in vitro permeability of the cyanotoxin microcystin-LR across a Caco-2 monolayer: with identification of the limiting factors using modelling.

Henri J, Huguet A, Delmas JM, Besson A, Sanders P, Fessard V.

Toxicon. 2014 Dec;91:5-14. doi: 10.1016/j.toxicon.2014.07.023. Epub 2014 Aug 8.

PMID:
25110175
27.

Modulation of chromatin remodelling induced by the freshwater cyanotoxin cylindrospermopsin in human intestinal caco-2 cells.

Huguet A, Hatton A, Villot R, Quenault H, Blanchard Y, Fessard V.

PLoS One. 2014 Jun 12;9(6):e99121. doi: 10.1371/journal.pone.0099121. eCollection 2014.

28.

Integrated approach to the in vivo genotoxic effects of a titanium dioxide nanomaterial using LacZ plasmid-based transgenic mice.

Louro H, Tavares A, Vital N, Costa PM, Alverca E, Zwart E, de Jong WH, Fessard V, Lavinha J, Silva MJ.

Environ Mol Mutagen. 2014 Jul;55(6):500-9. doi: 10.1002/em.21864. Epub 2014 Mar 4.

PMID:
24590610
29.

CYP3A4 activity reduces the cytotoxic effects of okadaic acid in HepaRG cells.

Kittler K, Fessard V, Maul R, Hurtaud-Pessel D.

Arch Toxicol. 2014 Aug;88(8):1519-26. doi: 10.1007/s00204-014-1206-x. Epub 2014 Feb 7.

PMID:
24504163
30.

Absence of in vitro genotoxicity potential of the mycotoxin deoxynivalenol in bacteria and in human TK6 and HepaRG cell lines.

Takakura N, Nesslany F, Fessard V, Le Hegarat L.

Food Chem Toxicol. 2014 Apr;66:113-21. doi: 10.1016/j.fct.2014.01.029. Epub 2014 Jan 24.

PMID:
24468671
31.

Performance of comet and micronucleus assays in metabolic competent HepaRG cells to predict in vivo genotoxicity.

Le Hégarat L, Mourot A, Huet S, Vasseur L, Camus S, Chesné C, Fessard V.

Toxicol Sci. 2014 Apr;138(2):300-9. doi: 10.1093/toxsci/kfu004. Epub 2014 Jan 15.

PMID:
24431211
32.

A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems.

Daneshian M, Botana LM, Dechraoui Bottein MY, Buckland G, Campàs M, Dennison N, Dickey RW, Diogène J, Fessard V, Hartung T, Humpage A, Leist M, Molgó J, Quilliam MA, Rovida C, Suarez-Isla BA, Tubaro A, Wagner K, Zoller O, Dietrich D.

ALTEX. 2013;30(4):487-545. doi: 10.14573/altex.2013.4.487. Review.

33.

Cytotoxicity, fractionation and dereplication of extracts of the dinoflagellate Vulcanodinium rugosum, a producer of pinnatoxin G.

Geiger M, Desanglois G, Hogeveen K, Fessard V, Leprêtre T, Mondeguer F, Guitton Y, Hervé F, Séchet V, Grovel O, Pouchus YF, Hess P.

Mar Drugs. 2013 Sep 2;11(9):3350-71. doi: 10.3390/md11093350.

34.

DNA adducts of the tobacco carcinogens 2-amino-9H-pyrido[2,3-b]indole and 4-aminobiphenyl are formed at environmental exposure levels and persist in human hepatocytes.

Nauwelaërs G, Bellamri M, Fessard V, Turesky RJ, Langouët S.

Chem Res Toxicol. 2013 Sep 16;26(9):1367-77. doi: 10.1021/tx4002226. Epub 2013 Aug 16.

35.

The PERICLES research program: an integrated approach to characterize the combined effects of mixtures of pesticide residues to which the French population is exposed.

Crépet A, Héraud F, Béchaux C, Gouze ME, Pierlot S, Fastier A, Leblanc JCh, Le Hégarat L, Takakura N, Fessard V, Tressou J, Maximilien R, de Sousa G, Nawaz A, Zucchini-Pascal N, Rahmani R, Audebert M, Graillot V, Cravedi JP.

Toxicology. 2013 Nov 16;313(2-3):83-93. doi: 10.1016/j.tox.2013.04.005. Epub 2013 Apr 16.

PMID:
23603198
36.

Comparative cytotoxicity, oxidative stress, and cytokine secretion induced by two cyanotoxin variants, microcystin LR and RR, in human intestinal Caco-2 cells.

Huguet A, Henri J, Petitpas M, Hogeveen K, Fessard V.

J Biochem Mol Toxicol. 2013 May;27(5):253-8. doi: 10.1002/jbt.21482. Epub 2013 Apr 3.

PMID:
23554253
37.

In vitro combined cytotoxic effects of pesticide cocktails simultaneously found in the French diet.

Takakura N, Sanders P, Fessard V, Le Hégarat L.

Food Chem Toxicol. 2013 Feb;52:153-62. doi: 10.1016/j.fct.2012.11.011. Epub 2012 Nov 16.

PMID:
23165155
38.

A co-culture system of human intestinal Caco-2 cells and lymphoblastoid TK6 cells for investigating the genotoxicity of oral compounds.

Le Hégarat L, Huet S, Fessard V.

Mutagenesis. 2012 Nov;27(6):631-6. doi: 10.1093/mutage/ges028. Epub 2012 Jul 27.

PMID:
22844081
39.

Transcriptomic comparison of cyanotoxin variants in a human intestinal model revealed major differences in oxidative stress response: effects of MC-RR and MC-LR on Caco-2 cells.

Zeller P, Quenault H, Huguet A, Blanchard Y, Fessard V.

Ecotoxicol Environ Saf. 2012 Aug;82:13-21. doi: 10.1016/j.ecoenv.2012.05.001. Epub 2012 Jun 20.

PMID:
22721844
40.

Collaborative study for the detection of toxic compounds in shellfish extracts using cell-based assays. Part I: screening strategy and pre-validation study with lipophilic marine toxins.

Sérandour AL, Ledreux A, Morin B, Derick S, Augier E, Lanceleur R, Hamlaoui S, Moukha S, Furger C, Biré R, Krys S, Fessard V, Troussellier M, Bernard C.

Anal Bioanal Chem. 2012 Jun;403(7):1983-93. doi: 10.1007/s00216-012-6028-1. Epub 2012 Apr 27.

PMID:
22538779
41.

Collaborative study for the detection of toxic compounds in shellfish extracts using cell-based assays. Part II: application to shellfish extracts spiked with lipophilic marine toxins.

Ledreux A, Sérandour AL, Morin B, Derick S, Lanceleur R, Hamlaoui S, Furger C, Biré R, Krys S, Fessard V, Troussellier M, Bernard C.

Anal Bioanal Chem. 2012 Jun;403(7):1995-2007. doi: 10.1007/s00216-012-6029-0. Epub 2012 Apr 26.

PMID:
22535441
42.

Genotoxicity of pesticide mixtures present in the diet of the French population.

Graillot V, Takakura N, Hegarat LL, Fessard V, Audebert M, Cravedi JP.

Environ Mol Mutagen. 2012 Apr;53(3):173-84. doi: 10.1002/em.21676. Epub 2012 Jan 4.

PMID:
22389207
43.

Similar uptake profiles of microcystin-LR and -RR in an in vitro human intestinal model.

Zeller P, Clément M, Fessard V.

Toxicology. 2011 Nov 28;290(1):7-13. doi: 10.1016/j.tox.2011.08.005. Epub 2011 Aug 22.

PMID:
21872638
44.

DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.

Nauwelaers G, Bessette EE, Gu D, Tang Y, Rageul J, Fessard V, Yuan JM, Yu MC, Langouët S, Turesky RJ.

Chem Res Toxicol. 2011 Jun 20;24(6):913-25. doi: 10.1021/tx200091y. Epub 2011 Apr 19.

45.

Cytotoxic and genotoxic effects of cylindrospermopsin in mice treated by gavage or intraperitoneal injection.

Bazin E, Huet S, Jarry G, Le Hégarat L, Munday JS, Humpage AR, Fessard V.

Environ Toxicol. 2012 May;27(5):277-84. doi: 10.1002/tox.20640. Epub 2010 Aug 19.

PMID:
20725938
46.

Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays.

Le Hegarat L, Dumont J, Josse R, Huet S, Lanceleur R, Mourot A, Poul JM, Guguen-Guillouzo C, Guillouzo A, Fessard V.

Mutagenesis. 2010 Nov;25(6):555-60. doi: 10.1093/mutage/geq039. Epub 2010 Jul 30.

PMID:
20675360
47.

Characterization of cylindrospermopsin chlorination.

Merel S, Clément M, Mourot A, Fessard V, Thomas O.

Sci Total Environ. 2010 Jul 15;408(16):3433-42. doi: 10.1016/j.scitotenv.2010.04.033. Epub 2010 May 21.

PMID:
20488507
48.

A strategy to study genotoxicity: application to aquatic toxins, limits and solutions.

Fessard V, Le Hégarat L.

Anal Bioanal Chem. 2010 Jul;397(5):1715-22. doi: 10.1007/s00216-010-3699-3. Epub 2010 May 7. Review.

PMID:
20446082
49.

Morphological cell transformation of Syrian hamster embryo (SHE) cells by the cyanotoxin, cylindrospermopsin.

Maire MA, Bazin E, Fessard V, Rast C, Humpage AR, Vasseur P.

Toxicon. 2010 Jun 15;55(7):1317-22. doi: 10.1016/j.toxicon.2010.01.025. Epub 2010 Feb 6.

PMID:
20144639
50.

Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG.

Bazin E, Mourot A, Humpage AR, Fessard V.

Environ Mol Mutagen. 2010 Apr;51(3):251-9. doi: 10.1002/em.20539.

PMID:
19902517

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