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Lap Time Variability From a 400-m Walk Is Associated With Future Mild Cognitive Impairment and Alzheimer's Disease.

Tian Q, Resnick SM, Studenski SA, Ferrucci L.

J Am Med Dir Assoc. 2019 Jun 18. pii: S1525-8610(19)30387-1. doi: 10.1016/j.jamda.2019.04.019. [Epub ahead of print]


An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.

Liu J, Carnero-Montoro E, van Dongen J, Lent S, Nedeljkovic I, Ligthart S, Tsai PC, Martin TC, Mandaviya PR, Jansen R, Peters MJ, Duijts L, Jaddoe VWV, Tiemeier H, Felix JF, Willemsen G, de Geus EJC, Chu AY, Levy D, Hwang SJ, Bressler J, Gondalia R, Salfati EL, Herder C, Hidalgo BA, Tanaka T, Moore AZ, Lemaitre RN, Jhun MA, Smith JA, Sotoodehnia N, Bandinelli S, Ferrucci L, Arnett DK, Grallert H, Assimes TL, Hou L, Baccarelli A, Whitsel EA, van Dijk KW, Amin N, Uitterlinden AG, Sijbrands EJG, Franco OH, Dehghan A, Spector TD, Dupuis J, Hivert MF, Rotter JI, Meigs JB, Pankow JS, van Meurs JBJ, Isaacs A, Boomsma DI, Bell JT, Demirkan A, van Duijn CM.

Nat Commun. 2019 Jun 13;10(1):2581. doi: 10.1038/s41467-019-10487-4.


Understanding and Enhancing Sepsis Survivorship: Priorities for Research and Practice.

Prescott HC, Iwashyna TJ, Blackwood B, Calandra T, Chlan LL, Choong K, Connolly B, Dark P, Ferrucci L, Finfer S, Girard TD, Hodgson C, Hopkins RO, Hough CL, Jackson JC, Machado FR, Marshall JC, Misak C, Needham DM, Panigrahi P, Reinhart K, Yende S, Zafonte R, Rowan KM, Angus DC; International Sepsis Forum.

Am J Respir Crit Care Med. 2019 Jun 4. doi: 10.1164/rccm.201812-2383CP. [Epub ahead of print]


Effects of reward size and context on learning in macaque monkeys.

Ferrucci L, Nougaret S, Brunamonti E, Genovesio A.

Behav Brain Res. 2019 May 26;372:111983. doi: 10.1016/j.bbr.2019.111983. [Epub ahead of print]


Measuring successful aging: an exploratory factor analysis of the InCHIANTI Study into different health domains.

Mount S, Ferrucci L, Wesselius A, Zeegers MP, Schols AM.

Aging (Albany NY). 2019 May 24;11(10):3023-3040. doi: 10.18632/aging.101957.


Association Between Adiposity and Perceived Physical Fatigability in Mid- to Late Life.

Martinez-Amezcua P, Simonsick EM, Wanigatunga AA, Urbanek JK, Chiles Shaffer N, Ferrucci L, Schrack JA.

Obesity (Silver Spring). 2019 Jul;27(7):1177-1183. doi: 10.1002/oby.22500. Epub 2019 May 25.


Moderate-to-Vigorous Physical Activity Is Associated With Higher Muscle Oxidative Capacity in Older Adults.

Adelnia F, Urbanek J, Osawa Y, Shardell M, Brennan NA, Fishbein KW, Spencer RG, Simonsick EM, Schrack JA, Ferrucci L.

J Am Geriatr Soc. 2019 May 22. doi: 10.1111/jgs.15991. [Epub ahead of print]


Declining Skeletal Muscle Mitochondrial Function Associated With Increased Risk of Depression in Later Life.

Brown PJ, Brennan N, Ciarleglio A, Chen C, Garcia CM, Gomez S, Roose SP, Rutherford BR, Simonsick EM, Spencer RG, Ferrucci L.

Am J Geriatr Psychiatry. 2019 Apr 6. pii: S1064-7481(19)30333-1. doi: 10.1016/j.jagp.2019.03.022. [Epub ahead of print]


Tetra-linoleoyl cardiolipin depletion plays a major role in the pathogenesis of sarcopenia.

Semba RD, Moaddel R, Zhang P, Ramsden CE, Ferrucci L.

Med Hypotheses. 2019 Jun;127:142-149. doi: 10.1016/j.mehy.2019.04.015. Epub 2019 Apr 17.


Role of the social actor during social interaction and learning in human-monkey paradigms.

Nougaret S, Ferrucci L, Genovesio A.

Neurosci Biobehav Rev. 2019 Jul;102:242-250. doi: 10.1016/j.neubiorev.2019.05.004. Epub 2019 May 6. Review.


An emergent integrated aging process conserved across primates.

Wey TW, Roberge É, Legeault V, Kemnitz JW, Ferrucci L, Cohen AA.

J Gerontol A Biol Sci Med Sci. 2019 May 2. pii: glz110. doi: 10.1093/gerona/glz110. [Epub ahead of print]


Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary.

Walston J, Bandeen-Roche K, Buta B, Bergman H, Gill TM, Morley JE, Fried LP, Robinson TN, Afilalo J, Newman AB, López-Otín C, De Cabo R, Theou O, Studenski S, Cohen HJ, Ferrucci L.

J Am Geriatr Soc. 2019 May 2. doi: 10.1111/jgs.15928. [Epub ahead of print]


The Role of Muscle Perfusion in the Age-Associated Decline of Mitochondrial Function in Healthy Individuals.

Adelnia F, Cameron D, Bergeron CM, Fishbein KW, Spencer RG, Reiter DA, Ferrucci L.

Front Physiol. 2019 Apr 12;10:427. doi: 10.3389/fphys.2019.00427. eCollection 2019.


Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging.

Ubaida-Mohien C, Gonzalez-Freire M, Lyashkov A, Moaddel R, Chia CW, Simonsick EM, Sen R, Ferrucci L.

Front Physiol. 2019 Mar 26;10:312. doi: 10.3389/fphys.2019.00312. eCollection 2019.


Using the RE-AIM framework for dissemination and implementation of psychosocial distress screening.

Lazenby M, Ercolano E, Tan H, Ferrucci L, Badger T, Grant M, Jacobsen P, McCorkle R.

Eur J Cancer Care (Engl). 2019 Apr 10:e13036. doi: 10.1111/ecc.13036. [Epub ahead of print]


Sex differences in the association between amyloid and longitudinal brain volume change in cognitively normal older adults.

Armstrong NM, Huang CW, Williams OA, Bilgel M, An Y, Doshi J, Erus G, Davatzikos C, Wong DF, Ferrucci L, Resnick SM.

Neuroimage Clin. 2019;22:101769. doi: 10.1016/j.nicl.2019.101769. Epub 2019 Mar 11.


The Association of Olfactory Dysfunction, Frailty, and Mortality Is Mediated by Inflammation: Results from the InCHIANTI Study.

Laudisio A, Navarini L, Margiotta DPE, Fontana DO, Chiarella I, Spitaleri D, Bandinelli S, Gemma A, Ferrucci L, Incalzi RA.

J Immunol Res. 2019 Feb 20;2019:3128231. doi: 10.1155/2019/3128231. eCollection 2019.


Semi-automated 3D segmentation of human skeletal muscle using Focused Ion Beam-Scanning Electron Microscopic images.

Caffrey BJ, Maltsev AV, Gonzalez-Freire M, Hartnell LM, Ferrucci L, Subramaniam S.

J Struct Biol. 2019 Jul 1;207(1):1-11. doi: 10.1016/j.jsb.2019.03.008. Epub 2019 Mar 23.


Elevated Plasma Growth and Differentiation Factor-15 is Associated with Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults.

Semba RD, Gonzalez-Freire M, Tanaka T, Biancotto A, Zhang P, Shardell M, Moaddel R, Ferrucci L; CHI Consortium.

J Gerontol A Biol Sci Med Sci. 2019 Mar 15. pii: glz071. doi: 10.1093/gerona/glz071. [Epub ahead of print]


A prospective study of focal brain atrophy, mobility and fitness.

Tian Q, Resnick SM, Davatzikos C, Erus G, Simonsick EM, Studenski SA, Ferrucci L.

J Intern Med. 2019 Jul;286(1):88-100. doi: 10.1111/joim.12894. Epub 2019 Apr 11.


Diffusion-weighted MRI with intravoxel incoherent motion modeling for assessment of muscle perfusion in the thigh during post-exercise hyperemia in younger and older adults.

Adelnia F, Shardell M, Bergeron CM, Fishbein KW, Spencer RG, Ferrucci L, Reiter DA.

NMR Biomed. 2019 May;32(5):e4072. doi: 10.1002/nbm.4072. Epub 2019 Mar 12.


Association between PUFA intake and serum concentration and mortality in older adults: A cohort study.

Lelli D, Antonelli Incalzi R, Ferrucci L, Bandinelli S, Pedone C.

Clin Nutr. 2019 Feb 23. pii: S0261-5614(19)30084-6. doi: 10.1016/j.clnu.2019.02.030. [Epub ahead of print]


Endocrine-related quality of life in a randomized trial of exercise on aromatase inhibitor-induced arthralgias in breast cancer survivors.

Baglia ML, Lin IH, Cartmel B, Sanft T, Ligibel J, Hershman DL, Harrigan M, Ferrucci LM, Li FY, Irwin ML.

Cancer. 2019 Mar 6. doi: 10.1002/cncr.32051. [Epub ahead of print]


Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle.

Demarest TG, Truong GTD, Lovett J, Mohanty JG, Mattison JA, Mattson MP, Ferrucci L, Bohr VA, Moaddel R.

Anal Biochem. 2019 May 1;572:1-8. doi: 10.1016/j.ab.2019.02.019. Epub 2019 Feb 27.


Association between non-invasive liver fibrosis scores and occurrence of health adverse outcomes in older people.

De Vincentis A, Costanzo L, Vespasiani-Gentilucci U, Picardi A, Bandinelli S, Ferrucci L, Antonelli Incalzi R, Pedone C.

Dig Liver Dis. 2019 Feb 3. pii: S1590-8658(19)30052-0. doi: 10.1016/j.dld.2019.01.017. [Epub ahead of print]


Correction: A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study.

Liu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M.

PLoS Med. 2019 Feb 25;16(2):e1002760. doi: 10.1371/journal.pmed.1002760. eCollection 2019 Feb.


The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women.

Liu Z, Chen BH, Assimes TL, Ferrucci L, Horvath S, Levine ME.

Psychoneuroendocrinology. 2019 Jun;104:18-24. doi: 10.1016/j.psyneuen.2019.01.028. Epub 2019 Feb 6.


Physical activity fragmentation as a potential phenotype of accelerated aging.

Wanigatunga AA, Ferrucci L, Schrack JA.

Oncotarget. 2019 Jan 25;10(8):807-809. doi: 10.18632/oncotarget.26631. eCollection 2019 Jan 25. No abstract available.


Sarcopenia and variation in the Human Leukocyte Antigen complex.

Jones G, Pilling LC, Kuo CL, Kuchel G, Ferrucci L, Melzer D.

J Gerontol A Biol Sci Med Sci. 2019 Feb 17. pii: glz042. doi: 10.1093/gerona/glz042. [Epub ahead of print]


Predictive Capacity of Frailty Phenotype Toward Patterns of Disability Identified Using Latent Class Analysis.

Costanzo L, Cesari M, Ferrucci L, Bandinelli S, Antonelli Incalzi R, Pedone C.

J Am Med Dir Assoc. 2019 Feb 13. pii: S1525-8610(18)30727-8. doi: 10.1016/j.jamda.2018.12.018. [Epub ahead of print]


Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank.

Bowman K, Jones L, Pilling LC, Delgado J, Kuchel GA, Ferrucci L, Fortinsky RH, Melzer D.

Neurology. 2019 Mar 19;92(12):e1387-e1394. doi: 10.1212/WNL.0000000000007136. Epub 2019 Feb 15.


Conservation of physiological dysregulation signatures of aging across primates.

Dansereau G, Wey TW, Legault V, Brunet MA, Kemnitz JW, Ferrucci L, Cohen AA.

Aging Cell. 2019 Apr;18(2):e12925. doi: 10.1111/acel.12925. Epub 2019 Feb 11.


Obesity and Longer Term Risks of Dementia in 65-74 Year Olds.

Bowman K, Thambisetty M, Kuchel GA, Ferrucci L, Melzer D.

Age Ageing. 2019 May 1;48(3):367-373. doi: 10.1093/ageing/afz002.


Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging.

Semba RD, Zhang P, Adelnia F, Sun K, Gonzalez-Freire M, Salem N Jr, Brennan N, Spencer RG, Fishbein K, Khadeer M, Shardell M, Moaddel R, Ferrucci L.

Aging Cell. 2019 Apr;18(2):e12915. doi: 10.1111/acel.12915. Epub 2019 Feb 4.


Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells.

Søraas A, Matsuyama M, de Lima M, Wald D, Buechner J, Gedde-Dahl T, Søraas CL, Chen B, Ferrucci L, Dahl JA, Horvath S, Matsuyama S.

Aging Cell. 2019 Apr;18(2):e12897. doi: 10.1111/acel.12897. Epub 2019 Feb 2.


Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.

Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R.

J Am Geriatr Soc. 2019 Mar;67(3):428-433. doi: 10.1111/jgs.15788. Epub 2019 Jan 29.


Macaque monkeys learn by observation in the ghost display condition in the object-in-place task with differential reward to the observer.

Ferrucci L, Nougaret S, Genovesio A.

Sci Rep. 2019 Jan 23;9(1):401. doi: 10.1038/s41598-018-36803-4.


DNA methylation GrimAge strongly predicts lifespan and healthspan.

Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Assimes TL, Ferrucci L, Horvath S.

Aging (Albany NY). 2019 Jan 21;11(2):303-327. doi: 10.18632/aging.101684.


Racial Differences in the Effect of Granulocyte Macrophage Colony-Stimulating Factor on Improved Walking Distance in Peripheral Artery Disease: The PROPEL Randomized Clinical Trial.

McDermott MM, Polonsky TS, Guralnik JM, Ferrucci L, Tian L, Zhao L, Stein J, Domanchuk K, Criqui MH, Taylor DA, Li L, Kibbe MR.

J Am Heart Assoc. 2019 Jan 22;8(2):e011001. doi: 10.1161/JAHA.118.011001.


Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants.

Tamosauskaite J, Atkins JL, Pilling LC, Kuo CL, Kuchel GA, Ferrucci L, Melzer D.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):337-342. doi: 10.1093/gerona/gly270.


Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank.

Pilling LC, Tamosauskaite J, Jones G, Wood AR, Jones L, Kuo CL, Kuchel GA, Ferrucci L, Melzer D.

BMJ. 2019 Jan 16;364:k5222. doi: 10.1136/bmj.k5222.


Of aging mice and men: gait speed decline is a translatable trait, with species-specific underlying properties.

Bair WN, Petr M, Alfaras I, Mitchell SJ, Bernier M, Ferrucci L, Studenski SA, de Cabo R.

J Gerontol A Biol Sci Med Sci. 2019 Jan 14. doi: 10.1093/gerona/glz015. [Epub ahead of print]


Serum lipids in adults with late age-related macular degeneration: a case-control study.

Semba RD, Moaddel R, Cotch MF, Jonasson F, Eiriksdottir G, Harris TB, Launer LJ, Sun K, Klein R, Schaumberg DA, Jónsson P, Gudnason V, Ferrucci L.

Lipids Health Dis. 2019 Jan 8;18(1):7. doi: 10.1186/s12944-018-0954-7.


A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study.

Liu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M.

PLoS Med. 2018 Dec 31;15(12):e1002718. doi: 10.1371/journal.pmed.1002718. eCollection 2018 Dec. Erratum in: PLoS Med. 2019 Feb 25;16(2):e1002760.


Anticholinergic Drug Induced Cognitive and Physical Impairment: Results from the InCHIANTI Study.

Sargent L, Nalls M, Amella EJ, Mueller M, Lageman SK, Bandinelli S, Colpo M, Slattum PW, Singleton A, Ferrucci L.

J Gerontol A Biol Sci Med Sci. 2018 Dec 26. doi: 10.1093/gerona/gly289. [Epub ahead of print]


Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction.

Ward-Caviness CK, Agha G, Chen BH, Pfeiffer L, Wilson R, Wolf P, Gieger C, Schwartz J, Vokonas PS, Hou L, Just AC, Bandinelli S, Hernandez DG, Singleton AB, Prokisch H, Meitinger T, Kastenmüller G, Ferrucci L, Baccarelli AA, Waldenberger M, Peters A.

Clin Epigenetics. 2018 Dec 27;10(1):161. doi: 10.1186/s13148-018-0588-7.


Durability of Benefits From Supervised Treadmill Exercise in People With Peripheral Artery Disease.

McDermott MM, Kibbe MR, Guralnik JM, Ferrucci L, Criqui MH, Domanchuk K, Tian L, Zhao L, Li L, Patel K, Polonsky TS.

J Am Heart Assoc. 2019 Jan 8;8(1):e009380. doi: 10.1161/JAHA.118.009380.


Predictors of neurodegeneration differ between cognitively normal and subsequently impaired older adults.

Armstrong NM, An Y, Beason-Held L, Doshi J, Erus G, Ferrucci L, Davatzikos C, Resnick SM.

Neurobiol Aging. 2019 Mar;75:178-186. doi: 10.1016/j.neurobiolaging.2018.10.024. Epub 2018 Nov 2.


Adherence to a Mediterranean Diet Protects from Cognitive Decline in the Invecchiare in Chianti Study of Aging.

Tanaka T, Talegawkar SA, Jin Y, Colpo M, Ferrucci L, Bandinelli S.

Nutrients. 2018 Dec 19;10(12). pii: E2007. doi: 10.3390/nu10122007.


Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults.

Williams OA, An Y, Beason-Held L, Huo Y, Ferrucci L, Landman BA, Resnick SM.

Neuroimage. 2019 Mar;188:572-583. doi: 10.1016/j.neuroimage.2018.12.009. Epub 2018 Dec 15.


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