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Association of Total Daily Physical Activity and Fragmented Physical Activity With Mortality in Older Adults.

Wanigatunga AA, Di J, Zipunnikov V, Urbanek JK, Kuo PL, Simonsick EM, Ferrucci L, Schrack JA.

JAMA Netw Open. 2019 Oct 2;2(10):e1912352. doi: 10.1001/jamanetworkopen.2019.12352.


Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.

Williams OA, An Y, Armstrong NM, Shafer AT, Helphrey J, Kitner-Triolo M, Ferrucci L, Resnick SM.

Alzheimers Dement. 2019 Sep 24. pii: S1552-5260(19)35134-9. doi: 10.1016/j.jalz.2019.07.011. [Epub ahead of print]


Older women are frailer, but less often die then men: a prospective study of older hospitalized people.

Veronese N, Siri G, Cella A, Daragjati J, Cruz-Jentoft AJ, Polidori MC, Mattace-Raso F, Paccalin M, Topinkova E, Greco A, Mangoni AA, Maggi S, Ferrucci L, Pilotto A; MPI AGE Investigators.

Maturitas. 2019 Oct;128:81-86. doi: 10.1016/j.maturitas.2019.07.025. Epub 2019 Aug 3.


Sarcopenia: A Time for Action. An SCWD Position Paper.

Bauer J, Morley JE, Schols AMWJ, Ferrucci L, Cruz-Jentoft AJ, Dent E, Baracos VE, Crawford JA, Doehner W, Heymsfield SB, Jatoi A, Kalantar-Zadeh K, Lainscak M, Landi F, Laviano A, Mancuso M, Muscaritoli M, Prado CM, Strasser F, von Haehling S, Coats AJS, Anker SD.

J Cachexia Sarcopenia Muscle. 2019 Sep 15. doi: 10.1002/jcsm.12483. [Epub ahead of print]


Tau pathology in cognitively normal older adults.

Ziontz J, Bilgel M, Shafer AT, Moghekar A, Elkins W, Helphrey J, Gomez G, June D, McDonald MA, Dannals RF, Azad BB, Ferrucci L, Wong DF, Resnick SM.

Alzheimers Dement (Amst). 2019 Sep 6;11:637-645. doi: 10.1016/j.dadm.2019.07.007. eCollection 2019 Dec.


Skewed macrophage polarization in aging skeletal muscle.

Cui CY, Driscoll RK, Piao Y, Chia CW, Gorospe M, Ferrucci L.

Aging Cell. 2019 Sep 2:e13032. doi: 10.1111/acel.13032. [Epub ahead of print]


Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.

Kuo CL, Pilling LC, Kuchel GA, Ferrucci L, Melzer D.

Aging Cell. 2019 Aug 24:e13017. doi: 10.1111/acel.13017. [Epub ahead of print]


Bimanual Gesture Imitation Links to Cognition and Olfaction.

Tian Q, Chastan N, Thambisetty M, Resnick SM, Ferrucci L, Studenski SA.

J Am Geriatr Soc. 2019 Aug 23. doi: 10.1111/jgs.16151. [Epub ahead of print]


Reply to From Frailty to Gerastenia.

Walston J, Bandeen-Roche K, Ferrucci L.

J Am Geriatr Soc. 2019 Aug 23. doi: 10.1111/jgs.16142. [Epub ahead of print] No abstract available.


A Tale of Two Databases: The DoD and VA Infrastructure for Clinical Intelligence (DaVINCI).

DuVall SL, Matheny ME, Ibragimov IR, Oats TD, Tucker JN, South BR, Turano A, Saoudian H, Kangas C, Hofmann K, Funk W, Nichols C, Bonnema A, Ferrucci L, Nebeker JR.

Stud Health Technol Inform. 2019 Aug 21;264:1660-1661. doi: 10.3233/SHTI190584.


The Longevity Associated Sh2b3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects.

Kuo CL, Joaquim M, Kuchel GA, Ferrucci L, Harries L, Pilling LC, Melzer D.

J Gerontol A Biol Sci Med Sci. 2019 Aug 20. pii: glz191. doi: 10.1093/gerona/glz191. [Epub ahead of print]


Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease.

Agha G, Mendelson MM, Ward-Caviness CK, Joehanes R, Huan T, Gondalia R, Salfati E, Brody JA, Fiorito G, Bressler J, Chen BH, Ligthart S, Guarrera S, Colicino E, Just AC, Wahl S, Gieger C, Vandiver AR, Tanaka T, Hernandez DG, Pilling LC, Singleton AB, Sacerdote C, Krogh V, Panico S, Tumino R, Li Y, Zhang G, Stewart JD, Floyd JS, Wiggins KL, Rotter JI, Multhaup M, Bakulski K, Horvath S, Tsao PS, Absher DM, Vokonas P, Hirschhorn J, Fallin MD, Liu C, Bandinelli S, Boerwinkle E, Dehghan A, Schwartz JD, Psaty BM, Feinberg AP, Hou L, Ferrucci L, Sotoodehnia N, Matullo G, Peters A, Fornage M, Assimes TL, Whitsel EA, Levy D, Baccarelli AA.

Circulation. 2019 Aug 20;140(8):645-657. doi: 10.1161/CIRCULATIONAHA.118.039357. Epub 2019 Aug 19.


DNA methylation-based estimator of telomere length.

Lu AT, Seeboth A, Tsai PC, Sun D, Quach A, Reiner AP, Kooperberg C, Ferrucci L, Hou L, Baccarelli AA, Li Y, Harris SE, Corley J, Taylor A, Deary IJ, Stewart JD, Whitsel EA, Assimes TL, Chen W, Li S, Mangino M, Bell JT, Wilson JG, Aviv A, Marioni RE, Raj K, Horvath S.

Aging (Albany NY). 2019 Aug 18;11(16):5895-5923. doi: 10.18632/aging.102173. Epub 2019 Aug 18.


Association Between Cardiovascular Risk and Perceived Fatigability in Mid-to-Late Life.

Qiao Y, Martinez-Amezcua P, Wanigatunga AA, Urbanek JK, Simonsick EM, Ferrucci L, Schrack JA.

J Am Heart Assoc. 2019 Aug 20;8(16):e013049. doi: 10.1161/JAHA.119.013049. Epub 2019 Aug 14.


A serum protein signature of APOE genotypes in centenarians.

Sebastiani P, Monti S, Morris M, Gurinovich A, Toshiko T, Andersen SL, Sweigart B, Ferrucci L, Jennings LL, Glass DJ, Perls TT.

Aging Cell. 2019 Aug 5:e13023. doi: 10.1111/acel.13023. [Epub ahead of print]


Subclinical Longitudinal Change in Ankle-Brachial Index With Aging in a Community-Dwelling Population Is Associated With Central Arterial Stiffening.

Oberdier MT, Morrell CH, Lakatta EG, Ferrucci L, AlGhatrif M.

J Am Heart Assoc. 2019 Aug 6;8(15):e011650. doi: 10.1161/JAHA.118.011650. Epub 2019 Aug 5.


Uric acid within the "normal" range predict 9-year cardiovascular mortality in older individuals. The InCHIANTI study.

Brombo G, Bonetti F, Volpato S, Morieri ML, Napoli E, Bandinelli S, Cherubini A, Maggio M, Guralnik J, Ferrucci L, Zuliani G.

Nutr Metab Cardiovasc Dis. 2019 Oct;29(10):1061-1067. doi: 10.1016/j.numecd.2019.06.018. Epub 2019 Jun 28.


Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies.

Wildisen L, Moutzouri E, Beglinger S, Syrogiannouli L, Cappola AR, Åsvold BO, Bakker SJL, Ceresini G, Dullaart R, Ferrucci L, Grabe H, Jukema JW, Nauck M, Trompet S, Völzke H, Westendorp RGJ, Gussekloo J, Peeters RP, Klöppel S, Aujesky D, Bauer DC, Rodondi N, Del Giovane C, Feller M; Thyroid Studies Collaboration.

BMJ Open. 2019 Jul 26;9(7):e029716. doi: 10.1136/bmjopen-2019-029716.


Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors.

Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, Fuldner R, Ferrucci L, Gallicchio L, Gavrilov L, Gavrilova N, Green PA, Jhappan C, Kohanski R, Krull K, Mandelblatt J, Ness KK, O'Mara A, Price N, Schrack J, Studenski S, Theou O, Tracy RP, Hurria A.

J Natl Cancer Inst. 2019 Jul 18. pii: djz136. doi: 10.1093/jnci/djz136. [Epub ahead of print]


Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging.

Kapogiannis D, Mustapic M, Shardell MD, Berkowitz ST, Diehl TC, Spangler RD, Tran J, Lazaropoulos MP, Chawla S, Gulyani S, Eitan E, An Y, Huang CW, Oh ES, Lyketsos CG, Resnick SM, Goetzl EJ, Ferrucci L.

JAMA Neurol. 2019 Jul 15. doi: 10.1001/jamaneurol.2019.2462. [Epub ahead of print]


The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood.

Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW.

Biogerontology. 2019 Oct;20(5):649-663. doi: 10.1007/s10522-019-09819-0. Epub 2019 Jul 10.


Interaction between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-year Follow-up Data of Older Adults from InCHIANTI.

Kositsawat J, Kuo CL, Barry L, Melzer D, Bandinelli S, Ferrucci L, Wu R, Kuchel GA.

J Gerontol A Biol Sci Med Sci. 2019 Jul 6. pii: glz165. doi: 10.1093/gerona/glz165. [Epub ahead of print]


Sex differences in brain aging and predictors of neurodegeneration in cognitively healthy older adults.

Armstrong NM, An Y, Beason-Held L, Doshi J, Erus G, Ferrucci L, Davatzikos C, Resnick SM.

Neurobiol Aging. 2019 Sep;81:146-156. doi: 10.1016/j.neurobiolaging.2019.05.020. Epub 2019 Jun 5.


Changes in knee extension peak torque and body composition and their relationship with change in gait speed.

Osawa Y, Chiles Shaffer N, Shardell MD, Studenski SA, Ferrucci L.

J Cachexia Sarcopenia Muscle. 2019 Jul 4. doi: 10.1002/jcsm.12458. [Epub ahead of print]


Association of Midlife Hearing Impairment With Late-Life Temporal Lobe Volume Loss.

Armstrong NM, An Y, Doshi J, Erus G, Ferrucci L, Davatzikos C, Deal JA, Lin FR, Resnick SM.

JAMA Otolaryngol Head Neck Surg. 2019 Jul 3. doi: 10.1001/jamaoto.2019.1610. [Epub ahead of print]


Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease.

Polonsky TS, Tian L, Zhang D, Bazzano LA, Criqui MH, Ferrucci L, Guralnik JM, Kibbe MR, Leeuwenburgh C, Sufit RL, McDermott MM.

J Am Heart Assoc. 2019 Jul 2;8(13):e010890. doi: 10.1161/JAHA.118.010890. Epub 2019 Jun 29.


Lap Time Variability From a 400-m Walk Is Associated With Future Mild Cognitive Impairment and Alzheimer's Disease.

Tian Q, Resnick SM, Studenski SA, Ferrucci L.

J Am Med Dir Assoc. 2019 Jun 18. pii: S1525-8610(19)30387-1. doi: 10.1016/j.jamda.2019.04.019. [Epub ahead of print]


An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.

Liu J, Carnero-Montoro E, van Dongen J, Lent S, Nedeljkovic I, Ligthart S, Tsai PC, Martin TC, Mandaviya PR, Jansen R, Peters MJ, Duijts L, Jaddoe VWV, Tiemeier H, Felix JF, Willemsen G, de Geus EJC, Chu AY, Levy D, Hwang SJ, Bressler J, Gondalia R, Salfati EL, Herder C, Hidalgo BA, Tanaka T, Moore AZ, Lemaitre RN, Jhun MA, Smith JA, Sotoodehnia N, Bandinelli S, Ferrucci L, Arnett DK, Grallert H, Assimes TL, Hou L, Baccarelli A, Whitsel EA, van Dijk KW, Amin N, Uitterlinden AG, Sijbrands EJG, Franco OH, Dehghan A, Spector TD, Dupuis J, Hivert MF, Rotter JI, Meigs JB, Pankow JS, van Meurs JBJ, Isaacs A, Boomsma DI, Bell JT, Demirkan A, van Duijn CM.

Nat Commun. 2019 Jun 13;10(1):2581. doi: 10.1038/s41467-019-10487-4.


Understanding and Enhancing Sepsis Survivorship: Priorities for Research and Practice.

Prescott HC, Iwashyna TJ, Blackwood B, Calandra T, Chlan LL, Choong K, Connolly B, Dark P, Ferrucci L, Finfer S, Girard TD, Hodgson C, Hopkins RO, Hough CL, Jackson JC, Machado FR, Marshall JC, Misak C, Needham DM, Panigrahi P, Reinhart K, Yende S, Zafonte R, Rowan KM, Angus DC; International Sepsis Forum.

Am J Respir Crit Care Med. 2019 Jun 4. doi: 10.1164/rccm.201812-2383CP. [Epub ahead of print]


Effects of reward size and context on learning in macaque monkeys.

Ferrucci L, Nougaret S, Brunamonti E, Genovesio A.

Behav Brain Res. 2019 Oct 17;372:111983. doi: 10.1016/j.bbr.2019.111983. Epub 2019 May 26.


Measuring successful aging: an exploratory factor analysis of the InCHIANTI Study into different health domains.

Mount S, Ferrucci L, Wesselius A, Zeegers MP, Schols AM.

Aging (Albany NY). 2019 May 24;11(10):3023-3040. doi: 10.18632/aging.101957.


Association Between Adiposity and Perceived Physical Fatigability in Mid- to Late Life.

Martinez-Amezcua P, Simonsick EM, Wanigatunga AA, Urbanek JK, Chiles Shaffer N, Ferrucci L, Schrack JA.

Obesity (Silver Spring). 2019 Jul;27(7):1177-1183. doi: 10.1002/oby.22500. Epub 2019 May 25.


Moderate-to-Vigorous Physical Activity Is Associated With Higher Muscle Oxidative Capacity in Older Adults.

Adelnia F, Urbanek J, Osawa Y, Shardell M, Brennan NA, Fishbein KW, Spencer RG, Simonsick EM, Schrack JA, Ferrucci L.

J Am Geriatr Soc. 2019 Aug;67(8):1695-1699. doi: 10.1111/jgs.15991. Epub 2019 May 22.


Declining Skeletal Muscle Mitochondrial Function Associated With Increased Risk of Depression in Later Life.

Brown PJ, Brennan N, Ciarleglio A, Chen C, Garcia CM, Gomez S, Roose SP, Rutherford BR, Simonsick EM, Spencer RG, Ferrucci L.

Am J Geriatr Psychiatry. 2019 Sep;27(9):963-971. doi: 10.1016/j.jagp.2019.03.022. Epub 2019 Apr 6.


Tetra-linoleoyl cardiolipin depletion plays a major role in the pathogenesis of sarcopenia.

Semba RD, Moaddel R, Zhang P, Ramsden CE, Ferrucci L.

Med Hypotheses. 2019 Jun;127:142-149. doi: 10.1016/j.mehy.2019.04.015. Epub 2019 Apr 17.


Role of the social actor during social interaction and learning in human-monkey paradigms.

Nougaret S, Ferrucci L, Genovesio A.

Neurosci Biobehav Rev. 2019 Jul;102:242-250. doi: 10.1016/j.neubiorev.2019.05.004. Epub 2019 May 6. Review.


An Emergent Integrated Aging Process Conserved Across Primates.

Wey TW, Roberge É, Legault V, Kemnitz JW, Ferrucci L, Cohen AA.

J Gerontol A Biol Sci Med Sci. 2019 Oct 4;74(11):1689-1698. doi: 10.1093/gerona/glz110.


Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary.

Walston J, Bandeen-Roche K, Buta B, Bergman H, Gill TM, Morley JE, Fried LP, Robinson TN, Afilalo J, Newman AB, López-Otín C, De Cabo R, Theou O, Studenski S, Cohen HJ, Ferrucci L.

J Am Geriatr Soc. 2019 Aug;67(8):1559-1564. doi: 10.1111/jgs.15928. Epub 2019 May 2.


The Role of Muscle Perfusion in the Age-Associated Decline of Mitochondrial Function in Healthy Individuals.

Adelnia F, Cameron D, Bergeron CM, Fishbein KW, Spencer RG, Reiter DA, Ferrucci L.

Front Physiol. 2019 Apr 12;10:427. doi: 10.3389/fphys.2019.00427. eCollection 2019.


Physical Activity Associated Proteomics of Skeletal Muscle: Being Physically Active in Daily Life May Protect Skeletal Muscle From Aging.

Ubaida-Mohien C, Gonzalez-Freire M, Lyashkov A, Moaddel R, Chia CW, Simonsick EM, Sen R, Ferrucci L.

Front Physiol. 2019 Mar 26;10:312. doi: 10.3389/fphys.2019.00312. eCollection 2019.


Using the RE-AIM framework for dissemination and implementation of psychosocial distress screening.

Lazenby M, Ercolano E, Tan H, Ferrucci L, Badger T, Grant M, Jacobsen P, McCorkle R.

Eur J Cancer Care (Engl). 2019 Jul;28(4):e13036. doi: 10.1111/ecc.13036. Epub 2019 Apr 10.


Sex differences in the association between amyloid and longitudinal brain volume change in cognitively normal older adults.

Armstrong NM, Huang CW, Williams OA, Bilgel M, An Y, Doshi J, Erus G, Davatzikos C, Wong DF, Ferrucci L, Resnick SM.

Neuroimage Clin. 2019;22:101769. doi: 10.1016/j.nicl.2019.101769. Epub 2019 Mar 11.


The Association of Olfactory Dysfunction, Frailty, and Mortality Is Mediated by Inflammation: Results from the InCHIANTI Study.

Laudisio A, Navarini L, Margiotta DPE, Fontana DO, Chiarella I, Spitaleri D, Bandinelli S, Gemma A, Ferrucci L, Incalzi RA.

J Immunol Res. 2019 Feb 20;2019:3128231. doi: 10.1155/2019/3128231. eCollection 2019.


Semi-automated 3D segmentation of human skeletal muscle using Focused Ion Beam-Scanning Electron Microscopic images.

Caffrey BJ, Maltsev AV, Gonzalez-Freire M, Hartnell LM, Ferrucci L, Subramaniam S.

J Struct Biol. 2019 Jul 1;207(1):1-11. doi: 10.1016/j.jsb.2019.03.008. Epub 2019 Mar 23.


Elevated Plasma Growth and Differentiation Factor-15 is Associated with Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults.

Semba RD, Gonzalez-Freire M, Tanaka T, Biancotto A, Zhang P, Shardell M, Moaddel R, Ferrucci L; CHI Consortium.

J Gerontol A Biol Sci Med Sci. 2019 Mar 15. pii: glz071. doi: 10.1093/gerona/glz071. [Epub ahead of print]


A prospective study of focal brain atrophy, mobility and fitness.

Tian Q, Resnick SM, Davatzikos C, Erus G, Simonsick EM, Studenski SA, Ferrucci L.

J Intern Med. 2019 Jul;286(1):88-100. doi: 10.1111/joim.12894. Epub 2019 Apr 11.


Diffusion-weighted MRI with intravoxel incoherent motion modeling for assessment of muscle perfusion in the thigh during post-exercise hyperemia in younger and older adults.

Adelnia F, Shardell M, Bergeron CM, Fishbein KW, Spencer RG, Ferrucci L, Reiter DA.

NMR Biomed. 2019 May;32(5):e4072. doi: 10.1002/nbm.4072. Epub 2019 Mar 12.


Association between PUFA intake and serum concentration and mortality in older adults: A cohort study.

Lelli D, Antonelli Incalzi R, Ferrucci L, Bandinelli S, Pedone C.

Clin Nutr. 2019 Feb 23. pii: S0261-5614(19)30084-6. doi: 10.1016/j.clnu.2019.02.030. [Epub ahead of print]


Endocrine-related quality of life in a randomized trial of exercise on aromatase inhibitor-induced arthralgias in breast cancer survivors.

Baglia ML, Lin IH, Cartmel B, Sanft T, Ligibel J, Hershman DL, Harrigan M, Ferrucci LM, Li FY, Irwin ML.

Cancer. 2019 Mar 6. doi: 10.1002/cncr.32051. [Epub ahead of print]


Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle.

Demarest TG, Truong GTD, Lovett J, Mohanty JG, Mattison JA, Mattson MP, Ferrucci L, Bohr VA, Moaddel R.

Anal Biochem. 2019 May 1;572:1-8. doi: 10.1016/j.ab.2019.02.019. Epub 2019 Feb 27.


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