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A proteomic atlas of senescence-associated secretomes for aging biomarker development.

Basisty N, Kale A, Jeon OH, Kuehnemann C, Payne T, Rao C, Holtz A, Shah S, Sharma V, Ferrucci L, Campisi J, Schilling B.

PLoS Biol. 2020 Jan 16;18(1):e3000599. doi: 10.1371/journal.pbio.3000599. eCollection 2020 Jan.


Longitudinal Association Between Energy Regulation and Fatigability in Mid-to-Late Life.

Schrack JA, Wanigatunga AA, Zipunnikov V, Kuo PL, Simonsick EM, Ferrucci L.

J Gerontol A Biol Sci Med Sci. 2020 Jan 14. pii: glaa011. doi: 10.1093/gerona/glaa011. [Epub ahead of print]


Macrophages in skeletal muscle aging.

Cui CY, Ferrucci L.

Aging (Albany NY). 2020 Jan 11;12(1):3-4. doi: 10.18632/aging.102740. Epub 2020 Jan 11. No abstract available.


Association between coffee drinking and telomere length in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Steiner B, Ferrucci LM, Mirabello L, Lan Q, Hu W, Liao LM, Savage SA, De Vivo I, Hayes RB, Rajaraman P, Huang WY, Freedman ND, Loftfield E.

PLoS One. 2020 Jan 8;15(1):e0226972. doi: 10.1371/journal.pone.0226972. eCollection 2020.


Comparing 6-minute walk versus treadmill walking distance as outcomes in randomized trials of peripheral artery disease.

McDermott MM, Guralnik JM, Tian L, Zhao L, Polonsky TS, Kibbe MR, Criqui MH, Zhang D, Conte MS, Domanchuk K, Li L, Sufit R, Leeuwenburgh C, Ferrucci L.

J Vasc Surg. 2019 Dec 21. pii: S0741-5214(19)31736-7. doi: 10.1016/j.jvs.2019.05.058. [Epub ahead of print]


Measuring biological aging in humans: A quest.

Ferrucci L, Gonzalez-Freire M, Fabbri E, Simonsick E, Tanaka T, Moore Z, Salimi S, Sierra F, de Cabo R.

Aging Cell. 2019 Dec 12:e13080. doi: 10.1111/acel.13080. [Epub ahead of print] Review.


Longitudinal Association Between Perceived Fatigability and Cognitive Function in Older Adults: Results from the Baltimore Longitudinal Study of Aging.

Salerno EA, Wanigatunga AA, An Y, Urbanek JK, Simonsick EM, Ferrucci L, Resnick SM, Schrack JA.

J Gerontol A Biol Sci Med Sci. 2019 Dec 12. pii: glz287. doi: 10.1093/gerona/glz287. [Epub ahead of print]


Age and Muscle Function Are More Closely Associated With Intracellular Magnesium, as Assessed by 31P Magnetic Resonance Spectroscopy, Than With Serum Magnesium.

Cameron D, Welch AA, Adelnia F, Bergeron CM, Reiter DA, Dominguez LJ, Brennan NA, Fishbein KW, Spencer RG, Ferrucci L.

Front Physiol. 2019 Nov 27;10:1454. doi: 10.3389/fphys.2019.01454. eCollection 2019.


circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan.

Haque S, Ames RM, Moore K, Pilling LC, Peters LL, Bandinelli S, Ferrucci L, Harries LW.

Geroscience. 2019 Dec 6. doi: 10.1007/s11357-019-00120-z. [Epub ahead of print]


Chronic inflammation in the etiology of disease across the life span.

Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM.

Nat Med. 2019 Dec;25(12):1822-1832. doi: 10.1038/s41591-019-0675-0. Epub 2019 Dec 5. Review.


Corrigendum to: The Longevity-Associated SH2B3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects.

Kuo CL, Joaquim M, Kuchel GA, Ferrucci L, Harries LW, Pilling LC, Melzer D.

J Gerontol A Biol Sci Med Sci. 2019 Nov 29. pii: glz268. doi: 10.1093/gerona/glz268. [Epub ahead of print] No abstract available.


Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.

Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, Leonard HL, Grenn FP, Ruskey JA, Sabir M, Ahmed S, Makarious MB, Pihlstrøm L, Toft M, van Hilten JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K, Eerola-Rautio J, Tienari PJ; 23andMe Research Team, Pantelyat A, Hillis AE, Dawson TM, Rosenthal LS, Albert MS, Resnick SM, Ferrucci L, Morris CM, Pletnikova O, Troncoso J, Grosset D, Lesage S, Corvol JC, Brice A, Noyce AJ, Masliah E, Wood N, Hardy J, Shulman LM, Jankovic J, Shulman JM, Heutink P, Gasser T, Cannon P, Scholz SW, Morris H, Cookson MR, Nalls MA, Gan-Or Z, Singleton AB.

Brain. 2020 Jan 1;143(1):234-248. doi: 10.1093/brain/awz350.


Habitual Nut Exposure, Assessed by Dietary and Multiple Urinary Metabolomic Markers, and Cognitive Decline in Older Adults: The InCHIANTI Study.

Rabassa M, Zamora-Ros R, Palau-Rodriguez M, Tulipani S, Miñarro A, Bandinelli S, Ferrucci L, Cherubini A, Andres-Lacueva C.

Mol Nutr Food Res. 2019 Nov 22:e1900532. doi: 10.1002/mnfr.201900532. [Epub ahead of print]


Gait speed as predictor of transition into cognitive impairment: Findings from three longitudinal studies on aging.

Hoogendijk EO, Rijnhart JJM, Skoog J, Robitaille A, van den Hout A, Ferrucci L, Huisman M, Skoog I, Piccinin AM, Hofer SM, Muniz Terrera G.

Exp Gerontol. 2020 Jan;129:110783. doi: 10.1016/j.exger.2019.110783. Epub 2019 Nov 18.


Adult brain aging investigated using BMC-mcDESPOT-based myelin water fraction imaging.

Bouhrara M, Rejimon AC, Cortina LE, Khattar N, Bergeron CM, Ferrucci L, Resnick SM, Spencer RG.

Neurobiol Aging. 2020 Jan;85:131-139. doi: 10.1016/j.neurobiolaging.2019.10.003. Epub 2019 Oct 14.


Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology.

Newman AB, Kritchevsky SB, Guralnik JM, Cummings SR, Salive M, Kuchel GA, Schrack J, Morris MC, Weir D, Baccarelli A, Murabito JM, Ben-Shlomo Y, Espeland MA, Kirkland J, Melzer D, Ferrucci L.

J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):77-86. doi: 10.1093/gerona/glz230.


Longitudinal Change in Cortisol Levels Across the Adult Life Span.

Moffat SD, An Y, Resnick SM, Diamond MP, Ferrucci L.

J Gerontol A Biol Sci Med Sci. 2019 Nov 12. pii: gly279. doi: 10.1093/gerona/gly279. [Epub ahead of print]


Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy.

Bektas A, Schurman SH, Gonzalez-Freire M, Dunn CA, Singh AK, Macian F, Cuervo AM, Sen R, Ferrucci L.

Aging (Albany NY). 2019 Nov 9;11(21):9234-9263. doi: 10.18632/aging.102438. Epub 2019 Nov 9.


The genetics of human ageing.

Melzer D, Pilling LC, Ferrucci L.

Nat Rev Genet. 2019 Nov 5. doi: 10.1038/s41576-019-0183-6. [Epub ahead of print] Review.


Biomarkers in the path from cellular senescence to frailty.

Zampino M, Ferrucci L, Semba RD.

Exp Gerontol. 2020 Jan;129:110750. doi: 10.1016/j.exger.2019.110750. Epub 2019 Oct 31. Review. No abstract available.


Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline.

Lye JJ, Latorre E, Lee BP, Bandinelli S, Holley JE, Gutowski NJ, Ferrucci L, Harries LW.

Geroscience. 2019 Oct;41(5):561-573. doi: 10.1007/s11357-019-00100-3. Epub 2019 Oct 25.


Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria.

Ubaida-Mohien C, Lyashkov A, Gonzalez-Freire M, Tharakan R, Shardell M, Moaddel R, Semba RD, Chia CW, Gorospe M, Sen R, Ferrucci L.

Elife. 2019 Oct 23;8. pii: e49874. doi: 10.7554/eLife.49874.


Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management.

Dent E, Morley JE, Cruz-Jentoft AJ, Woodhouse L, Rodríguez-Mañas L, Fried LP, Woo J, Aprahamian I, Sanford A, Lundy J, Landi F, Beilby J, Martin FC, Bauer JM, Ferrucci L, Merchant RA, Dong B, Arai H, Hoogendijk EO, Won CW, Abbatecola A, Cederholm T, Strandberg T, Gutiérrez Robledo LM, Flicker L, Bhasin S, Aubertin-Leheudre M, Bischoff-Ferrari HA, Guralnik JM, Muscedere J, Pahor M, Ruiz J, Negm AM, Reginster JY, Waters DL, Vellas B.

J Nutr Health Aging. 2019;23(9):771-787. doi: 10.1007/s12603-019-1273-z.


Association of Total Daily Physical Activity and Fragmented Physical Activity With Mortality in Older Adults.

Wanigatunga AA, Di J, Zipunnikov V, Urbanek JK, Kuo PL, Simonsick EM, Ferrucci L, Schrack JA.

JAMA Netw Open. 2019 Oct 2;2(10):e1912352. doi: 10.1001/jamanetworkopen.2019.12352.


Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.

Williams OA, An Y, Armstrong NM, Shafer AT, Helphrey J, Kitner-Triolo M, Ferrucci L, Resnick SM.

Alzheimers Dement. 2019 Dec;15(12):1558-1567. doi: 10.1016/j.jalz.2019.07.011. Epub 2019 Sep 24.


Older women are frailer, but less often die then men: a prospective study of older hospitalized people.

Veronese N, Siri G, Cella A, Daragjati J, Cruz-Jentoft AJ, Polidori MC, Mattace-Raso F, Paccalin M, Topinkova E, Greco A, Mangoni AA, Maggi S, Ferrucci L, Pilotto A; MPI AGE Investigators.

Maturitas. 2019 Oct;128:81-86. doi: 10.1016/j.maturitas.2019.07.025. Epub 2019 Aug 3.


Sarcopenia: A Time for Action. An SCWD Position Paper.

Bauer J, Morley JE, Schols AMWJ, Ferrucci L, Cruz-Jentoft AJ, Dent E, Baracos VE, Crawford JA, Doehner W, Heymsfield SB, Jatoi A, Kalantar-Zadeh K, Lainscak M, Landi F, Laviano A, Mancuso M, Muscaritoli M, Prado CM, Strasser F, von Haehling S, Coats AJS, Anker SD.

J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):956-961. doi: 10.1002/jcsm.12483. Epub 2019 Sep 15.


Tau pathology in cognitively normal older adults.

Ziontz J, Bilgel M, Shafer AT, Moghekar A, Elkins W, Helphrey J, Gomez G, June D, McDonald MA, Dannals RF, Azad BB, Ferrucci L, Wong DF, Resnick SM.

Alzheimers Dement (Amst). 2019 Sep 6;11:637-645. doi: 10.1016/j.dadm.2019.07.007. eCollection 2019 Dec.


Skewed macrophage polarization in aging skeletal muscle.

Cui CY, Driscoll RK, Piao Y, Chia CW, Gorospe M, Ferrucci L.

Aging Cell. 2019 Dec;18(6):e13032. doi: 10.1111/acel.13032. Epub 2019 Sep 2.


Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.

Kuo CL, Pilling LC, Kuchel GA, Ferrucci L, Melzer D.

Aging Cell. 2019 Dec;18(6):e13017. doi: 10.1111/acel.13017. Epub 2019 Aug 24.


Bimanual Gesture Imitation Links to Cognition and Olfaction.

Tian Q, Chastan N, Thambisetty M, Resnick SM, Ferrucci L, Studenski SA.

J Am Geriatr Soc. 2019 Dec;67(12):2581-2586. doi: 10.1111/jgs.16151. Epub 2019 Aug 23.


Reply to From Frailty to Gerastenia.

Walston J, Bandeen-Roche K, Ferrucci L.

J Am Geriatr Soc. 2019 Oct;67(10):2210-2211. doi: 10.1111/jgs.16142. Epub 2019 Aug 23. No abstract available.


A Tale of Two Databases: The DoD and VA Infrastructure for Clinical Intelligence (DaVINCI).

DuVall SL, Matheny ME, Ibragimov IR, Oats TD, Tucker JN, South BR, Turano A, Saoudian H, Kangas C, Hofmann K, Funk W, Nichols C, Bonnema A, Ferrucci L, Nebeker JR.

Stud Health Technol Inform. 2019 Aug 21;264:1660-1661. doi: 10.3233/SHTI190584.


The Longevity Associated Sh2b3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects.

Kuo CL, Joaquim M, Kuchel GA, Ferrucci L, Harries L, Pilling LC, Melzer D.

J Gerontol A Biol Sci Med Sci. 2019 Aug 20. pii: glz191. doi: 10.1093/gerona/glz191. [Epub ahead of print]


Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease.

Agha G, Mendelson MM, Ward-Caviness CK, Joehanes R, Huan T, Gondalia R, Salfati E, Brody JA, Fiorito G, Bressler J, Chen BH, Ligthart S, Guarrera S, Colicino E, Just AC, Wahl S, Gieger C, Vandiver AR, Tanaka T, Hernandez DG, Pilling LC, Singleton AB, Sacerdote C, Krogh V, Panico S, Tumino R, Li Y, Zhang G, Stewart JD, Floyd JS, Wiggins KL, Rotter JI, Multhaup M, Bakulski K, Horvath S, Tsao PS, Absher DM, Vokonas P, Hirschhorn J, Fallin MD, Liu C, Bandinelli S, Boerwinkle E, Dehghan A, Schwartz JD, Psaty BM, Feinberg AP, Hou L, Ferrucci L, Sotoodehnia N, Matullo G, Peters A, Fornage M, Assimes TL, Whitsel EA, Levy D, Baccarelli AA.

Circulation. 2019 Aug 20;140(8):645-657. doi: 10.1161/CIRCULATIONAHA.118.039357. Epub 2019 Aug 19.


DNA methylation-based estimator of telomere length.

Lu AT, Seeboth A, Tsai PC, Sun D, Quach A, Reiner AP, Kooperberg C, Ferrucci L, Hou L, Baccarelli AA, Li Y, Harris SE, Corley J, Taylor A, Deary IJ, Stewart JD, Whitsel EA, Assimes TL, Chen W, Li S, Mangino M, Bell JT, Wilson JG, Aviv A, Marioni RE, Raj K, Horvath S.

Aging (Albany NY). 2019 Aug 18;11(16):5895-5923. doi: 10.18632/aging.102173. Epub 2019 Aug 18.


Association Between Cardiovascular Risk and Perceived Fatigability in Mid-to-Late Life.

Qiao Y, Martinez-Amezcua P, Wanigatunga AA, Urbanek JK, Simonsick EM, Ferrucci L, Schrack JA.

J Am Heart Assoc. 2019 Aug 20;8(16):e013049. doi: 10.1161/JAHA.119.013049. Epub 2019 Aug 14.


A serum protein signature of APOE genotypes in centenarians.

Sebastiani P, Monti S, Morris M, Gurinovich A, Toshiko T, Andersen SL, Sweigart B, Ferrucci L, Jennings LL, Glass DJ, Perls TT.

Aging Cell. 2019 Dec;18(6):e13023. doi: 10.1111/acel.13023. Epub 2019 Aug 5.


Subclinical Longitudinal Change in Ankle-Brachial Index With Aging in a Community-Dwelling Population Is Associated With Central Arterial Stiffening.

Oberdier MT, Morrell CH, Lakatta EG, Ferrucci L, AlGhatrif M.

J Am Heart Assoc. 2019 Aug 6;8(15):e011650. doi: 10.1161/JAHA.118.011650. Epub 2019 Aug 5.


Uric acid within the "normal" range predict 9-year cardiovascular mortality in older individuals. The InCHIANTI study.

Brombo G, Bonetti F, Volpato S, Morieri ML, Napoli E, Bandinelli S, Cherubini A, Maggio M, Guralnik J, Ferrucci L, Zuliani G.

Nutr Metab Cardiovasc Dis. 2019 Oct;29(10):1061-1067. doi: 10.1016/j.numecd.2019.06.018. Epub 2019 Jun 28.


Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies.

Wildisen L, Moutzouri E, Beglinger S, Syrogiannouli L, Cappola AR, Åsvold BO, Bakker SJL, Ceresini G, Dullaart R, Ferrucci L, Grabe H, Jukema JW, Nauck M, Trompet S, Völzke H, Westendorp RGJ, Gussekloo J, Peeters RP, Klöppel S, Aujesky D, Bauer DC, Rodondi N, Del Giovane C, Feller M; Thyroid Studies Collaboration.

BMJ Open. 2019 Jul 26;9(7):e029716. doi: 10.1136/bmjopen-2019-029716.


Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors.

Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, Fuldner R, Ferrucci L, Gallicchio L, Gavrilov L, Gavrilova N, Green PA, Jhappan C, Kohanski R, Krull K, Mandelblatt J, Ness KK, O'Mara A, Price N, Schrack J, Studenski S, Theou O, Tracy RP, Hurria A.

J Natl Cancer Inst. 2019 Dec 1;111(12):1245-1254. doi: 10.1093/jnci/djz136.


Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging.

Kapogiannis D, Mustapic M, Shardell MD, Berkowitz ST, Diehl TC, Spangler RD, Tran J, Lazaropoulos MP, Chawla S, Gulyani S, Eitan E, An Y, Huang CW, Oh ES, Lyketsos CG, Resnick SM, Goetzl EJ, Ferrucci L.

JAMA Neurol. 2019 Jul 15. doi: 10.1001/jamaneurol.2019.2462. [Epub ahead of print]


The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood.

Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW.

Biogerontology. 2019 Oct;20(5):649-663. doi: 10.1007/s10522-019-09819-0. Epub 2019 Jul 10.


Interaction between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-year Follow-up Data of Older Adults from InCHIANTI.

Kositsawat J, Kuo CL, Barry L, Melzer D, Bandinelli S, Ferrucci L, Wu R, Kuchel GA.

J Gerontol A Biol Sci Med Sci. 2019 Jul 6. pii: glz165. doi: 10.1093/gerona/glz165. [Epub ahead of print]


Sex differences in brain aging and predictors of neurodegeneration in cognitively healthy older adults.

Armstrong NM, An Y, Beason-Held L, Doshi J, Erus G, Ferrucci L, Davatzikos C, Resnick SM.

Neurobiol Aging. 2019 Sep;81:146-156. doi: 10.1016/j.neurobiolaging.2019.05.020. Epub 2019 Jun 5.


Changes in knee extension peak torque and body composition and their relationship with change in gait speed.

Osawa Y, Chiles Shaffer N, Shardell MD, Studenski SA, Ferrucci L.

J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):1000-1008. doi: 10.1002/jcsm.12458. Epub 2019 Jul 4.


Association of Midlife Hearing Impairment With Late-Life Temporal Lobe Volume Loss.

Armstrong NM, An Y, Doshi J, Erus G, Ferrucci L, Davatzikos C, Deal JA, Lin FR, Resnick SM.

JAMA Otolaryngol Head Neck Surg. 2019 Jul 3. doi: 10.1001/jamaoto.2019.1610. [Epub ahead of print]


Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease.

Polonsky TS, Tian L, Zhang D, Bazzano LA, Criqui MH, Ferrucci L, Guralnik JM, Kibbe MR, Leeuwenburgh C, Sufit RL, McDermott MM.

J Am Heart Assoc. 2019 Jul 2;8(13):e010890. doi: 10.1161/JAHA.118.010890. Epub 2019 Jun 29.


Lap Time Variability From a 400-m Walk Is Associated With Future Mild Cognitive Impairment and Alzheimer's Disease.

Tian Q, Resnick SM, Studenski SA, Ferrucci L.

J Am Med Dir Assoc. 2019 Dec;20(12):1535-1539.e3. doi: 10.1016/j.jamda.2019.04.019. Epub 2019 Jun 18.


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