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Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells.

Dasgupta S, Fishman MA, Castro LM, Tashima AK, Ferro ES, Fricker LD.

Biomolecules. 2019 May 28;9(6). pii: E207. doi: 10.3390/biom9060207.


Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain.

Teixeira CMM, Correa CN, Iwai LK, Ferro ES, Castro LM.

Zebrafish. 2019 Jun;16(3):240-251. doi: 10.1089/zeb.2018.1718. Epub 2019 Apr 24.


Intracellular Peptides in Cell Biology and Pharmacology.

de Araujo CB, Heimann AS, Remer RA, Russo LC, Colquhoun A, Forti FL, Ferro ES.

Biomolecules. 2019 Apr 16;9(4). pii: E150. doi: 10.3390/biom9040150. Review.


Neurolysin: From Initial Detection to Latest Advances.

Checler F, Ferro ES.

Neurochem Res. 2018 Nov;43(11):2017-2024. doi: 10.1007/s11064-018-2624-6. Epub 2018 Aug 29. Review.


Substrate Capture Assay Using Inactive Oligopeptidases to Identify Novel Peptides.

Rioli V, Ferro ES.

Methods Mol Biol. 2018;1719:97-105. doi: 10.1007/978-1-4939-7537-2_6.


Correction: Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states.

Heimann AS, Gupta A, Gomes I, Rahman R, Schlessinger A, Ferro ES, Unterwald EM, Devi LA.

PLoS One. 2018 Feb 15;13(2):e0193322. doi: 10.1371/journal.pone.0193322. eCollection 2018.


Edelfosine: An Antitumor Drug Prototype.

Teixeira SF, Rodrigues CP, Costa CJS, Pettinati TN, de Azevedo RA, Mambelli LI, Jorge SD, Ramos RN, Ferro ES, Barbuto JAM, Ferreira AK.

Anticancer Agents Med Chem. 2018;18(6):865-874. doi: 10.2174/1871520618666180105165431.


A novel peptide that improves metabolic parameters without adverse central nervous system effects.

Reckziegel P, Festuccia WT, Britto LRG, Jang KLL, Romão CM, Heimann JC, Fogaça MV, Rodrigues NS, Silva NR, Guimarães FS, Eichler RAS, Gupta A, Gomes I, Devi LA, Heimann AS, Ferro ES.

Sci Rep. 2017 Nov 1;7(1):14781. doi: 10.1038/s41598-017-13690-9.


Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states.

Heimann AS, Gupta A, Gomes I, Rayees R, Schlessinger A, Ferro ES, Unterwald EM, Devi LA.

PLoS One. 2017 Nov 1;12(11):e0187306. doi: 10.1371/journal.pone.0187306. eCollection 2017. Erratum in: PLoS One. 2018 Feb 15;13(2):e0193322.


Analysis of the Yeast Peptidome and Comparison with the Human Peptidome.

Dasgupta S, Yang C, Castro LM, Tashima AK, Ferro ES, Moir RD, Willis IM, Fricker LD.

PLoS One. 2016 Sep 29;11(9):e0163312. doi: 10.1371/journal.pone.0163312. eCollection 2016.


Interferon-gamma activity is potentiated by an intracellular peptide derived from the human 19S ATPase regulatory subunit 4 of the proteasome.

Monte ER, Rossato C, Llanos RP, Russo LC, de Castro LM, Gozzo FC, de Araujo CB, Peron JP, Sant'Anna OA, Ferro ES, Rioli V.

J Proteomics. 2017 Jan 16;151:74-82. doi: 10.1016/j.jprot.2016.08.003. Epub 2016 Aug 11.


A Cyclin D2-derived peptide acts on specific cell cycle phases by activating ERK1/2 to cause the death of breast cancer cells.

Russo LC, Araujo CB, Iwai LK, Ferro ES, Forti FL.

J Proteomics. 2017 Jan 16;151:24-32. doi: 10.1016/j.jprot.2016.06.028. Epub 2016 Jun 29.


Peptidomic analysis of the anterior temporal lobe and corpus callosum from schizophrenia patients.

Café-Mendes CC, Ferro ES, Torrão AS, Crunfli F, Rioli V, Schmitt A, Falkai P, Britto LR, Turck CW, Martins-de-Souza D.

J Proteomics. 2017 Jan 16;151:97-105. doi: 10.1016/j.jprot.2016.05.025. Epub 2016 Jun 16.


Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.

Dasgupta S, Fishman MA, Mahallati H, Castro LM, Tashima AK, Ferro ES, Fricker LD.

PLoS One. 2015 Dec 21;10(12):e0145333. doi: 10.1371/journal.pone.0145333. eCollection 2015.


Anxiogenic-like effects induced by hemopressin in rats.

Fogaça MV, Sonego AB, Rioli V, Gozzo FC, Dale CS, Ferro ES, Guimarães FS.

Pharmacol Biochem Behav. 2015 Feb;129:7-13. doi: 10.1016/j.pbb.2014.11.013. Epub 2014 Nov 22.


Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.

Dasgupta S, Castro LM, Dulman R, Yang C, Schmidt M, Ferro ES, Fricker LD.

PLoS One. 2014 Jul 31;9(7):e103604. doi: 10.1371/journal.pone.0103604. eCollection 2014.


A novel intracellular peptide derived from g1/s cyclin d2 induces cell death.

de Araujo CB, Russo LC, Castro LM, Forti FL, do Monte ER, Rioli V, Gozzo FC, Colquhoun A, Ferro ES.

J Biol Chem. 2014 Jun 13;289(24):16711-26. doi: 10.1074/jbc.M113.537118. Epub 2014 Apr 24.


Peptidomic analysis of the neurolysin-knockout mouse brain.

Castro LM, Cavalcanti DM, Araujo CB, Rioli V, Icimoto MY, Gozzo FC, Juliano M, Juliano L, Oliveira V, Ferro ES.

J Proteomics. 2014 Dec 5;111:238-48. doi: 10.1016/j.jprot.2014.03.043. Epub 2014 Apr 13.


Neurolysin knockout mice generation and initial phenotype characterization.

Cavalcanti DM, Castro LM, Rosa Neto JC, Seelaender M, Neves RX, Oliveira V, Forti FL, Iwai LK, Gozzo FC, Todiras M, Schadock I, Barros CC, Bader M, Ferro ES.

J Biol Chem. 2014 May 30;289(22):15426-40. doi: 10.1074/jbc.M113.539148. Epub 2014 Apr 9.


Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats.

Toniolo EF, Maique ET, Ferreira WA Jr, Heimann AS, Ferro ES, Ramos-Ortolaza DL, Miller L, Devi LA, Dale CS.

Peptides. 2014 Jun;56:125-31. doi: 10.1016/j.peptides.2014.03.016. Epub 2014 Apr 3.


Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?

Xapelli S, Agasse F, Grade S, Bernardino L, Ribeiro FF, Schitine CS, Heimann AS, Ferro ES, Sebastião AM, De Melo Reis RA, Malva JO.

Front Cell Neurosci. 2014 Feb 27;8:59. doi: 10.3389/fncel.2014.00059. eCollection 2014.


Using mass spectrometry-based peptidomics to understand the brain and disorders such as Parkinson's disease and schizophrenia.

Cafe-Mendes CC, Ferro ES, Britto LR, Martins-de-Souza D.

Curr Top Med Chem. 2014;14(3):369-81. Review.


AGH is a new hemoglobin alpha-chain fragment with antinociceptive activity.

Ribeiro NM, Toniolo EF, Castro LM, Russo LC, Rioli V, Ferro ES, Dale CS.

Peptides. 2013 Oct;48:10-20. doi: 10.1016/j.peptides.2013.07.011. Epub 2013 Aug 2.


Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases.

Torrão AS, Café-Mendes CC, Real CC, Hernandes MS, Ferreira AF, Santos TO, Chaves-Kirsten GP, Mazucanti CH, Ferro ES, Scavone C, Britto LR.

Braz J Psychiatry. 2012 Oct;34 Suppl 2:S194-205. Review. English, Portuguese.


Alterations of the intracellular peptidome in response to the proteasome inhibitor bortezomib.

Gelman JS, Sironi J, Berezniuk I, Dasgupta S, Castro LM, Gozzo FC, Ferro ES, Fricker LD.

PLoS One. 2013;8(1):e53263. doi: 10.1371/journal.pone.0053263. Epub 2013 Jan 7.


Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction.

Russo LC, Castro LM, Gozzo FC, Ferro ES.

FEBS Lett. 2012 Sep 21;586(19):3287-92. doi: 10.1016/j.febslet.2012.07.002. Epub 2012 Jul 10.


The cysteine-rich protein thimet oligopeptidase as a model of the structural requirements for S-glutathiolation and oxidative oligomerization.

Malvezzi A, Higa PM, T-do Amaral A, Silva GM, Gozzo FC, Ferro ES, Castro LM, de Rezende L, Monteiro G, Demasi M.

PLoS One. 2012;7(6):e39408. doi: 10.1371/journal.pone.0039408. Epub 2012 Jun 25.


Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3ε and calmodulin.

Russo LC, Asega AF, Castro LM, Negraes PD, Cruz L, Gozzo FC, Ulrich H, Camargo AC, Rioli V, Ferro ES.

Proteomics. 2012 Aug;12(17):2641-55. doi: 10.1002/pmic.201200032. Epub 2012 Jul 26.


Identification of intracellular peptides in rat adipose tissue: Insights into insulin resistance.

Berti DA, Russo LC, Castro LM, Cruz L, Gozzo FC, Heimann JC, Lima FB, Oliveira AC, Andreotti S, Prada PO, Heimann AS, Ferro ES.

Proteomics. 2012 Aug;12(17):2668-81. doi: 10.1002/pmic.201200051. Epub 2012 Jul 26.


The intracellular pharmacokinetics of terminally capped peptides.

Ruttekolk IR, Witsenburg JJ, Glauner H, Bovee-Geurts PH, Ferro ES, Verdurmen WP, Brock R.

Mol Pharm. 2012 May 7;9(5):1077-86. doi: 10.1021/mp200331g. Epub 2012 Apr 24.


Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain.

Dalio FM, Visniauskas B, Bicocchi ES, Perry JC, Freua R, Gesteira TF, Nader HB, Machado MF, Tufik S, Ferro ES, Andersen ML, Toledo CA, Chagas JR, Oliveira V.

Biochem Biophys Res Commun. 2012 Mar 23;419(4):724-7. doi: 10.1016/j.bbrc.2012.02.088. Epub 2012 Feb 24.


Peptidomic analysis of HEK293T cells: effect of the proteasome inhibitor epoxomicin on intracellular peptides.

Fricker LD, Gelman JS, Castro LM, Gozzo FC, Ferro ES.

J Proteome Res. 2012 Mar 2;11(3):1981-90. doi: 10.1021/pr2012076. Epub 2012 Feb 16.


Peptidomic analysis of human cell lines.

Gelman JS, Sironi J, Castro LM, Ferro ES, Fricker LD.

J Proteome Res. 2011 Apr 1;10(4):1583-92. doi: 10.1021/pr100952f. Epub 2011 Feb 17.


Hemoglobin-derived peptides as novel type of bioactive signaling molecules.

Gomes I, Dale CS, Casten K, Geigner MA, Gozzo FC, Ferro ES, Heimann AS, Devi LA.

AAPS J. 2010 Dec;12(4):658-69. doi: 10.1208/s12248-010-9217-x. Epub 2010 Sep 2. Review.


Similar intracellular peptide profile of TAP1/β2 microglobulin double-knockout mice and C57BL/6 wild-type mice as revealed by peptidomic analysis.

Castro LM, Berti DA, Russo LC, Coelho V, Gozzo FC, Oliveira V, Ferro ES.

AAPS J. 2010 Dec;12(4):608-16. doi: 10.1208/s12248-010-9224-y. Epub 2010 Jul 28.


Catalytic properties of thimet oligopeptidase H600A mutant.

Machado MF, Marcondes MF, Rioli V, Ferro ES, Juliano MA, Juliano L, Oliveira V.

Biochem Biophys Res Commun. 2010 Apr 2;394(2):429-33. doi: 10.1016/j.bbrc.2010.03.045. Epub 2010 Mar 10.


Hemopressins and other hemoglobin-derived peptides in mouse brain: comparison between brain, blood, and heart peptidome and regulation in Cpefat/fat mice.

Gelman JS, Sironi J, Castro LM, Ferro ES, Fricker LD.

J Neurochem. 2010 May;113(4):871-80. doi: 10.1111/j.1471-4159.2010.06653.x. Epub 2010 Feb 24.


CCP1/Nna1 functions in protein turnover in mouse brain: Implications for cell death in Purkinje cell degeneration mice.

Berezniuk I, Sironi J, Callaway MB, Castro LM, Hirata IY, Ferro ES, Fricker LD.

FASEB J. 2010 Jun;24(6):1813-23. doi: 10.1096/fj.09-147942. Epub 2010 Jan 8.


Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation.

Russo LC, Goñi CN, Castro LM, Asega AF, Camargo AC, Trujillo CA, Ulrich H, Glucksman MJ, Scavone C, Ferro ES.

FEBS J. 2009 Aug;276(16):4358-71. doi: 10.1111/j.1742-4658.2009.07144.x. Epub 2009 Jul 15.


Novel endogenous peptide agonists of cannabinoid receptors.

Gomes I, Grushko JS, Golebiewska U, Hoogendoorn S, Gupta A, Heimann AS, Ferro ES, Scarlata S, Fricker LD, Devi LA.

FASEB J. 2009 Sep;23(9):3020-9. doi: 10.1096/fj.09-132142. Epub 2009 Apr 20.


Analysis of intracellular substrates and products of thimet oligopeptidase in human embryonic kidney 293 cells.

Berti DA, Morano C, Russo LC, Castro LM, Cunha FM, Zhang X, Sironi J, Klitzke CF, Ferro ES, Fricker LD.

J Biol Chem. 2009 May 22;284(21):14105-16. doi: 10.1074/jbc.M807916200. Epub 2009 Mar 12.


Intracellular peptides as natural regulators of cell signaling.

Cunha FM, Berti DA, Ferreira ZS, Klitzke CF, Markus RP, Ferro ES.

J Biol Chem. 2008 Sep 5;283(36):24448-59. doi: 10.1074/jbc.M801252200. Epub 2008 Jul 10.


A novel bradykinin potentiating peptide isolated from Bothrops jararacussu venom using catallytically inactive oligopeptidase EP24.15.

Rioli V, Prezoto BC, Konno K, Melo RL, Klitzke CF, Ferro ES, Ferreira-Lopes M, Camargo AC, Portaro FC.

FEBS J. 2008 May;275(10):2442-54. doi: 10.1111/j.1742-4658.2008.06389.x. Epub 2008 Apr 8.


Oligomerization of the cysteinyl-rich oligopeptidase EP24.15 is triggered by S-glutathionylation.

Demasi M, Piassa Filho GM, Castro LM, Ferreira JC, Rioli V, Ferro ES.

Free Radic Biol Med. 2008 Mar 15;44(6):1180-90. doi: 10.1016/j.freeradbiomed.2007.12.012. Epub 2007 Dec 23.


Hemopressin is an inverse agonist of CB1 cannabinoid receptors.

Heimann AS, Gomes I, Dale CS, Pagano RL, Gupta A, de Souza LL, Luchessi AD, Castro LM, Giorgi R, Rioli V, Ferro ES, Devi LA.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20588-93. Epub 2007 Dec 12.


The role of Tyr605 and Ala607 of thimet oligopeptidase and Tyr606 and Gly608 of neurolysin in substrate hydrolysis and inhibitor binding.

Machado MF, Rioli V, Dalio FM, Castro LM, Juliano MA, Tersariol IL, Ferro ES, Juliano L, Oliveira V.

Biochem J. 2007 Jun 1;404(2):279-88.


Conformation state-sensitive antibodies to G-protein-coupled receptors.

Gupta A, Décaillot FM, Gomes I, Tkalych O, Heimann AS, Ferro ES, Devi LA.

J Biol Chem. 2007 Feb 23;282(8):5116-24. Epub 2006 Dec 4.


Role of the Cys18-Cys274 disulfide bond and of the third extracellular loop in the constitutive activation and internalization of angiotensin II type 1 receptor.

Correa SA, Pignatari GC, Ferro ES, Pacheco NA, Costa-Neto CM, Pesquero JB, Oliveira L, Paiva AC, Shimuta SI.

Regul Pept. 2006 May 15;134(2-3):132-40. Epub 2006 Apr 19.


A role for transmembrane domains V and VI in ligand binding and maturation of the angiotensin II AT1 receptor.

Pignatari GC, Rozenfeld R, Ferro ES, Oliveira L, Paiva AC, Devi LA.

Biol Chem. 2006 Mar;387(3):269-76.


Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia.

Jeske NA, Berg KA, Cousins JC, Ferro ES, Clarke WP, Glucksman MJ, Roberts JL.

J Neurochem. 2006 Apr;97(1):13-21. Epub 2006 Mar 3.

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