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Items: 26

1.

(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase.

de Castro S, Ferrer-Orta C, Mills A, Fernández-Cureses G, Gago F, Verdaguer N, Camarasa MJ.

Molecules. 2019 Jun 26;24(13). pii: E2360. doi: 10.3390/molecules24132360.

2.

Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis.

de la Higuera I, Ferrer-Orta C, Moreno E, de Ávila AI, Soria ME, Singh K, Caridi F, Sobrino F, Sarafianos SG, Perales C, Verdaguer N, Domingo E.

J Virol. 2018 Sep 26;92(20). pii: e01119-18. doi: 10.1128/JVI.01119-18. Print 2018 Oct 15.

3.

Viral RNA-Dependent RNA Polymerases: A Structural Overview.

Ferrero D, Ferrer-Orta C, Verdaguer N.

Subcell Biochem. 2018;88:39-71. doi: 10.1007/978-981-10-8456-0_3. Review.

PMID:
29900492
4.

Structural characterization of the Rabphilin-3A-SNAP25 interaction.

Ferrer-Orta C, Pérez-Sánchez MD, Coronado-Parra T, Silva C, López-Martínez D, Baltanás-Copado J, Gómez-Fernández JC, Corbalán-García S, Verdaguer N.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5343-E5351. doi: 10.1073/pnas.1702542114. Epub 2017 Jun 20.

5.

Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.

de la Higuera I, Ferrer-Orta C, de Ávila AI, Perales C, Sierra M, Singh K, Sarafianos SG, Dehouck Y, Bastolla U, Verdaguer N, Domingo E.

Genome Biol Evol. 2017 May 1;9(5):1212-1228. doi: 10.1093/gbe/evx075.

6.

Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.

Herod MR, Ferrer-Orta C, Loundras EA, Ward JC, Verdaguer N, Rowlands DJ, Stonehouse NJ.

J Virol. 2016 Jul 11;90(15):6864-6883. doi: 10.1128/JVI.00469-16. Print 2016 Aug 1.

7.

RNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory Mechanisms.

Ferrer-Orta C, Ferrero D, Verdaguer N.

Viruses. 2015 Aug 6;7(8):4438-60. doi: 10.3390/v7082829. Review.

8.

Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.

Ferrer-Orta C, de la Higuera I, Caridi F, Sánchez-Aparicio MT, Moreno E, Perales C, Singh K, Sarafianos SG, Sobrino F, Domingo E, Verdaguer N.

J Virol. 2015 Jul;89(13):6848-59. doi: 10.1128/JVI.03283-14. Epub 2015 Apr 22.

9.

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ.

PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar.

10.

The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site.

Vives-Adrian L, Lujan C, Oliva B, van der Linden L, Selisko B, Coutard B, Canard B, van Kuppeveld FJ, Ferrer-Orta C, Verdaguer N.

J Virol. 2014 May;88(10):5595-607. doi: 10.1128/JVI.03502-13. Epub 2014 Mar 5.

11.

Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1.

Guillén J, Ferrer-Orta C, Buxaderas M, Pérez-Sánchez D, Guerrero-Valero M, Luengo-Gil G, Pous J, Guerra P, Gómez-Fernández JC, Verdaguer N, Corbalán-García S.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20503-8. doi: 10.1073/pnas.1316179110. Epub 2013 Dec 3.

12.

Role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity.

Garriga D, Ferrer-Orta C, Querol-Audí J, Oliva B, Verdaguer N.

J Mol Biol. 2013 Jul 10;425(13):2279-87. doi: 10.1016/j.jmb.2013.03.034. Epub 2013 Mar 28. Review.

PMID:
23542342
13.

Conformational changes in motif D of RdRPs as fidelity determinant.

Verdaguer N, Ferrer-Orta C.

Structure. 2012 Sep 5;20(9):1448-50. doi: 10.1016/j.str.2012.08.014.

14.

A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.

Agudo R, Ferrer-Orta C, Arias A, de la Higuera I, Perales C, Pérez-Luque R, Verdaguer N, Domingo E.

PLoS Pathog. 2010 Aug 26;6(8):e1001072. doi: 10.1371/journal.ppat.1001072.

15.

Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin.

Ferrer-Orta C, Sierra M, Agudo R, de la Higuera I, Arias A, Pérez-Luque R, Escarmís C, Domingo E, Verdaguer N.

J Virol. 2010 Jun;84(12):6188-99. doi: 10.1128/JVI.02420-09. Epub 2010 Apr 14.

16.

Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase.

Ferrer-Orta C, Agudo R, Domingo E, Verdaguer N.

Curr Opin Struct Biol. 2009 Dec;19(6):752-8. doi: 10.1016/j.sbi.2009.10.016. Epub 2009 Nov 13. Review.

PMID:
19914060
17.

Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2.

Guerrero-Valero M, Ferrer-Orta C, Querol-Audí J, Marin-Vicente C, Fita I, Gómez-Fernández JC, Verdaguer N, Corbalán-García S.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6603-7. doi: 10.1073/pnas.0813099106. Epub 2009 Apr 3.

18.

Structural insights into the multifunctional protein VP3 of birnaviruses.

Casañas A, Navarro A, Ferrer-Orta C, González D, Rodríguez JF, Verdaguer N.

Structure. 2008 Jan;16(1):29-37. doi: 10.1016/j.str.2007.10.023.

19.

The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane.

Fort J, de la Ballina LR, Burghardt HE, Ferrer-Costa C, Turnay J, Ferrer-Orta C, Usón I, Zorzano A, Fernández-Recio J, Orozco M, Lizarbe MA, Fita I, Palacín M.

J Biol Chem. 2007 Oct 26;282(43):31444-52. Epub 2007 Aug 26.

20.

Sequential structures provide insights into the fidelity of RNA replication.

Ferrer-Orta C, Arias A, Pérez-Luque R, Escarmís C, Domingo E, Verdaguer N.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9463-8. Epub 2007 May 21.

21.

The X-ray crystal structures of two constitutively active mutants of the Escherichia coli PhoB receiver domain give insights into activation.

Arribas-Bosacoma R, Kim SK, Ferrer-Orta C, Blanco AG, Pereira PJ, Gomis-Rüth FX, Wanner BL, Coll M, Solà M.

J Mol Biol. 2007 Feb 16;366(2):626-41. Epub 2006 Nov 14.

22.

The structure of a protein primer-polymerase complex in the initiation of genome replication.

Ferrer-Orta C, Arias A, Agudo R, Pérez-Luque R, Escarmís C, Domingo E, Verdaguer N.

EMBO J. 2006 Feb 22;25(4):880-8. Epub 2006 Feb 2.

23.

A comparison of viral RNA-dependent RNA polymerases.

Ferrer-Orta C, Arias A, Escarmís C, Verdaguer N.

Curr Opin Struct Biol. 2006 Feb;16(1):27-34. Epub 2005 Dec 20. Review.

PMID:
16364629
24.

Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding.

Arias A, Agudo R, Ferrer-Orta C, Pérez-Luque R, Airaksinen A, Brocchi E, Domingo E, Verdaguer N, Escarmís C.

J Mol Biol. 2005 Nov 11;353(5):1021-32. Epub 2005 Sep 26.

PMID:
16216271
25.

Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA.

Ferrer-Orta C, Arias A, Perez-Luque R, Escarmís C, Domingo E, Verdaguer N.

J Biol Chem. 2004 Nov 5;279(45):47212-21. Epub 2004 Aug 3.

26.

Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI).

Barbosa Pereira PJ, Segura-Martín S, Oliva B, Ferrer-Orta C, Avilés FX, Coll M, Gomis-Rüth FX, Vendrell J.

J Mol Biol. 2002 Aug 16;321(3):537-47.

PMID:
12162965

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