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Items: 1 to 50 of 138

1.

1-(2',5'-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of α7 Nicotinic Receptors with Analgesic and Neuroprotective Activity.

Pérez de Vega MJ, Fernandez-Mendivil C, de la Torre Martínez R, González-Rodríguez S, Mullet J, Sala F, Sala S, Criado M, Moreno-Fernández S, Miguel M, Fernández-Carvajal A, Ferrer-Montiel A, López MG, González-Muñiz R.

ACS Chem Neurosci. 2019 Aug 21;10(8):3900-3909. doi: 10.1021/acschemneuro.9b00364. Epub 2019 Aug 2.

PMID:
31322853
2.

The calmodulin-binding tetraleucine motif of KCNE4 is responsible for association with Kv1.3.

Solé L, Roig SR, Sastre D, Vallejo-Gracia A, Serrano-Albarrás A, Ferrer-Montiel A, Fernández-Ballester G, Tamkun MM, Felipe A.

FASEB J. 2019 Jul;33(7):8263-8279. doi: 10.1096/fj.201801164RR. Epub 2019 Apr 10.

PMID:
30969795
3.

Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain.

Arribas-Blázquez M, Olivos-Oré LA, Barahona MV, Sánchez de la Muela M, Solar V, Jiménez E, Gualix J, McIntosh JM, Ferrer-Montiel A, Miras-Portugal MT, Artalejo AR.

Int J Mol Sci. 2019 Jan 3;20(1). pii: E155. doi: 10.3390/ijms20010155.

4.

The Spanish Ion Channel Initiative (SICI) Consortium: Ten Years (2008⁻2018) of a Network of Excellence on Ion Channel Research.

Felipe A, Ferrer-Montiel A.

Int J Mol Sci. 2018 Nov 8;19(11). pii: E3514. doi: 10.3390/ijms19113514.

5.

Recent progress in non-opioid analgesic peptides.

Pérez de Vega MJ, Ferrer-Montiel A, González-Muñiz R.

Arch Biochem Biophys. 2018 Dec 15;660:36-52. doi: 10.1016/j.abb.2018.10.011. Epub 2018 Oct 17. Review.

PMID:
30342013
6.

TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain.

Artero-Morales M, González-Rodríguez S, Ferrer-Montiel A.

Front Mol Biosci. 2018 Aug 14;5:73. doi: 10.3389/fmolb.2018.00073. eCollection 2018. Review.

7.

Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity.

Bertamino A, Iraci N, Ostacolo C, Ambrosino P, Musella S, Di Sarno V, Ciaglia T, Pepe G, Sala M, Soldovieri MV, Mosca I, Gonzalez-Rodriguez S, Fernandez-Carvajal A, Ferrer-Montiel A, Novellino E, Taglialatela M, Campiglia P, Gomez-Monterrey I.

J Med Chem. 2018 Jul 26;61(14):6140-6152. doi: 10.1021/acs.jmedchem.8b00545. Epub 2018 Jul 10.

PMID:
29939028
8.

Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders.

Serafini M, Griglio A, Aprile S, Seiti F, Travelli C, Pattarino F, Grosa G, Sorba G, Genazzani AA, Gonzalez-Rodriguez S, Butron L, Devesa I, Fernandez-Carvajal A, Pirali T, Ferrer-Montiel A.

J Med Chem. 2018 May 24;61(10):4436-4455. doi: 10.1021/acs.jmedchem.8b00109. Epub 2018 May 15.

PMID:
29722529
9.

Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity.

Balsera B, Mulet J, Sala S, Sala F, de la Torre-Martínez R, González-Rodríguez S, Plata A, Naesens L, Fernández-Carvajal A, Ferrer-Montiel A, Criado M, Pérez de Vega MJ, González-Muñiz R.

Eur J Med Chem. 2018 Jan 1;143:157-165. doi: 10.1016/j.ejmech.2017.10.083. Epub 2017 Nov 2.

PMID:
29174812
10.

Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation.

Quarta S, Camprubí-Robles M, Schweigreiter R, Matusica D, Haberberger RV, Proia RL, Bandtlow CE, Ferrer-Montiel A, Kress M.

Front Mol Neurosci. 2017 Oct 10;10:317. doi: 10.3389/fnmol.2017.00317. eCollection 2017.

11.

Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists.

de la Torre-Martínez R, Bonache MA, Llabrés-Campaner PJ, Balsera B, Fernández-Carvajal A, Fernández-Ballester G, Ferrer-Montiel A, Pérez de Vega MJ, González-Muñiz R.

Sci Rep. 2017 Sep 7;7(1):10766. doi: 10.1038/s41598-017-10913-x.

12.

Lipids as central modulators of sensory TRP channels.

Ciardo MG, Ferrer-Montiel A.

Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1615-1628. doi: 10.1016/j.bbamem.2017.04.012. Epub 2017 Apr 18. Review.

13.

Effect of econazole and benzydamine on sensory neurons in culture.

Mathivanan S, de la Torre-Martinez R, Wolf C, Mangano G, Polenzani L, Milanese C, Ferrer-Montiel A.

J Physiol Pharmacol. 2016 Dec;67(6):851-858.

14.

Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier.

Vázquez-Jiménez L, Garrido M, Miceli M, Prats E, Ferrer-Montiel A, Teixidó M, Jimeno C, Messeguer A.

Eur J Med Chem. 2016 Nov 10;123:788-802. doi: 10.1016/j.ejmech.2016.08.007. Epub 2016 Aug 6.

PMID:
27541262
15.

Increased expression of Trpv1 in peripheral terminals mediates thermal nociception in Fabry disease mouse model.

Lakomá J, Rimondini R, Ferrer Montiel A, Donadio V, Liguori R, Caprini M.

Mol Pain. 2016 Aug 16;12. pii: 1744806916663729. doi: 10.1177/1744806916663729. Print 2016.

16.

Bradykinin Induces TRPV1 Exocytotic Recruitment in Peptidergic Nociceptors.

Mathivanan S, Devesa I, Changeux JP, Ferrer-Montiel A.

Front Pharmacol. 2016 Jun 23;7:178. doi: 10.3389/fphar.2016.00178. eCollection 2016.

17.

Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer.

Pérez de Vega MJ, Gómez-Monterrey I, Ferrer-Montiel A, González-Muñiz R.

J Med Chem. 2016 Nov 23;59(22):10006-10029. Epub 2016 Aug 1. Review.

PMID:
27437828
18.

1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties.

Criado M, Balsera B, Mulet J, Sala S, Sala F, de la Torre-Martínez R, Fernández-Carvajal A, Ferrer-Montiel A, Moreno-Fernández S, Miguel M, Pérez de Vega MJ, González-Muñiz R.

Future Med Chem. 2016 May;8(7):731-49. doi: 10.4155/fmc-2015-0001. Epub 2016 May 10.

19.

Calcium Entry Through Thermosensory Channels.

Taberner FJ, Devesa I, Ferrer-Montiel A.

Adv Exp Med Biol. 2016;898:265-304. doi: 10.1007/978-3-319-26974-0_12. Review.

PMID:
27161233
20.

Specific promoter deacetylation of histone H3 is conserved across mouse models of Huntington's disease in the absence of bulk changes.

Guiretti D, Sempere A, Lopez-Atalaya JP, Ferrer-Montiel A, Barco A, Valor LM.

Neurobiol Dis. 2016 May;89:190-201. doi: 10.1016/j.nbd.2016.02.004. Epub 2016 Feb 3.

PMID:
26851501
21.

Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators.

Bertamino A, Ostacolo C, Ambrosino P, Musella S, Di Sarno V, Ciaglia T, Soldovieri MV, Iraci N, Fernandez Carvajal A, de la Torre-Martinez R, Ferrer-Montiel A, Gonzalez Muniz R, Novellino E, Taglialatela M, Campiglia P, Gomez-Monterrey I.

J Med Chem. 2016 Mar 10;59(5):2179-91. doi: 10.1021/acs.jmedchem.5b01914. Epub 2016 Feb 17.

PMID:
26847872
22.

Whirlin increases TRPV1 channel expression and cellular stability.

Ciardo MG, Andrés-Bordería A, Cuesta N, Valente P, Camprubí-Robles M, Yang J, Planells-Cases R, Ferrer-Montiel A.

Biochim Biophys Acta. 2016 Jan;1863(1):115-27. doi: 10.1016/j.bbamcr.2015.10.016. Epub 2015 Oct 26.

23.

TRPV1 channel modulation by hyaluronan reduces pain.

de la Peña E, Gomis A, Ferrer-Montiel A, Belmonte C.

Channels (Austin). 2016;10(2):81-2. doi: 10.1080/19336950.2015.1109300. Epub 2015 Oct 30. No abstract available.

24.

Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain.

Caires R, Luis E, Taberner FJ, Fernandez-Ballester G, Ferrer-Montiel A, Balazs EA, Gomis A, Belmonte C, de la Peña E.

Nat Commun. 2015 Aug 27;6:8095. doi: 10.1038/ncomms9095.

25.

The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating.

Gregorio-Teruel L, Valente P, Liu B, Fernández-Ballester G, Qin F, Ferrer-Montiel A.

Biophys J. 2015 Aug 4;109(3):529-41. doi: 10.1016/j.bpj.2015.06.039.

26.

TRP channels interaction with lipids and its implications in disease.

Taberner FJ, Fernández-Ballester G, Fernández-Carvajal A, Ferrer-Montiel A.

Biochim Biophys Acta. 2015 Sep;1848(9):1818-27. doi: 10.1016/j.bbamem.2015.03.022. Epub 2015 Mar 30. Review.

27.

αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors.

Devesa I, Ferrándiz-Huertas C, Mathivanan S, Wolf C, Luján R, Changeux JP, Ferrer-Montiel A.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18345-50. doi: 10.1073/pnas.1420252111. Epub 2014 Dec 8.

28.

Adamantyl analogues of paracetamol as potent analgesic drugs via inhibition of TRPA1.

Fresno N, Pérez-Fernández R, Goicoechea C, Alkorta I, Fernández-Carvajal A, de la Torre-Martínez R, Quirce S, Ferrer-Montiel A, Martín MI, Goya P, Elguero J.

PLoS One. 2014 Dec 1;9(12):e113841. doi: 10.1371/journal.pone.0113841. eCollection 2014.

29.

Trafficking of ThermoTRP Channels.

Ferrandiz-Huertas C, Mathivanan S, Wolf CJ, Devesa I, Ferrer-Montiel A.

Membranes (Basel). 2014 Aug 19;4(3):525-64. doi: 10.3390/membranes4030525. Review.

30.

Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: a new target for a privileged structure.

Balsera B, Mulet J, Fernández-Carvajal A, de la Torre-Martínez R, Ferrer-Montiel A, Hernández-Jiménez JG, Estévez-Herrera J, Borges R, Freitas AE, López MG, García-López MT, González-Muñiz R, Pérez de Vega MJ, Valor LM, Svobodová L, Sala S, Sala F, Criado M.

Eur J Med Chem. 2014 Oct 30;86:724-39. doi: 10.1016/j.ejmech.2014.09.039. Epub 2014 Sep 16.

PMID:
25232969
31.

The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.

Taberner FJ, López-Córdoba A, Fernández-Ballester G, Korchev Y, Ferrer-Montiel A.

J Biol Chem. 2014 Oct 10;289(41):28579-94. doi: 10.1074/jbc.M114.577478. Epub 2014 Aug 25.

32.

De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators.

Bonache MÁ, Balsera B, López-Méndez B, Millet O, Brancaccio D, Gómez-Monterrey I, Carotenuto A, Pavone LM, Reille-Seroussi M, Gagey-Eilstein N, Vidal M, de la Torre-Martinez R, Fernández-Carvajal A, Ferrer-Montiel A, García-López MT, Martín-Martínez M, de Vega MJ, González-Muñiz R.

ACS Comb Sci. 2014 May 12;16(5):250-8. doi: 10.1021/co500005x. Epub 2014 Apr 22.

33.

Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation.

Gregorio-Teruel L, Valente P, González-Ros JM, Fernández-Ballester G, Ferrer-Montiel A.

J Gen Physiol. 2014 Mar;143(3):361-75. doi: 10.1085/jgp.201311070.

34.

Neurotrophins, endocannabinoids and thermo-transient receptor potential: a threesome in pain signalling.

Devesa I, Ferrer-Montiel A.

Eur J Neurosci. 2014 Feb;39(3):353-62. doi: 10.1111/ejn.12455. Review.

PMID:
24494676
35.

A non-canonical di-acidic signal at the C-terminus of Kv1.3 determines anterograde trafficking and surface expression.

Martínez-Mármol R, Pérez-Verdaguer M, Roig SR, Vallejo-Gracia A, Gotsi P, Serrano-Albarrás A, Bahamonde MI, Ferrer-Montiel A, Fernández-Ballester G, Comes N, Felipe A.

J Cell Sci. 2013 Dec 15;126(Pt 24):5681-91. doi: 10.1242/jcs.134825. Epub 2013 Oct 21.

36.

Identification of voltage-gated K(+) channel beta 2 (Kvβ2) subunit as a novel interaction partner of the pain transducer Transient Receptor Potential Vanilloid 1 channel (TRPV1).

Bavassano C, Marvaldi L, Langeslag M, Sarg B, Lindner H, Klimaschewski L, Kress M, Ferrer-Montiel A, Knaus HG.

Biochim Biophys Acta. 2013 Dec;1833(12):3166-3175. doi: 10.1016/j.bbamcr.2013.09.001. Epub 2013 Sep 11.

37.

Local delivery of molecules from a nanopipette for quantitative receptor mapping on live cells.

Babakinejad B, Jönsson P, López Córdoba A, Actis P, Novak P, Takahashi Y, Shevchuk A, Anand U, Anand P, Drews A, Ferrer-Montiel A, Klenerman D, Korchev YE.

Anal Chem. 2013 Oct 1;85(19):9333-42. doi: 10.1021/ac4021769. Epub 2013 Sep 20.

PMID:
24004146
38.

Targeting protein-protein interactions to rescue Δf508-cftr: a novel corrector approach to treat cystic fibrosis.

Devesa I, Fernández-Ballester G, Ferrer-Montiel A.

EMBO Mol Med. 2013 Oct;5(10):1462-4. doi: 10.1002/emmm.201303301. Epub 2013 Aug 27. No abstract available.

39.

Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver disease.

Belghiti M, Estévez-Herrera J, Giménez-Garzó C, González-Usano A, Montoliu C, Ferrer-Montiel A, Felipo V, Planells-Cases R.

J Biol Chem. 2013 Apr 5;288(14):9675-85. doi: 10.1074/jbc.M113.455162. Epub 2013 Feb 13.

40.

Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor.

Camprubí-Robles M, Mair N, Andratsch M, Benetti C, Beroukas D, Rukwied R, Langeslag M, Proia RL, Schmelz M, Ferrer Montiel AV, Haberberger RV, Kress M.

J Neurosci. 2013 Feb 6;33(6):2582-92. doi: 10.1523/JNEUROSCI.4479-12.2013.

41.

Highly functionalized 1,2-diamino compounds through reductive amination of amino acid-derived β-keto esters.

Pérez-Faginas P, Aranda MT, García-López MT, Infantes L, Fernández-Carvajal A, González-Ros JM, Ferrer-Montiel A, González-Muñiz R.

PLoS One. 2013;8(1):e53231. doi: 10.1371/journal.pone.0053231. Epub 2013 Jan 7.

42.

Detergent-labile, supramolecular assemblies of KcsA: relative abundance and interactions involved.

Giudici AM, Molina ML, Ayala JL, Montoya E, Renart ML, Fernández AM, Encinar JA, Ferrer-Montiel AV, Poveda JA, González-Ros JM.

Biochim Biophys Acta. 2013 Feb;1828(2):193-200. doi: 10.1016/j.bbamem.2012.09.020. Epub 2012 Sep 27.

43.

Advances in modulating thermosensory TRP channels.

Ferrer-Montiel A, Fernández-Carvajal A, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Messeguer A, González-Muñiz R.

Expert Opin Ther Pat. 2012 Sep;22(9):999-1017. doi: 10.1517/13543776.2012.711320. Epub 2012 Jul 27. Review.

PMID:
22835143
44.

Contribution of ion binding affinity to ion selectivity and permeation in KcsA, a model potassium channel.

Renart ML, Montoya E, Fernández AM, Molina ML, Poveda JA, Encinar JA, Ayala JL, Ferrer-Montiel AV, Gómez J, Morales A, González Ros JM.

Biochemistry. 2012 May 8;51(18):3891-900. doi: 10.1021/bi201497n. Epub 2012 Apr 27.

PMID:
22509943
45.

Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation.

Sanz-Salvador L, Andrés-Borderia A, Ferrer-Montiel A, Planells-Cases R.

J Biol Chem. 2012 Jun 1;287(23):19462-71. doi: 10.1074/jbc.M111.289751. Epub 2012 Apr 6.

46.

Mutation of Ser-50 and Cys-66 in Snapin modulates protein structure and stability.

Navarro A, Encinar JA, López-Méndez B, Aguado-Llera D, Prieto J, Gómez J, Martínez-Cruz LA, Millet O, González-Ros JM, Fernández-Ballester G, Neira JL, Ferrer-Montiel A.

Biochemistry. 2012 Apr 24;51(16):3470-84. doi: 10.1021/bi201574t. Epub 2012 Apr 11.

PMID:
22471585
47.

An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain.

Ponsati B, Carreño C, Curto-Reyes V, Valenzuela B, Duart MJ, Van den Nest W, Cauli O, Beltran B, Fernandez J, Borsini F, Caprioli A, Di Serio S, Veretchy M, Baamonde A, Menendez L, Barros F, de la Pena P, Borges R, Felipo V, Planells-Cases R, Ferrer-Montiel A.

J Pharmacol Exp Ther. 2012 Jun;341(3):634-45. doi: 10.1124/jpet.111.190678. Epub 2012 Mar 5.

PMID:
22393248
48.

Role of the transient receptor potential vanilloid 1 in inflammation and sepsis.

Devesa I, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Ferrer-Montiel A, Fernández-Carvajal A.

J Inflamm Res. 2011;4:67-81. doi: 10.2147/JIR.S12978. Epub 2011 May 24.

49.

Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis.

Vidal-Mosquera M, Fernández-Carvajal A, Moure A, Valente P, Planells-Cases R, González-Ros JM, Bujons J, Ferrer-Montiel A, Messeguer A.

J Med Chem. 2011 Nov 10;54(21):7441-52. doi: 10.1021/jm200981s. Epub 2011 Oct 10.

PMID:
21950613
50.

Solid-phase synthesis of a library of amphipatic hydantoins. Discovery of new hits for TRPV1 blockade.

Gerona-Navarro G, González-Muñiz R, Fernández-Carvajal A, González-Ros JM, Ferrer-Montiel A, Carreño C, Albericio F, Royo M.

ACS Comb Sci. 2011 Sep 12;13(5):458-65. doi: 10.1021/co1000986. Epub 2011 Jul 8.

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