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Items: 1 to 50 of 126


Spontaneous emergence of cell-like organization in Xenopus egg extracts.

Cheng X, Ferrell JE Jr.

Science. 2019 Nov 1;366(6465):631-637. doi: 10.1126/science.aav7793.


A compact synthetic pathway rewires cancer signaling to therapeutic effector release.

Chung HK, Zou X, Bajar BT, Brand VR, Huo Y, Alcudia JF, Ferrell JE Jr, Lin MZ.

Science. 2019 May 3;364(6439). pii: eaat6982. doi: 10.1126/science.aat6982.


Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization.

Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE Jr, Theriot JA.

Dev Cell. 2019 Apr 22;49(2):189-205.e6. doi: 10.1016/j.devcel.2019.03.025.


Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease.

Roake CM, Chen L, Chakravarthy AL, Ferrell JE Jr, Raffa GD, Artandi SE.

Mol Cell. 2019 May 16;74(4):688-700.e3. doi: 10.1016/j.molcel.2019.02.033. Epub 2019 Mar 28.


Apoptosis propagates through the cytoplasm as trigger waves.

Cheng X, Ferrell JE Jr.

Science. 2018 Aug 10;361(6402):607-612. doi: 10.1126/science.aah4065.


Robustly Cycling Xenopus laevis Cell-Free Extracts in Teflon Chambers.

Chang JB, Ferrell JE Jr.

Cold Spring Harb Protoc. 2018 Aug 1;2018(8). doi: 10.1101/pdb.prot097212.


Desynchronizing Embryonic Cell Division Waves Reveals the Robustness of Xenopus laevis Development.

Anderson GA, Gelens L, Baker JC, Ferrell JE Jr.

Cell Rep. 2017 Oct 3;21(1):37-46. doi: 10.1016/j.celrep.2017.09.017.


Calcium Ion Induced Structural Changes Promote Dimerization of Secretagogin, Which Is Required for Its Insulin Secretory Function.

Lee JJ, Yang SY, Park J, Ferrell JE Jr, Shin DH, Lee KJ.

Sci Rep. 2017 Aug 1;7(1):6976. doi: 10.1038/s41598-017-07072-4.


The Temporal Ordering of Cell-Cycle Phosphorylation.

Kamenz J, Ferrell JE Jr.

Mol Cell. 2017 Feb 2;65(3):371-373. doi: 10.1016/j.molcel.2017.01.025.


The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks.

Ha SH, Kim SY, Ferrell JE Jr.

Cell Rep. 2016 Aug 16;16(7):2047. doi: 10.1016/j.celrep.2016.07.073. No abstract available.


Thresholds and ultrasensitivity from negative cooperativity.

Ha SH, Ferrell JE Jr.

Science. 2016 May 20;352(6288):990-3. doi: 10.1126/science.aad5937. Epub 2016 May 12.


Perfect and Near-Perfect Adaptation in Cell Signaling.

Ferrell JE Jr.

Cell Syst. 2016 Feb 24;2(2):62-7. doi: 10.1016/j.cels.2016.02.006. Epub 2016 Feb 24.


The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks.

Ha SH, Kim SY, Ferrell JE Jr.

Cell Rep. 2016 Feb 16;14(6):1408-1421. doi: 10.1016/j.celrep.2016.01.033. Epub 2016 Feb 4.


How Does the Xenopus laevis Embryonic Cell Cycle Avoid Spatial Chaos?

Gelens L, Huang KC, Ferrell JE Jr.

Cell Rep. 2015 Aug 4;12(5):892-900. doi: 10.1016/j.celrep.2015.06.070. Epub 2015 Jul 23.


Ultrasensitivity part III: cascades, bistable switches, and oscillators.

Ferrell JE Jr, Ha SH.

Trends Biochem Sci. 2014 Dec;39(12):612-8. doi: 10.1016/j.tibs.2014.10.002. Epub 2014 Nov 10. Review.


Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback.

Ferrell JE Jr, Ha SH.

Trends Biochem Sci. 2014 Nov;39(11):556-69. doi: 10.1016/j.tibs.2014.09.003. Epub 2014 Oct 23. Review.


Spatial trigger waves: positive feedback gets you a long way.

Gelens L, Anderson GA, Ferrell JE Jr.

Mol Biol Cell. 2014 Nov 5;25(22):3486-93. doi: 10.1091/mbc.E14-08-1306.


Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity.

Ferrell JE Jr, Ha SH.

Trends Biochem Sci. 2014 Oct;39(10):496-503. doi: 10.1016/j.tibs.2014.08.003. Epub 2014 Sep 18. Review.


Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos.

Tsai TY, Theriot JA, Ferrell JE Jr.

PLoS Biol. 2014 Feb 11;12(2):e1001788. doi: 10.1371/journal.pbio.1001788. eCollection 2014 Feb.


Feedback loops and reciprocal regulation: recurring motifs in the systems biology of the cell cycle.

Ferrell JE Jr.

Curr Opin Cell Biol. 2013 Dec;25(6):676-86. doi: 10.1016/ Epub 2013 Aug 5. Review.


Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle.

Chang JB, Ferrell JE Jr.

Nature. 2013 Aug 29;500(7464):603-7. doi: 10.1038/nature12321. Epub 2013 Jul 17.


The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch.

Yang Q, Ferrell JE Jr.

Nat Cell Biol. 2013 May;15(5):519-25. doi: 10.1038/ncb2737. Epub 2013 Apr 28.


Bistability in one equation or fewer.

Anderson GA, Liu X, Ferrell JE Jr.

Methods Mol Biol. 2012;880:53-67. doi: 10.1007/978-1-61779-833-7_4. Review.


Spatial positive feedback at the onset of mitosis.

Santos SD, Wollman R, Meyer T, Ferrell JE Jr.

Cell. 2012 Jun 22;149(7):1500-13. doi: 10.1016/j.cell.2012.05.028.


Bistability, bifurcations, and Waddington's epigenetic landscape.

Ferrell JE Jr.

Curr Biol. 2012 Jun 5;22(11):R458-66. doi: 10.1016/j.cub.2012.03.045. Review.


Dora B. Goldstein 1922-2011.

Ferrell JE Jr.

Addiction. 2012 May;107(5):1013-4. doi: 10.1111/j.1360-0443.2011.03746.x. Epub 2012 Feb 11. No abstract available.


A mechanism for the evolution of phosphorylation sites.

Pearlman SM, Serber Z, Ferrell JE Jr.

Cell. 2011 Nov 11;147(4):934-46. doi: 10.1016/j.cell.2011.08.052.


Simple rules for complex processes: new lessons from the budding yeast cell cycle.

Ferrell JE Jr.

Mol Cell. 2011 Aug 19;43(4):497-500. doi: 10.1016/j.molcel.2011.08.002. No abstract available.


Modeling the cell cycle: why do certain circuits oscillate?

Ferrell JE Jr, Tsai TY, Yang Q.

Cell. 2011 Mar 18;144(6):874-85. doi: 10.1016/j.cell.2011.03.006.


Ultrasensitivity in the Regulation of Cdc25C by Cdk1.

Trunnell NB, Poon AC, Kim SY, Ferrell JE Jr.

Mol Cell. 2011 Feb 4;41(3):263-74. doi: 10.1016/j.molcel.2011.01.012.


The roles of cyclin A2, B1, and B2 in early and late mitotic events.

Gong D, Ferrell JE Jr.

Mol Biol Cell. 2010 Sep 15;21(18):3149-61. doi: 10.1091/mbc.E10-05-0393. Epub 2010 Jul 21.


Systems biologists seek fuller integration of systems biology approaches in new cancer research programs.

Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE Jr, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R.

Cancer Res. 2010 Jan 1;70(1):12-3. doi: 10.1158/0008-5472.CAN-09-2676. Epub 2009 Dec 22.


Signaling motifs and Weber's law.

Ferrell JE Jr.

Mol Cell. 2009 Dec 11;36(5):724-7. doi: 10.1016/j.molcel.2009.11.032.


Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA.

Hendrickson DG, Hogan DJ, McCullough HL, Myers JW, Herschlag D, Ferrell JE, Brown PO.

PLoS Biol. 2009 Nov;7(11):e1000238. doi: 10.1371/journal.pbio.1000238. Epub 2009 Nov 10.


Simple, realistic models of complex biological processes: positive feedback and bistability in a cell fate switch and a cell cycle oscillator.

Ferrell JE Jr, Pomerening JR, Kim SY, Trunnell NB, Xiong W, Huang CY, Machleder EM.

FEBS Lett. 2009 Dec 17;583(24):3999-4005. doi: 10.1016/j.febslet.2009.10.068. Review.


Q&A: Cooperativity.

Ferrell JE Jr.

J Biol. 2009;8(6):53. doi: 10.1186/jbiol157. Epub 2009 Jun 16. No abstract available.


Tuning the activation threshold of a kinase network by nested feedback loops.

Justman QA, Serber Z, Ferrell JE Jr, El-Samad H, Shokat KM.

Science. 2009 Apr 24;324(5926):509-12. doi: 10.1126/science.1169498.


Q&A: systems biology.

Ferrell JE Jr.

J Biol. 2009;8(1):2. doi: 10.1186/jbiol107. Epub 2009 Jan 26. No abstract available.


Systems biology: On the cell cycle and its switches.

Santos SD, Ferrell JE.

Nature. 2008 Jul 17;454(7202):288-9. doi: 10.1038/454288a. No abstract available.


Robust, tunable biological oscillations from interlinked positive and negative feedback loops.

Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE Jr.

Science. 2008 Jul 4;321(5885):126-9. doi: 10.1126/science.1156951.


Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF.

Pomerening JR, Ubersax JA, Ferrell JE Jr.

Mol Biol Cell. 2008 Aug;19(8):3426-41. doi: 10.1091/mbc.E08-02-0172. Epub 2008 May 14.


Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance.

Hendrickson DG, Hogan DJ, Herschlag D, Ferrell JE, Brown PO.

PLoS One. 2008 May 7;3(5):e2126. doi: 10.1371/journal.pone.0002126. Erratum in: PLoS ONE. 2008;3(11)


A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes.

Ríos-Cardona D, Ricardo-González RR, Chawla A, Ferrell JE Jr.

Dev Biol. 2008 May 1;317(1):380-8. doi: 10.1016/j.ydbio.2008.02.047. Epub 2008 Mar 7.


Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses.

Ferrell JE Jr.

Curr Biol. 2008 Mar 25;18(6):R244-5. doi: 10.1016/j.cub.2008.02.035. No abstract available.


Systems biology. A clock with a flip switch.

Poon AC, Ferrell JE Jr.

Science. 2007 Nov 2;318(5851):757-8. No abstract available.


Mechanisms of specificity in protein phosphorylation.

Ubersax JA, Ferrell JE Jr.

Nat Rev Mol Cell Biol. 2007 Jul;8(7):530-41. Review. Erratum in: Nat Rev Mol Cell Biol. 2007 Aug;8(8):665.


Legal and ethical considerations in the transfusion of infected or untested autologous blood.

Brooks JP, Ferrell JE.

Am J Clin Pathol. 2007 Jul;128(1):135-42.


Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy.

Serber Z, Selenko P, Hänsel R, Reckel S, Löhr F, Ferrell JE Jr, Wagner G, Dötsch V.

Nat Protoc. 2006;1(6):2701-9.


Emi2 at the crossroads: where CSF meets MPF.

Hansen DV, Pomerening JR, Summers MK, Miller JJ, Ferrell JE Jr, Jackson PK.

Cell Cycle. 2007 Mar 15;6(6):732-8. Epub 2007 Mar 14.


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