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Items: 1 to 50 of 153

1.

Acute and chronic neurological consequences of early-life Zika virus infection in mice.

Nem de Oliveira Souza I, Frost PS, França JV, Nascimento-Viana JB, Neris RLS, Freitas L, Pinheiro DJLL, Nogueira CO, Neves G, Chimelli L, De Felice FG, Cavalheiro ÉA, Ferreira ST, Assunção-Miranda I, Figueiredo CP, Da Poian AT, Clarke JR.

Sci Transl Med. 2018 Jun 6;10(444). pii: eaar2749. doi: 10.1126/scitranslmed.aar2749.

PMID:
29875203
2.

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers.

Mendes ND, Fernandes A, Almeida GM, Santos LE, Selles MC, Lyra-Silva N, Machado CM, Horta-Júnior JAC, Louzada PR, De Felice FG, Alvez-Leon S, Marcondes J, Assirati JA Jr, Matias CM, Klein WL, Garcia-Cairasco N, Ferreira ST, Neder L, Sebollela A.

J Neurosci Methods. 2018 May 31. pii: S0165-0270(18)30159-6. doi: 10.1016/j.jneumeth.2018.05.021. [Epub ahead of print]

PMID:
29859877
3.

Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

Hölscher C, De Felice FG, Greig N, Ferreira ST.

Neuropharmacology. 2018 May 18. pii: S0028-3908(18)30250-8. doi: 10.1016/j.neuropharm.2018.05.021. [Epub ahead of print] No abstract available.

PMID:
29782874
4.

Brain Inflammation Connects Cognitive and Non-Cognitive Symptoms in Alzheimer's Disease.

Selles MC, Oliveira MM, Ferreira ST.

J Alzheimers Dis. 2018;64(s1):S313-S327. doi: 10.3233/JAD-179925.

PMID:
29710716
5.

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.

Batista AF, Forny-Germano L, Clarke JR, Lyra E Silva NM, Brito-Moreira J, Boehnke SE, Winterborn A, Coe BC, Lablans A, Vital JF, Marques SA, Martinez AM, Gralle M, Holscher C, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG.

J Pathol. 2018 May;245(1):85-100. doi: 10.1002/path.5056. Epub 2018 Apr 2.

6.

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

de Godoy MA, Saraiva LM, de Carvalho LRP, Vasconcelos-Dos-Santos A, Beiral HJV, Ramos AB, Silva LRP, Leal RB, Monteiro VHS, Braga CV, de Araujo-Silva CA, Sinis LC, Bodart-Santos V, Kasai-Brunswick TH, Alcantara CL, Lima APCA, da Cunha-E Silva NL, Galina A, Vieyra A, De Felice FG, Mendez-Otero R, Ferreira ST.

J Biol Chem. 2018 Feb 9;293(6):1957-1975. doi: 10.1074/jbc.M117.807180. Epub 2017 Dec 28.

PMID:
29284679
7.

Crosstalk between endoplasmic reticulum stress and brain inflammation in Alzheimer's disease.

Santos LE, Ferreira ST.

Neuropharmacology. 2017 Nov 10. pii: S0028-3908(17)30525-7. doi: 10.1016/j.neuropharm.2017.11.016. [Epub ahead of print] Review.

PMID:
29129774
8.

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL.

Mol Biol Cell. 2017 Oct 1;28(20):2623-2636. doi: 10.1091/mbc.E17-06-0416. Epub 2017 Aug 9.

9.

A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.

Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, Bebenek AM, Velasco PT, Viola KL, Lacor PN, Ferreira ST, Klein WL.

J Neurochem. 2017 Jul 3. doi: 10.1111/jnc.14118. [Epub ahead of print]

PMID:
28670737
10.

Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.

Fortuna JTS, Gralle M, Beckman D, Neves FS, Diniz LP, Frost PS, Barros-Aragão F, Santos LE, Gonçalves RA, Romão L, Zamberlan DC, Soares FAA, Braga C, Foguel D, Gomes FCA, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP.

Behav Brain Res. 2017 Aug 30;333:150-160. doi: 10.1016/j.bbr.2017.06.047. Epub 2017 Jun 29.

PMID:
28668282
11.

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model.

Diniz LP, Tortelli V, Matias I, Morgado J, Bérgamo Araujo AP, Melo HM, Seixas da Silva GS, Alves-Leon SV, de Souza JM, Ferreira ST, De Felice FG, Gomes FCA.

J Neurosci. 2017 Jul 12;37(28):6797-6809. doi: 10.1523/JNEUROSCI.3351-16.2017. Epub 2017 Jun 12.

12.

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.

Kincheski GC, Valentim IS, Clarke JR, Cozachenco D, Castelo-Branco MTL, Ramos-Lobo AM, Rumjanek VMBD, Donato J Jr, De Felice FG, Ferreira ST.

Brain Behav Immun. 2017 Aug;64:140-151. doi: 10.1016/j.bbi.2017.04.007. Epub 2017 Apr 13.

PMID:
28412140
13.

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.

Seixas da Silva GS, Melo HM, Lourenco MV, Lyra E Silva NM, de Carvalho MB, Alves-Leon SV, de Souza JM, Klein WL, da-Silva WS, Ferreira ST, De Felice FG.

J Biol Chem. 2017 May 5;292(18):7395-7406. doi: 10.1074/jbc.M116.753525. Epub 2017 Mar 16.

14.

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice.

Brito-Moreira J, Lourenco MV, Oliveira MM, Ribeiro FC, Ledo JH, Diniz LP, Vital JFS, Magdesian MH, Melo HM, Barros-Aragão F, de Souza JM, Alves-Leon SV, Gomes FCA, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST.

J Biol Chem. 2017 May 5;292(18):7327-7337. doi: 10.1074/jbc.M116.761189. Epub 2017 Mar 10.

15.

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?

Vieira MN, Lyra E Silva NM, Ferreira ST, De Felice FG.

Front Aging Neurosci. 2017 Jan 31;9:7. doi: 10.3389/fnagi.2017.00007. eCollection 2017.

16.

Diazepam Inhibits Electrically Evoked and Tonic Dopamine Release in the Nucleus Accumbens and Reverses the Effect of Amphetamine.

Gomez-A A, Fiorenza AM, Boschen SL, Sugi AH, Beckman D, Ferreira ST, Lee K, Blaha CD, Da Cunha C.

ACS Chem Neurosci. 2017 Feb 15;8(2):300-309. doi: 10.1021/acschemneuro.6b00358. Epub 2017 Jan 26.

PMID:
28038309
17.

Getting a "GRiP" on Hypothalamic Endoplasmic Reticulum Stress to Combat Obesity.

De Felice FG, Ferreira ST.

Diabetes. 2017 Jan;66(1):17-19. doi: 10.2337/dbi16-0057. No abstract available.

18.

Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.

Neves FS, Marques PT, Barros-Aragão F, Nunes JB, Venancio AM, Cozachenco D, Frozza RL, Passos GF, Costa R, de Oliveira J, Engel DF, De Bem AF, Benjamim CF, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP.

Mol Neurobiol. 2018 Jan;55(1):435-444. doi: 10.1007/s12035-016-0307-3. Epub 2016 Dec 13.

PMID:
27966074
19.

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.

Ledo JH, Azevedo EP, Beckman D, Ribeiro FC, Santos LE, Razolli DS, Kincheski GC, Melo HM, Bellio M, Teixeira AL, Velloso LA, Foguel D, De Felice FG, Ferreira ST.

J Neurosci. 2016 Nov 30;36(48):12106-12116.

20.

Analysis of uni and bi-parental markers in mixture samples: Lessons from the 22nd GHEP-ISFG Intercomparison Exercise.

Toscanini U, Gusmão L, Álava Narváez MC, Álvarez JC, Baldassarri L, Barbaro A, Berardi G, Betancor Hernández E, Camargo M, Carreras-Carbonell J, Castro J, Costa SC, Coufalova P, Domínguez V, Fagundes de Carvalho E, Ferreira STG, Furfuro S, García O, Goios A, González R, de la Vega AG, Gorostiza A, Hernández A, Jiménez Moreno S, Lareu MV, León Almagro A, Marino M, Martínez G, Miozzo MC, Modesti NM, Onofri V, Pagano S, Pardo Arias B, Pedrosa S, Penacino GA, Pontes ML, Porto MJ, Puente-Prieto J, Pérez RR, Ribeiro T, Rodríguez Cardozo B, Rodríguez Lesmes YM, Sala A, Santiago B, Saragoni VG, Serrano A, Streitenberger ER, Torres Morales MA, Vannelli Rey SA, Velázquez Miranda M, Whittle MR, Fernández K, Salas A.

Forensic Sci Int Genet. 2016 Nov;25:63-72. doi: 10.1016/j.fsigen.2016.07.010. Epub 2016 Jul 19.

PMID:
27500650
21.

Skin rash: a manifestation of early congenital syphilis.

Ferreira ST, Correia C, Marçal M, Tuna ML.

BMJ Case Rep. 2016 Jun 6;2016. pii: bcr2016216148. doi: 10.1136/bcr-2016-216148. No abstract available.

22.

Microglial dysfunction connects depression and Alzheimer's disease.

Santos LE, Beckman D, Ferreira ST.

Brain Behav Immun. 2016 Jul;55:151-165. doi: 10.1016/j.bbi.2015.11.011. Epub 2015 Nov 27. Review.

PMID:
26612494
23.

USP46: a new piece of the memory puzzle?

Ribeiro FC, Santos LE, Ferreira ST.

J Neurochem. 2015 Sep;134(6):979-81. doi: 10.1111/jnc.13227. Epub 2015 Aug 3.

24.

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.

Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG.

Front Cell Neurosci. 2015 May 26;9:191. doi: 10.3389/fncel.2015.00191. eCollection 2015. Review.

25.

d-serine levels in Alzheimer's disease: implications for novel biomarker development.

Madeira C, Lourenco MV, Vargas-Lopes C, Suemoto CK, Brandão CO, Reis T, Leite RE, Laks J, Jacob-Filho W, Pasqualucci CA, Grinberg LT, Ferreira ST, Panizzutti R.

Transl Psychiatry. 2015 May 5;5:e561. doi: 10.1038/tp.2015.52.

26.

Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson's disease.

Acquarone M, de Melo TM, Meireles F, Brito-Moreira J, Oliveira G, Ferreira ST, Castro NG, Tovar-Moll F, Houzel JC, Rehen SK.

Front Cell Neurosci. 2015 Apr 8;9:97. doi: 10.3389/fncel.2015.00097. eCollection 2015.

27.

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes.

Lourenco MV, Ferreira ST, De Felice FG.

Prog Neurobiol. 2015 Jun;129:37-57. doi: 10.1016/j.pneurobio.2015.03.003. Epub 2015 Apr 6. Review.

PMID:
25857551
28.

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG.

EMBO Mol Med. 2015 Feb;7(2):190-210. doi: 10.15252/emmm.201404183.

29.

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG.

J Neurosci. 2014 Oct 8;34(41):13629-43. doi: 10.1523/JNEUROSCI.1353-14.2014.

30.

Stenotrophomonas maltophilia: rare cause of meningitis.

Correia CR, Ferreira ST, Nunes P.

Pediatr Int. 2014 Aug;56(4):e21-2. doi: 10.1111/ped.12352.

PMID:
25252064
31.

Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease.

De Felice FG, Ferreira ST.

Diabetes. 2014 Jul;63(7):2262-72. doi: 10.2337/db13-1954. Epub 2014 Jun 15. Review.

32.

Accumulation of intraneuronal amyloid-β is common in normal brain.

Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG.

Curr Alzheimer Res. 2014 May;11(4):317-24.

PMID:
24597504
33.

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease.

Ferreira ST, Clarke JR, Bomfim TR, De Felice FG.

Alzheimers Dement. 2014 Feb;10(1 Suppl):S76-83. doi: 10.1016/j.jalz.2013.12.010. Review.

34.

How does brain insulin resistance develop in Alzheimer's disease?

De Felice FG, Lourenco MV, Ferreira ST.

Alzheimers Dement. 2014 Feb;10(1 Suppl):S26-32. doi: 10.1016/j.jalz.2013.12.004. Review.

35.

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG.

Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.

36.

2,4-Dinitrophenol induces neural differentiation of murine embryonic stem cells.

Freitas-Correa L, Lourenco MV, Acquarone M, da Costa RF, Galina A, Rehen SK, Ferreira ST.

Stem Cell Res. 2013 Nov;11(3):1407-16. doi: 10.1016/j.scr.2013.09.016. Epub 2013 Oct 6.

37.

The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity.

Ostapchenko VG, Beraldo FH, Mohammad AH, Xie YF, Hirata PH, Magalhaes AC, Lamour G, Li H, Maciejewski A, Belrose JC, Teixeira BL, Fahnestock M, Ferreira ST, Cashman NR, Hajj GN, Jackson MF, Choy WY, MacDonald JF, Martins VR, Prado VF, Prado MA.

J Neurosci. 2013 Oct 16;33(42):16552-64. doi: 10.1523/JNEUROSCI.3214-13.2013. Erratum in: J Neurosci. 2015 Jan 28;35(4):1816.

38.

Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis.

Azevedo EP, Ledo JH, Barbosa G, Sobrinho M, Diniz L, Fonseca AC, Gomes F, Romão L, Lima FR, Palhano FL, Ferreira ST, Foguel D.

Cell Death Dis. 2013 Sep 5;4:e789. doi: 10.1038/cddis.2013.325.

39.

Rescue of amyloid-Beta-induced inhibition of nicotinic acetylcholine receptors by a peptide homologous to the nicotine binding domain of the alpha 7 subtype.

Nery AA, Magdesian MH, Trujillo CA, Sathler LB, Juliano MA, Juliano L, Ulrich H, Ferreira ST.

PLoS One. 2013 Jul 22;8(7):e67194. doi: 10.1371/journal.pone.0067194. Print 2013.

40.

Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons.

Ramser EM, Gan KJ, Decker H, Fan EY, Suzuki MM, Ferreira ST, Silverman MA.

Mol Biol Cell. 2013 Aug;24(16):2494-505. doi: 10.1091/mbc.E12-12-0858. Epub 2013 Jun 19.

41.

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST.

J Neurosci. 2013 Jun 5;33(23):9626-34. doi: 10.1523/JNEUROSCI.0482-13.2013.

42.

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease.

Paula-Lima AC, Brito-Moreira J, Ferreira ST.

J Neurochem. 2013 Jul;126(2):191-202. doi: 10.1111/jnc.12304. Epub 2013 May 28. Review.

43.

Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice.

Ledo JH, Azevedo EP, Clarke JR, Ribeiro FC, Figueiredo CP, Foguel D, De Felice FG, Ferreira ST.

Mol Psychiatry. 2013 Oct;18(10):1053-4. doi: 10.1038/mp.2012.168. Epub 2012 Nov 27. No abstract available.

44.

Plasma levels of D-serine in Brazilian individuals with schizophrenia.

Calcia MA, Madeira C, Alheira FV, Silva TC, Tannos FM, Vargas-Lopes C, Goldenstein N, Brasil MA, Ferreira ST, Panizzutti R.

Schizophr Res. 2012 Dec;142(1-3):83-7. doi: 10.1016/j.schres.2012.09.014. Epub 2012 Oct 12.

PMID:
23063707
45.

Human apolipoprotein A-I natural variants: molecular mechanisms underlying amyloidogenic propensity.

Ramella NA, Schinella GR, Ferreira ST, Prieto ED, Vela ME, Ríos JL, Tricerri MA, Rimoldi OJ.

PLoS One. 2012;7(8):e43755. doi: 10.1371/journal.pone.0043755. Epub 2012 Aug 28.

46.

Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers.

Nunes-Tavares N, Santos LE, Stutz B, Brito-Moreira J, Klein WL, Ferreira ST, de Mello FG.

J Biol Chem. 2012 Jun 1;287(23):19377-85. doi: 10.1074/jbc.M111.321448. Epub 2012 Apr 13.

47.

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.

Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG.

J Clin Invest. 2012 Apr;122(4):1339-53. doi: 10.1172/JCI57256.

48.

Amyloid-β oligomers induce differential gene expression in adult human brain slices.

Sebollela A, Freitas-Correa L, Oliveira FF, Paula-Lima AC, Saraiva LM, Martins SM, Mota LD, Torres C, Alves-Leon S, de Souza JM, Carraro DM, Brentani H, De Felice FG, Ferreira ST.

J Biol Chem. 2012 Mar 2;287(10):7436-45. doi: 10.1074/jbc.M111.298471. Epub 2012 Jan 10.

49.

α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death.

Guillot-Sestier MV, Sunyach C, Ferreira ST, Marzolo MP, Bauer C, Thevenet A, Checler F.

J Biol Chem. 2012 Feb 10;287(7):5021-32. doi: 10.1074/jbc.M111.323626. Epub 2011 Dec 19. Erratum in: J Biol Chem. 2013 Jul 19;288(29):21210.

50.

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease.

Ferreira ST, Klein WL.

Neurobiol Learn Mem. 2011 Nov;96(4):529-43. doi: 10.1016/j.nlm.2011.08.003. Epub 2011 Sep 6. Review.

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