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Items: 1 to 50 of 105

1.

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

Cho KI, Yoon D, Yu M, Peachey NS, Ferreira PA.

Cell Mol Life Sci. 2019 Apr 3. doi: 10.1007/s00018-019-03078-5. [Epub ahead of print]

PMID:
30944974
2.

Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice.

Edfawy M, Guedes JR, Pereira MI, Laranjo M, Carvalho MJ, Gao X, Ferreira PA, Caldeira G, Franco LO, Wang D, Cardoso AL, Feng G, Carvalho AL, Peça J.

Nat Commun. 2019 Mar 29;10(1):1431. doi: 10.1038/s41467-019-09382-9.

3.

Correction to: The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration.

Ferreira PA.

Cell Mol Life Sci. 2019 Jun;76(12):2275. doi: 10.1007/s00018-019-03073-w.

PMID:
30919023
4.

The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration.

Ferreira PA.

Cell Mol Life Sci. 2019 Jun;76(12):2247-2273. doi: 10.1007/s00018-019-03029-0. Epub 2019 Feb 11. Review. Erratum in: Cell Mol Life Sci. 2019 Mar 28;:.

PMID:
30742233
5.

Growth, biochemical response and nutritional status of Angico-Vermelho (Parapiptadenia rigida (Bentham) Brenan) under the application of soil amendment in Cu-contaminated soil.

Bicalho da Silva IC, Tiecher TL, Schneider JM, Trentin E, De Conti L, Ferreira PAA, Ceretta CA, Araújo MM, Tarouco CP, Garlet LP, Hammerschmitt RK, Brunetto G.

Int J Phytoremediation. 2018;20(14):1380-1388. doi: 10.1080/15226514.2018.1474438. Epub 2019 Jan 17.

PMID:
30652487
6.

Alcohol use and associated factors among physicians and nurses in northeast Brazil.

Tobias JSP, da Silva DLF, Ferreira PAM, da Silva AAM, Ribeiro RS, Ferreira ASP.

Alcohol. 2019 Mar;75:105-112. doi: 10.1016/j.alcohol.2018.07.002. Epub 2018 Jul 19.

PMID:
30640073
7.

Impacts of deforestation on plant-pollinator networks assessed using an agent based model.

Newton AC, Boscolo D, Ferreira PA, Lopes LE, Evans P.

PLoS One. 2018 Dec 31;13(12):e0209406. doi: 10.1371/journal.pone.0209406. eCollection 2018.

8.

Historical Pollution of an Urban Watershed Based in Geochemical, Geoacumulation, and EROD Activity in PLHC-1 Analyses in Sediment Cores.

Vieira LM, Rizzi J, do Couto EV, Souza DC, Ferreira PAL, Figueira R, Froehner S.

Arch Environ Contam Toxicol. 2019 Feb;76(2):191-205. doi: 10.1007/s00244-018-0573-3. Epub 2018 Oct 11.

PMID:
30310949
9.

Factors that control the spatial and temporal distributions of phosphorus, nitrogen, and carbon in the sediments of a tropical reservoir.

Cardoso-Silva S, Ferreira PAL, Figueira RCL, da Silva DCVR, Moschini-Carlos V, Pompêo MLM.

Environ Sci Pollut Res Int. 2018 Nov;25(31):31776-31789. doi: 10.1007/s11356-018-2923-0. Epub 2018 Aug 29.

PMID:
30159844
10.

Hazard potential of widespread but hidden historic offshore heavy metal (Pb, Zn) contamination (Gulf of Cadiz, Spain).

Hanebuth TJJ, King ML, Mendes I, Lebreiro S, Lobo FJ, Oberle FK, Antón L, Ferreira PA, Reguera MI.

Sci Total Environ. 2018 Oct 1;637-638:561-576. doi: 10.1016/j.scitotenv.2018.04.352. Epub 2018 May 10.

PMID:
29754090
11.

Depositional history of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and polycyclic aromatic hydrocarbons (PAHs) in an Amazon estuary during the last century.

Neves PA, Colabuono FI, Ferreira PAL, Kawakami SK, Taniguchi S, Figueira RCL, Mahiques MM, Montone RC, Bícego MC.

Sci Total Environ. 2018 Feb 15;615:1262-1270. doi: 10.1016/j.scitotenv.2017.09.303. Epub 2017 Oct 17.

PMID:
29751431
12.

Controlled attenuation parameter for steatosis grading in chronic hepatitis C compared with digital morphometric analysis of liver biopsy: impact of individual elastography measurement quality.

Mendes LC, Ferreira PA, Miotto N, Zanaga L, Lazarini MS, Gonçales ESL, Pedro MN, Gonçales FL Júnior, Stucchi RSB, Vigani AG.

Eur J Gastroenterol Hepatol. 2018 Aug;30(8):959-966. doi: 10.1097/MEG.0000000000001145.

PMID:
29727388
13.

Higher Income and Integration into the Workforce Are the Main Factors Associated with Quality of Life in Acromegalic Patients in Northeastern Brazil.

GuimarãesSá AM, Ferreira PAM, Souza MT, Nascimento GC, da Silva Pereira Damianse S, de Carvalho Rocha VC, Dos Santos Faria M, de Souza Paiva Ferreira A.

Int J Endocrinol. 2018 Feb 27;2018:6135080. doi: 10.1155/2018/6135080. eCollection 2018.

14.

Soil amendment as a strategy for the growth of young vines when replanting vineyards in soils with high copper content.

Ferreira PAA, Marchezan C, Ceretta CA, Tarouco CP, Lourenzi CR, Silva LS, Soriani HH, Nicoloso FT, Cesco S, Mimmo T, Brunetto G.

Plant Physiol Biochem. 2018 May;126:152-162. doi: 10.1016/j.plaphy.2018.03.003. Epub 2018 Mar 2.

PMID:
29524802
15.

Critical evaluation of different methods to calculate the Geoaccumulation Index for environmental studies: A new approach for Baixada Santista - Southeastern Brazil.

Kim BSM, Angeli JLF, Ferreira PAL, de Mahiques MM, Figueira RCL.

Mar Pollut Bull. 2018 Feb;127:548-552. doi: 10.1016/j.marpolbul.2017.12.049. Epub 2017 Dec 22.

PMID:
29475696
16.

Health risk assessment and soil and plant heavy metal and bromine contents in field plots after ten years of organic and mineral fertilization.

da Rosa Couto R, Faversani J, Ceretta CA, Ferreira PAA, Marchezan C, Basso Facco D, Garlet LP, Silva JS, Comin JJ, Bizzi CA, Flores EMM, Brunetto G.

Ecotoxicol Environ Saf. 2018 May 30;153:142-150. doi: 10.1016/j.ecoenv.2018.01.046. Epub 2018 Feb 6.

PMID:
29425845
17.

Effects of Rhizophagus clarus and P availability in the tolerance and physiological response of Mucuna cinereum to copper.

Ferreira PAA, Tiecher T, Tiecher TL, Rangel WM, Soares CRFS, Deuner S, Tarouco CP, Giachini AJ, Nicoloso FT, Brunetto G, Coronas MV, Ceretta CA.

Plant Physiol Biochem. 2018 Jan;122:46-56. doi: 10.1016/j.plaphy.2017.11.006. Epub 2017 Nov 21.

PMID:
29175636
18.

Elastogram quality assessment score in vibration-controlled transient elastography: Diagnostic performance compared to digital morphometric analysis of liver biopsy in chronic hepatitis C.

Mendes LC, Ferreira PA, Miotto N, Zanaga L, Gonçales ESL, Pedro MN, Lazarini MS, Júnior FLG, Stucchi RSB, Vigani AG.

J Viral Hepat. 2018 Apr;25(4):335-343. doi: 10.1111/jvh.12822. Epub 2017 Dec 28.

PMID:
29091321
19.

Biomass burning particles in the Brazilian Amazon region: Mutagenic effects of nitro and oxy-PAHs and assessment of health risks.

de Oliveira Galvão MF, de Oliveira Alves N, Ferreira PA, Caumo S, de Castro Vasconcellos P, Artaxo P, de Souza Hacon S, Roubicek DA, Batistuzzo de Medeiros SR.

Environ Pollut. 2018 Feb;233:960-970. doi: 10.1016/j.envpol.2017.09.068. Epub 2017 Oct 12.

PMID:
29031407
20.

Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy.

Teixeira LB, Parreiras-E-Silva LT, Bruder-Nascimento T, Duarte DA, Simões SC, Costa RM, Rodríguez DY, Ferreira PAB, Silva CAA, Abrao EP, Oliveira EB, Bouvier M, Tostes RC, Costa-Neto CM.

Sci Rep. 2017 Sep 19;7(1):11903. doi: 10.1038/s41598-017-12074-3.

22.

Leguminosae native nodulating bacteria from a gold mine As-contaminated soil: Multi-resistance to trace elements, and possible role in plant growth and mineral nutrition.

Rangel WM, de Oliveira Longatti SM, Ferreira PAA, Bonaldi DS, Guimarães AA, Thijs S, Weyens N, Vangronsveld J, Moreira FMS.

Int J Phytoremediation. 2017 Oct 3;19(10):925-936. doi: 10.1080/15226514.2017.1303812.

PMID:
28323446
23.

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

Cho KI, Yoon D, Qiu S, Danziger Z, Grill WM, Wetsel WC, Ferreira PA.

Dis Model Mech. 2017 May 1;10(5):559-579. doi: 10.1242/dmm.027730. Epub 2017 Jan 18.

24.

Use of a chemometric tool to establish the regional background and assess trace metal enrichment at Baixada Santista - southeastern Brazil.

Kim BSM, Angeli JLF, Ferreira PAL, Sartoretto JR, Miyoshi C, de Mahiques MM, Figueira RCL.

Chemosphere. 2017 Jan;166:372-379. doi: 10.1016/j.chemosphere.2016.09.132. Epub 2016 Oct 2.

PMID:
27705824
25.

Historical economic and environmental policies influencing trace metal inputs in Montevideo Bay, Río de la Plata.

Bueno C, Brugnoli E, Figueira RC, Muniz P, Ferreira PA, García Rodríguez F.

Mar Pollut Bull. 2016 Dec 15;113(1-2):141-146. doi: 10.1016/j.marpolbul.2016.08.082. Epub 2016 Sep 3.

PMID:
27595618
26.

Transient elastography and APRI score: looking at false positives and false negatives. Diagnostic performance and association to fibrosis staging in chronic hepatitis C.

Mendes LC, Ferreira PA, Miotto N, Zanaga L, Gonçales E, Lazarini MS, Gonçales FL Júnior, Stucchi RS, Vigani AG.

Braz J Med Biol Res. 2016 Aug 1;49(9):e5432. doi: 10.1590/1414-431X20165432.

27.

Physiological and nutritional status of black oat (Avena strigosa Schreb.) grown in soil with interaction of high doses of copper and zinc.

Tiecher TL, Tiecher T, Ceretta CA, Ferreira PA, Nicoloso FT, Soriani HH, Tassinari A, Paranhos JT, De Conti L, Brunetto G.

Plant Physiol Biochem. 2016 Sep;106:253-63. doi: 10.1016/j.plaphy.2016.05.015. Epub 2016 May 12.

PMID:
27209215
28.

Effects of zinc addition to a copper-contaminated vineyard soil on sorption of Zn by soil and plant physiological responses.

Tiecher TL, Ceretta CA, Tiecher T, Ferreira PA, Nicoloso FT, Soriani HH, Rossato LV, Mimmo T, Cesco S, Lourenzi CR, Giachini AJ, Brunetto G.

Ecotoxicol Environ Saf. 2016 Jul;129:109-19. doi: 10.1016/j.ecoenv.2016.03.016. Epub 2016 Mar 21.

PMID:
27011111
29.

ERICA: prevalences of hypertension and obesity in Brazilian adolescents.

Bloch KV, Klein CH, Szklo M, Kuschnir MC, Abreu Gde A, Barufaldi LA, da Veiga GV, Schaan B, da Silva TL, de Vasconcellos MT, Moraes AJ, Borges AL, de Oliveira AM, Tavares BM, de Oliveira CL, Cunha Cde F, Giannini DT, Belfort DR, Santos EL, de Leon EB, Fujimori E, Oliveira ER, Magliano Eda S, Vasconcelos Fde A, Azevedo GD, Brunken GS, Guimarães IC, Faria Neto JR, Oliveira JS, de Carvalho KM, Gonçalves LG, Monteiro MI, Santos MM, Jardim PC, Ferreira PA, Montenegro RM Jr, Gurgel RQ, Vianna RP, Vasconcelos SM, Goldberg TB.

Rev Saude Publica. 2016 Feb;50 Suppl 1:9s. doi: 10.1590/S01518-8787.2016050006685. Epub 2016 Feb 23. English, Portuguese.

30.

ERICA: prevalence of metabolic syndrome in Brazilian adolescents.

Kuschnir MC, Bloch KV, Szklo M, Klein CH, Barufaldi LA, Abreu Gde A, Schaan B, da Veiga GV, da Silva TL, de Vasconcellos MT, de Moraes AJ, Borges AL, de Oliveira AM, Tavares BM, de Oliveira CL, Cunha Cde F, Giannini DT, Belfort DR, Santos EL, de Leon EB, Fujimori E, Oliveira ER, Magliano Eda S, Vasconcelos Fde A, Azevedo GD, Brunken GS, Guimarães IC, Faria Neto JR, Oliveira JS, de Carvalho KM, Gonçalves LG, Monteiro MI, Santos MM, Muniz PT, Jardim PC, Ferreira PA, Montenegro RM Jr, Gurgel RQ, Vianna RP, Vasconcelos SM, Martins SM, Goldberg TB.

Rev Saude Publica. 2016 Feb;50 Suppl 1:11s. doi: 10.1590/S01518-8787.2016050006701. Epub 2016 Feb 23. English, Portuguese. Erratum in: Rev Saude Publica. 2016 Dec 22;50:11serr.

31.

Spatial distribution and enrichment assessment of heavy metals in surface sediments from Baixada Santista, Southeastern Brazil.

Kim BSM, Salaroli AB, Ferreira PAL, Sartoretto JR, Mahiques MM, Figueira RCL.

Mar Pollut Bull. 2016 Feb 15;103(1-2):333-338. doi: 10.1016/j.marpolbul.2015.12.041. Epub 2016 Jan 7.

PMID:
26774439
32.

Beneficial use of industrial by-products for phytoremediation of an arsenic-rich soil from a gold mining area.

Lopes G, Ferreira PA, Pereira FG, Curi N, Rangel WM, Guilherme LR.

Int J Phytoremediation. 2016 Aug 2;18(8):777-84. doi: 10.1080/15226514.2015.1131240.

PMID:
26710183
33.

Effect of arbuscular mycorrhizal fungi on young vines in copper-contaminated soil.

Ambrosini VG, Voges JG, Canton L, Couto Rda R, Ferreira PA, Comin JJ, de Melo GW, Brunetto G, Soares CR.

Braz J Microbiol. 2015 Oct-Dec;46(4):1045-52. doi: 10.1590/S1517-838246420140622.

34.

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

Cho KI, Haney V, Yoon D, Hao Y, Ferreira PA.

FEBS Lett. 2015 Dec 21;589(24 Pt B):3959-68. doi: 10.1016/j.febslet.2015.11.037. Epub 2015 Nov 26.

35.

Final Results of the Telaprevir Access Program: FibroScan Values Predict Safety and Efficacy in Hepatitis C Patients with Advanced Fibrosis or Cirrhosis.

Lepida A, Colombo M, Fernandez I, Abdurakhmanov D, Ferreira PA, Strasser SI, Urbanek P, Mangia A, Calleja JL, Iraqi W, DeMasi R, Lonjon-Domanec I, Moreno C, Wedemeyer H.

PLoS One. 2015 Sep 23;10(9):e0138503. doi: 10.1371/journal.pone.0138503. eCollection 2015.

36.

Erratum to: The study of cardiovascular risk in adolescents--ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents.

Bloch KV, Szklo M, Kuschnir MC, de Azevedo Abreu G, Barufaldi LA, Klein CH, de Vasconcelos MT, da Veiga GV, Figueiredo VC, Dias A, Moraes AJ, Sousa AL, Borges AL, Andrade de Oliveira AM, Schaan BD, Tavares BM, de Oliveira CL, de Freitas Cunha C, Giannini DT, Belfort DR, Ribas DL, Santos EL, de Leon EB, Fujimori E, Oliveira ER, da Silva Magliano E, de Assis Guedes Vasconcelos F, Azevedo GD, Brunken GS, Dias GM, Filho HR, Monteiro MI, Guimarães IC, Faria Neto JR, Oliveira JS, de Carvalho KM, Gonzaga de Oliveira Gonçalves L, Santos MM, Muniz PT, Veiga Jardim PC, Ferreira PA, Montenegro RM, Gurgel RQ, Vianna RP, Vasconcelos SM, Silva da Matta S, Martins SM, Goldberg TB, Nogueira da Silva TL.

BMC Public Health. 2015 Sep 3;15:850. doi: 10.1186/s12889-015-2083-9. No abstract available.

37.

Coupling spectroscopic and chromatographic techniques for evaluation of the depositional history of hydrocarbons in a subtropical estuary.

Martins CC, Doumer ME, Gallice WC, Dauner AL, Cabral AC, Cardoso FD, Dolci NN, Camargo LM, Ferreira PA, Figueira RC, Mangrich AS.

Environ Pollut. 2015 Oct;205:403-14. doi: 10.1016/j.envpol.2015.07.016. Epub 2015 Jul 24.

PMID:
26210796
38.

Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin.

Cho KI, Orry A, Park SE, Ferreira PA.

ACS Chem Neurosci. 2015 Aug 19;6(8):1476-85. doi: 10.1021/acschemneuro.5b00134. Epub 2015 Jun 12.

39.

The Study of Cardiovascular Risk in Adolescents--ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents.

Bloch KV, Szklo M, Kuschnir MC, Abreu Gde A, Barufaldi LA, Klein CH, de Vasconcelos MT, da Veiga GV, Figueiredo VC, Dias A, Moraes AJ, Souza AL, de Oliveira AM, Schaan BD, Tavares BM, de Oliveira CL, Cunha Cde F, Giannini DT, Belfort DR, Ribas DL, Santos EL, de Leon EB, Fujimori E, Oliveira ER, Magliano Eda S, Vasconcelos Fde A, Azevedo GD, Brunken GS, Dias GM, Filho HR, Monteiro MI, Guimarães IC, Faria Neto JR, Oliveira JS, de Carvalho KM, Gonçalves LG, Santos MM, Muniz PT, Jardim PC, Ferreira PA, Montenegro RM Jr, Gurgel RQ, Vianna RP, Vasconcelos SM, da Matta SS, Martins SM, Goldberg TB, da Silva TL.

BMC Public Health. 2015 Feb 7;15:94. doi: 10.1186/s12889-015-1442-x. Erratum in: BMC Public Health. 2015;15:850.

40.

Forms of phosphorus transfer in runoff under no-tillage in a soil treated with successive swine effluents applications.

Lourenzi CR, Ceretta CA, Tiecher TL, Lorensini F, Cancian A, Stefanello L, Girotto E, Vieira RC, Ferreira PA, Brunetto G.

Environ Monit Assess. 2015 Apr;187(4):209. doi: 10.1007/s10661-015-4437-2. Epub 2015 Mar 25.

PMID:
25805372
41.

Theoretical and practical knowledge of nursing professionals on indirect blood pressure measurement at a coronary care unit.

Machado JP, Veiga EV, Ferreira PA, Martins JC, Daniel AC, Oliveira Ados S, Silva PC.

Einstein (Sao Paulo). 2014 Sep;12(3):330-5. English, Portuguese.

42.

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

Patil H, Saha A, Senda E, Cho KI, Haque M, Yu M, Qiu S, Yoon D, Hao Y, Peachey NS, Ferreira PA.

J Biol Chem. 2014 Oct 24;289(43):29767-89. doi: 10.1074/jbc.M114.586834. Epub 2014 Sep 3.

43.

Assessment of historical fecal contamination in Curitiba, Brazil, in the last 400 years using fecal sterols.

Machado KS, Froehner S, Sánez J, Figueira RC, Ferreira PA.

Sci Total Environ. 2014 Sep 15;493:1065-72. doi: 10.1016/j.scitotenv.2014.06.104. Epub 2014 Jul 11.

PMID:
25016471
44.

Sedimentary record of PAHs in the Barigui River and its relation to the socioeconomic development of Curitiba, Brazil.

Machado KS, Figueira RC, Côcco LC, Froehner S, Fernandes CV, Ferreira PA.

Sci Total Environ. 2014 Jun 1;482-483:42-52. doi: 10.1016/j.scitotenv.2014.02.106. Epub 2014 Mar 15.

PMID:
24636886
45.

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

Cho KI, Patil H, Senda E, Wang J, Yi H, Qiu S, Yoon D, Yu M, Orry A, Peachey NS, Ferreira PA.

J Biol Chem. 2014 Feb 21;289(8):4600-25. doi: 10.1074/jbc.M113.538215. Epub 2014 Jan 8.

46.

Bioaccumulation of potentially toxic trace elements in benthic organisms of Admiralty Bay (King George Island, Antarctica).

Majer AP, Petti MA, Corbisier TN, Ribeiro AP, Theophilo CY, Ferreira PA, Figueira RC.

Mar Pollut Bull. 2014 Feb 15;79(1-2):321-5. doi: 10.1016/j.marpolbul.2013.12.015. Epub 2013 Dec 22.

PMID:
24368117
47.

Safety and on-treatment efficacy of telaprevir: the early access programme for patients with advanced hepatitis C.

Colombo M, Fernández I, Abdurakhmanov D, Ferreira PA, Strasser SI, Urbanek P, Moreno C, Streinu-Cercel A, Verheyen A, Iraqi W, DeMasi R, Hill A, Läuffer JM, Lonjon-Domanec I, Wedemeyer H.

Gut. 2014 Jul;63(7):1150-8. doi: 10.1136/gutjnl-2013-305667. Epub 2013 Nov 7.

48.

IL23R polymorphisms influence phenotype and response to therapy in patients with ulcerative colitis.

Cravo ML, Ferreira PA, Sousa P, Moura-Santos P, Velho S, Tavares L, de Deus JR, Ministro P, Peixe P, Correia LA, Velosa JF, Maio RF, Brito M.

Eur J Gastroenterol Hepatol. 2014 Jan;26(1):26-32. doi: 10.1097/MEG.0000000000000004.

PMID:
24168842
49.

Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil.

Alvarado-Mora MV, Botelho-Lima LS, Santana RA, Sitnik R, Ferreira PA, do Amaral Mello F, Mangueira CP, Carrilho FJ, Rebello Pinho JR.

BMC Res Notes. 2013 Oct 21;6:423. doi: 10.1186/1756-0500-6-423.

50.

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

Cho KI, Haque M, Wang J, Yu M, Hao Y, Qiu S, Pillai IC, Peachey NS, Ferreira PA.

PLoS Genet. 2013 Jun;9(6):e1003555. doi: 10.1371/journal.pgen.1003555. Epub 2013 Jun 20.

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