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Items: 1 to 50 of 56

1.

Exome Sequencing Reveals Immune Genes as Susceptibility Modifiers in Individuals with α1-Antitrypsin Deficiency.

Rigobello C, Baraldo S, Tinè M, Ferrarotti I, Corsico AG, Bazzan E, Turato G, Balestro E, Biondini D, Valle G, Saetta M, Cosio MG.

Sci Rep. 2019 Sep 11;9(1):13088. doi: 10.1038/s41598-019-49409-1.

2.

Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration.

Bari E, Ferrarotti I, Di Silvestre D, Grisoli P, Barzon V, Balderacchi A, Torre ML, Rossi R, Mauri P, Corsico AG, Perteghella S.

Cells. 2019 Aug 23;8(9). pii: E965. doi: 10.3390/cells8090965.

3.

Mesenchymal stem/stromal cell secretome for lung regeneration: The long way through "pharmaceuticalization" for the best formulation.

Bari E, Ferrarotti I, Torre ML, Corsico AG, Perteghella S.

J Control Release. 2019 Jul 18;309:11-24. doi: 10.1016/j.jconrel.2019.07.022. [Epub ahead of print] Review.

PMID:
31326462
4.

A Pilot Study to Investigate the Balance between Proteases and α1-Antitrypsin in Bronchoalveolar Lavage Fluid of Lung Transplant Recipients.

Cagnone M, Piloni D, Ferrarotti I, Di Venere M, Viglio S, Magni S, Bardoni A, Salvini R, Fumagalli M, Iadarola P, Martinello S, Meloni F.

High Throughput. 2019 Feb 13;8(1). pii: E5. doi: 10.3390/ht8010005.

5.

The European Alpha-1 Research Collaboration (EARCO): a new ERS Clinical Research Collaboration to promote research in alpha-1 antitrypsin deficiency.

Miravitlles M, Chorostowska-Wynimko J, Ferrarotti I, McElvaney NG, O'Hara K, Stolk J, Stockley RA, Turner A, Wilkens M, Greulich T; EARCO Clinical Research Collaboration; Members of the EARCO Clinical Research Collaboration.

Eur Respir J. 2019 Feb 14;53(2). pii: 1900138. doi: 10.1183/13993003.00138-2019. Print 2019 Feb. No abstract available.

PMID:
30765486
6.

Author Correction: α1-Antitrypsin deficiency.

Greene CM, Marciniak SJ, Teckman J, Ferrarotti I, Brantly ML, Lomas DA, Stoller JK, McElvaney NG.

Nat Rev Dis Primers. 2018 Oct 29;4(1):40. doi: 10.1038/s41572-018-0043-2.

PMID:
30374103
7.

Update on α1-antitrypsin deficiency.

Ferrarotti I, Ottaviani S, De Silvestri A, Corsico AG.

Breathe (Sheff). 2018 Jun;14(2):e17-e24. doi: 10.1183/20734735.015018. Review.

8.

Real-world clinical applicability of pathogenicity predictors assessed on SERPINA1 mutations in alpha-1-antitrypsin deficiency.

Giacopuzzi E, Laffranchi M, Berardelli R, Ravasio V, Ferrarotti I, Gooptu B, Borsani G, Fra A.

Hum Mutat. 2018 Sep;39(9):1203-1213. doi: 10.1002/humu.23562. Epub 2018 Jun 28.

PMID:
29882371
9.

Alpha-1 antitrypsin deficiency: From the lung to the heart?

Curjuric I, Imboden M, Bettschart R, Caviezel S, Dratva J, Pons M, Rothe T, Schmidt-Trucksäss A, Stolz D, Thun GA, von Eckardstein A, Kronenberg F, Ferrarotti I, Probst-Hensch NM.

Atherosclerosis. 2018 Mar;270:166-172. doi: 10.1016/j.atherosclerosis.2018.01.042. Epub 2018 Jan 31.

PMID:
29432934
10.

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications.

Chapman KR, Chorostowska-Wynimko J, Koczulla AR, Ferrarotti I, McElvaney NG.

Int J Chron Obstruct Pulmon Dis. 2018 Jan 31;13:419-432. doi: 10.2147/COPD.S149429. eCollection 2018. Review.

11.

European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency.

Miravitlles M, Dirksen A, Ferrarotti I, Koblizek V, Lange P, Mahadeva R, McElvaney NG, Parr D, Piitulainen E, Roche N, Stolk J, Thabut G, Turner A, Vogelmeier C, Stockley RA.

Eur Respir J. 2017 Nov 30;50(5). pii: 1700610. doi: 10.1183/13993003.00610-2017. Print 2017 Nov. Review.

12.

Case-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD.

Zhumagaliyeva A, Ottaviani S, Greulich T, Gorrini M, Vogelmeier C, Karazhanova L, Nurgazina G, DeSilvestri A, Kotke V, Barzon V, Zorzetto M, Corsico A, Ferrarotti I.

Multidiscip Respir Med. 2017 Oct 25;12:23. doi: 10.1186/s40248-017-0104-5. eCollection 2017.

13.

The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization.

Miranda E, Ferrarotti I, Berardelli R, Laffranchi M, Cerea M, Gangemi F, Haq I, Ottaviani S, Lomas DA, Irving JA, Fra A.

FEBS J. 2017 Jul;284(13):2110-2126. doi: 10.1111/febs.14111. Epub 2017 Jun 8.

14.

Advances in Identifying Urine/Serum Biomarkers in Alpha-1 Antitrypsin Deficiency for More Personalized Future Treatment Strategies.

Ferrarotti I, Corsico AG, Stolk J, Ottaviani S, Fumagalli M, Janciauskiene S, Iadarola P.

COPD. 2017 Feb;14(1):56-65. doi: 10.1080/15412555.2016.1241760. Epub 2016 Nov 9. Review.

PMID:
27827549
15.

α1-Antitrypsin deficiency.

Greene CM, Marciniak SJ, Teckman J, Ferrarotti I, Brantly ML, Lomas DA, Stoller JK, McElvaney NG.

Nat Rev Dis Primers. 2016 Jul 28;2:16051. doi: 10.1038/nrdp.2016.51. Review. Erratum in: Nat Rev Dis Primers. 2018 Oct 29;4(1):40.

PMID:
27465791
16.

Efficacy of augmentation therapy for emphysema associated with α1-antitrypsin deficiency: enough is enough.

Balbi B, Ferrarotti I, Miravitlles M.

Eur Respir J. 2016 Jan;47(1):35-8. doi: 10.1183/13993003.01145-2015. No abstract available.

17.

How Can We Improve the Detection of Alpha1-Antitrypsin Deficiency?

Ferrarotti I, Poplawska-Wisniewska B, Trevisan MT, Koepke J, Dresel M, Koczulla R, Ottaviani S, Baldo R, Gorrini M, Sala G, Cavallon L, Welte T, Chorostowska-Wynimko J, Luisetti M, Janciauskiene S.

PLoS One. 2015 Aug 13;10(8):e0135316. doi: 10.1371/journal.pone.0135316. eCollection 2015.

18.

Alternative transcripts of the SERPINA1 gene in alpha-1 antitrypsin deficiency.

Matamala N, Martínez MT, Lara B, Pérez L, Vázquez I, Jimenez A, Barquín M, Ferrarotti I, Blanco I, Janciauskiene S, Martinez-Delgado B.

J Transl Med. 2015 Jul 4;13:211. doi: 10.1186/s12967-015-0585-y.

19.

Italian registry of patients with alpha-1 antitrypsin deficiency: general data and quality of life evaluation.

Luisetti M, Ferrarotti I, Corda L, Ottaviani S, Gatta N, Tinelli C, Bruletti G, Bertella E, Balestroni G, Confalonieri M, Seebacher C, Iannacci L, Ferrari S, Salerno FG, Mariani F, Carone M, Balbi B.

COPD. 2015 May;12 Suppl 1:52-7. doi: 10.3109/15412555.2015.1023393.

PMID:
25938293
20.

Identification and characterisation of eight novel SERPINA1 Null mutations.

Ferrarotti I, Carroll TP, Ottaviani S, Fra AM, O'Brien G, Molloy K, Corda L, Medicina D, Curran DR, McElvaney NG, Luisetti M.

Orphanet J Rare Dis. 2014 Nov 26;9:172. doi: 10.1186/s13023-014-0172-y.

21.

Immune activation in α1-antitrypsin-deficiency emphysema. Beyond the protease-antiprotease paradigm.

Baraldo S, Turato G, Lunardi F, Bazzan E, Schiavon M, Ferrarotti I, Molena B, Cazzuffi R, Damin M, Balestro E, Luisetti M, Rea F, Calabrese F, Cosio MG, Saetta M.

Am J Respir Crit Care Med. 2015 Feb 15;191(4):402-9. doi: 10.1164/rccm.201403-0529OC.

PMID:
25412116
22.

Inherited alpha1-antitrypsin deficiency: is the level the key message?

Ottaviani S, Gorrini M, Ferrarotti I, Luisetti M.

Rev Mal Respir. 2014 Oct;31(8):687-90. doi: 10.1016/j.rmr.2014.06.003. Epub 2014 Sep 23. No abstract available.

PMID:
25391502
23.

Severe alpha-1 antitrypsin deficiency in composite heterozygotes inheriting a new splicing mutation QOMadrid.

Lara B, Martínez MT, Blanco I, Hernández-Moro C, Velasco EA, Ferrarotti I, Rodriguez-Frias F, Perez L, Vazquez I, Alonso J, Posada M, Martínez-Delgado B.

Respir Res. 2014 Oct 7;15:125. doi: 10.1186/s12931-014-0125-y.

24.

The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency.

Pini L, Tiberio L, Venkatesan N, Bezzi M, Corda L, Luisetti M, Ferrarotti I, Malerba M, Lomas DA, Janciauskiene S, Vizzardi E, Modina D, Schiaffonati L, Tantucci C.

Respir Res. 2014 Sep 14;15:112. doi: 10.1186/s12931-014-0112-3.

25.

Rare α₁-antitrypsin genotype in a grass seed worker.

Malling TH, Carlsen LS, Ferrarotti I, Omland O.

Eur Respir J. 2014 Dec;44(6):1703-4. doi: 10.1183/09031936.00118214. Epub 2014 Sep 3. No abstract available.

26.

COPD: no gene left unturned.

Ferrarotti I, Luisetti M.

Lancet Respir Med. 2014 Mar;2(3):171-2. doi: 10.1016/S2213-2600(14)70026-8. Epub 2014 Feb 7. No abstract available.

PMID:
24621676
27.

Interactions between SERPINA1 PiMZ genotype, occupational exposure and lung function decline.

Mehta AJ, Thun GA, Imboden M, Ferrarotti I, Keidel D, Künzli N, Kromhout H, Miedinger D, Phuleria H, Rochat T, Russi EW, Schindler C, Schwartz J, Vermeulen R, Luisetti M, Probst-Hensch N; SAPALDIA team.

Occup Environ Med. 2014 Apr;71(4):234-40. doi: 10.1136/oemed-2013-101592. Epub 2013 Nov 8.

PMID:
24213563
28.

α₁-Antitrypsin level and pheno/genotypes.

Ferrarotti I, Thun GA, Probst-Hensch NM, Luisetti M.

Chest. 2013 Nov;144(5):1732-1733. doi: 10.1378/chest.13-1464. No abstract available.

PMID:
24189872
29.

Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels.

Thun GA, Imboden M, Ferrarotti I, Kumar A, Obeidat M, Zorzetto M, Haun M, Curjuric I, Couto Alves A, Jackson VE, Albrecht E, Ried JS, Teumer A, Lopez LM, Huffman JE, Enroth S, Bossé Y, Hao K, Timens W, Gyllensten U, Polasek O, Wilson JF, Rudan I, Hayward C, Sandford AJ, Deary IJ, Koch B, Reischl E, Schulz H, Hui J, James AL, Rochat T, Russi EW, Jarvelin MR, Strachan DP, Hall IP, Tobin MD, Dahl M, Fallgaard Nielsen S, Nordestgaard BG, Kronenberg F, Luisetti M, Probst-Hensch NM.

PLoS Genet. 2013;9(8):e1003585. doi: 10.1371/journal.pgen.1003585. Epub 2013 Aug 22.

30.

Alpha1-antitrypsin deficiency - diagnostic testing and disease awareness in Germany and Italy.

Greulich T, Ottaviani S, Bals R, Lepper PM, Vogelmeier C, Luisetti M, Ferrarotti I.

Respir Med. 2013 Sep;107(9):1400-8. doi: 10.1016/j.rmed.2013.04.023. Epub 2013 Jun 17.

31.

Clinical phenotypes of Italian and Spanish patients with α1-antitrypsin deficiency.

Piras B, Ferrarotti I, Lara B, Martinez MT, Bustamante A, Ottaviani S, Pirina P, Luisetti M, Miravitlles M.

Eur Respir J. 2013 Jul;42(1):54-64. doi: 10.1183/09031936.00104712. Epub 2012 Dec 6.

32.

SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort.

Thun GA, Ferrarotti I, Imboden M, Rochat T, Gerbase M, Kronenberg F, Bridevaux PO, Zemp E, Zorzetto M, Ottaviani S, Russi EW, Luisetti M, Probst-Hensch NM.

PLoS One. 2012;7(8):e42728. doi: 10.1371/journal.pone.0042728. Epub 2012 Aug 13.

33.

Three new alpha1-antitrypsin deficiency variants help to define a C-terminal region regulating conformational change and polymerization.

Fra AM, Gooptu B, Ferrarotti I, Miranda E, Scabini R, Ronzoni R, Benini F, Corda L, Medicina D, Luisetti M, Schiaffonati L.

PLoS One. 2012;7(6):e38405. doi: 10.1371/journal.pone.0038405. Epub 2012 Jun 18.

34.

Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency.

Koczulla AR, Jonigk D, Wolf T, Herr C, Noeske S, Klepetko W, Vogelmeier C, von Neuhoff N, Rische J, Wrenger S, Golpon H, Voswinckel R, Luisetti M, Ferrarotti I, Welte T, Janciauskiene S.

Orphanet J Rare Dis. 2012 May 23;7:29. doi: 10.1186/1750-1172-7-29.

35.

Serum levels and genotype distribution of α1-antitrypsin in the general population.

Ferrarotti I, Thun GA, Zorzetto M, Ottaviani S, Imboden M, Schindler C, von Eckardstein A, Rohrer L, Rochat T, Russi EW, Probst-Hensch NM, Luisetti M.

Thorax. 2012 Aug;67(8):669-74. doi: 10.1136/thoraxjnl-2011-201321. Epub 2012 Mar 16.

PMID:
22426792
36.

C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants.

Ottaviani S, Gorrini M, Scabini R, Kadija Z, Paracchini E, Mariani F, Ferrarotti I, Luisetti M.

Transl Res. 2011 Jun;157(6):332-8. doi: 10.1016/j.trsl.2010.12.014. Epub 2011 Jan 27.

PMID:
21575917
37.

Clinical utility gene card for: α-1-antitrypsin deficiency.

Janciauskiene S, Ferrarotti I, Laenger F, Jonigk D, Luisetti M.

Eur J Hum Genet. 2011 May;19(5). doi: 10.1038/ejhg.2010.246. Epub 2011 Jan 19. No abstract available.

38.

Laboratory testing of individuals with severe alpha1-antitrypsin deficiency in three European centres.

Miravitlles M, Herr C, Ferrarotti I, Jardi R, Rodriguez-Frias F, Luisetti M, Bals R.

Eur Respir J. 2010 May;35(5):960-8. doi: 10.1183/09031936.00069709.

39.

The problems of clinical trials and registries in rare diseases.

Luisetti M, Campo I, Scabini R, Zorzetto M, Kadija Z, Mariani F, Ferrarotti I.

Respir Med. 2010 Jul;104 Suppl 1:S42-4. doi: 10.1016/j.rmed.2010.03.016. Epub 2010 Apr 21.

40.

Screening for Alpha 1 antitrypsin deficiency in Tunisian subjects with obstructive lung disease: a feasibility report.

Denden S, Zorzetto M, Amri F, Knani J, Ottaviani S, Scabini R, Gorrini M, Ferrarotti I, Campo I, Chibani JB, Khelil AH, Luisetti M.

Orphanet J Rare Dis. 2009 Apr 15;4:12. doi: 10.1186/1750-1172-4-12.

41.

SERPINA1 gene variants in individuals from the general population with reduced alpha1-antitrypsin concentrations.

Zorzetto M, Russi E, Senn O, Imboden M, Ferrarotti I, Tinelli C, Campo I, Ottaviani S, Scabini R, von Eckardstein A, Berger W, Brändli O, Rochat T, Luisetti M, Probst-Hensch N; SAPALDIA Team.

Clin Chem. 2008 Aug;54(8):1331-8. doi: 10.1373/clinchem.2007.102798. Epub 2008 May 29.

42.

Secondary outputs of alpha1-antitrypsin deficiency targeted detection programme.

Ferrarotti I, Gorrini M, Scabini R, Ottaviani S, Mazzola P, Campo I, Zorzetto M, Luisetti M.

Respir Med. 2008 Mar;102(3):354-8.

43.

Pro-inflammatory variants of DRB1 and RAGE genes are associated with susceptibility to pediatric type 1 diabetes: a new hypothesis on the adaptive role of autoimmunity.

Damiani G, Campo I, Zorzetto M, Bozzi V, Disabella E, Caroli A, Ferrarotti I, D'Annunzio G, Pasi A, Martinetti M, Cuccia M.

Riv Biol. 2007 May-Aug;100(2):285-304. Review.

PMID:
17987563
44.

Protein expression in sputum of smokers and chronic obstructive pulmonary disease patients: a pilot study by CapLC-ESI-Q-TOF.

Casado B, Iadarola P, Pannell LK, Luisetti M, Corsico A, Ansaldo E, Ferrarotti I, Boschetto P, Baraniuk JN.

J Proteome Res. 2007 Dec;6(12):4615-23. Epub 2007 Nov 1.

PMID:
17973440
45.

Laboratory diagnosis of alpha1-antitrypsin deficiency.

Ferrarotti I, Scabini R, Campo I, Ottaviani S, Zorzetto M, Gorrini M, Luisetti M.

Transl Res. 2007 Nov;150(5):267-74. Epub 2007 Sep 14. Review. Erratum in: Transl Res. 2008 Apr;151(4):232.

PMID:
17964515
46.

Expression of receptor for advanced glycation end products in sarcoid granulomas.

Campo I, Morbini P, Zorzetto M, Tinelli C, Brunetta E, Villa C, Bombieri C, Cuccia M, Agostini C, Bozzi V, Facoetti A, Ferrarotti I, Mazzola P, Scabini R, Semenzato G, Pignatti PF, Pozzi E, Luisetti M.

Am J Respir Crit Care Med. 2007 Mar 1;175(5):498-506. Epub 2006 Dec 14.

PMID:
17170388
47.

Validation of a rapid, simple method to measure alpha1-antitrypsin in human dried blood spots.

Gorrini M, Ferrarotti I, Lupi A, Bosoni T, Mazzola P, Scabini R, Campo I, Zorzetto M, Novazi F, Luisetti M.

Clin Chem. 2006 May;52(5):899-901. No abstract available.

48.

NOD2/CARD15 gene polymorphisms in idiopathic pulmonary fibrosis.

Zorzetto M, Ferrarotti I, Campo I, Trisolini R, Poletti V, Scabini R, Ceruti M, Mazzola P, Crippa E, Ottaviani S, Agostini C, Semenzato G, Pozzi E, Luisetti M.

Sarcoidosis Vasc Diffuse Lung Dis. 2005 Oct;22(3):180-5.

PMID:
16315780
49.

Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles.

de Serres FJ, Luisetti M, Ferrarotti I, Blanco I, Fernández-Bustillo E.

Monaldi Arch Chest Dis. 2005 Sep;63(3):133-41.

PMID:
16312203
50.

CR1 gene polymorphism in Finland.

Zorzetto M, Ferrarotti I, Campo I, Luisetti M.

Respir Med. 2006 Jan;100(1):186-7; author reply 188. Epub 2005 Aug 26. No abstract available.

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