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Items: 1 to 50 of 78

1.

Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis.

Nácher-Juan J, Terencio MC, Alcaraz MJ, Ferrándiz ML.

Int J Mol Sci. 2019 Aug 7;20(16). pii: E3845. doi: 10.3390/ijms20163845.

2.

Emerging therapeutic agents in osteoarthritis.

Alcaraz MJ, Guillén MI, Ferrándiz ML.

Biochem Pharmacol. 2019 Jul;165:4-16. doi: 10.1016/j.bcp.2019.02.034. Epub 2019 Feb 28. Review.

PMID:
30826327
3.

Nrf2 as a therapeutic target for rheumatic diseases.

Ferrándiz ML, Nacher-Juan J, Alcaraz MJ.

Biochem Pharmacol. 2018 Jun;152:338-346. doi: 10.1016/j.bcp.2018.04.010. Epub 2018 Apr 13. Review.

PMID:
29660314
4.

Myeloid Heme Oxygenase-1 Regulates the Acute Inflammatory Response to Zymosan in the Mouse Air Pouch.

Brines R, Catalán L, Alcaraz MJ, Ferrándiz ML.

Oxid Med Cell Longev. 2018 Feb 11;2018:5053091. doi: 10.1155/2018/5053091. eCollection 2018.

5.

Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles.

García-Fernández A, García-Laínez G, Ferrándiz ML, Aznar E, Sancenón F, Alcaraz MJ, Murguía JR, Marcos MD, Martínez-Máñez R, Costero AM, Orzáez M.

J Control Release. 2017 Feb 28;248:60-70. doi: 10.1016/j.jconrel.2017.01.002. Epub 2017 Jan 6.

6.

Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats.

Terencio MC, Ferrándiz ML, Carceller MC, Ruhí R, Dalmau P, Vergés J, Montell E, Torrent A, Alcaraz MJ.

Biomed Pharmacother. 2016 Apr;79:120-8. doi: 10.1016/j.biopha.2016.02.005. Epub 2016 Feb 18.

PMID:
27044820
7.

Paracrine in vivo inhibitory effects of adipose tissue-derived mesenchymal stromal cells in the early stages of the acute inflammatory response.

Carceller MC, Guillén MI, Ferrándiz ML, Alcaraz MJ.

Cytotherapy. 2015 Sep;17(9):1230-9. doi: 10.1016/j.jcyt.2015.06.001.

PMID:
26276006
8.

Effects of BIS076 in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats.

Ferrándiz ML, Terencio MC, Carceller MC, Ruhí R, Dalmau P, Vergés J, Montell E, Torrent A, Alcaraz MJ.

BMC Musculoskelet Disord. 2015 Apr 17;16:92. doi: 10.1186/s12891-015-0547-9.

9.

Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis.

Rosillo MÁ, Alcaraz MJ, Sánchez-Hidalgo M, Fernández-Bolaños JG, Alarcón-de-la-Lastra C, Ferrándiz ML.

J Nutr Biochem. 2014 Dec;25(12):1275-81. doi: 10.1016/j.jnutbio.2014.07.006. Epub 2014 Sep 16.

PMID:
25294776
10.

Effects of Nrf2 deficiency on bone microarchitecture in an experimental model of osteoporosis.

Ibáñez L, Ferrándiz ML, Brines R, Guede D, Cuadrado A, Alcaraz MJ.

Oxid Med Cell Longev. 2014;2014:726590. doi: 10.1155/2014/726590. Epub 2014 Jul 7.

11.

Influence of age on osteoarthritis progression after anterior cruciate ligament transection in rats.

Ferrándiz ML, Terencio MC, Ruhí R, Vergés J, Montell E, Torrent A, Alcaraz MJ.

Exp Gerontol. 2014 Jul;55:44-8. doi: 10.1016/j.exger.2014.03.010. Epub 2014 Mar 22.

PMID:
24667123
12.

Heme oxygenase-1 regulates the progression of K/BxN serum transfer arthritis.

Brines R, Maicas N, Ferrándiz ML, Loboda A, Jozkowicz A, Dulak J, Alcaraz MJ.

PLoS One. 2012;7(12):e52435. doi: 10.1371/journal.pone.0052435. Epub 2012 Dec 20.

13.

Downregulation of the inflammatory response by CORM-3 results in protective effects in a model of postmenopausal arthritis.

Ibáñez L, Alcaraz MJ, Maicas N, Guede D, Caeiro JR, Motterlini R, Ferrándiz ML.

Calcif Tissue Int. 2012 Jul;91(1):69-80. doi: 10.1007/s00223-012-9612-7. Epub 2012 May 29.

PMID:
22644323
14.

Analysis of early biochemical markers and regulation by tin protoporphyrin IX in a model of spontaneous osteoarthritis.

Braza-Boïls A, Ferrándiz ML, Terencio MC, Alcaraz MJ.

Exp Gerontol. 2012 May;47(5):406-9. doi: 10.1016/j.exger.2012.03.005. Epub 2012 Mar 17.

PMID:
22459696
15.

Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis.

Maicas N, Ibáñez L, Alcaraz MJ, Úbeda A, Ferrándiz ML.

Arthritis Rheum. 2012 Jan;64(1):130-40. doi: 10.1002/art.30656.

16.

Regulation of the inflammatory response by tin protoporphyrin IX in the rat anterior cruciate ligament transection model of osteoarthritis.

Braza-Boïls A, Alcaraz MJ, Ferrándiz ML.

J Orthop Res. 2011 Sep;29(9):1375-82. doi: 10.1002/jor.21411. Epub 2011 Mar 28.

17.

Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease.

Maicas N, Ferrándiz ML, Brines R, Ibáñez L, Cuadrado A, Koenders MI, van den Berg WB, Alcaraz MJ.

Antioxid Redox Signal. 2011 Aug 15;15(4):889-901. doi: 10.1089/ars.2010.3835. Epub 2011 May 25.

18.

Up-regulation of the inflammatory response by ovariectomy in collagen-induced arthritis. effects of tin protoporphyrin IX.

Ibáñez L, Alcaraz MJ, Maicas N, Guede D, Caeiro JR, Koenders MI, van den Berg WB, Ferrándiz ML.

Inflammation. 2011 Dec;34(6):585-96. doi: 10.1007/s10753-010-9266-4.

PMID:
21046213
19.

The CO-releasing molecule CORM-3 protects against articular degradation in the K/BxN serum transfer arthritis model.

Maicas N, Ferrándiz ML, Devesa I, Motterlini R, Koenders MI, van den Berg WB, Alcaraz MJ.

Eur J Pharmacol. 2010 May 25;634(1-3):184-91. doi: 10.1016/j.ejphar.2010.02.028. Epub 2010 Feb 23.

PMID:
20184873
20.

Inducers of heme oxygenase-1.

Ferrándiz ML, Devesa I.

Curr Pharm Des. 2008;14(5):473-86. Review.

PMID:
18289074
21.

Carbon monoxide-releasing molecules: a pharmacological expedient to counteract inflammation.

Alcaraz MJ, Guillen MI, Ferrandiz ML, Megías J, Motterlini R.

Curr Pharm Des. 2008;14(5):465-72.

PMID:
18289073
22.

Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis.

Ferrándiz ML, Maicas N, Garcia-Arnandis I, Terencio MC, Motterlini R, Devesa I, Joosten LA, van den Berg WB, Alcaraz MJ.

Ann Rheum Dis. 2008 Sep;67(9):1211-7. Epub 2007 Dec 6.

PMID:
18063671
23.

Evaluation of the anti-inflammatory and analgesic activity of Me-UCH9, a dual cyclooxygenase-2/5-lipoxygenase inhibitor.

Araico A, Terencio MC, Alcaraz MJ, Domínguez JN, León C, Ferrándiz ML.

Life Sci. 2007 May 16;80(23):2108-2117. doi: 10.1016/j.lfs.2007.03.017. Epub 2007 Apr 4.

PMID:
17490689
24.

Phenylsulphonyl urenyl chalcone derivatives as dual inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase.

Araico A, Terencio MC, Alcaraz MJ, Domínguez JN, León C, Ferrándiz ML.

Life Sci. 2006 May 15;78(25):2911-8. Epub 2005 Dec 20.

PMID:
16360707
25.

Effects of heme oxygenase-1 inducers on established rat adjuvant arthritis.

Devesa I, Ferrándiz ML, Busserolles J, Alcaraz MJ.

Cell Mol Biol (Noisy-le-grand). 2005 Oct 3;51(5):479-85.

PMID:
16309570
26.

Influence of heme oxygenase 1 modulation on the progression of murine collagen-induced arthritis.

Devesa I, Ferrándiz ML, Terencio MC, Joosten LA, van den Berg WB, Alcaraz MJ.

Arthritis Rheum. 2005 Oct;52(10):3230-8.

27.

Potential role of heme oxygenase-1 in the progression of rat adjuvant arthritis.

Devesa I, Ferrándiz ML, Guillén I, Cerdá JM, Alcaraz MJ.

Lab Invest. 2005 Jan;85(1):34-44.

28.

Role of nuclear factor-kappaB and heme oxygenase-1 in the mechanism of action of an anti-inflammatory chalcone derivative in RAW 264.7 cells.

Alcaraz MJ, Vicente AM, Araico A, Dominguez JN, Terencio MC, Ferrándiz ML.

Br J Pharmacol. 2004 Aug;142(7):1191-9. Epub 2004 Jul 12.

29.

Toll-like receptor 2 is dispensable for acquired host immune resistance to Candida albicans in a murine model of disseminated candidiasis.

Villamón E, Gozalbo D, Roig P, O'Connor JE, Ferrandiz ML, Fradelizi D, Gil ML.

Microbes Infect. 2004 May;6(6):542-8.

PMID:
15158187
30.

A new pyrazolo pyrimidine derivative inhibitor of cyclooxygenase-2 with anti-angiogenic activity.

Devesa I, Alcaraz MJ, Riguera R, Ferrándiz ML.

Eur J Pharmacol. 2004 Mar 19;488(1-3):225-30.

PMID:
15044055
31.

Therapeutic administration of 3,4,5-trimethoxy-4'-fluorochalcone, a selective inhibitor of iNOS expression, attenuates the development of adjuvant-induced arthritis in rats.

Rojas J, Payá M, Devesa I, Dominguez JN, Ferrándiz ML.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):225-33. Epub 2003 Aug 2.

PMID:
12904830
32.

ttCH, a selective inhibitor of inducible nitric oxide synthase expression with antiarthritic properties.

Rojas J, Payá M, Domínguez JN, Ferrándiz ML.

Eur J Pharmacol. 2003 Mar 28;465(1-2):183-9.

PMID:
12650848
33.

6-Dimethylamino 1H-pyrazolo[3,4-d]pyrimidine derivatives as new inhibitors of inflammatory mediators in intact cells.

Quintela JM, Peinador C, González L, Devesa I, Ferrándiz ML, Alcaraz MJ, Riguera R.

Bioorg Med Chem. 2003 Mar 20;11(6):863-8.

PMID:
12614871
34.

Synthesis and inhibitory activity of dimethylamino-chalcone derivatives on the induction of nitric oxide synthase.

Rojas J, Domínguez JN, Charris JE, Lobo G, Payá M, Ferrándiz ML.

Eur J Med Chem. 2002 Aug;37(8):699-705.

PMID:
12161067
35.

Nitric oxide-scavenging properties of some chalcone derivatives.

Herencia F, López-García MP, Ubeda A, Ferrándiz ML.

Nitric Oxide. 2002 Mar;6(2):242-6.

PMID:
11890750
36.

Effect of some hexahydroimidazo[1,2-c]pyrimidines in inflammatory responses involving leucocytes and macrophages.

Vidal A, Ferrándiz ML, Ubeda A, Acero-Alarcon A, Sepulveda-Arques J, Alcaraz MJ.

J Pharm Pharmacol. 2001 Oct;53(10):1379-85.

PMID:
11697546
37.

Effect of imidazo[1,2-a]pyrimidine derivatives on leukocyte function.

Vidal A, Ferrándiz ML, Ubeda A, Acero-Alarcón A, Sepulveda-Arques J, Alcaraz MJ.

Inflamm Res. 2001 Jun;50(6):317-20.

PMID:
11475333
38.

Inhibition of 5-lipoxygenase activity by the natural anti-inflammatory compound aethiopinone.

Benrezzouk R, Terencio MC, Ferrandiz ML, Hernandez-Perez M, Rabanal R, Alcaraz MJ.

Inflamm Res. 2001 Feb;50(2):96-101.

PMID:
11289660
39.

4-dimethylamino-3',4'-dimethoxychalcone downregulates iNOS expression and exerts anti-inflammatory effects.

Herencia F, Ferrándiz ML, Ubeda A, Guillén I, Dominguez JN, Charris JE, Lobo GM, Alcaraz MJ.

Free Radic Biol Med. 2001 Jan 1;30(1):43-50.

PMID:
11134894
40.

Effects of some isoxazolpyrimidine derivatives on nitric oxide and eicosanoid biosynthesis.

Vidal A, Ferrándiz ML, Ubeda A, Guillén I, Riguera R, Quintela JM, Peinador C, Moreira MJ, Alcaraz MJ.

Life Sci. 2000 Jan 21;66(9):PL125-31.

PMID:
10698360
41.

Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation.

Posadas I, Terencio MC, Guillén I, Ferrándiz ML, Coloma J, Payá M, Alcaraz MJ.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Jan;361(1):98-106.

PMID:
10651154
42.

Novel anti-inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages.

Herencia F, Ferrándiz ML, Ubeda A, Guillén I, Dominguez JN, Charris JE, Lobo GM, Alcaraz MJ.

FEBS Lett. 1999 Jun 18;453(1-2):129-34.

43.

Inhibition of human sPLA2 and 5-lipoxygenase activities by two neo-clerodane diterpenoids.

Benrezzouk R, Terencio MC, Ferrándiz ML, San Feliciano A, Gordaliza M, Miguel del Corral JM, de la Puente ML, Alcaraz MJ.

Life Sci. 1999;64(19):PL205-11.

PMID:
10353635
44.

Hypothesis: can N-acetylcysteine be beneficial in Parkinson's disease?

Martínez M, Martínez N, Hernández AI, Ferrándiz ML.

Life Sci. 1999;64(15):1253-7. Review.

PMID:
10227580
45.

Synthesis and anti-inflammatory activity of chalcone derivatives.

Herencia F, Ferrándiz ML, Ubeda A, Domínguez JN, Charris JE, Lobo GM, Alcaraz MJ.

Bioorg Med Chem Lett. 1998 May 19;8(10):1169-74.

PMID:
9871729
46.

A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.

De Rosa S, Crispino A, De Giulio A, Iodice C, Benrezzouk R, Terencio MC, Ferrándiz ML, Alcaraz MJ, Payá M.

J Nat Prod. 1998 Jul;61(7):931-5.

PMID:
9677277
47.

Suppression of leukotriene B4 and tumour necrosis factor alpha release in acute inflammatory responses by novel prenylated hydroquinone derivatives.

Terencio MC, Ferrándiz ML, Posadas I, Roig E, de Rosa S, De Giulio A, Payá M, Alcaraz MJ.

Naunyn Schmiedebergs Arch Pharmacol. 1998 May;357(5):565-72.

PMID:
9650811
48.

Anti-inflammatory activity in mice of extracts from Mediterranean marine invertebrates.

Herencia F, Ubeda A, Ferrándiz ML, Terencio MC, Alcaraz MJ, García-Carrascosa M, Capaccioni R, Payá M.

Life Sci. 1998;62(9):PL115-20.

PMID:
9496704
49.

N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria.

Banaclocha MM, Hernández AI, Martínez N, Ferrándiz ML.

Brain Res. 1997 Jul 11;762(1-2):256-8.

PMID:
9262186
50.

Variabilin: a dual inhibitor of human secretory and cytosolic phospholipase A2 with anti-inflammatory activity.

Escrig V, Ubeda A, Ferrandiz ML, Darias J, Sanchez JM, Alcaraz MJ, Paya M.

J Pharmacol Exp Ther. 1997 Jul;282(1):123-31.

PMID:
9223548

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