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Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189.

Jolivalt CG, Marquez A, Quach D, Navarro Diaz MC, Anaya C, Kifle B, Muttalib N, Sanchez G, Guernsey L, Hefferan M, Smith DR, Fernyhough P, Johe K, Calcutt NA.

Diabetes. 2019 Nov;68(11):2143-2154. doi: 10.2337/db19-0271. Epub 2019 Sep 6.


Poly(ADP-ribose) polymerase-1 inhibits mitochondrial respiration by suppressing PGC-1α activity in neurons.

Lu P, Hogan-Cann AD, Kamboj A, Roy Chowdhury SK, Aghanoori MR, Fernyhough P, Anderson CM.

Neuropharmacology. 2019 Dec 1;160:107755. doi: 10.1016/j.neuropharm.2019.107755. Epub 2019 Sep 2.



Fernyhough P, Calcutt NA.

Int Rev Neurobiol. 2019;145:xi-xii. doi: 10.1016/S0074-7742(19)30043-1. No abstract available.


Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes.

Aghanoori MR, Smith DR, Shariati-Ievari S, Ajisebutu A, Nguyen A, Desmond F, Jesus CHA, Zhou X, Calcutt NA, Aliani M, Fernyhough P.

Mol Metab. 2019 Feb;20:149-165. doi: 10.1016/j.molmet.2018.11.008. Epub 2018 Nov 28.


Muscarinic receptor antagonists activate ERK-CREB signaling to augment neurite outgrowth of adult sensory neurons.

Sabbir MG, Fernyhough P.

Neuropharmacology. 2018 Dec;143:268-281. doi: 10.1016/j.neuropharm.2018.09.020. Epub 2018 Sep 22.


High glucose concentration suppresses a SIRT2 regulated pathway that enhances neurite outgrowth in cultured adult sensory neurons.

Schartner E, Sabbir MG, Saleh A, Silva RV, Roy Chowdhury S, Smith DR, Fernyhough P.

Exp Neurol. 2018 Nov;309:134-147. doi: 10.1016/j.expneurol.2018.08.001. Epub 2018 Aug 10.


Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents.

Roy Chowdhury S, Djordjevic J, Thomson E, Smith DR, Albensi BC, Fernyhough P.

Mol Cell Neurosci. 2018 May 23;90:49-59. doi: 10.1016/j.mcn.2018.05.006. [Epub ahead of print]


Early passaging of mesenchymal stem cells does not instigate significant modifications in their immunological behavior.

Sareen N, Sequiera GL, Chaudhary R, Abu-El-Rub E, Chowdhury SR, Sharma V, Surendran A, Moudgil M, Fernyhough P, Ravandi A, Dhingra S.

Stem Cell Res Ther. 2018 May 2;9(1):121. doi: 10.1186/s13287-018-0867-4.


Chronic dietary creatine enhances hippocampal-dependent spatial memory, bioenergetics, and levels of plasticity-related proteins associated with NF-κB.

Snow WM, Cadonic C, Cortes-Perez C, Roy Chowdhury SK, Djordjevic J, Thomson E, Bernstein MJ, Suh M, Fernyhough P, Albensi BC.

Learn Mem. 2018 Jan 16;25(2):54-66. doi: 10.1101/lm.046284.117. Print 2018 Feb.


Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats.

Aghanoori MR, Smith DR, Roy Chowdhury S, Sabbir MG, Calcutt NA, Fernyhough P.

Exp Neurol. 2017 Nov;297:148-157. doi: 10.1016/j.expneurol.2017.08.005. Epub 2017 Aug 10.


Brain region- and sex-specific alterations in mitochondrial function and NF-κB signaling in the TgCRND8 mouse model of Alzheimer's disease.

Djordjevic J, Thomson E, Chowdhury SR, Snow WM, Perez C, Wong TP, Fernyhough P, Albensi BC.

Neuroscience. 2017 Oct 11;361:81-92. doi: 10.1016/j.neuroscience.2017.08.006. Epub 2017 Aug 9.


A model of chronic diabetic polyneuropathy: benefits from intranasal insulin are modified by sex and RAGE deletion.

de la Hoz CL, Cheng C, Fernyhough P, Zochodne DW.

Am J Physiol Endocrinol Metab. 2017 May 1;312(5):E407-E419. doi: 10.1152/ajpendo.00444.2016. Epub 2017 Feb 21.


Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy.

Calcutt NA, Smith DR, Frizzi K, Sabbir MG, Chowdhury SK, Mixcoatl-Zecuatl T, Saleh A, Muttalib N, Van der Ploeg R, Ochoa J, Gopaul A, Tessler L, Wess J, Jolivalt CG, Fernyhough P.

J Clin Invest. 2017 Feb 1;127(2):608-622. doi: 10.1172/JCI88321. Epub 2017 Jan 17.


Gentisic acid sodium salt, a phenolic compound, is superior to norepinephrine in reversing cardiovascular collapse, hepatic mitochondrial dysfunction and lactic acidemia in Pseudomonas aeruginosa septic shock in dogs.

Mink S, Roy Chowdhury SK, Gotes J, Cheng ZQ, Kasian K, Fernyhough P.

Intensive Care Med Exp. 2016 Dec;4(1):24. doi: 10.1186/s40635-016-0095-0. Epub 2016 Jul 26.


New Directions in Diabetic Neuropathy: Evolution or Extinction?

Fernyhough P, Calcutt NA.

Int Rev Neurobiol. 2016;127:229-34. doi: 10.1016/bs.irn.2016.03.009. Epub 2016 Apr 5. No abstract available.


An Introduction to the History and Controversies of the Pathogenesis of Diabetic Neuropathy.

Fernyhough P, Calcutt NA.

Int Rev Neurobiol. 2016;127:115-20. doi: 10.1016/bs.irn.2016.03.012. Epub 2016 Apr 6. No abstract available.


An Introduction to the History and Controversies of Animal Models of Diabetic Neuropathy.

Calcutt NA, Fernyhough P.

Int Rev Neurobiol. 2016;127:45-52. doi: 10.1016/bs.irn.2016.03.011. Epub 2016 Apr 6. No abstract available.


A Brief Introduction to the History and Controversies of Clinical Trials in Diabetic Neuropathy.

Calcutt NA, Fernyhough P.

Int Rev Neurobiol. 2016;127:3-8. doi: 10.1016/bs.irn.2016.03.014. Epub 2016 Apr 6. No abstract available.


Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria.

Chowdhury SR, Djordjevic J, Albensi BC, Fernyhough P.

Biosci Rep. 2015 Dec 8;36(1):e00286. doi: 10.1042/BSR20150244.


Mitochondrial dysfunction in diabetic neuropathy: a series of unfortunate metabolic events.

Fernyhough P.

Curr Diab Rep. 2015 Nov;15(11):89. doi: 10.1007/s11892-015-0671-9. Review.


The proinflammatory cytokine, interleukin-17A, augments mitochondrial function and neurite outgrowth of cultured adult sensory neurons derived from normal and diabetic rats.

Habash T, Saleh A, Roy Chowdhury SK, Smith DR, Fernyhough P.

Exp Neurol. 2015 Nov;273:177-89. doi: 10.1016/j.expneurol.2015.08.016. Epub 2015 Aug 28.


Rabies virus phosphoprotein interacts with mitochondrial Complex I and induces mitochondrial dysfunction and oxidative stress.

Kammouni W, Wood H, Saleh A, Appolinario CM, Fernyhough P, Jackson AC.

J Neurovirol. 2015 Aug;21(4):370-82. doi: 10.1007/s13365-015-0320-8. Epub 2015 Feb 20.


Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling.

Dhingra R, Margulets V, Chowdhury SR, Thliveris J, Jassal D, Fernyhough P, Dorn GW 2nd, Kirshenbaum LA.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5537-44. doi: 10.1073/pnas.1414665111. Epub 2014 Dec 8.


Mechanisms of disease: Mitochondrial dysfunction in sensory neuropathy and other complications in diabetes.

Fernyhough P, McGavock J.

Handb Clin Neurol. 2014;126:353-77. doi: 10.1016/B978-0-444-53480-4.00027-8. Review.


Calcium signalling in sensory neurones and peripheral glia in the context of diabetic neuropathies.

Verkhratsky A, Fernyhough P.

Cell Calcium. 2014 Nov;56(5):362-71. doi: 10.1016/j.ceca.2014.07.005. Epub 2014 Aug 1. Review.


Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab).

Biessels GJ, Bril V, Calcutt NA, Cameron NE, Cotter MA, Dobrowsky R, Feldman EL, Fernyhough P, Jakobsen J, Malik RA, Mizisin AP, Oates PJ, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt RE, Tesfaye S, Veves A, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D, Zochodne DW.

J Peripher Nerv Syst. 2014 Jun;19(2):77-87. doi: 10.1111/jns5.12072. Review.


Temporal dystrophic remodeling within the intrinsic cardiac nervous system of the streptozotocin-induced diabetic rat model.

Menard CE, Durston M, Zherebitskaya E, Smith DR, Freed D, Glazner GW, Tian G, Fernyhough P, Arora RC.

Acta Neuropathol Commun. 2014 Jun 4;2:60. doi: 10.1186/2051-5960-2-60.


Ciliary neurotrophic factor reverses aberrant mitochondrial bioenergetics through the JAK/STAT pathway in cultured sensory neurons derived from streptozotocin-induced diabetic rodents.

Chowdhury SR, Saleh A, Akude E, Smith DR, Morrow D, Tessler L, Calcutt NA, Fernyhough P.

Cell Mol Neurobiol. 2014 Jul;34(5):643-9. doi: 10.1007/s10571-014-0054-9. Epub 2014 Mar 30.


Mitochondrial dysfunction in rabies virus infection of neurons.

Alandijany T, Kammouni W, Roy Chowdhury SK, Fernyhough P, Jackson AC.

J Neurovirol. 2013 Dec;19(6):537-49. doi: 10.1007/s13365-013-0214-6. Epub 2013 Nov 26.


Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons.

Saleh A, Chowdhury SK, Smith DR, Balakrishnan S, Tessler L, Schartner E, Bilodeau A, Van Der Ploeg R, Fernyhough P.

Mol Brain. 2013 Oct 24;6:45. doi: 10.1186/1756-6606-6-45.


Receptor for advanced glycation end-products (RAGE) activates divergent signaling pathways to augment neurite outgrowth of adult sensory neurons.

Saleh A, Smith DR, Tessler L, Mateo AR, Martens C, Schartner E, Van der Ploeg R, Toth C, Zochodne DW, Fernyhough P.

Exp Neurol. 2013 Nov;249:149-59. doi: 10.1016/j.expneurol.2013.08.018. Epub 2013 Sep 10.


Guaifenesin derivatives promote neurite outgrowth and protect diabetic mice from neuropathy.

Hadimani MB, Purohit MK, Vanampally C, Van der Ploeg R, Arballo V, Morrow D, Frizzi KE, Calcutt NA, Fernyhough P, Kotra LP.

J Med Chem. 2013 Jun 27;56(12):5071-8. doi: 10.1021/jm400401y. Epub 2013 Jun 13.


Normalization of NF-κB activity in dorsal root ganglia neurons cultured from diabetic rats reverses neuropathy-linked markers of cellular pathology.

Saleh A, Schapansky J, Smith DR, Young N, Odero GL, Aulston B, Fernyhough P, Glazner GW.

Exp Neurol. 2013 Mar;241:169-78. doi: 10.1016/j.expneurol.2012.11.009. Epub 2012 Nov 15.


Ciliary neurotrophic factor activates NF-κB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents.

Saleh A, Roy Chowdhury SK, Smith DR, Balakrishnan S, Tessler L, Martens C, Morrow D, Schartner E, Frizzi KE, Calcutt NA, Fernyhough P.

Neuropharmacology. 2013 Feb;65:65-73. doi: 10.1016/j.neuropharm.2012.09.015. Epub 2012 Sep 26.


Role of nuclear factor-κB in oxidative stress associated with rabies virus infection of adult rat dorsal root ganglion neurons.

Kammouni W, Hasan L, Saleh A, Wood H, Fernyhough P, Jackson AC.

J Virol. 2012 Aug;86(15):8139-46. doi: 10.1128/JVI.00550-12. Epub 2012 May 23.


Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes.

Roy Chowdhury SK, Smith DR, Saleh A, Schapansky J, Marquez A, Gomes S, Akude E, Morrow D, Calcutt NA, Fernyhough P.

Brain. 2012 Jun;135(Pt 6):1751-66. doi: 10.1093/brain/aws097. Epub 2012 May 4.


The role of aberrant mitochondrial bioenergetics in diabetic neuropathy.

Chowdhury SK, Smith DR, Fernyhough P.

Neurobiol Dis. 2013 Mar;51:56-65. doi: 10.1016/j.nbd.2012.03.016. Epub 2012 Mar 9. Review.


Sensory neurons derived from diabetic rats have diminished internal Ca2+ stores linked to impaired re-uptake by the endoplasmic reticulum.

Zherebitskaya E, Schapansky J, Akude E, Smith DR, Van der Ploeg R, Solovyova N, Verkhratsky A, Fernyhough P.

ASN Neuro. 2012 Jan 18;4(1). pii: e00072. doi: 10.1042/AN20110038.


Tumor necrosis factor-α elevates neurite outgrowth through an NF-κB-dependent pathway in cultured adult sensory neurons: Diminished expression in diabetes may contribute to sensory neuropathy.

Saleh A, Smith DR, Balakrishnan S, Dunn L, Martens C, Tweed CW, Fernyhough P.

Brain Res. 2011 Nov 14;1423:87-95. doi: 10.1016/j.brainres.2011.09.029. Epub 2011 Sep 22.


Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes.

Chowdhury SK, Dobrowsky RT, Fernyhough P.

Mitochondrion. 2011 Nov;11(6):845-54. doi: 10.1016/j.mito.2011.06.007. Epub 2011 Jul 2. Review.


Role of oxidative stress in rabies virus infection.

Jackson AC, Kammouni W, Fernyhough P.

Adv Virus Res. 2011;79:127-38. doi: 10.1016/B978-0-12-387040-7.00008-1. Review.


Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats.

Akude E, Zherebitskaya E, Chowdhury SK, Smith DR, Dobrowsky RT, Fernyhough P.

Diabetes. 2011 Jan;60(1):288-97. doi: 10.2337/db10-0818. Epub 2010 Sep 28.


Mitochondrial stress and the pathogenesis of diabetic neuropathy.

Fernyhough P, Roy Chowdhury SK, Schmidt RE.

Expert Rev Endocrinol Metab. 2010 Jan 1;5(1):39-49.


Role of oxidative stress in rabies virus infection of adult mouse dorsal root ganglion neurons.

Jackson AC, Kammouni W, Zherebitskaya E, Fernyhough P.

J Virol. 2010 May;84(9):4697-705. doi: 10.1128/JVI.02654-09. Epub 2010 Feb 24.


Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment.

Chowdhury SK, Zherebitskaya E, Smith DR, Akude E, Chattopadhyay S, Jolivalt CG, Calcutt NA, Fernyhough P.

Diabetes. 2010 Apr;59(4):1082-91. doi: 10.2337/db09-1299. Epub 2010 Jan 26.


Abnormal calcium homeostasis in peripheral neuropathies.

Fernyhough P, Calcutt NA.

Cell Calcium. 2010 Feb;47(2):130-9. doi: 10.1016/j.ceca.2009.11.008. Epub 2009 Dec 24. Review.


Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats.

Malisza KL, Jones C, Gruwel ML, Foreman D, Fernyhough P, Calcutt NA.

J Magn Reson Imaging. 2009 Aug;30(2):271-6. doi: 10.1002/jmri.21856.


4-Hydroxy-2-nonenal induces mitochondrial dysfunction and aberrant axonal outgrowth in adult sensory neurons that mimics features of diabetic neuropathy.

Akude E, Zherebitskaya E, Roy Chowdhury SK, Girling K, Fernyhough P.

Neurotox Res. 2010 Jan;17(1):28-38. doi: 10.1007/s12640-009-9074-5. Epub 2009 Jun 26.


Nuclear factor-kappaB activation in axons and Schwann cells in experimental sciatic nerve injury and its role in modulating axon regeneration: studies with etanercept.

Smith D, Tweed C, Fernyhough P, Glazner GW.

J Neuropathol Exp Neurol. 2009 Jun;68(6):691-700. doi: 10.1097/NEN.0b013e3181a7c14e.

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