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Items: 13


Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin.

Flydal MI, Alcorlo-Pagés M, Johannessen FG, Martínez-Caballero S, Skjærven L, Fernandez-Leiro R, Martinez A, Hermoso JA.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11229-11234. doi: 10.1073/pnas.1902639116. Epub 2019 May 22.


Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM.

Muñoz-Hernández H, Pal M, Rodríguez CF, Fernandez-Leiro R, Prodromou C, Pearl LH, Llorca O.

Sci Adv. 2019 May 1;5(5):eaaw1616. doi: 10.1126/sciadv.aaw1616. eCollection 2019 May.


A pipeline approach to single-particle processing in RELION.

Fernandez-Leiro R, Scheres SHW.

Acta Crystallogr D Struct Biol. 2017 Jun 1;73(Pt 6):496-502. doi: 10.1107/S2059798316019276. Epub 2017 Apr 20.


Self-correcting mismatches during high-fidelity DNA replication.

Fernandez-Leiro R, Conrad J, Yang JC, Freund SM, Scheres SH, Lamers MH.

Nat Struct Mol Biol. 2017 Feb;24(2):140-143. doi: 10.1038/nsmb.3348. Epub 2017 Jan 9.


Dual function of Ixr1 in transcriptional regulation and recognition of cisplatin-DNA adducts is caused by differential binding through its two HMG-boxes.

Vizoso-Vázquez A, Lamas-Maceiras M, Fernández-Leiro R, Rico-Díaz A, Becerra M, Cerdán ME.

Biochim Biophys Acta Gene Regul Mech. 2017 Feb;1860(2):256-269. doi: 10.1016/j.bbagrm.2016.11.005. Epub 2016 Nov 19.


Unravelling biological macromolecules with cryo-electron microscopy.

Fernandez-Leiro R, Scheres SH.

Nature. 2016 Sep 15;537(7620):339-46. doi: 10.1038/nature19948. Review.


Structure and organization of heteromeric AMPA-type glutamate receptors.

Herguedas B, García-Nafría J, Cais O, Fernández-Leiro R, Krieger J, Ho H, Greger IH.

Science. 2016 Apr 29;352(6285):aad3873. doi: 10.1126/science.aad3873. Epub 2016 Mar 10.


cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ.

Fernandez-Leiro R, Conrad J, Scheres SH, Lamers MH.

Elife. 2015 Oct 24;4. pii: e11134. doi: 10.7554/eLife.11134.


Structural basis of specificity in tetrameric Kluyveromyces lactis β-galactosidase.

Pereira-Rodríguez A, Fernández-Leiro R, González-Siso MI, Cerdán ME, Becerra M, Sanz-Aparicio J.

J Struct Biol. 2012 Feb;177(2):392-401. doi: 10.1016/j.jsb.2011.11.031. Epub 2011 Dec 13.


Structural analysis of Saccharomyces cerevisiae alpha-galactosidase and its complexes with natural substrates reveals new insights into substrate specificity of GH27 glycosidases.

Fernández-Leiro R, Pereira-Rodríguez A, Cerdán ME, Becerra M, Sanz-Aparicio J.

J Biol Chem. 2010 Sep 3;285(36):28020-33. doi: 10.1074/jbc.M110.144584. Epub 2010 Jun 30.


Ixr1p regulates oxygen-dependent HEM13 transcription.

Castro-Prego R, Lamas-Maceiras M, Soengas P, Fernández-Leiro R, Carneiro I, Becerra M, González-Siso MI, Cerdán ME.

FEMS Yeast Res. 2010 May;10(3):309-21. doi: 10.1111/j.1567-1364.2010.00616.x. Epub 2010 Mar 1.


Crystallization and preliminary X-ray crystallographic analysis of beta-galactosidase from Kluyveromyces lactis.

Pereira-Rodríguez A, Fernández-Leiro R, González Siso MI, Cerdán ME, Becerra M, Sanz-Aparicio J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):297-300. doi: 10.1107/S1744309109054931. Epub 2010 Feb 24.


Crystallization and preliminary X-ray diffraction data of alpha-galactosidase from Saccharomyces cerevisiae.

Fernández-Leiro R, Pereira-Rodríguez A, Cerdán ME, Becerra M, Sanz-Aparicio J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):44-7. doi: 10.1107/S1744309109047794. Epub 2009 Dec 25.

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