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Items: 35


D159 and S167 are protective residues in the prion protein from dog and horse, two prion-resistant animals.

Sanchez-Garcia J, Fernandez-Funez P.

Neurobiol Dis. 2018 Nov;119:1-12. doi: 10.1016/j.nbd.2018.07.011. Epub 2018 Jul 24.


Engineered Hsp70 chaperones prevent Aβ42-induced memory impairments in a Drosophila model of Alzheimer's disease.

Martín-Peña A, Rincón-Limas DE, Fernandez-Fúnez P.

Sci Rep. 2018 Jul 2;8(1):9915. doi: 10.1038/s41598-018-28341-w.


Short Aβ peptides attenuate Aβ42 toxicity in vivo.

Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, Rincon-Limas D, Fernandez-Funez P, Golde TE.

J Exp Med. 2018 Jan 2;215(1):283-301. doi: 10.1084/jem.20170600. Epub 2017 Dec 5.


Genetics of Parkinson's disease and related disorders.

Zhang PL, Chen Y, Zhang CH, Wang YX, Fernandez-Funez P.

J Med Genet. 2018 Feb;55(2):73-80. doi: 10.1136/jmedgenet-2017-105047. Epub 2017 Nov 18.


Anti-Aβ single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer's disease.

Martin-Peña A, Rincon-Limas DE, Fernandez-Funez P.

Sci Rep. 2017 Sep 12;7(1):11268. doi: 10.1038/s41598-017-11594-2.


Lessons from Anti-Amyloid-β Immunotherapies in Alzheimer Disease: Aiming at a Moving Target.

Wang Y, Yan T, Lu H, Yin W, Lin B, Fan W, Zhang X, Fernandez-Funez P.

Neurodegener Dis. 2017;17(6):242-250. doi: 10.1159/000478741. Epub 2017 Aug 9. Review.


A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking.

Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, Nordenskjöld M, Wirdefeldt K, Rincon-Limas DE, Lewis J, Kaczmarek LK, Fernandez-Funez P, Nick HS, Waters MF.

PLoS One. 2017 May 3;12(5):e0173565. doi: 10.1371/journal.pone.0173565. eCollection 2017.


Drosophila models of prionopathies: insight into prion protein function, transmission, and neurotoxicity.

Fernandez-Funez P, Sanchez-Garcia J, Rincon-Limas DE.

Curr Opin Genet Dev. 2017 Jun;44:141-148. doi: 10.1016/j.gde.2017.03.013. Epub 2017 Apr 14. Review.


secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids.

De Mena L, Chhangani D, Fernandez-Funez P, Rincon-Limas DE.

Fly (Austin). 2017 Jul 3;11(3):179-184. doi: 10.1080/19336934.2017.1291104. Epub 2017 Feb 6.


Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila.

Fernandez-Funez P, Sanchez-Garcia J, de Mena L, Zhang Y, Levites Y, Khare S, Golde TE, Rincon-Limas DE.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5212-21. doi: 10.1073/pnas.1608045113. Epub 2016 Aug 16.


A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila.

Sanchez-Garcia J, Jensen K, Zhang Y, Rincon-Limas DE, Fernandez-Funez P.

Neurobiol Dis. 2016 Nov;95:204-9. doi: 10.1016/j.nbd.2016.07.025. Epub 2016 Jul 28.


Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease.

Fernandez-Funez P, Zhang Y, Sanchez-Garcia J, de Mena L, Khare S, Golde TE, Levites Y, Rincon-Limas DE.

Hum Mol Genet. 2015 Nov 1;24(21):6093-105. doi: 10.1093/hmg/ddv321. Epub 2015 Aug 7.


Modeling the complex pathology of Alzheimer's disease in Drosophila.

Fernandez-Funez P, de Mena L, Rincon-Limas DE.

Exp Neurol. 2015 Dec;274(Pt A):58-71. doi: 10.1016/j.expneurol.2015.05.013. Epub 2015 May 27. Review.


Visualization of synaptic domains in the Drosophila brain by magnetic resonance microscopy at 10 micron isotropic resolution.

Lee CH, Blackband SJ, Fernandez-Funez P.

Sci Rep. 2015 Mar 10;5:8920. doi: 10.1038/srep08920.


KCNC3(R420H), a K(+) channel mutation causative in spinocerebellar ataxia 13 displays aberrant intracellular trafficking.

Gallego-Iradi C, Bickford JS, Khare S, Hall A, Nick JA, Salmasinia D, Wawrowsky K, Bannykh S, Huynh DP, Rincon-Limas DE, Pulst SM, Nick HS, Fernandez-Funez P, Waters MF.

Neurobiol Dis. 2014 Nov;71:270-9. doi: 10.1016/j.nbd.2014.08.020. Epub 2014 Aug 22.


Launching Hsp70 neuroprotection: two drugs better than one.

Fernandez-Funez P, Rincon-Limas DE.

Cell Cycle. 2014;13(11):1657-8. doi: 10.4161/cc.29148. Epub 2014 May 8. No abstract available.


Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.

Zhang Y, Casas-Tinto S, Rincon-Limas DE, Fernandez-Funez P.

PLoS One. 2014 Feb 11;9(2):e88522. doi: 10.1371/journal.pone.0088522. eCollection 2014.


Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking.

Sanchez-Garcia J, Arbelaez D, Jensen K, Rincon-Limas DE, Fernandez-Funez P.

Hum Mol Genet. 2013 Nov 1;22(21):4253-66. doi: 10.1093/hmg/ddt276. Epub 2013 Jun 13.


p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila.

Zhang Y, Arcia S, Perez B, Fernandez-Funez P, Rincon-Limas DE.

Mol Biol Rep. 2013 Sep;40(9):5407-15. doi: 10.1007/s11033-013-2639-7. Epub 2013 May 17.


Purification of transcripts and metabolites from Drosophila heads.

Jensen K, Sanchez-Garcia J, Williams C, Khare S, Mathur K, Graze RM, Hahn DA, McIntyre LM, Rincon-Limas DE, Fernandez-Funez P.

J Vis Exp. 2013 Mar 15;(73):e50245. doi: 10.3791/50245.


Differential activation of the ER stress factor XBP1 by oligomeric assemblies.

Castillo-Carranza DL, Zhang Y, Guerrero-Muñoz MJ, Kayed R, Rincon-Limas DE, Fernandez-Funez P.

Neurochem Res. 2012 Aug;37(8):1707-17. doi: 10.1007/s11064-012-0780-7. Epub 2012 Apr 21.


Drosophila models of proteinopathies: the little fly that could.

Rincon-Limas DE, Jensen K, Fernandez-Funez P.

Curr Pharm Des. 2012;18(8):1108-22. Review.


Pulling rabbits to reveal the secrets of the prion protein.

Fernandez-Funez P, Zhang Y, Sanchez-Garcia J, Jensen K, Zou WQ, Rincon-Limas DE.

Commun Integr Biol. 2011 May;4(3):262-6. doi: 10.4161/cib.4.3.15054. Epub 2011 May 1.


Activation of JNK signaling mediates amyloid-ß-dependent cell death.

Tare M, Modi RM, Nainaparampil JJ, Puli OR, Bedi S, Fernandez-Funez P, Kango-Singh M, Singh A.

PLoS One. 2011;6(9):e24361. doi: 10.1371/journal.pone.0024361. Epub 2011 Sep 14.


Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.

Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, Fernandez-Funez P, Lee HG, Smith MA, Petersen RB, Guo JP.

J Biol Chem. 2011 Apr 29;286(17):15095-105. doi: 10.1074/jbc.M110.199356. Epub 2011 Mar 10.


The ER stress factor XBP1s prevents amyloid-beta neurotoxicity.

Casas-Tinto S, Zhang Y, Sanchez-Garcia J, Gomez-Velazquez M, Rincon-Limas DE, Fernandez-Funez P.

Hum Mol Genet. 2011 Jun 1;20(11):2144-60. doi: 10.1093/hmg/ddr100. Epub 2011 Mar 9.


Sequence-dependent prion protein misfolding and neurotoxicity.

Fernandez-Funez P, Zhang Y, Casas-Tinto S, Xiao X, Zou WQ, Rincon-Limas DE.

J Biol Chem. 2010 Nov 19;285(47):36897-908. doi: 10.1074/jbc.M110.174391. Epub 2010 Sep 3.


Exploring prion protein biology in flies: genetics and beyond.

Rincon-Limas DE, Casas-Tinto S, Fernandez-Funez P.

Prion. 2010 Jan-Mar;4(1):1-8. Epub 2010 Jan 30.


In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms.

Fernandez-Funez P, Casas-Tinto S, Zhang Y, Gómez-Velazquez M, Morales-Garza MA, Cepeda-Nieto AC, Castilla J, Soto C, Rincon-Limas DE.

PLoS Genet. 2009 Jun;5(6):e1000507. doi: 10.1371/journal.pgen.1000507. Epub 2009 Jun 5.


FoxK mediates TGF-beta signalling during midgut differentiation in flies.

Casas-Tinto S, Gomez-Velazquez M, Granadino B, Fernandez-Funez P.

J Cell Biol. 2008 Dec 15;183(6):1049-60. doi: 10.1083/jcb.200808149.


Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases.

Branco J, Al-Ramahi I, Ukani L, Pérez AM, Fernandez-Funez P, Rincón-Limas D, Botas J.

Hum Mol Genet. 2008 Feb 1;17(3):376-90. Epub 2007 Nov 5.


Age-independent synaptogenesis by phosphoinositide 3 kinase.

Martín-Peña A, Acebes A, Rodríguez JR, Sorribes A, de Polavieja GG, Fernández-Fúnez P, Ferrús A.

J Neurosci. 2006 Oct 4;26(40):10199-208.


Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

Chen HK, Fernandez-Funez P, Acevedo SF, Lam YC, Kaytor MD, Fernandez MH, Aitken A, Skoulakis EM, Orr HT, Botas J, Zoghbi HY.

Cell. 2003 May 16;113(4):457-68.


Identification of genes that modify ataxin-1-induced neurodegeneration.

Fernandez-Funez P, Nino-Rosales ML, de Gouyon B, She WC, Luchak JM, Martinez P, Turiegano E, Benito J, Capovilla M, Skinner PJ, McCall A, Canal I, Orr HT, Zoghbi HY, Botas J.

Nature. 2000 Nov 2;408(6808):101-6.


The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing.

Fernández-Fúnez P, Lu CH, Rincón-Limas DE, García-Bellido A, Botas J.

EMBO J. 1998 Dec 1;17(23):6846-53.

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