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Items: 15


A Novel GUCY2C-CD3 T cell Engaging Bispecific construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.

Mathur D, Root AR, Bugaj-Gaweda B, Bisulco S, Tan X, Fang W, Kearney JC, Lucas J, Guffroy M, Golas J, Rohde CM, Stevens C, Kamperschroer C, Kelleher K, Lawrence-Henderson RF, Upeslacis E, Yao J, Narula J, LaVallie ER, Fernandez DR, Buetow BS, Rosfjord E, Bloom L, King LE, Tchistiakova L, Nguyen A, Sapra P.

Clin Cancer Res. 2020 Jan 29. pii: clincanres.3275.2019. doi: 10.1158/1078-0432.CCR-19-3275. [Epub ahead of print]


CD8 T cells and mTOR: new concepts and targets for systemic lupus erythematosus.

Fernandez DR, Crow MK.

Lancet. 2018 Mar 24;391(10126):1126-1127. doi: 10.1016/S0140-6736(18)30544-0. Epub 2018 Mar 15. No abstract available.


HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE.

Caza TN, Fernandez DR, Talaber G, Oaks Z, Haas M, Madaio MP, Lai ZW, Miklossy G, Singh RR, Chudakov DM, Malorni W, Middleton F, Banki K, Perl A.

Ann Rheum Dis. 2014 Oct;73(10):1888-97. doi: 10.1136/annrheumdis-2013-203794. Epub 2013 Jul 29.


Mathematical modelling of the lower urinary tract.

Paya AS, Fernandez DR, Gil D, Garcia Chamizo JM, Perez FM.

Comput Methods Programs Biomed. 2013 Mar;109(3):323-38. doi: 10.1016/j.cmpb.2012.09.005. Epub 2012 Oct 26.


Partial plasma cell differentiation as a mechanism of lost major histocompatibility complex class II expression in diffuse large B-cell lymphoma.

Wilkinson ST, Vanpatten KA, Fernandez DR, Brunhoeber P, Garsha KE, Glinsmann-Gibson BJ, Grogan TM, Teruya-Feldstein J, Rimsza LM.

Blood. 2012 Feb 9;119(6):1459-67. doi: 10.1182/blood-2011-07-363820. Epub 2011 Dec 13.


Decreased major histocompatibility complex class II expression in diffuse large B-cell lymphoma does not correlate with CpG methylation of class II transactivator promoters III and IV.

Wilkinson ST, Fernandez DR, Murphy SP, Braziel RM, Campo E, Chan WC, Delabie J, Gascoyne RD, Staudt LM, Jaffe ES, Rosenwald A, Rimsza LM.

Leuk Lymphoma. 2009 Nov;50(11):1875-8. doi: 10.3109/10428190903297531. No abstract available.


T-cell and B-cell signaling biomarkers and treatment targets in lupus.

Perl A, Fernandez DR, Telarico T, Doherty E, Francis L, Phillips PE.

Curr Opin Rheumatol. 2009 Sep;21(5):454-64. doi: 10.1097/BOR.0b013e32832e977c. Review.


Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine.

Hanczko R, Fernandez DR, Doherty E, Qian Y, Vas G, Niland B, Telarico T, Garba A, Banerjee S, Middleton FA, Barrett D, Barcza M, Banki K, Landas SK, Perl A.

J Clin Invest. 2009 Jun;119(6):1546-57. doi: 10.1172/JCI35722. Epub 2009 May 11.


HER1-ECD vaccination dispenses with emulsification to elicit HER1-specific anti-proliferative effects.

Alpízar YA, Ramírez BS, Fernández DR, Capote AR, Hidalgo GG, Rodríguez RP, Molina LE.

Hum Vaccin. 2009 Mar;5(3):158-65. Epub 2009 Mar 6.


Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation.

Fernandez DR, Telarico T, Bonilla E, Li Q, Banerjee S, Middleton FA, Phillips PE, Crow MK, Oess S, Muller-Esterl W, Perl A.

J Immunol. 2009 Feb 15;182(4):2063-73. doi: 10.4049/jimmunol.0803600.


Anti-EGFR activation, anti-proliferative and pro-apoptotic effects of polyclonal antibodies induced by EGFR-based cancer vaccine.

Ramírez BS, Alpízar YA, Fernández DR, Hidalgo GG, Capote AR, Rodríguez RP, Fernández LE.

Vaccine. 2008 Sep 8;26(38):4918-26. doi: 10.1016/j.vaccine.2008.07.018. Epub 2008 Jul 29.


The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines.

Bouker KB, Skaar TC, Harburger DS, Riggins RB, Fernandez DR, Zwart A, Clarke R.

Cancer Genet Cytogenet. 2007 May;175(1):61-4.


Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.

Bouker KB, Skaar TC, Riggins RB, Harburger DS, Fernandez DR, Zwart A, Wang A, Clarke R.

Carcinogenesis. 2005 Sep;26(9):1527-35. Epub 2005 May 5.


interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant).

Bouker KB, Skaar TC, Fernandez DR, O'Brien KA, Riggins RB, Cao D, Clarke R.

Cancer Res. 2004 Jun 1;64(11):4030-9.


Fatty acid, amino acid, and trace mineral analyses of five weaning foods from Jos, Nigeria.

Fernandez DR, Vanderjagt DJ, Williams M, Huang YS, Chuang LT, Millson M, Andrews R, Pastuszyn A, Glew RH.

Plant Foods Hum Nutr. 2002 Fall;57(3-4):257-74.


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