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Items: 1 to 50 of 94

1.

ATR is required to complete meiotic recombination in mice.

Pacheco S, Maldonado-Linares A, Marcet-Ortega M, Rojas C, Martínez-Marchal A, Fuentes-Lazaro J, Lange J, Jasin M, Keeney S, Fernández-Capetillo O, Garcia-Caldés M, Roig I.

Nat Commun. 2018 Jul 5;9(1):2622. doi: 10.1038/s41467-018-04851-z.

2.

Targeting ATR in cancer.

Lecona E, Fernandez-Capetillo O.

Nat Rev Cancer. 2018 Jun 13. doi: 10.1038/s41568-018-0034-3. [Epub ahead of print] Review.

PMID:
29899559
3.

ERF deletion rescues RAS deficiency in mouse embryonic stem cells.

Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, Fernandez-Capetillo O.

Genes Dev. 2018 Apr 1;32(7-8):568-576. doi: 10.1101/gad.310086.117. Epub 2018 Apr 12.

PMID:
29650524
4.

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity.

Lynch CJ, Bernad R, Calvo I, Nóbrega-Pereira S, Ruiz S, Ibarz N, Martinez-Val A, Graña-Castro O, Gómez-López G, Andrés-León E, Espinosa Angarica V, Del Sol A, Ortega S, Fernandez-Capetillo O, Rojo E, Munoz J, Serrano M.

Cell Rep. 2018 Jan 9;22(2):396-410. doi: 10.1016/j.celrep.2017.12.062.

5.

A p53-dependent response limits the viability of mammalian haploid cells.

Olbrich T, Mayor-Ruiz C, Vega-Sendino M, Gomez C, Ortega S, Ruiz S, Fernandez-Capetillo O.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9367-9372. doi: 10.1073/pnas.1705133114. Epub 2017 Aug 14.

6.

TrapSeq: An RNA Sequencing-Based Pipeline for the Identification of Gene-Trap Insertions in Mammalian Cells.

Mayor-Ruiz C, Dominguez O, Fernandez-Capetillo O.

J Mol Biol. 2017 Sep 1;429(18):2780-2789. doi: 10.1016/j.jmb.2017.07.020. Epub 2017 Aug 4.

PMID:
28782559
7.

Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells.

Chaudhuri AR, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A.

Nature. 2016 Nov 17;539(7629):456. doi: 10.1038/nature19826. Epub 2016 Sep 28. No abstract available.

PMID:
27680696
8.

A SUMO and ubiquitin code coordinates protein traffic at replication factories.

Lecona E, Fernandez-Capetillo O.

Bioessays. 2016 Dec;38(12):1209-1217. doi: 10.1002/bies.201600129. Epub 2016 Sep 26. Review.

PMID:
27667742
9.

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

Morgado-Palacin I, Day A, Murga M, Lafarga V, Anton ME, Tubbs A, Chen HT, Ergan A, Anderson R, Bhandoola A, Pike KG, Barlaam B, Cadogan E, Wang X, Pierce AJ, Hubbard C, Armstrong SA, Nussenzweig A, Fernandez-Capetillo O.

Sci Signal. 2016 Sep 13;9(445):ra91. doi: 10.1126/scisignal.aad8243.

10.

Efficacy of ATR inhibitors as single agents in Ewing sarcoma.

Nieto-Soler M, Morgado-Palacin I, Lafarga V, Lecona E, Murga M, Callen E, Azorin D, Alonso J, Lopez-Contreras AJ, Nussenzweig A, Fernandez-Capetillo O.

Oncotarget. 2016 Sep 13;7(37):58759-58767. doi: 10.18632/oncotarget.11643.

11.

POLD3 Is Haploinsufficient for DNA Replication in Mice.

Murga M, Lecona E, Kamileri I, Díaz M, Lugli N, Sotiriou SK, Anton ME, Méndez J, Halazonetis TD, Fernandez-Capetillo O.

Mol Cell. 2016 Sep 1;63(5):877-83. doi: 10.1016/j.molcel.2016.07.007. Epub 2016 Aug 11.

12.

Replication fork stability confers chemoresistance in BRCA-deficient cells.

Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A.

Nature. 2016 Jul 21;535(7612):382-7. doi: 10.1038/nature18325. Erratum in: Nature. 2016 Nov 17;539(7629):456.

13.

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors.

Ruiz S, Mayor-Ruiz C, Lafarga V, Murga M, Vega-Sendino M, Ortega S, Fernandez-Capetillo O.

Mol Cell. 2016 Apr 21;62(2):307-313. doi: 10.1016/j.molcel.2016.03.006. Epub 2016 Apr 7.

14.

USP7 is a SUMO deubiquitinase essential for DNA replication.

Lecona E, Rodriguez-Acebes S, Specks J, Lopez-Contreras AJ, Ruppen I, Murga M, Muñoz J, Mendez J, Fernandez-Capetillo O.

Nat Struct Mol Biol. 2016 Apr;23(4):270-7. doi: 10.1038/nsmb.3185. Epub 2016 Mar 7.

15.

The (elusive) role of the SMC5/6 complex.

Fernandez-Capetillo O.

Cell Cycle. 2016;15(6):775-6. doi: 10.1080/15384101.2015.1137713. No abstract available.

16.

Reducing genomic instability in iPSCs.

Ruiz S, Fernandez-Capetillo O.

Oncotarget. 2015 Oct 27;6(33):34045-6. doi: 10.18632/oncotarget.6212. No abstract available.

17.

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Alvarez S, Díaz M, Flach J, Rodriguez-Acebes S, López-Contreras AJ, Martínez D, Cañamero M, Fernández-Capetillo O, Isern J, Passegué E, Méndez J.

Nat Commun. 2015 Oct 12;6:8548. doi: 10.1038/ncomms9548.

18.

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.

Jacome A, Gutierrez-Martinez P, Schiavoni F, Tenaglia E, Martinez P, Rodríguez-Acebes S, Lecona E, Murga M, Méndez J, Blasco MA, Fernandez-Capetillo O.

EMBO J. 2015 Nov 3;34(21):2604-19. doi: 10.15252/embj.201591829. Epub 2015 Oct 6.

19.

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells.

Ruiz S, Lopez-Contreras AJ, Gabut M, Marion RM, Gutierrez-Martinez P, Bua S, Ramirez O, Olalde I, Rodrigo-Perez S, Li H, Marques-Bonet T, Serrano M, Blasco MA, Batada NN, Fernandez-Capetillo O.

Nat Commun. 2015 Aug 21;6:8036. doi: 10.1038/ncomms9036.

20.

A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.

Specks J, Lecona E, Lopez-Contreras AJ, Fernandez-Capetillo O.

Mol Cell Biol. 2015 Sep 1;35(17):2910-7. doi: 10.1128/MCB.00475-15. Epub 2015 Jun 15.

21.

Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.

Lopez-Contreras AJ, Specks J, Barlow JH, Ambrogio C, Desler C, Vikingsson S, Rodrigo-Perez S, Green H, Rasmussen LJ, Murga M, Nussenzweig A, Fernandez-Capetillo O.

Genes Dev. 2015 Apr 1;29(7):690-5. doi: 10.1101/gad.256958.114.

22.

Modeling the study of DNA damage responses in mice.

Specks J, Nieto-Soler M, Lopez-Contreras AJ, Fernandez-Capetillo O.

Methods Mol Biol. 2015;1267:413-37. doi: 10.1007/978-1-4939-2297-0_21. Review.

23.

Hopes for the year ahead.

Fernández-Capetillo Ó, Yan N, Dionne J, Bassett D, Sebastian S, Hendon C, Schlichting H, Baker M.

Nature. 2015 Jan 1;517(7532):111-3. No abstract available.

PMID:
25568916
24.

PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.

Farrés J, Llacuna L, Martin-Caballero J, Martínez C, Lozano JJ, Ampurdanés C, López-Contreras AJ, Florensa L, Navarro J, Ottina E, Dantzer F, Schreiber V, Villunger A, Fernández-Capetillo O, Yélamos J.

Cell Death Differ. 2015 Jul;22(7):1144-57. doi: 10.1038/cdd.2014.202. Epub 2014 Dec 12.

25.

When the going gets tough: scientists' personal challenges.

Lengerke C, Fernandez-Capetillo O, Tolic-Norrelykke I, Barna M, Coleman T, Zamboni D.

Cell. 2014 Oct 9;159(2):225-6. No abstract available.

26.

Replication stress and cancer: it takes two to tango.

Lecona E, Fernández-Capetillo O.

Exp Cell Res. 2014 Nov 15;329(1):26-34. doi: 10.1016/j.yexcr.2014.09.019. Epub 2014 Sep 26. Review.

27.

The maternal side of Fanconi Anemia.

Ruiz S, Fernandez-Capetillo O.

Mol Cell. 2014 Sep 18;55(6):803-804. doi: 10.1016/j.molcel.2014.08.029.

28.

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

Winter GE, Radic B, Mayor-Ruiz C, Blomen VA, Trefzer C, Kandasamy RK, Huber KVM, Gridling M, Chen D, Klampfl T, Kralovics R, Kubicek S, Fernandez-Capetillo O, Brummelkamp TR, Superti-Furga G.

Nat Chem Biol. 2014 Sep;10(9):768-773. doi: 10.1038/nchembio.1590. Epub 2014 Jul 27.

29.

Fos-dependent induction of Chk1 protects osteoblasts from replication stress.

Schulze J, Lopez-Contreras AJ, Uluçkan Ö, Graña-Castro O, Fernandez-Capetillo O, Wagner EF.

Cell Cycle. 2014;13(12):1980-6. doi: 10.4161/cc.28923. Epub 2014 Apr 24.

30.

Late-replicating CNVs as a source of new genes.

Juan D, Rico D, Marques-Bonet T, Fernández-Capetillo O, Valencia A.

Biol Open. 2014 Mar 15;3(3). pii: 231. doi: 10.1242/bio.20147815. No abstract available.

31.

A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens.

Eguren M, Álvarez-Fernández M, García F, López-Contreras AJ, Fujimitsu K, Yaguchi H, Luque-García JL, Fernández-Capetillo O, Muñoz J, Yamano H, Malumbres M.

Cell Rep. 2014 Feb 27;6(4):670-83. doi: 10.1016/j.celrep.2014.01.017. Epub 2014 Feb 6.

32.

Emergence and evolutionary analysis of the human DDR network: implications in comparative genomics and downstream analyses.

Arcas A, Fernández-Capetillo O, Cases I, Rojas AM.

Mol Biol Evol. 2014 Apr;31(4):940-61. doi: 10.1093/molbev/msu046. Epub 2014 Jan 16.

33.

Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.

Lecona E, Rojas LA, Bonasio R, Johnston A, Fernández-Capetillo O, Reinberg D.

PLoS Biol. 2013 Dec;11(12):e1001737. doi: 10.1371/journal.pbio.1001737. Epub 2013 Dec 17.

34.

Late-replicating CNVs as a source of new genes.

Juan D, Rico D, Marques-Bonet T, Fernández-Capetillo O, Valencia A.

Biol Open. 2013 Dec 15;2(12):1402-11. doi: 10.1242/bio.20136924.

35.

Naked replication forks break apRPArt.

Fernandez-Capetillo O, Nussenzweig A.

Cell. 2013 Nov 21;155(5):979-80. doi: 10.1016/j.cell.2013.10.049.

36.

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.

Saiz-Ladera C, Lara MF, Garín M, Ruiz S, Santos M, Lorz C, García-Escudero R, Martínez-Fernández M, Bravo A, Fernández-Capetillo O, Segrelles C, Paramio JM.

Oncogene. 2014 Sep 11;33(37):4599-4612. doi: 10.1038/onc.2013.417. Epub 2013 Oct 14.

37.

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A.

Cell. 2013 Jun 6;153(6):1266-80. doi: 10.1016/j.cell.2013.05.023. Epub 2013 May 30.

38.

INK4a/ARF limits the expansion of cells suffering from replication stress.

Monasor A, Murga M, Lopez-Contreras AJ, Navas C, Gomez G, Pisano DG, Fernandez-Capetillo O.

Cell Cycle. 2013 Jun 15;12(12):1948-54. doi: 10.4161/cc.25017. Epub 2013 May 15.

39.

A proteomic characterization of factors enriched at nascent DNA molecules.

Lopez-Contreras AJ, Ruppen I, Nieto-Soler M, Murga M, Rodriguez-Acebes S, Remeseiro S, Rodrigo-Perez S, Rojas AM, Mendez J, Muñoz J, Fernandez-Capetillo O.

Cell Rep. 2013 Apr 25;3(4):1105-16. doi: 10.1016/j.celrep.2013.03.009. Epub 2013 Mar 28.

40.

Identification of early replicating fragile sites that contribute to genome instability.

Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A.

Cell. 2013 Jan 31;152(3):620-32. doi: 10.1016/j.cell.2013.01.006. Epub 2013 Jan 24. Review.

41.

Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression.

Marqués-Torrejón MÁ, Porlan E, Banito A, Gómez-Ibarlucea E, Lopez-Contreras AJ, Fernández-Capetillo O, Vidal A, Gil J, Torres J, Fariñas I.

Cell Stem Cell. 2013 Jan 3;12(1):88-100. doi: 10.1016/j.stem.2012.12.001. Epub 2012 Dec 20.

42.

BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.

Bunting SF, Callén E, Kozak ML, Kim JM, Wong N, López-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A.

Mol Cell. 2012 Apr 27;46(2):125-35. doi: 10.1016/j.molcel.2012.02.015. Epub 2012 Mar 22.

43.

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation.

López-Contreras AJ, Gutierrez-Martinez P, Specks J, Rodrigo-Perez S, Fernandez-Capetillo O.

J Exp Med. 2012 Mar 12;209(3):455-61. doi: 10.1084/jem.20112147. Epub 2012 Feb 27.

44.

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.

Schoppy DW, Ragland RL, Gilad O, Shastri N, Peters AA, Murga M, Fernandez-Capetillo O, Diehl JA, Brown EJ.

J Clin Invest. 2012 Jan;122(1):241-52. doi: 10.1172/JCI58928. Epub 2011 Dec 1.

45.

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.

Murga M, Campaner S, Lopez-Contreras AJ, Toledo LI, Soria R, Montaña MF, Artista L, Schleker T, Guerra C, Garcia E, Barbacid M, Hidalgo M, Amati B, Fernandez-Capetillo O.

Nat Struct Mol Biol. 2011 Nov 27;18(12):1331-1335. doi: 10.1038/nsmb.2189.

46.

CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.

Choi S, Toledo LI, Fernandez-Capetillo O, Bakkenist CJ.

DNA Repair (Amst). 2011 Oct 10;10(10):1000-1; author reply 1002. doi: 10.1016/j.dnarep.2011.07.013. Epub 2011 Aug 23. No abstract available.

47.

Lac operator repeats generate a traceable fragile site in mammalian cells.

Jacome A, Fernandez-Capetillo O.

EMBO Rep. 2011 Sep 30;12(10):1032-8. doi: 10.1038/embor.2011.158.

48.

Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs.

Toledo LI, Murga M, Fernandez-Capetillo O.

Mol Oncol. 2011 Aug;5(4):368-73. doi: 10.1016/j.molonc.2011.07.002. Epub 2011 Jul 28. Review.

49.

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

Toledo LI, Murga M, Zur R, Soria R, Rodriguez A, Martinez S, Oyarzabal J, Pastor J, Bischoff JR, Fernandez-Capetillo O.

Nat Struct Mol Biol. 2011 Jun;18(6):721-7. doi: 10.1038/nsmb.2076. Epub 2011 May 8.

50.

Genomic instability in iPS: time for a break.

Blasco MA, Serrano M, Fernandez-Capetillo O.

EMBO J. 2011 Mar 16;30(6):991-3. doi: 10.1038/emboj.2011.50. No abstract available.

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