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Gene silencing based on RNA-guided catalytically inactive Cas9 (dCas9): a new tool for genetic engineering in Leptospira.

Fernandes LGV, Guaman LP, Vasconcellos SA, Heinemann MB, Picardeau M, Nascimento ALTO.

Sci Rep. 2019 Feb 12;9(1):1839. doi: 10.1038/s41598-018-37949-x.


The Senses of Birth intervention to decrease cesarean and prematurity rates in Brazil.

Lansky S, Oliveira BJ, Peixoto ERM, Souza KV, Fernandes LMM, Friche AAL.

Int J Gynaecol Obstet. 2019 Jan 23. doi: 10.1002/ijgo.12765. [Epub ahead of print]


Complexation of whey protein with caffeic acid or (-)-epigallocatechin-3-gallate as a strategy to induce oral tolerance to whey allergenic proteins.

Pessato TB, de Carvalho NC, de Figueiredo D, Colomeu TC, Fernandes LGR, Netto FM, de L Zollner R.

Int Immunopharmacol. 2019 Mar;68:115-123. doi: 10.1016/j.intimp.2018.12.047. Epub 2019 Jan 5.


Guava-flavored whey beverage processed by cold plasma technology: Bioactive compounds, fatty acid profile and volatile compounds.

Silveira MR, Coutinho NM, Esmerino EA, Moraes J, Fernandes LM, Pimentel TC, Freitas MQ, Silva MC, Raices RSL, Senaka Ranadheera C, Borges FO, Neto RPC, Tavares MIB, Fernandes FAN, Fonteles TV, Nazzaro F, Rodrigues S, Cruz AG.

Food Chem. 2019 May 1;279:120-127. doi: 10.1016/j.foodchem.2018.11.128. Epub 2018 Dec 5.


Influence of the hyrax expander screw position on stress distribution in the maxilla: A study with finite elements.

Fernandes LC, Farinazzo Vitral RW, Noritomi PY, Schmitberger CA, José da Silva Campos M.

Am J Orthod Dentofacial Orthop. 2019 Jan;155(1):80-87. doi: 10.1016/j.ajodo.2018.03.019.


Antiangiogenic effects of the chemopreventive agent tributyrin, a butyric acid prodrug, during the promotion phase of hepatocarcinogenesis.

Andrade FO, Furtado KS, Heidor R, Sandri S, Hebeda CB, Miranda MLP, Fernandes LHG, Yamamoto RC, Horst MA, Farsky SHP, Moreno FS.

Carcinogenesis. 2018 Dec 24. doi: 10.1093/carcin/bgy190. [Epub ahead of print]


The Portuguese Severe Asthma Registry: Development, Features, and Data Sharing Policies.

Sá-Sousa A, Fonseca JA, Pereira AM, Ferreira A, Arrobas A, Mendes A, Drummond M, Videira W, Costa T, Farinha P, Soares J, Rocha P, Todo-Bom A, Sokolova A, Costa A, Fernandes B, Chaves Loureiro C, Longo C, Pardal C, Costa C, Cruz C, Loureiro CC, Lopes C, Mesquita D, Faria E, Magalhães E, Menezes F, Todo-Bom F, Carvalho F, Regateiro FS, Falcão H, Fernandes I, Gaspar-Marques J, Viana J, Ferreira J, Silva JM, Simão L, Almeida L, Fernandes L, Ferreira L, van Zeller M, Quaresma M, Castanho M, André N, Cortesão N, Leiria-Pinto P, Pinto P, Rosa P, Carreiro-Martins P, Gerardo R, Silva R, Lucas S, Almeida T, Calvo T.

Biomed Res Int. 2018 Nov 21;2018:1495039. doi: 10.1155/2018/1495039. eCollection 2018.


Processing chocolate milk drink by low-pressure cold plasma technology.

Coutinho NM, Silveira MR, Fernandes LM, Moraes J, Pimentel TC, Freitas MQ, Silva MC, Raices RSL, Ranadheera CS, Borges FO, Neto RPC, Tavares MIB, Fernandes FAN, Fonteles TV, Nazzaro F, Rodrigues S, Cruz AG.

Food Chem. 2019 Apr 25;278:276-283. doi: 10.1016/j.foodchem.2018.11.061. Epub 2018 Nov 12.


In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor.

Bacalhau P, Fernandes L, Rosário Martins M, Candeias F, Carreiro EP, López Ó, Teresa Caldeira A, Totobenazara J, Guedes RC, Burke AJ.

Bioorg Med Chem. 2019 Jan 15;27(2):354-363. doi: 10.1016/j.bmc.2018.12.007. Epub 2018 Dec 10.


Symptomatic treatment of dengue: Should the NSAID contraindication be reconsidered?

Kellstein D, Fernandes L.

Postgrad Med. 2018 Dec 21. doi: 10.1080/00325481.2019.1561916. [Epub ahead of print]


FDA Approval Summary: Atezolizumab or Pembrolizumab for the Treatment of Patients with Advanced Urothelial Carcinoma Ineligible for Cisplatin-Containing Chemotherapy.

Suzman DL, Agrawal S, Ning YM, Maher VE, Fernandes LL, Karuri S, Tang S, Sridhara R, Schroeder J, Goldberg KB, Ibrahim A, McKee AE, Pazdur R, Beaver JA.

Oncologist. 2018 Dec 12. pii: theoncologist.2018-0084. doi: 10.1634/theoncologist.2018-0084. [Epub ahead of print]


Impact of Heart Transplantation on the Recovery of Peripheral and Respiratory Muscle Mass and Strength in Patients With Chronic Heart Failure.

Fernandes LCBC, de Oliveira IM, Fernandes PFCBC, de Souza Neto JD, Farias MDSQ, de Freitas NA, Magalhães NC, Bacal F.

Transplant Direct. 2018 Oct 1;4(11):e395. doi: 10.1097/TXD.0000000000000837. eCollection 2018 Nov.


New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids.

Gorjao R, Dos Santos CMM, Serdan TDA, Diniz VLS, Alba-Loureiro TC, Cury-Boaventura MF, Hatanaka E, Levada-Pires AC, Sato FT, Pithon-Curi TC, Fernandes LC, Curi R, Hirabara SM.

Pharmacol Ther. 2018 Dec 4. pii: S0163-7258(18)30217-1. doi: 10.1016/j.pharmthera.2018.12.001. [Epub ahead of print] Review.


Chronic ethanol forced administration from adolescence to adulthood reduces cell density in the rat spinal cord.

Fernandes RM, Nascimento PC, Bittencourt LO, de Oliveira ACA, Puty B, Leão LKR, Fernandes LMP, Cartágenes S, Maia CSF, Lima RR.

Tissue Cell. 2018 Dec;55:77-82. doi: 10.1016/j.tice.2018.10.001. Epub 2018 Oct 24.


Self-care support for the management of type 1 diabetes during the transition from childhood to adolescence.

Collet N, Batista AFMB, Nóbrega VMD, Souza MHDN, Fernandes LTB.

Rev Esc Enferm USP. 2018 Nov 23;52:e03376. doi: 10.1590/S1980-220X2017038503376. English, Portuguese.


A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans.

Paes HC, Derengowski LDS, Peconick LDF, Albuquerque P, Pappas GJ Jr, Nicola AM, Silva FBA, Vallim MA, Alspaugh JA, Felipe MSS, Fernandes L.

Front Cell Infect Microbiol. 2018 Nov 13;8:369. doi: 10.3389/fcimb.2018.00369. eCollection 2018.


A Novel Highly Divergent Strain of Cell Fusing Agent Virus (CFAV) in Mosquitoes from the Brazilian Amazon Region.

Fernandes LN, Coletti TM, Monteiro FJC, Rego MODS, Ribeiro ESD, Ribeiro GO, Marinho RDSS, Komninakis SV, Witkin SS, Deng X, Delwart E, Sabino EC, Leal É, Costa ACD.

Viruses. 2018 Nov 24;10(12). pii: E666. doi: 10.3390/v10120666.


Low doses of methylmercury exposure during adulthood in rats display oxidative stress, neurodegeneration in the motor cortex and lead to impairment of motor skills.

Santana LNDS, Bittencourt LO, Nascimento PC, Fernandes RM, Teixeira FB, Fernandes LMP, Freitas Silva MC, Nogueira LS, Amado LL, Crespo-Lopez ME, Maia CDSF, Lima RR.

J Trace Elem Med Biol. 2019 Jan;51:19-27. doi: 10.1016/j.jtemb.2018.09.004. Epub 2018 Sep 11.


Social networks and health practices: influence of a diabetes online community on adherence to treatment.

Fernandes LS, Calado C, Araujo CAS.

Cien Saude Colet. 2018 Oct;23(10):3357-3368. doi: 10.1590/1413-812320182310.14122018. Portuguese, English.


Antifungal drugs: New insights in research & development.

Nicola AM, Albuquerque P, Paes HC, Fernandes L, Costa FF, Kioshima ES, Abadio AKR, Bocca AL, Felipe MS.

Pharmacol Ther. 2018 Oct 19. pii: S0163-7258(18)30192-X. doi: 10.1016/j.pharmthera.2018.10.008. [Epub ahead of print] Review.


Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood.

Fernandes LMP, Lopes KS, Santana LNS, Fontes-Júnior EA, Ribeiro CHMA, Silva MCF, de Oliveira Paraense RS, Crespo-López ME, Gomes ARQ, Lima RR, Monteiro MC, Maia CSF.

Oxid Med Cell Longev. 2018 Sep 19;2018:3467531. doi: 10.1155/2018/3467531. eCollection 2018.


Editorial: Mood and Cognition in Old Age.

Fernandes L, Wang H.

Front Aging Neurosci. 2018 Sep 25;10:286. doi: 10.3389/fnagi.2018.00286. eCollection 2018. No abstract available.


The use of drugs and medical students: a literature review.

Candido FJ, Souza R, Stumpf MA, Fernandes LG, Veiga R, Santin M, Kluthcovsky A.

Rev Assoc Med Bras (1992). 2018 May;64(5):462-468. doi: 10.1590/1806-9282.64.05.462. Review.


Effect of alginate coating on the physico-chemical and microbial quality of pansies (Viola × wittrockiana) during storage.

Fernandes L, Casal S, Pereira JA, Pereira EL, Saraiva JA, Ramalhosa E.

Food Sci Biotechnol. 2018 Feb 12;27(4):987-996. doi: 10.1007/s10068-018-0326-0. eCollection 2018 Aug.


Optical coherence tomography follow-up of patients treated from periodontal disease.

Fernandes LO, Mota CCBO, Oliveira HO, Neves JK, Santiago LM, Gomes ASL.

J Biophotonics. 2019 Feb;12(2):e201800209. doi: 10.1002/jbio.201800209. Epub 2018 Oct 31.


Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice.

Fernandes LM, Al-Dwairi A, Simmen RCM, Marji M, Brown DM, Jewell SW, Simmen FA.

Sci Rep. 2018 Sep 24;8(1):14268. doi: 10.1038/s41598-018-32532-w.


Patients with asthma have reduced functional capacity and sedentary behavior.

Reimberg MM, Pachi JRS, Scalco RS, Serra AJ, Fernandes L, Politti F, Wandalsen GF, Solé D, Dal Corso S, Lanza FC.

J Pediatr (Rio J). 2018 Sep 18. pii: S0021-7557(18)30555-2. doi: 10.1016/j.jped.2018.07.011. [Epub ahead of print]


The use of mouthguards and prevalence of dento-alveolar trauma among athletes: A systematic review and meta-analysis.

Fernandes LM, Neto JCL, Lima TFR, Magno MB, Santiago BM, Cavalcanti YW, de Almeida LFD.

Dent Traumatol. 2019 Feb;35(1):54-72. doi: 10.1111/edt.12441. Epub 2018 Oct 16.


Astragaloside IV supplementation promotes a neuroprotective effect in experimental models of neurological disorders: a systematic review.

Costa IM, Lima FOV, Fernandes LCB, Norrara B, Neta FI, Alves RD, Cavalcanti JRLP, Lucena EES, Cavalcante JS, Rego ACM, Filho IA, Queiroz DB, Freire MAM, Guzen FP.

Curr Neuropharmacol. 2018 Sep 11. doi: 10.2174/1570159X16666180911123341. [Epub ahead of print]



Andrade CLO, Lemos AC, Machado GC, Fernandes LDC, Silva LL, Oliveira HB, Ramos HE, Alves CAD.

Rev Paul Pediatr. 2019 Jan-Mar;37(1):82-89. doi: 10.1590/1984-0462/;2019;37;1;00014. Epub 2018 Aug 30. Portuguese, English.


Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis.

Brown DM, Lee HC, Liu S, Quick CM, Fernandes LM, Simmen FA, Tsai SJ, Simmen RCM.

J Endocr Soc. 2018 May 25;2(7):765-778. doi: 10.1210/js.2018-00007. eCollection 2018 Jul 1.


Intrauterine Malnutrition Reduced Long Leptin Receptor Isoform Expression and Proinflammatory Cytokine Production in Male Rat Pulmonary Endothelial Cells Stimulated by Lipopolysaccharide.

Balbino AM, Silva MM, Azevedo GA, Gil NL, Ferreira RR, Dos Santos LA, Gasparin RM, Fernandes L, Landgraf MA, Landgraf RG.

Mediators Inflamm. 2018 Jul 9;2018:8597361. doi: 10.1155/2018/8597361. eCollection 2018.


Effect of vildagliptin versus glibenclamide on endothelial function and arterial stiffness in patients with type 2 diabetes and hypertension: a randomized controlled trial.

Cosenso-Martin LN, Giollo-Júnior LT, Fernandes LAB, Cesarino CB, Nakazone MA, Machado MN, Yugar-Toledo JC, Vilela-Martin JF.

Acta Diabetol. 2018 Dec;55(12):1237-1245. doi: 10.1007/s00592-018-1204-1. Epub 2018 Aug 9.


The Antidiabetic Drug Liraglutide Minimizes the Non-Cholinergic Neurotoxicity of the Pesticide Mipafox in SH-SY5Y Cells.

Fernandes LS, Dos Santos NAG, Emerick GL, Dos Santos AC.

Neurotox Res. 2019 Jan;35(1):150-159. doi: 10.1007/s12640-018-9941-z. Epub 2018 Aug 7.


KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control.

Tie CH, Fernandes L, Conde L, Robbez-Masson L, Sumner RP, Peacock T, Rodriguez-Plata MT, Mickute G, Gifford R, Towers GJ, Herrero J, Rowe HM.

EMBO Rep. 2018 Oct;19(10). pii: e45000. doi: 10.15252/embr.201745000. Epub 2018 Jul 30.


Recent Advances in the Therapeutic and Diagnostic Use of Liposomes and Carbon Nanomaterials in Ischemic Stroke.

Fernandes LF, Bruch GE, Massensini AR, Frézard F.

Front Neurosci. 2018 Jul 5;12:453. doi: 10.3389/fnins.2018.00453. eCollection 2018. Review.


Evaluation of Lsa46 and Lsa77 Leptospiral Proteins for Their Immunoprotective Activities in Hamster Model of Leptospirosis.

Teixeira AF, Fernandes LGV, Souza Filho A, Souza GO, Vasconcellos SA, Heinemann MB, Nascimento ALTO.

Biomed Res Int. 2018 Jun 10;2018:1813745. doi: 10.1155/2018/1813745. eCollection 2018.


Treatment of symptomatic benign migratory glossitis: a systematic review.

de Campos WG, Esteves CV, Fernandes LG, Domaneschi C, Júnior CAL.

Clin Oral Investig. 2018 Sep;22(7):2487-2493. doi: 10.1007/s00784-018-2553-4. Epub 2018 Jul 7.


Validation of a high performance functional assay for individual radiosensitivity in pediatric oncology: a prospective cohort study (ARPEGE).

Bernier-Chastagner V, Hettal L, Gillon V, Fernandes L, Huin-Schohn C, Vazel M, Tosti P, Salleron J, François A, Cérimèle E, Perreira S, Peiffert D, Chastagner P, Vogin G.

BMC Cancer. 2018 Jul 6;18(1):719. doi: 10.1186/s12885-018-4652-7.


Immunomodulatory and Antitumoral Properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) Medicinal Mushrooms.

Rubel R, Santa HSD, Dos Santos LF, Fernandes LC, Figueiredo BC, Soccol CR.

Int J Med Mushrooms. 2018;20(4):393-403. doi: 10.1615/IntJMedMushrooms.2018025979.


Signatures of Microevolutionary Processes in Phylogenetic Patterns.

Costa CLN, Lemos-Costa P, Marquitti FMD, Fernandes LD, Ramos MF, Schneider DM, Martins AB, de Aguiar MAM.

Syst Biol. 2019 Jan 1;68(1):131-144. doi: 10.1093/sysbio/syy049.


A case of the giggles: Diagnosis and management of giggle incontinence.

Fernandes L, Martin D, Hum S.

Can Fam Physician. 2018 Jun;64(6):445-447. No abstract available.


Questionnaire to avoid transfers to healthcare: a Brazilian experience.

Alvarenga CW, Fernandes LH, Pazin-Filho A, Dos Santos LL.

Int J Prison Health. 2018 Jun 11;14(2):142-150. doi: 10.1108/IJPH-04-2017-0018.


Heavy Chronic Ethanol Exposure From Adolescence to Adulthood Induces Cerebellar Neuronal Loss and Motor Function Damage in Female Rats.

da Silva FBR, Cunha PA, Ribera PC, Barros MA, Cartágenes SC, Fernandes LMP, Teixeira FB, Fontes-Júnior EA, Prediger RD, Lima RR, Maia CSF.

Front Behav Neurosci. 2018 May 15;12:88. doi: 10.3389/fnbeh.2018.00088. eCollection 2018.


Exposure to Inorganic Mercury Causes Oxidative Stress, Cell Death, and Functional Deficits in the Motor Cortex.

Teixeira FB, de Oliveira ACA, Leão LKR, Fagundes NCF, Fernandes RM, Fernandes LMP, da Silva MCF, Amado LL, Sagica FES, de Oliveira EHC, Crespo-Lopez ME, Maia CSF, Lima RR.

Front Mol Neurosci. 2018 May 15;11:125. doi: 10.3389/fnmol.2018.00125. eCollection 2018.


Hippocampal Dysfunction Provoked by Mercury Chloride Exposure: Evaluation of Cognitive Impairment, Oxidative Stress, Tissue Injury and Nature of Cell Death.

Aragão WAB, Teixeira FB, Fagundes NCF, Fernandes RM, Fernandes LMP, da Silva MCF, Amado LL, Sagica FES, Oliveira EHC, Crespo-Lopez ME, Maia CSF, Lima RR.

Oxid Med Cell Longev. 2018 Apr 10;2018:7878050. doi: 10.1155/2018/7878050. eCollection 2018.


Sensorineural hearing loss in children with sickle cell anemia and its association with endothelial dysfunction.

Lago MRR, Fernandes LDC, Lyra IM, Ramos RT, Teixeira R, Salles C, Ladeia AMT.

Hematology. 2018 Dec;23(10):849-855. doi: 10.1080/10245332.2018.1478494. Epub 2018 May 28.


Unravelling motor behaviour hallmarks in intoxicated adolescents: methylmercury subtoxic-dose exposure and binge ethanol intake paradigm in rats.

Oliveira AN, Pinheiro AM, Belém-Filho IJA, Fernandes LMP, Cartágenes SC, Ribera PC, Fontes-Júnior EA, Crespo-Lopez ME, Monteiro MC, Lima MO, Maia CSF.

Environ Sci Pollut Res Int. 2018 Aug;25(22):21937-21948. doi: 10.1007/s11356-018-2235-4. Epub 2018 May 24.


Cathodal tDCS of the Left Posterior Parietal Cortex Increases Proprioceptive Drift.

Ventura de Oliveira JR, Romano-Silva MA, Ugrinowitsch H, Apolinário-Souza T, Fernandes LA, Parma JO, Lage GM.

J Mot Behav. 2018 May 23:1-9. doi: 10.1080/00222895.2018.1468311. [Epub ahead of print]


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