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Items: 46

1.

Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort.

Prieto P, Jaén RI, Calle D, Gómez-Serrano M, Núñez E, Fernández-Velasco M, Martín-Sanz P, Alonso S, Vázquez J, Cerdán S, Peinado MÁ, Boscá L.

World J Gastroenterol. 2019 Jan 28;25(4):433-446. doi: 10.3748/wjg.v25.i4.433.

2.

Fibroblast growth factor-23 promotes rhythm alterations and contractile dysfunction in adult ventricular cardiomyocytes.

Navarro-García JA, Delgado C, Fernández-Velasco M, Val-Blasco A, Rodríguez-Sánchez E, Aceves-Ripoll J, Gómez-Hurtado N, Bada-Bosch T, Mérida-Herrero E, Hernández E, Praga M, Salguero R, Solís J, Arribas F, Delgado JF, Bueno H, Kuro-O M, Ruilope LM, Ruiz-Hurtado G.

Nephrol Dial Transplant. 2019 Jan 9. doi: 10.1093/ndt/gfy392. [Epub ahead of print]

PMID:
30629224
3.

Calcitriol, the Bioactive Metabolite of Vitamin D, Increases Ventricular K+ Currents in Isolated Mouse Cardiomyocytes.

Tamayo M, Martin-Nunes L, Val-Blasco A, Piedras MJ, Larriba MJ, Gómez-Hurtado N, Fernández-Velasco M, Delgado C.

Front Physiol. 2018 Aug 24;9:1186. doi: 10.3389/fphys.2018.01186. eCollection 2018.

4.

Deficiency of NOD1 Improves the β-Adrenergic Modulation of Ca2+ Handling in a Mouse Model of Heart Failure.

Val-Blasco A, Navarro-García JA, Tamayo M, Piedras MJ, Prieto P, Delgado C, Ruiz-Hurtado G, Rozas-Romero L, Gil-Fernández M, Zaragoza C, Boscá L, Fernández-Velasco M.

Front Physiol. 2018 Jun 14;9:702. doi: 10.3389/fphys.2018.00702. eCollection 2018.

5.

PTH, vitamin D, and the FGF-23-klotho axis and heart: Going beyond the confines of nephrology.

Navarro-García JA, Fernández-Velasco M, Delgado C, Delgado JF, Kuro-O M, Ruilope LM, Ruiz-Hurtado G.

Eur J Clin Invest. 2018 Apr;48(4). doi: 10.1111/eci.12902. Epub 2018 Feb 21. Review.

PMID:
29394451
6.

PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p.

Brea R, Motiño O, Francés D, García-Monzón C, Vargas J, Fernández-Velasco M, Boscá L, Casado M, Martín-Sanz P, Agra N.

Biochim Biophys Acta Mol Basis Dis. 2018 Feb;1864(2):325-337. doi: 10.1016/j.bbadis.2017.11.001. Epub 2017 Nov 3.

7.

Beneficial effects of leptin treatment in a setting of cardiac dysfunction induced by transverse aortic constriction in mouse.

Gómez-Hurtado N, Domínguez-Rodríguez A, Mateo P, Fernández-Velasco M, Val-Blasco A, Aizpún R, Sabourin J, Gómez AM, Benitah JP, Delgado C.

J Physiol. 2017 Jul 1;595(13):4227-4243. doi: 10.1113/JP274030. Epub 2017 May 23.

8.

Mild and Short-Term Caloric Restriction Prevents Obesity-Induced Cardiomyopathy in Young Zucker Rats without Changing in Metabolites and Fatty Acids Cardiac Profile.

Ruiz-Hurtado G, García-Prieto CF, Pulido-Olmo H, Velasco-Martín JP, Villa-Valverde P, Fernández-Valle ME, Boscá L, Fernández-Velasco M, Regadera J, Somoza B, Fernández-Alfonso MS.

Front Physiol. 2017 Feb 1;8:42. doi: 10.3389/fphys.2017.00042. eCollection 2017.

9.

Role of NOD1 in Heart Failure Progression via Regulation of Ca2+ Handling.

Val-Blasco A, Piedras MJGM, Ruiz-Hurtado G, Suarez N, Prieto P, Gonzalez-Ramos S, Gómez-Hurtado N, Delgado C, Pereira L, Benito G, Zaragoza C, Domenech N, Crespo-Leiro MG, Vasquez-Echeverri D, Nuñez G, Lopez-Collazo E, Boscá L, Fernández-Velasco M.

J Am Coll Cardiol. 2017 Jan 31;69(4):423-433. doi: 10.1016/j.jacc.2016.10.073.

10.

Calcitriol (1,25-dihydroxyvitamin D3) increases L-type calcium current via protein kinase A signaling and modulates calcium cycling and contractility in isolated mouse ventricular myocytes.

Tamayo M, Manzanares E, Bas M, Martín-Nunes L, Val-Blasco A, Jesús Larriba M, Fernández-Velasco M, Delgado C.

Heart Rhythm. 2017 Mar;14(3):432-439. doi: 10.1016/j.hrthm.2016.12.013. Epub 2016 Dec 15.

PMID:
27989685
11.

Cell Expansion-Dependent Inflammatory and Metabolic Profile of Human Bone Marrow Mesenchymal Stem Cells.

Prieto P, Fernández-Velasco M, Fernández-Santos ME, Sánchez PL, Terrón V, Martín-Sanz P, Fernández-Avilés F, Boscá L.

Front Physiol. 2016 Nov 16;7:548. eCollection 2016.

12.

NOD1 activation in cardiac fibroblasts induces myocardial fibrosis in a murine model of type 2 diabetes.

Val-Blasco A, Prieto P, Gonzalez-Ramos S, Benito G, Vallejo-Cremades MT, Pacheco I, González-Peramato P, Agra N, Terrón V, Delgado C, Martín-Sanz P, Boscá L, Fernández-Velasco M.

Biochem J. 2017 Feb 1;474(3):399-410. doi: 10.1042/BCJ20160556. Epub 2016 Nov 1.

PMID:
27803247
13.

Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation.

Boscá L, González-Ramos S, Prieto P, Fernández-Velasco M, Mojena M, Martín-Sanz P, Alemany S.

Biochem Soc Trans. 2015 Aug;43(4):740-4. doi: 10.1042/BST20150107. Epub 2015 Aug 3.

PMID:
26551722
14.

Activation of autophagy in macrophages by pro-resolving lipid mediators.

Prieto P, Rosales-Mendoza CE, Terrón V, Toledano V, Cuadrado A, López-Collazo E, Bannenberg G, Martín-Sanz P, Fernández-Velasco M, Boscá L.

Autophagy. 2015;11(10):1729-44. doi: 10.1080/15548627.2015.1078958.

15.

Reconciling depressed Ca2+ sparks occurrence with enhanced RyR2 activity in failing mice cardiomyocytes.

Ruiz-Hurtado G, Li L, Fernández-Velasco M, Rueda A, Lefebvre F, Wang Y, Mateo P, Cassan C, Gellen B, Benitah JP, Gómez AM.

J Gen Physiol. 2015 Oct;146(4):295-306. doi: 10.1085/jgp.201511366. Epub 2015 Sep 14.

16.

Regulation of MicroRNA 183 by Cyclooxygenase 2 in Liver Is DEAD-Box Helicase p68 (DDX5) Dependent: Role in Insulin Signaling.

Motiño O, Francés DE, Mayoral R, Castro-Sánchez L, Fernández-Velasco M, Boscá L, García-Monzón C, Brea R, Casado M, Agra N, Martín-Sanz P.

Mol Cell Biol. 2015 Jul;35(14):2554-67. doi: 10.1128/MCB.00198-15. Epub 2015 May 11.

17.

HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages.

Tawakol A, Singh P, Mojena M, Pimentel-Santillana M, Emami H, MacNabb M, Rudd JH, Narula J, Enriquez JA, Través PG, Fernández-Velasco M, Bartrons R, Martín-Sanz P, Fayad ZA, Tejedor A, Boscá L.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1463-71. doi: 10.1161/ATVBAHA.115.305551. Epub 2015 Apr 16.

18.

NOD1, a new player in cardiac function and calcium handling.

Delgado C, Ruiz-Hurtado G, Gómez-Hurtado N, González-Ramos S, Rueda A, Benito G, Prieto P, Zaragoza C, Delicado EG, Pérez-Sen R, Miras-Portugal MT, Núñez G, Boscá L, Fernández-Velasco M.

Cardiovasc Res. 2015 Jun 1;106(3):375-86. doi: 10.1093/cvr/cvv118. Epub 2015 Mar 30.

PMID:
25824149
19.

A labdane diterpene exerts ex vivo and in vivo cardioprotection against post-ischemic injury: involvement of AKT-dependent mechanisms.

Cuadrado-Berrocal I, Gómez-Gaviro MV, Benito Y, Barrio A, Bermejo J, Fernández-Santos ME, Sánchez PL, Desco M, Fernández-Avilés F, Fernández-Velasco M, Boscá L, de Las Heras B.

Biochem Pharmacol. 2015 Feb 15;93(4):428-39. doi: 10.1016/j.bcp.2014.12.011. Epub 2014 Dec 31.

PMID:
25557296
20.

Ca(2+) handling alterations and vascular dysfunction in diabetes.

Fernández-Velasco M, Ruiz-Hurtado G, Gómez AM, Rueda A.

Cell Calcium. 2014 Nov;56(5):397-407. doi: 10.1016/j.ceca.2014.08.007. Epub 2014 Aug 17. Review.

PMID:
25218935
21.

NOD1 receptor is up-regulated in diabetic human and murine myocardium.

Prieto P, Vallejo-Cremades MT, Benito G, González-Peramato P, Francés D, Agra N, Terrón V, Gónzalez-Ramos S, Delgado C, Ruiz-Gayo M, Pacheco I, Velasco-Martín JP, Regadera J, Martín-Sanz P, López-Collazo E, Boscá L, Fernández-Velasco M.

Clin Sci (Lond). 2014 Dec;127(12):665-77. doi: 10.1042/CS20140180.

PMID:
24934088
22.

Mitochondrial DAMPs induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction.

Fernández-Ruiz I, Arnalich F, Cubillos-Zapata C, Hernández-Jiménez E, Moreno-González R, Toledano V, Fernández-Velasco M, Vallejo-Cremades MT, Esteban-Burgos L, de Diego RP, Llamas-Matias MA, García-Arumi E, Martí R, Boscá L, Andreu AL, López-Sendón JL, López-Collazo E.

PLoS One. 2014 May 5;9(5):e95073. doi: 10.1371/journal.pone.0095073. eCollection 2014.

23.

Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases.

Fernández-Velasco M, González-Ramos S, Boscá L.

Biochem J. 2014 Mar 1;458(2):187-93. doi: 10.1042/BJ20131501. Review.

PMID:
24524191
24.

Prolonged leptin treatment increases transient outward K⁺ current via upregulation of Kv4.2 and Kv4.3 channel subunits in adult rat ventricular myocytes.

Gómez-Hurtado N, Fernández-Velasco M, Fernández-Alfonso MS, Boscá L, Delgado C.

Pflugers Arch. 2014 May;466(5):903-14. doi: 10.1007/s00424-013-1348-3. Epub 2013 Sep 18.

PMID:
24046152
25.

Abnormal Ca2+ spark/STOC coupling in cerebral artery smooth muscle cells of obese type 2 diabetic mice.

Rueda A, Fernández-Velasco M, Benitah JP, Gómez AM.

PLoS One. 2013;8(1):e53321. doi: 10.1371/journal.pone.0053321. Epub 2013 Jan 3.

26.

NOD1 activation induces cardiac dysfunction and modulates cardiac fibrosis and cardiomyocyte apoptosis.

Fernández-Velasco M, Prieto P, Terrón V, Benito G, Flores JM, Delgado C, Zaragoza C, Lavin B, Gómez-Parrizas M, López-Collazo E, Martín-Sanz P, Boscá L.

PLoS One. 2012;7(9):e45260. doi: 10.1371/journal.pone.0045260. Epub 2012 Sep 18.

27.

Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes.

Ruiz-Hurtado G, Domínguez-Rodríguez A, Pereira L, Fernández-Velasco M, Cassan C, Lezoualc'h F, Benitah JP, Gómez AM.

J Mol Cell Cardiol. 2012 Nov;53(5):617-25. doi: 10.1016/j.yjmcc.2012.08.004. Epub 2012 Aug 19.

PMID:
22910094
28.

Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.

Ruiz-Hurtado G, Gómez-Hurtado N, Fernández-Velasco M, Calderón E, Smani T, Ordoñez A, Cachofeiro V, Boscá L, Díez J, Gómez AM, Delgado C.

Cardiovasc Res. 2012 Oct 1;96(1):81-9. doi: 10.1093/cvr/cvs234. Epub 2012 Jul 11.

PMID:
22787135
29.

Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.

García-Hoz C, Sánchez-Fernández G, García-Escudero R, Fernández-Velasco M, Palacios-García J, Ruiz-Meana M, Díaz-Meco MT, Leitges M, Moscat J, García-Dorado D, Boscá L, Mayor F Jr, Ribas C.

J Biol Chem. 2012 Mar 2;287(10):7792-802. doi: 10.1074/jbc.M111.282210. Epub 2012 Jan 9.

30.

Labdane diterpenes protect against anoxia/reperfusion injury in cardiomyocytes: involvement of AKT activation.

Cuadrado I, Fernández-Velasco M, Boscá L, de Las Heras B.

Cell Death Dis. 2011 Nov 10;2:e229. doi: 10.1038/cddis.2011.113.

31.

RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.

Fernández-Velasco M, Ruiz-Hurtado G, Rueda A, Neco P, Mercado-Morales M, Delgado C, Napolitano C, Priori SG, Richard S, Gómez AM, Benitah JP.

PLoS One. 2011;6(6):e20863. doi: 10.1371/journal.pone.0020863. Epub 2011 Jun 6.

32.

Mechanisms underlying the activation of L-type calcium channels by urocortin in rat ventricular myocytes.

Smani T, Calderón-Sanchez E, Gómez-Hurtado N, Fernández-Velasco M, Cachofeiro V, Lahera V, Ordoñez A, Delgado C.

Cardiovasc Res. 2010 Aug 1;87(3):459-66. doi: 10.1093/cvr/cvq063. Epub 2010 Feb 26.

33.

[Psychopathological characteristics of female victims of intimate partner violence].

Labrador Encinas FJ, Fernández-Velasco MR, Rincón P.

Psicothema. 2010 Feb;22(1):99-105. Spanish.

PMID:
20100434
34.

Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways.

Prieto P, Cuenca J, Través PG, Fernández-Velasco M, Martín-Sanz P, Boscá L.

Cell Death Differ. 2010 Jul;17(7):1179-88. doi: 10.1038/cdd.2009.220. Epub 2010 Jan 22.

35.

Cardiac L-type calcium current is increased in a model of hyperaldosteronism in the rat.

Martin-Fernandez B, Miana M, De Las Heras N, Ruiz-Hurtado G, Fernandez-Velasco M, Bas M, Ballesteros S, Lahera V, Cachofeiro V, Delgado C.

Exp Physiol. 2009 Jun;94(6):675-83. doi: 10.1113/expphysiol.2009.047688. Epub 2009 Apr 24.

36.

Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia.

Fernández-Velasco M, Rueda A, Rizzi N, Benitah JP, Colombi B, Napolitano C, Priori SG, Richard S, Gómez AM.

Circ Res. 2009 Jan 30;104(2):201-9, 12p following 209. doi: 10.1161/CIRCRESAHA.108.177493. Epub 2008 Dec 18.

37.

Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling.

Loyer X, Gómez AM, Milliez P, Fernandez-Velasco M, Vangheluwe P, Vinet L, Charue D, Vaudin E, Zhang W, Sainte-Marie Y, Robidel E, Marty I, Mayer B, Jaisser F, Mercadier JJ, Richard S, Shah AM, Bénitah JP, Samuel JL, Heymes C.

Circulation. 2008 Jun 24;117(25):3187-98. doi: 10.1161/CIRCULATIONAHA.107.741702. Epub 2008 Jun 9.

PMID:
18541744
38.

Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling.

Gellen B, Fernández-Velasco M, Briec F, Vinet L, LeQuang K, Rouet-Benzineb P, Bénitah JP, Pezet M, Palais G, Pellegrin N, Zhang A, Perrier R, Escoubet B, Marniquet X, Richard S, Jaisser F, Gómez AM, Charpentier F, Mercadier JJ.

Circulation. 2008 Apr 8;117(14):1778-86. doi: 10.1161/CIRCULATIONAHA.107.731893. Epub 2008 Mar 31.

PMID:
18378612
39.

LA419, a novel nitric oxide donor, prevents pathological cardiac remodeling in pressure-overloaded rats via endothelial nitric oxide synthase pathway regulation.

Ruiz-Hurtado G, Fernández-Velasco M, Mourelle M, Delgado C.

Hypertension. 2007 Dec;50(6):1049-56. Epub 2007 Nov 5.

PMID:
17984372
40.

The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes.

Pereira L, Métrich M, Fernández-Velasco M, Lucas A, Leroy J, Perrier R, Morel E, Fischmeister R, Richard S, Bénitah JP, Lezoualc'h F, Gómez AM.

J Physiol. 2007 Sep 1;583(Pt 2):685-94. Epub 2007 Jun 28.

41.

TNF-alpha downregulates transient outward potassium current in rat ventricular myocytes through iNOS overexpression and oxidant species generation.

Fernández-Velasco M, Ruiz-Hurtado G, Hurtado O, Moro MA, Delgado C.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H238-45. Epub 2007 Mar 2.

42.

Unzipping RyR2 in adult cardiomyocytes: getting closer to mechanisms of inherited ventricular arrhythmias?

Fernandez-Velasco M, Gomez AM, Richard S.

Cardiovasc Res. 2006 Jun 1;70(3):407-9. Epub 2006 Apr 18. No abstract available.

PMID:
16690043
43.

I K1 and I f in ventricular myocytes isolated from control and hypertrophied rat hearts.

Fernández-Velasco M, Ruiz-Hurtado G, Delgado C.

Pflugers Arch. 2006 May;452(2):146-54. Epub 2006 Jan 5.

PMID:
16395601
44.

Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model.

Zicha S, Fernández-Velasco M, Lonardo G, L'Heureux N, Nattel S.

Cardiovasc Res. 2005 Jun 1;66(3):472-81. Epub 2005 Mar 21.

PMID:
15914112
45.
46.

Neuropeptide Y increases 4-aminopyridine-sensitive transient outward potassium current in rat ventricular myocytes.

Heredia MP, Fernández-Velasco M, Benito G, Delgado C.

Br J Pharmacol. 2002 Apr;135(7):1701-6. Erratum in: Br J Pharmacol. 2002 Aug;136(7):1079.

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