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Items: 1 to 50 of 51

1.

Mutations in the ND2 Subunit of Mitochondrial Complex I Are Sufficient to Confer Increased Tumorigenic and Metastatic Potential to Cancer Cells.

Marco-Brualla J, Al-Wasaby S, Soler R, Romanos E, Conde B, Justo-Méndez R, Enríquez JA, Fernández-Silva P, Martínez-Lostao L, Villalba M, Moreno-Loshuertos R, Anel A.

Cancers (Basel). 2019 Jul 21;11(7). pii: E1027. doi: 10.3390/cancers11071027.

2.

Corrigendum: Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.

Latorre-Pellicer A, Moreno-Loshuertos R, Lechuga-Vieco AV, Sánchez-Cabo F, Torroja C, Acín-Pérez R, Calvo E, Aix E, González-Guerra A, Logan A, Bernad-Miana ML, Romanos E, Cruz R, Cogliati S, Sobrino B, Carracedo Á, Pérez-Martos A, Fernández-Silva P, Ruíz-Cabello J, Murphy MP, Flores I, Vázquez J, Enríquez JA.

Nature. 2017 Feb 2;542(7639):124. doi: 10.1038/nature20773. Epub 2016 Dec 7. No abstract available.

PMID:
27926738
3.

Adjusting MtDNA Quantification in Whole Blood for Peripheral Blood Platelet and Leukocyte Counts.

Hurtado-Roca Y, Ledesma M, Gonzalez-Lazaro M, Moreno-Loshuertos R, Fernandez-Silva P, Enriquez JA, Laclaustra M.

PLoS One. 2016 Oct 13;11(10):e0163770. doi: 10.1371/journal.pone.0163770. eCollection 2016.

4.

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.

Latorre-Pellicer A, Moreno-Loshuertos R, Lechuga-Vieco AV, Sánchez-Cabo F, Torroja C, Acín-Pérez R, Calvo E, Aix E, González-Guerra A, Logan A, Bernad-Miana ML, Romanos E, Cruz R, Cogliati S, Sobrino B, Carracedo Á, Pérez-Martos A, Fernández-Silva P, Ruíz-Cabello J, Murphy MP, Flores I, Vázquez J, Enríquez JA.

Nature. 2016 Jul 28;535(7613):561-5. Epub 2016 Jul 6.

PMID:
27383793
5.

The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency.

Guarás A, Perales-Clemente E, Calvo E, Acín-Pérez R, Loureiro-Lopez M, Pujol C, Martínez-Carrascoso I, Nuñez E, García-Marqués F, Rodríguez-Hernández MA, Cortés A, Diaz F, Pérez-Martos A, Moraes CT, Fernández-Silva P, Trifunovic A, Navas P, Vazquez J, Enríquez JA.

Cell Rep. 2016 Apr 5;15(1):197-209. doi: 10.1016/j.celrep.2016.03.009. Epub 2016 Mar 24.

6.

Role of Δ1-pyrroline-5-carboxylate dehydrogenase supports mitochondrial metabolism and host-cell invasion of Trypanosoma cruzi.

Mantilla BS, Paes LS, Pral EM, Martil DE, Thiemann OH, Fernández-Silva P, Bastos EL, Silber AM.

J Biol Chem. 2015 Mar 20;290(12):7767-90. doi: 10.1074/jbc.M114.574525. Epub 2015 Jan 26.

7.

Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic apoptosis inducing factor.

Ferreira P, Villanueva R, Martínez-Júlvez M, Herguedas B, Marcuello C, Fernandez-Silva P, Cabon L, Hermoso JA, Lostao A, Susin SA, Medina M.

Biochemistry. 2014 Jul 1;53(25):4204-15. doi: 10.1021/bi500343r. Epub 2014 Jun 20.

PMID:
24914854
8.

ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.

Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sanchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G, Enríquez JA.

Cell Metab. 2014 Jun 3;19(6):1020-33. doi: 10.1016/j.cmet.2014.04.015. Epub 2014 May 22.

9.

Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency.

Cogliati S, Frezza C, Soriano ME, Varanita T, Quintana-Cabrera R, Corrado M, Cipolat S, Costa V, Casarin A, Gomes LC, Perales-Clemente E, Salviati L, Fernandez-Silva P, Enriquez JA, Scorrano L.

Cell. 2013 Sep 26;155(1):160-71. doi: 10.1016/j.cell.2013.08.032. Epub 2013 Sep 19.

10.

Length variation in the mouse mitochondrial tRNA(Arg) DHU loop size promotes oxidative phosphorylation functional differences.

Moreno-Loshuertos R, Pérez-Martos A, Fernández-Silva P, Enríquez JA.

FEBS J. 2013 Oct;280(20):4983-98. doi: 10.1111/febs.12466. Epub 2013 Sep 2.

11.

Supercomplex assembly determines electron flux in the mitochondrial electron transport chain.

Lapuente-Brun E, Moreno-Loshuertos R, Acín-Pérez R, Latorre-Pellicer A, Colás C, Balsa E, Perales-Clemente E, Quirós PM, Calvo E, Rodríguez-Hernández MA, Navas P, Cruz R, Carracedo Á, López-Otín C, Pérez-Martos A, Fernández-Silva P, Fernández-Vizarra E, Enríquez JA.

Science. 2013 Jun 28;340(6140):1567-70. doi: 10.1126/science.1230381.

PMID:
23812712
12.

Evolution meets disease: penetrance and functional epistasis of mitochondrial tRNA mutations.

Moreno-Loshuertos R, Ferrín G, Acín-Pérez R, Gallardo ME, Viscomi C, Pérez-Martos A, Zeviani M, Fernández-Silva P, Enríquez JA.

PLoS Genet. 2011 Apr;7(4):e1001379. doi: 10.1371/journal.pgen.1001379. Epub 2011 Apr 21.

13.

A genome-wide shRNA screen for new OxPhos related genes.

Bayona-Bafaluy MP, Sánchez-Cabo F, Fernández-Silva P, Pérez-Martos A, Enríquez JA.

Mitochondrion. 2011 May;11(3):467-75. doi: 10.1016/j.mito.2011.01.007. Epub 2011 Feb 1.

PMID:
21292037
14.

Tissue-specific differences in mitochondrial activity and biogenesis.

Fernández-Vizarra E, Enríquez JA, Pérez-Martos A, Montoya J, Fernández-Silva P.

Mitochondrion. 2011 Jan;11(1):207-13. doi: 10.1016/j.mito.2010.09.011. Epub 2010 Oct 7.

PMID:
20933104
15.

Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?

Perales-Clemente E, Fernández-Silva P, Acín-Pérez R, Pérez-Martos A, Enríquez JA.

Nucleic Acids Res. 2011 Jan;39(1):225-34. doi: 10.1093/nar/gkq769. Epub 2010 Sep 7.

16.

Five entry points of the mitochondrially encoded subunits in mammalian complex I assembly.

Perales-Clemente E, Fernández-Vizarra E, Acín-Pérez R, Movilla N, Bayona-Bafaluy MP, Moreno-Loshuertos R, Pérez-Martos A, Fernández-Silva P, Enríquez JA.

Mol Cell Biol. 2010 Jun;30(12):3038-47. doi: 10.1128/MCB.00025-10. Epub 2010 Apr 12.

17.

Isolation of mitochondria for biogenetical studies: An update.

Fernández-Vizarra E, Ferrín G, Pérez-Martos A, Fernández-Silva P, Zeviani M, Enríquez JA.

Mitochondrion. 2010 Apr;10(3):253-62. doi: 10.1016/j.mito.2009.12.148. Epub 2009 Dec 23.

PMID:
20034597
18.

Functional genetic analysis of the mammalian mitochondrial DNA encoded peptides: a mutagenesis approach.

Bayona-Bafaluy MP, Movilla N, Pérez-Martos A, Fernández-Silva P, Enriquez JA.

Methods Mol Biol. 2008;457:379-90.

PMID:
19066042
19.

Respiratory active mitochondrial supercomplexes.

Acín-Pérez R, Fernández-Silva P, Peleato ML, Pérez-Martos A, Enriquez JA.

Mol Cell. 2008 Nov 21;32(4):529-39. doi: 10.1016/j.molcel.2008.10.021.

20.

Restoration of electron transport without proton pumping in mammalian mitochondria.

Perales-Clemente E, Bayona-Bafaluy MP, Pérez-Martos A, Barrientos A, Fernández-Silva P, Enriquez JA.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18735-9. doi: 10.1073/pnas.0810518105. Epub 2008 Nov 19.

21.

Mitochondrial gene expression is regulated at multiple levels and differentially in the heart and liver by thyroid hormones.

Fernández-Vizarra E, Enriquez JA, Pérez-Martos A, Montoya J, Fernández-Silva P.

Curr Genet. 2008 Jul;54(1):13-22. doi: 10.1007/s00294-008-0194-x. Epub 2008 May 15.

PMID:
18481068
22.

Cisplatin-mediated impairment of mitochondrial DNA metabolism inversely correlates with glutathione levels.

Garrido N, Pérez-Martos A, Faro M, Lou-Bonafonte JM, Fernández-Silva P, López-Pérez MJ, Montoya J, Enríquez JA.

Biochem J. 2008 Aug 15;414(1):93-102. doi: 10.1042/BJ20071615.

PMID:
18426391
23.

In vivo and in organello analyses of mitochondrial translation.

Fernández-Silva P, Acín-Pérez R, Fernández-Vizarra E, Pérez-Martos A, Enriquez JA.

Methods Cell Biol. 2007;80:571-88. Review. No abstract available.

PMID:
17445714
24.

Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants.

Moreno-Loshuertos R, Acín-Pérez R, Fernández-Silva P, Movilla N, Pérez-Martos A, Rodriguez de Cordoba S, Gallardo ME, Enríquez JA.

Nat Genet. 2006 Nov;38(11):1261-8. Epub 2006 Oct 1.

PMID:
17013393
25.

The thankless task of playing genetics with mammalian mitochondrial DNA: a 30-year review.

Bayona-Bafaluy MP, Fernández-Silva P, Enríquez JA.

Mitochondrion. 2002 Nov;2(1-2):3-25.

PMID:
16120305
26.

In vitro transcription termination activity of the Drosophila mitochondrial DNA-binding protein DmTTF.

Roberti M, Fernandez-Silva P, Polosa PL, Fernandez-Vizarra E, Bruni F, Deceglie S, Montoya J, Gadaleta MN, Cantatore P.

Biochem Biophys Res Commun. 2005 May 27;331(1):357-62.

PMID:
15845400
27.

Respiratory complex III is required to maintain complex I in mammalian mitochondria.

Acín-Pérez R, Bayona-Bafaluy MP, Fernández-Silva P, Moreno-Loshuertos R, Pérez-Martos A, Bruno C, Moraes CT, Enríquez JA.

Mol Cell. 2004 Mar 26;13(6):805-15.

28.

Revisiting the mouse mitochondrial DNA sequence.

Bayona-Bafaluy MP, Acín-Pérez R, Mullikin JC, Park JS, Moreno-Loshuertos R, Hu P, Pérez-Martos A, Fernández-Silva P, Bai Y, Enríquez JA.

Nucleic Acids Res. 2003 Sep 15;31(18):5349-55.

29.

An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA.

Acín-Pérez R, Bayona-Bafaluy MP, Bueno M, Machicado C, Fernández-Silva P, Pérez-Martos A, Montoya J, López-Pérez MJ, Sancho J, Enríquez JA.

Hum Mol Genet. 2003 Feb 1;12(3):329-39.

PMID:
12554686
30.

Replication and transcription of mammalian mitochondrial DNA.

Fernández-Silva P, Enriquez JA, Montoya J.

Exp Physiol. 2003 Jan;88(1):41-56. Review.

31.

Sea urchin mtDBP is a two-faced transcription termination factor with a biased polarity depending on the RNA polymerase.

Fernandez-Silva P, Polosa PL, Roberti M, Di Ponzio B, Gadaleta MN, Montoya J, Cantatore P.

Nucleic Acids Res. 2001 Nov 15;29(22):4736-43.

32.

Iron(II) induces changes in the conformation of mammalian mitochondrial DNA resulting in a reduction of its transcriptional rate.

Asín J, Pérez-Martos A, Fernández-Silva P, Montoya J, Andreu AL.

FEBS Lett. 2000 Sep 1;480(2-3):161-4.

34.

[Recent advances in genetics of epilepsy. Genetic of mitochondrial epilepsy].

Montoya J, Playán A, Alcaine MJ, Solano A, Fernández-Silva P, Enríquez JA.

Rev Neurol. 2000 Feb 16-29;30(4):330-2. Spanish.

PMID:
10789142
35.

Autonomous regulation in mammalian mitochondrial DNA transcription.

Enríquez JA, Fernández-Sílva P, Montoya J.

Biol Chem. 1999 Jul-Aug;380(7-8):737-47. Review.

PMID:
10494823
36.

Direct regulation of mitochondrial RNA synthesis by thyroid hormone.

Enríquez JA, Fernández-Silva P, Garrido-Pérez N, López-Pérez MJ, Pérez-Martos A, Montoya J.

Mol Cell Biol. 1999 Jan;19(1):657-70.

38.

Disorders of mitochondria and related metabolism.

Zeviani M, Fernandez-Silva P, Tiranti V.

Curr Opin Neurol. 1997 Apr;10(2):160-7. Review.

PMID:
9146998
40.

The synthesis of mRNA in isolated mitochondria can be maintained for several hours and is inhibited by high levels of ATP.

Enríquez JA, Fernández-Silva P, Pérez-Martos A, López-Pérez MJ, Montoya J.

Eur J Biochem. 1996 May 1;237(3):601-10.

41.

In vivo footprinting of human mitochondrial DNA in cultured cell systems.

Micol V, Fernández-Silva P, Attardi G.

Methods Enzymol. 1996;264:3-11. No abstract available.

PMID:
8965703
42.

Isolation and assay of mitochondrial transcription termination factor from human cells.

Micol V, Fernández-Silva P, Attardi G.

Methods Enzymol. 1996;264:158-73. No abstract available.

PMID:
8965690
43.

Mitochondrial DNA transcription initiation and termination using mitochondrial lysates from cultured human cells.

Fernández-Silva P, Micol V, Attardi G.

Methods Enzymol. 1996;264:129-39. No abstract available.

PMID:
8965687
44.

RNA synthesis in isolated mitochondria from brain cortex, cerebellum and stem: evidence of different transcriptional rates.

Enríquez JA, Pérez-Martos A, Fernández-Silva P, López-Pérez MJ, Montoya J.

Int J Biochem. 1993 Dec;25(12):1951-6.

PMID:
7511118
45.

Specific increase of a mitochondrial RNA transcript in chronic ethanol-fed rats.

Enríquez JA, Pérez-Martos A, Fernández-Silva P, López-Pérez MJ, Montoya J.

FEBS Lett. 1992 Jun 15;304(2-3):285-8.

46.

A simple procedure for recovering the denaturing effect of methylmercury in agarose gel electrophoresis.

Fernández-Silva P, Enriquez JA, Montoya J.

Biotechniques. 1992 Apr;12(4):480-2.

PMID:
1380250
47.

Molecular characterization and cloning of sheep mitochondrial DNA.

Villalta M, Fernández-Silva P, Beltrán B, Enguita L, López-Pérez MJ, Montoya J.

Curr Genet. 1992 Mar;21(3):235-40.

PMID:
1563049
48.

Reduced synthesis of mtRNA in isolated mitochondria of senescent rat brain.

Fernandez-Silva P, Petruzzella V, Fracasso F, Gadaleta MN, Cantatore P.

Biochem Biophys Res Commun. 1991 Apr 30;176(2):645-53.

PMID:
1709016
49.

Estimation of the chloramphenicol and cycloheximide inhibition of protein synthesis in brain cholinergic synaptosomes.

Corbaton V, Muiño MT, Fernández-Silva P, López-Pérez MJ, Montoya J.

Brain Res. 1991 Mar 15;543(2):351-3.

PMID:
1711913
50.

Acetyl-L-carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver.

Gadaleta MN, Petruzzella V, Fracasso F, Fernandez-Silva P, Cantatore P.

FEBS Lett. 1990 Dec 17;277(1-2):191-3.

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