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Items: 31

1.

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo.

Derby N, Lal M, Aravantinou M, Kizima L, Barnable P, Rodriguez A, Lai M, Wesenberg A, Ugaonkar S, Levendosky K, Mizenina O, Kleinbeck K, Lifson JD, Peet MM, Lloyd Z, Benson M, Heneine W, O'Keefe BR, Robbiani M, Martinelli E, Grasperge B, Blanchard J, Gettie A, Teleshova N, Fernández-Romero JA, Zydowsky TM.

Nat Commun. 2018 Sep 24;9(1):3881. doi: 10.1038/s41467-018-06349-0.

2.

MIV-150 and zinc acetate combination provides potent and broad activity against HIV-1.

Mizenina O, Hsu M, Jean-Pierre N, Aravantinou M, Levendosky K, Paglini G, Zydowsky TM, Robbiani M, Fernández-Romero JA.

Drug Deliv Transl Res. 2017 Dec;7(6):859-866. doi: 10.1007/s13346-017-0421-4.

PMID:
28812250
3.

In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel.

Novetsky AP, Keller MJ, Gradissimo A, Chen Z, Morgan SL, Xue X, Strickler HD, Fernández-Romero JA, Burk R, Einstein MH.

Gynecol Oncol. 2016 Nov;143(2):313-318. doi: 10.1016/j.ygyno.2016.09.003. Epub 2016 Sep 10.

4.

MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa.

Calenda G, Villegas G, Barnable P, Litterst C, Levendosky K, Gettie A, Cooney ML, Blanchard J, Fernández-Romero JA, Zydowsky TM, Teleshova N.

J Acquir Immune Defic Syndr. 2017 Mar 1;74(3):e67-e74. doi: 10.1097/QAI.0000000000001167.

5.

First-in-Human Trial of MIV-150 and Zinc Acetate Coformulated in a Carrageenan Gel: Safety, Pharmacokinetics, Acceptability, Adherence, and Pharmacodynamics.

Friedland BA, Hoesley CJ, Plagianos M, Hoskin E, Zhang S, Teleshova N, Alami M, Novak L, Kleinbeck KR, Katzen LL, Zydowsky TM, Fernández-Romero JA, Creasy GW.

J Acquir Immune Defic Syndr. 2016 Dec 15;73(5):489-496.

6.

A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo.

Villegas G, Calenda G, Ugaonkar S, Zhang S, Kizima L, Mizenina O, Gettie A, Blanchard J, Cooney ML, Robbiani M, Fernández-Romero JA, Zydowsky TM, Teleshova N.

PLoS One. 2016 Jul 18;11(7):e0159332. doi: 10.1371/journal.pone.0159332. eCollection 2016.

7.

In Vitro Exposure to PC-1005 and Cervicovaginal Lavage Fluid from Women Vaginally Administered PC-1005 Inhibits HIV-1 and HSV-2 Infection in Human Cervical Mucosa.

Villegas G, Calenda G, Zhang S, Mizenina O, Kleinbeck K, Cooney ML, Hoesley CJ, Creasy GW, Friedland B, Fernández-Romero JA, Zydowsky TM, Teleshova N.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5459-66. doi: 10.1128/AAC.00392-16. Print 2016 Sep.

8.

Multipurpose Prevention Approaches with Antiretroviral-Based Formulations.

Jean-Pierre N, Barnable P, Kizima L, Rodríguez A, Seidor S, Cooney ML, Clark MR, Doncel GF, Robbiani M, Zydowsky TM, Teleshova N, Fernández-Romero JA.

Antimicrob Agents Chemother. 2015 Nov 23;60(2):1141-4. doi: 10.1128/AAC.02468-15. Print 2016 Feb.

9.

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus.

Levendosky K, Mizenina O, Martinelli E, Jean-Pierre N, Kizima L, Rodriguez A, Kleinbeck K, Bonnaire T, Robbiani M, Zydowsky TM, O'Keefe BR, Fernández-Romero JA.

Antimicrob Agents Chemother. 2015 Dec;59(12):7290-8. doi: 10.1128/AAC.01816-15. Epub 2015 Sep 14.

10.

A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy.

Ugaonkar SR, Wesenberg A, Wilk J, Seidor S, Mizenina O, Kizima L, Rodriguez A, Zhang S, Levendosky K, Kenney J, Aravantinou M, Derby N, Grasperge B, Gettie A, Blanchard J, Kumar N, Roberts K, Robbiani M, Fernández-Romero JA, Zydowsky TM.

J Control Release. 2015 Sep 10;213:57-68. doi: 10.1016/j.jconrel.2015.06.018. Epub 2015 Jun 17.

11.

MIV-150/zinc acetate gel inhibits cell-associated simian-human immunodeficiency virus reverse transcriptase infection in a macaque vaginal explant model.

Barnable P, Calenda G, Bonnaire T, Menon R, Levendosky K, Gettie A, Blanchard J, Cooney ML, Fernández-Romero JA, Zydowsky TM, Teleshova N.

Antimicrob Agents Chemother. 2015 Jul;59(7):3829-37. doi: 10.1128/AAC.00073-15. Epub 2015 Apr 13.

12.

Multipurpose prevention technologies: the future of HIV and STI protection.

Fernández-Romero JA, Deal C, Herold BC, Schiller J, Patton D, Zydowsky T, Romano J, Petro CD, Narasimhan M.

Trends Microbiol. 2015 Jul;23(7):429-436. doi: 10.1016/j.tim.2015.02.006. Epub 2015 Mar 7. Review.

13.

Preclinical assessments of vaginal microbicide candidate safety and efficacy.

Fernández-Romero JA, Teleshova N, Zydowsky TM, Robbiani M.

Adv Drug Deliv Rev. 2015 Sep 15;92:27-38. doi: 10.1016/j.addr.2014.12.005. Epub 2014 Dec 24. Review.

14.

[Microbicides for preventing sexually transmitted infections: Current status and strategies for preclinical evaluation of new candidates].

Fernández Romero JA, Gil PI, Ré V, Robbiani M, Paglini G.

Rev Argent Microbiol. 2014 Jul-Sep;46(3):256-68. doi: 10.1016/S0325-7541(14)70080-X. Epub 2014 Oct 15. Review. Spanish.

15.

A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants.

Barnable P, Calenda G, Ouattara L, Gettie A, Blanchard J, Jean-Pierre N, Kizima L, Rodríguez A, Abraham C, Menon R, Seidor S, Cooney ML, Roberts KD, Sperling R, Piatak M Jr, Lifson JD, Fernandez-Romero JA, Zydowsky TM, Robbiani M, Teleshova N.

PLoS One. 2014 Sep 26;9(9):e108109. doi: 10.1371/journal.pone.0108109. eCollection 2014.

16.

In vitro and in vivo evaluation of two carrageenan-based formulations to prevent HPV acquisition.

Rodríguez A, Kleinbeck K, Mizenina O, Kizima L, Levendosky K, Jean-Pierre N, Villegas G, Ford BE, Cooney ML, Teleshova N, Robbiani M, Herold BC, Zydowsky T, Fernández Romero JA.

Antiviral Res. 2014 Aug;108:88-93. doi: 10.1016/j.antiviral.2014.05.018. Epub 2014 Jun 5.

17.

A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV.

Kizima L, Rodríguez A, Kenney J, Derby N, Mizenina O, Menon R, Seidor S, Zhang S, Levendosky K, Jean-Pierre N, Pugach P, Villegas G, Ford BE, Gettie A, Blanchard J, Piatak M Jr, Lifson JD, Paglini G, Teleshova N, Zydowsky TM, Robbiani M, Fernández-Romero JA.

PLoS One. 2014 Apr 16;9(4):e94547. doi: 10.1371/journal.pone.0094547. eCollection 2014.

18.

MIV-150-containing intravaginal rings protect macaque vaginal explants against SHIV-RT infection.

Ouattara LA, Barnable P, Mawson P, Seidor S, Zydowsky TM, Kizima L, Rodriguez A, Fernández-Romero JA, Cooney ML, Roberts KD, Gettie A, Blanchard J, Robbiani M, Teleshova N.

Antimicrob Agents Chemother. 2014 May;58(5):2841-8. doi: 10.1128/AAC.01529-13. Epub 2014 Mar 10.

19.

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques.

Hsu M, Keele BF, Aravantinou M, Krawczyk N, Seidor S, Abraham CJ, Zhang S, Rodriguez A, Kizima L, Derby N, Jean-Pierre N, Mizenina O, Gettie A, Grasperge B, Blanchard J, Piatak MJ Jr, Lifson JD, Fernández-Romero JA, Zydowsky TM, Robbiani M.

PLoS One. 2014 Feb 27;9(2):e89300. doi: 10.1371/journal.pone.0089300. eCollection 2014.

20.

A combination microbicide gel protects macaques against vaginal simian human immunodeficiency virus-reverse transcriptase infection, but only partially reduces herpes simplex virus-2 infection after a single high-dose cochallenge.

Hsu M, Aravantinou M, Menon R, Seidor S, Goldman D, Kenney J, Derby N, Gettie A, Blanchard J, Piatak M Jr, Lifson JD, Fernández-Romero JA, Zydowsky TM, Robbiani M.

AIDS Res Hum Retroviruses. 2014 Feb;30(2):174-83. doi: 10.1089/AID.2013.0165. Epub 2013 Nov 22.

21.

A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo.

Kenney J, Rodríguez A, Kizima L, Seidor S, Menon R, Jean-Pierre N, Pugach P, Levendosky K, Derby N, Gettie A, Blanchard J, Piatak M Jr, Lifson JD, Paglini G, Zydowsky TM, Robbiani M, Fernández Romero JA.

Antimicrob Agents Chemother. 2013 Aug;57(8):4001-9. doi: 10.1128/AAC.00796-13. Epub 2013 Jun 10.

22.

An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques.

Singer R, Mawson P, Derby N, Rodriguez A, Kizima L, Menon R, Goldman D, Kenney J, Aravantinou M, Seidor S, Gettie A, Blanchard J, Piatak M Jr, Lifson JD, Fernández-Romero JA, Robbiani M, Zydowsky TM.

Sci Transl Med. 2012 Sep 5;4(150):150ra123. doi: 10.1126/scitranslmed.3003936.

23.

The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT Infection.

Aravantinou M, Singer R, Derby N, Calenda G, Mawson P, Abraham CJ, Menon R, Seidor S, Goldman D, Kenney J, Villegas G, Gettie A, Blanchard J, Lifson JD, Piatak M Jr, Fernández-Romero JA, Zydowsky TM, Teleshova N, Robbiani M.

AIDS Res Hum Retroviruses. 2012 Nov;28(11):1467-75. doi: 10.1089/AID.2012.0080. Epub 2012 Aug 27.

24.

A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use.

Kenney J, Singer R, Derby N, Aravantinou M, Abraham CJ, Menon R, Seidor S, Zhang S, Gettie A, Blanchard J, Piatak M Jr, Lifson JD, Fernández-Romero JA, Zydowsky TM, Robbiani M.

AIDS Res Hum Retroviruses. 2012 Nov;28(11):1476-84. doi: 10.1089/AID.2012.0087. Epub 2012 Jul 30.

25.

Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge.

Fernández-Romero JA, Abraham CJ, Rodriguez A, Kizima L, Jean-Pierre N, Menon R, Begay O, Seidor S, Ford BE, Gil PI, Peters J, Katz D, Robbiani M, Zydowsky TM.

Antimicrob Agents Chemother. 2012 Jan;56(1):358-68. doi: 10.1128/AAC.05461-11. Epub 2011 Nov 7.

26.

Validation of a dye stain assay for vaginally inserted hydroxyethylcellulose-filled microbicide applicators.

Katzen LL, Fernández-Romero JA, Sarna A, Murugavel KG, Gawarecki D, Zydowsky TM, Mensch BS.

Sex Transm Dis. 2011 Nov;38(11):1050-5. doi: 10.1097/OLQ.0b013e31822e6160.

27.

The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques.

Singer R, Derby N, Rodriguez A, Kizima L, Kenney J, Aravantinou M, Chudolij A, Gettie A, Blanchard J, Lifson JD, Piatak M Jr, Fernández-Romero JA, Zydowsky TM, Robbiani M.

J Virol. 2011 Jun;85(11):5504-12. doi: 10.1128/JVI.02422-10. Epub 2011 Mar 16.

28.

Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro.

Begay O, Jean-Pierre N, Abraham CJ, Chudolij A, Seidor S, Rodriguez A, Ford BE, Henderson M, Katz D, Zydowsky T, Robbiani M, Fernández-Romero JA.

AIDS Res Hum Retroviruses. 2011 Sep;27(9):1019-24. doi: 10.1089/AID.2010.0252. Epub 2011 Mar 8.

29.

An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques.

Kenney J, Aravantinou M, Singer R, Hsu M, Rodriguez A, Kizima L, Abraham CJ, Menon R, Seidor S, Chudolij A, Gettie A, Blanchard J, Lifson JD, Piatak M Jr, Fernández-Romero JA, Zydowsky TM, Robbiani M.

PLoS One. 2011 Jan 5;6(1):e15835. doi: 10.1371/journal.pone.0015835.

30.

Carrageenan/MIV-150 (PC-815), a combination microbicide.

Fernández-Romero JA, Thorn M, Turville SG, Titchen K, Sudol K, Li J, Miller T, Robbiani M, Maguire RA, Buckheit RW Jr, Hartman TL, Phillips DM.

Sex Transm Dis. 2007 Jan;34(1):9-14.

PMID:
16924181
31.

In vitro antiviral activity of Phyllanthus orbicularis extracts against herpes simplex virus type 1.

Fernández Romero JA, Del Barrio Alonso G, Romeu Alvarez B, Gutiérrez Y, Valdés VS, Parra F.

Phytother Res. 2003 Sep;17(8):980-2.

PMID:
13680841

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