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Items: 10


An unexpected tumor suppressor role for VAV1a.

Bustelo XR, Lorenzo-Martín LF, Cuadrado M, Fernández-Pisonero I, Robles-Valero J.

Mol Cell Oncol. 2018 Feb 23;5(3):e1432257. doi: 10.1080/23723556.2018.1432257. eCollection 2018.


Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.

Lorenzo-Martín LF, Citterio C, Menacho-Márquez M, Conde J, Larive RM, Rodríguez-Fdez S, García-Escudero R, Robles-Valero J, Cuadrado M, Fernández-Pisonero I, Dosil M, Sevilla MA, Montero MJ, Fernández-Salguero PM, Paramio JM, Bustelo XR.

Oncogene. 2019 Jan;38(2):209-227. doi: 10.1038/s41388-018-0433-7. Epub 2018 Aug 7.


RAS GTPase-dependent pathways in developmental diseases: old guys, new lads, and current challenges.

Bustelo XR, Crespo P, Fernández-Pisonero I, Rodríguez-Fdez S.

Curr Opin Cell Biol. 2018 Dec;55:42-51. doi: 10.1016/ Epub 2018 Jul 11. Review.


R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes.

Mendoza P, Martínez-Martín N, Bovolenta ER, Reyes-Garau D, Hernansanz-Agustín P, Delgado P, Diaz-Muñoz MD, Oeste CL, Fernández-Pisonero I, Castellano E, Martínez-Ruiz A, Alonso-Lopez D, Santos E, Bustelo XR, Kurosaki T, Alarcón B.

Sci Signal. 2018 May 29;11(532). pii: eaal1506. doi: 10.1126/scisignal.aal1506.


Rho guanosine nucleotide exchange factors are not such bad guys after all in cancera.

Robles-Valero J, Lorenzo-Martín LF, Fernández-Pisonero I, Bustelo XR.

Small GTPases. 2018 Jan 24:1-7. doi: 10.1080/21541248.2018.1423851. [Epub ahead of print]


A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Robles-Valero J, Lorenzo-Martín LF, Menacho-Márquez M, Fernández-Pisonero I, Abad A, Camós M, Toribio ML, Espinosa L, Bigas A, Bustelo XR.

Cancer Cell. 2017 Nov 13;32(5):608-623.e9. doi: 10.1016/j.ccell.2017.10.004.


Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells.

Fernández-Pisonero I, López J, Onecha E, Dueñas AI, Maeso P, Crespo MS, San Román JA, García-Rodríguez C.

PLoS One. 2014 Oct 2;9(9):e109081. doi: 10.1371/journal.pone.0109081. eCollection 2014.


Lipopolysaccharide and sphingosine-1-phosphate cooperate to induce inflammatory molecules and leukocyte adhesion in endothelial cells.

Fernández-Pisonero I, Dueñas AI, Barreiro O, Montero O, Sánchez-Madrid F, García-Rodríguez C.

J Immunol. 2012 Dec 1;189(11):5402-10. doi: 10.4049/jimmunol.1201309. Epub 2012 Oct 22.


Viral and bacterial patterns induce TLR-mediated sustained inflammation and calcification in aortic valve interstitial cells.

López J, Fernández-Pisonero I, Dueñas AI, Maeso P, San Román JA, Crespo MS, García-Rodríguez C.

Int J Cardiol. 2012 Jun 28;158(1):18-25. doi: 10.1016/j.ijcard.2010.12.089. Epub 2011 Jan 17.


Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate.

Dueñas AI, Aceves M, Fernández-Pisonero I, Gómez C, Orduña A, Crespo MS, García-Rodríguez C.

Cardiovasc Res. 2008 Aug 1;79(3):537-44. doi: 10.1093/cvr/cvn087. Epub 2008 Apr 14.


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