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Items: 13


Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis.

Hundehege P, Fernandez-Orth J, Römer P, Ruck T, Müntefering T, Eichler S, Cerina M, Epping L, Albrecht S, Menke AF, Birkner K, Göbel K, Budde T, Zipp F, Wiendl H, Gorji A, Bittner S, Meuth SG.

Neurosignals. 2018 Nov 27;26(1):77-93. doi: 10.1159/000495425. [Epub ahead of print]


Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants.

Alaimo A, Etxeberria A, Gómez-Posada JC, Gomis-Perez C, Fernández-Orth J, Malo C, Villarroel A.

Channels (Austin). 2018;12(1):299-310. doi: 10.1080/19336950.2018.1511512.


Impairment of frequency-specific responses associated with altered electrical activity patterns in auditory thalamus following focal and general demyelination.

Narayanan V, Cerina M, Göbel K, Meuth P, Herrmann AM, Fernandez-Orth J, Stangel M, Gudi V, Skripuletz T, Daldrup T, Lesting J, Schiffler P, Wiendl H, Seidenbecher T, Meuth SG, Budde T, Pape HC.

Exp Neurol. 2018 Nov;309:54-66. doi: 10.1016/j.expneurol.2018.07.010. Epub 2018 Jul 23.


Calmodulin confers calcium sensitivity to the stability of the distal intracellular assembly domain of Kv7.2 channels.

Alaimo A, Nuñez E, Aivar P, Fernández-Orth J, Gomis-Perez C, Bernardo-Seisdedos G, Malo C, Villarroel A.

Sci Rep. 2017 Oct 18;7(1):13425. doi: 10.1038/s41598-017-13811-4.


14-3-3 Proteins regulate K2P 5.1 surface expression on T lymphocytes.

Fernández-Orth J, Ehling P, Ruck T, Pankratz S, Hofmann MS, Landgraf P, Dieterich DC, Smalla KH, Kähne T, Seebohm G, Budde T, Wiendl H, Bittner S, Meuth SG.

Traffic. 2017 Jan;18(1):29-43. doi: 10.1111/tra.12455. Epub 2016 Nov 27.


The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion.

Hucke S, Herold M, Liebmann M, Freise N, Lindner M, Fleck AK, Zenker S, Thiebes S, Fernandez-Orth J, Buck D, Luessi F, Meuth SG, Zipp F, Hemmer B, Engel DR, Roth J, Kuhlmann T, Wiendl H, Klotz L.

Acta Neuropathol. 2016 Sep;132(3):413-31. doi: 10.1007/s00401-016-1593-6. Epub 2016 Jul 6.


An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.

Wemhöner K, Kanyshkova T, Silbernagel N, Fernandez-Orth J, Bittner S, Kiper AK, Rinné S, Netter MF, Meuth SG, Budde T, Decher N.

Front Mol Neurosci. 2015 Nov 3;8:63. doi: 10.3389/fnmol.2015.00063. eCollection 2015.


An unconventional calmodulin-anchoring site within the AB module of Kv7.2 channels.

Gomis-Perez C, Alaimo A, Fernandez-Orth J, Alberdi A, Aivar-Mateo P, Bernardo-Seisdedos G, Malo C, Areso P, Felipe A, Villarroel A.

J Cell Sci. 2015 Aug 15;128(16):3155-63. doi: 10.1242/jcs.174128. Epub 2015 Jul 6.


TREK-king the blood-brain-barrier.

Bittner S, Ruck T, Fernández-Orth J, Meuth SG.

J Neuroimmune Pharmacol. 2014 Jun;9(3):293-301. doi: 10.1007/s11481-014-9530-8. Epub 2014 Feb 21. Review.


Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex.

Alaimo A, Alberdi A, Gomis-Perez C, Fernández-Orth J, Bernardo-Seisdedos G, Malo C, Millet O, Areso P, Villarroel A.

PLoS One. 2014 Jan 28;9(1):e86711. doi: 10.1371/journal.pone.0086711. eCollection 2014.


Cooperativity between calmodulin-binding sites in Kv7.2 channels.

Alaimo A, Alberdi A, Gomis-Perez C, Fernández-Orth J, Gómez-Posada JC, Areso P, Villarroel A.

J Cell Sci. 2013 Jan 1;126(Pt 1):244-53. doi: 10.1242/jcs.114082. Epub 2012 Nov 30.


Surface expression and subunit specific control of steady protein levels by the Kv7.2 helix A-B linker.

Aivar P, Fernández-Orth J, Gomis-Perez C, Alberdi A, Alaimo A, Rodríguez MS, Giraldez T, Miranda P, Areso P, Villarroel A.

PLoS One. 2012;7(10):e47263. doi: 10.1371/journal.pone.0047263. Epub 2012 Oct 24.


Kv7 channels can function without constitutive calmodulin tethering.

Gómez-Posada JC, Aivar P, Alberdi A, Alaimo A, Etxeberría A, Fernández-Orth J, Zamalloa T, Roura-Ferrer M, Villace P, Areso P, Casis O, Villarroel A.

PLoS One. 2011;6(9):e25508. doi: 10.1371/journal.pone.0025508. Epub 2011 Sep 28.

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