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Items: 50

1.

Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: An in vitro and in vivo study in aortic stenosis.

Matilla L, Ibarrola J, Arrieta V, Garcia-Peña A, Martinez-Martinez E, Sádaba R, Alvarez V, Navarro A, Fernández-Celis A, Gainza A, Santamaría E, Fernández-Irigoyen J, Bayes-Genis A, Rossignol P, López-Andrés N.

Clin Sci (Lond). 2019 Jul 8. pii: CS20190475. doi: 10.1042/CS20190475. [Epub ahead of print]

PMID:
31285364
2.

Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer's Disease.

Lachen-Montes M, González-Morales A, Palomino M, Ausin K, Gómez-Ochoa M, Zelaya MV, Ferrer I, Pérez-Mediavilla A, Fernández-Irigoyen J, Santamaría E.

Front Aging Neurosci. 2019 Jun 11;11:141. doi: 10.3389/fnagi.2019.00141. eCollection 2019.

3.

The olfactory bulb proteotype differs across frontotemporal dementia spectrum.

Lachén-Montes M, González-Morales A, Schvartz D, Zelaya MV, Ausin K, Fernández-Irigoyen J, Sánchez JC, Santamaría E.

J Proteomics. 2019 Jun 15;201:37-47. doi: 10.1016/j.jprot.2019.04.011. Epub 2019 Apr 15.

PMID:
30999060
4.

Combined Transcriptomics and Proteomics in Frontal Cortex Area 8 in Frontotemporal Lobar Degeneration Linked to C9ORF72 Expansion.

Andrés-Benito P, Gelpi E, Povedano M, Ausín K, Fernández-Irigoyen J, Santamaría E, Ferrer I.

J Alzheimers Dis. 2019;68(3):1287-1307. doi: 10.3233/JAD-181123.

PMID:
30909235
5.

Olfactory proteotyping: towards the enlightenment of the neurodegeneration.

Fernández-Irigoyen J, Santamaría E.

Neural Regen Res. 2019 Jun;14(6):979-981. doi: 10.4103/1673-5374.249220. No abstract available.

6.

Multi-omic and physiologic approach to understand Lotus japonicus response upon exposure to 3,4 dimethylpyrazole phosphate nitrification inhibitor.

Rodrigues JM, Lasa B, Betti M, Fernández-Irigoyen J, Santamaría E, González-Murua C, Aparicio-Tejo PM, Marino D.

Sci Total Environ. 2019 Apr 10;660:1201-1209. doi: 10.1016/j.scitotenv.2019.01.047. Epub 2019 Jan 11.

PMID:
30743915
7.

CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation.

Martínez-Martínez E, Brugnolaro C, Ibarrola J, Ravassa S, Buonafine M, López B, Fernández-Celis A, Querejeta R, Santamaria E, Fernández-Irigoyen J, Rábago G, Moreno MU, Jaisser F, Díez J, González A, López-Andrés N.

Hypertension. 2019 Mar;73(3):602-611. doi: 10.1161/HYPERTENSIONAHA.118.11874.

PMID:
30612490
8.

Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).

Iridoy MO, Zubiri I, Zelaya MV, Martinez L, Ausín K, Lachen-Montes M, Santamaría E, Fernandez-Irigoyen J, Jericó I.

Int J Mol Sci. 2018 Dec 20;20(1). pii: E4. doi: 10.3390/ijms20010004. Review.

9.

Oncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy.

González-Morales A, Zabaleta A, García-Moure M, Alonso MM, Fernández-Irigoyen J, Santamaría E.

J Proteomics. 2019 Mar 1;194:168-178. doi: 10.1016/j.jprot.2018.11.020. Epub 2018 Nov 29.

PMID:
30503830
10.

Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling.

Lachén-Montes M, González-Morales A, Iloro I, Elortza F, Ferrer I, Gveric D, Fernández-Irigoyen J, Santamaría E.

Neurobiol Aging. 2019 Jan;73:123-134. doi: 10.1016/j.neurobiolaging.2018.09.018. Epub 2018 Sep 25.

11.

Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection.

González-Morales A, Zabaleta A, Guruceaga E, Alonso MM, García-Moure M, Fernández-Irigoyen J, Santamaría E.

Oncotarget. 2018 Jul 24;9(57):31045-31065. doi: 10.18632/oncotarget.25774. eCollection 2018 Jul 24.

12.

Anthracene drives sub-cellular proteome-wide alterations in the degradative system of Penicillium oxalicum.

Lucero Camacho-Morales R, García-Fontana C, Fernández-Irigoyen J, Santamaría E, González-López J, Manzanera M, Aranda E.

Ecotoxicol Environ Saf. 2018 Sep 15;159:127-135. doi: 10.1016/j.ecoenv.2018.04.051. Epub 2018 May 4.

PMID:
29734068
13.

Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12.

Ibarrola J, Sadaba R, Martinez-Martinez E, Garcia-Peña A, Arrieta V, Alvarez V, Fernández-Celis A, Gainza A, Cachofeiro V, Santamaria E, Fernandez-Irigoyen J, Jaisser F, Lopez-Andres N.

Sci Rep. 2018 May 1;8(1):6801. doi: 10.1038/s41598-018-25068-6.

14.

Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage.

Ibarrola J, Arrieta V, Sádaba R, Martinez-Martinez E, Garcia-Peña A, Alvarez V, Fernández-Celis A, Gainza A, Santamaría E, Fernández-Irigoyen J, Cachofeiro V, Zalba G, Fay R, Rossignol P, López-Andrés N.

Clin Sci (Lond). 2018 Jul 18;132(13):1471-1485. doi: 10.1042/CS20171389. Print 2018 Jul 18.

PMID:
29674526
15.

A role for fumarate hydratase in mediating oxidative effects of galectin-3 in human cardiac fibroblasts.

Ibarrola J, Sádaba R, Garcia-Peña A, Arrieta V, Martinez-Martinez E, Alvarez V, Fernández-Celis A, Gainza A, Santamaría E, Fernández-Irigoyen J, Cachofeiro V, Fay R, Rossignol P, López-Andrés N.

Int J Cardiol. 2018 May 1;258:217-223. doi: 10.1016/j.ijcard.2017.12.103.

PMID:
29544935
16.

Mass Spectrometry-Based Proteomic Profiling of Thrombotic Material Obtained by Endovascular Thrombectomy in Patients with Ischemic Stroke.

Muñoz R, Santamaría E, Rubio I, Ausín K, Ostolaza A, Labarga A, Roldán M, Zandio B, Mayor S, Bermejo R, Mendigaña M, Herrera M, Aymerich N, Olier J, Gállego J, Mendioroz M, Fernández-Irigoyen J.

Int J Mol Sci. 2018 Feb 7;19(2). pii: E498. doi: 10.3390/ijms19020498.

17.

Characterization of Macrophage Endogenous S-Nitrosoproteome Using a Cysteine-Specific Phosphonate Adaptable Tag in Combination with TiO2 Chromatography.

Ibáñez-Vea M, Huang H, Martínez de Morentin X, Pérez E, Gato M, Zuazo M, Arasanz H, Fernández-Irigoyen J, Santamaría E, Fernandez-Hinojal G, Larsen MR, Escors D, Kochan G.

J Proteome Res. 2018 Mar 2;17(3):1172-1182. doi: 10.1021/acs.jproteome.7b00812. Epub 2018 Jan 25.

PMID:
29338241
18.

Network-Driven Proteogenomics Unveils an Aging-Related Imbalance in the Olfactory IκBα-NFκB p65 Complex Functionality in Tg2576 Alzheimer's Disease Mouse Model.

Palomino-Alonso M, Lachén-Montes M, González-Morales A, Ausín K, Pérez-Mediavilla A, Fernández-Irigoyen J, Santamaría E.

Int J Mol Sci. 2017 Oct 27;18(11). pii: E2260. doi: 10.3390/ijms18112260.

19.

Progressive modulation of the human olfactory bulb transcriptome during Alzheimer´s disease evolution: novel insights into the olfactory signaling across proteinopathies.

Lachen-Montes M, Zelaya MV, Segura V, Fernández-Irigoyen J, Santamaría E.

Oncotarget. 2017 May 23;8(41):69663-69679. doi: 10.18632/oncotarget.18193. eCollection 2017 Sep 19.

20.

Differential Proteomics Identifies Reticulocalbin-3 as a Novel Negative Mediator of Collagen Production in Human Cardiac Fibroblasts.

Martínez-Martínez E, Ibarrola J, Fernández-Celis A, Santamaria E, Fernández-Irigoyen J, Rossignol P, Jaisser F, López-Andrés N.

Sci Rep. 2017 Sep 22;7(1):12192. doi: 10.1038/s41598-017-12305-7.

21.

MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation.

Erice O, Munoz-Garrido P, Vaquero J, Perugorria MJ, Fernandez-Barrena MG, Saez E, Santos-Laso A, Arbelaiz A, Jimenez-Agüero R, Fernandez-Irigoyen J, Santamaria E, Torrano V, Carracedo A, Ananthanarayanan M, Marzioni M, Prieto J, Beuers U, Oude Elferink RP, LaRusso NF, Bujanda L, Marin JJG, Banales JM.

Hepatology. 2018 Apr;67(4):1420-1440. doi: 10.1002/hep.29533. Epub 2018 Feb 21.

22.

Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression.

Lachén-Montes M, González-Morales A, Zelaya MV, Pérez-Valderrama E, Ausín K, Ferrer I, Fernández-Irigoyen J, Santamaría E.

Sci Rep. 2017 Aug 22;7(1):9115. doi: 10.1038/s41598-017-09481-x.

23.

Differential proteomics reveals S100-A11 as a key factor in aldosterone-induced collagen expression in human cardiac fibroblasts.

Martínez-Martínez E, Ibarrola J, Lachén-Montes M, Fernández-Celis A, Jaisser F, Santamaría E, Fernández-Irigoyen J, López-Andrés N.

J Proteomics. 2017 Aug 23;166:93-100. doi: 10.1016/j.jprot.2017.07.011. Epub 2017 Jul 22.

PMID:
28739510
24.

A multicentric study to evaluate the use of relative retention times in targeted proteomics.

Vialas V, Colomé-Calls N, Abian J, Aloria K, Alvarez-Llamas G, Antúnez O, Arizmendi JM, Azkargorta M, Barceló-Batllori S, Barderas MG, Blanco F, Casal JI, Casas V, de la Torre C, Chicano-Gálvez E, Elortza F, Espadas G, Estanyol JM, Fernandez-Irigoyen J, Fernandez-Puente P, Fidalgo MJ, Fuentes M, Gay M, Gil C, Hainard A, Hernaez ML, Ibarrola N, Kopylov AT, Lario A, Lopez JA, López-Lucendo M, Marcilla M, Marina-Ramírez A, Marko-Varga G, Martín L, Mora MI, Morato-López E, Muñoz J, Odena MA, de Oliveira E, Orera I, Ortea I, Pasquarello C, Ray KB, Rezeli M, Ruppen I, Sabidó E, Del Pino MMS, Sancho J, Santamaría E, Vazquez J, Vilaseca M, Vivanco F, Walters JJ, Zgoda VG, Corrales FJ, Canals F, Paradela A.

J Proteomics. 2017 Jan 30;152:138-149. doi: 10.1016/j.jprot.2016.10.014. Epub 2016 Oct 29.

PMID:
27989941
25.

An early dysregulation of FAK and MEK/ERK signaling pathways precedes the β-amyloid deposition in the olfactory bulb of APP/PS1 mouse model of Alzheimer's disease.

Lachén-Montes M, González-Morales A, de Morentin XM, Pérez-Valderrama E, Ausín K, Zelaya MV, Serna A, Aso E, Ferrer I, Fernández-Irigoyen J, Santamaría E.

J Proteomics. 2016 Oct 4;148:149-58. doi: 10.1016/j.jprot.2016.07.032. Epub 2016 Aug 3.

PMID:
27498392
26.

Deconstructing the molecular architecture of olfactory areas using proteomics.

Lachén-Montes M, Fernández-Irigoyen J, Santamaría E.

Proteomics Clin Appl. 2016 Dec;10(12):1178-1190. doi: 10.1002/prca.201500147. Epub 2016 Jun 20. Review.

PMID:
27226001
27.

Quantitative proteomics reveals the importance of nitrogen source to control glucosinolate metabolism in Arabidopsis thaliana and Brassica oleracea.

Marino D, Ariz I, Lasa B, Santamaría E, Fernández-Irigoyen J, González-Murua C, Aparicio Tejo PM.

J Exp Bot. 2016 May;67(11):3313-23. doi: 10.1093/jxb/erw147. Epub 2016 Apr 16.

28.

Olfactory bulb proteome dynamics during the progression of sporadic Alzheimer's disease: identification of common and distinct olfactory targets across Alzheimer-related co-pathologies.

Zelaya MV, Pérez-Valderrama E, de Morentin XM, Tuñon T, Ferrer I, Luquin MR, Fernandez-Irigoyen J, Santamaría E.

Oncotarget. 2015 Nov 24;6(37):39437-56. doi: 10.18632/oncotarget.6254.

29.

Drafting the proteome landscape of myeloid-derived suppressor cells.

Gato M, Blanco-Luquin I, Zudaire M, de Morentin XM, Perez-Valderrama E, Zabaleta A, Kochan G, Escors D, Fernandez-Irigoyen J, Santamaría E.

Proteomics. 2016 Jan;16(2):367-78. doi: 10.1002/pmic.201500229. Epub 2015 Dec 14. Review.

PMID:
26403437
30.

A core of kinase-regulated interactomes defines the neoplastic MDSC lineage.

Gato-Cañas M, Martinez de Morentin X, Blanco-Luquin I, Fernandez-Irigoyen J, Zudaire I, Liechtenstein T, Arasanz H, Lozano T, Casares N, Chaikuad A, Knapp S, Guerrero-Setas D, Escors D, Kochan G, Santamaría E.

Oncotarget. 2015 Sep 29;6(29):27160-75. doi: 10.18632/oncotarget.4746.

31.

New insights into the human brain proteome: Protein expression profiling of deep brain stimulation target areas.

Fernández-Irigoyen J, Zelaya MV, Perez-Valderrama E, Santamaría E.

J Proteomics. 2015 Sep 8;127(Pt B):395-405. doi: 10.1016/j.jprot.2015.03.032. Epub 2015 Apr 4.

PMID:
25845585
32.

Toward defining the anatomo-proteomic puzzle of the human brain: An integrative analysis.

Fernandez-Irigoyen J, Labarga A, Zabaleta A, de Morentin XM, Perez-Valderrama E, Zelaya MV, Santamaria E.

Proteomics Clin Appl. 2015 Oct;9(9-10):796-807. doi: 10.1002/prca.201400127. Epub 2015 Feb 24. Review.

PMID:
25418211
33.

Anatomo-proteomic characterization of human basal ganglia: focus on striatum and globus pallidus.

Fernández-Irigoyen J, Zelaya MV, Tuñon T, Santamaría E.

Mol Brain. 2014 Nov 18;7:83. doi: 10.1186/s13041-014-0083-9.

34.

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice.

Liechtenstein T, Perez-Janices N, Gato M, Caliendo F, Kochan G, Blanco-Luquin I, Van der Jeught K, Arce F, Guerrero-Setas D, Fernandez-Irigoyen J, Santamaria E, Breckpot K, Escors D.

Oncotarget. 2014 Sep 15;5(17):7843-57.

35.

Applying mass spectrometry-based qualitative proteomics to human amygdaloid complex.

Fernández-Irigoyen J, Zelaya MV, Santamaría E.

Front Cell Neurosci. 2014 Mar 20;8:80. doi: 10.3389/fncel.2014.00080. eCollection 2014.

36.

A combination of affinity chromatography, 2D DIGE, and mass spectrometry to analyze the phosphoproteome of liver progenitor cells.

Santamaría E, Sánchez-Quiles V, Fernández-Irigoyen J, Corrales FJ.

Methods Mol Biol. 2012;909:165-80. doi: 10.1007/978-1-61779-959-4_12.

PMID:
22903716
37.

Proteomic atlas of the human olfactory bulb.

Fernández-Irigoyen J, Corrales FJ, Santamaría E.

J Proteomics. 2012 Jul 16;75(13):4005-16. doi: 10.1016/j.jprot.2012.05.011. Epub 2012 May 15.

PMID:
22609191
38.

Contribution of MS-Based Proteomics to the Understanding of Herpes Simplex Virus Type 1 Interaction with Host Cells.

Santamaría E, Sánchez-Quiles V, Fernández-Irigoyen J, Corrales F.

Front Microbiol. 2012 Mar 20;3:107. doi: 10.3389/fmicb.2012.00107. eCollection 2012.

39.

Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine.

Schröder PC, Fernández-Irigoyen J, Bigaud E, Serna A, Renández-Alcoceba R, Lu SC, Mato JM, Prieto J, Corrales FJ.

J Proteomics. 2012 Jun 6;75(10):2855-68. doi: 10.1016/j.jprot.2012.01.009. Epub 2012 Jan 16.

40.

Enzymatic activity of methionine adenosyltransferase variants identified in patients with persistent hypermethioninemia.

Fernández-Irigoyen J, Santamaría E, Chien YH, Hwu WL, Korman SH, Faghfoury H, Schulze A, Hoganson GE, Stabler SP, Allen RH, Wagner C, Mudd SH, Corrales FJ.

Mol Genet Metab. 2010 Oct-Nov;101(2-3):172-7. doi: 10.1016/j.ymgme.2010.07.009. Epub 2010 Jul 15.

41.

Regulation of stathmin phosphorylation in mouse liver progenitor-29 cells during proteasome inhibition.

Santamaría E, Mora MI, Muñoz J, Sánchez-Quiles V, Fernández-Irigoyen J, Prieto J, Corrales FJ.

Proteomics. 2009 Oct;9(19):4495-506. doi: 10.1002/pmic.200900110.

42.

Identification of replication-competent HSV-1 Cgal+ strain targets in a mouse model of human hepatocarcinoma xenograft.

Santamaría E, Mora MI, Carro-Roldán E, Molina M, Fernández-Irigoyen J, Marconi P, Manservigi R, Greco A, Epstein AL, Prieto J, Hernández-Alcoceba R, Corrales FJ.

J Proteomics. 2009 Nov 2;73(1):153-60. doi: 10.1016/j.jprot.2009.06.008. Epub 2009 Jun 21.

43.

Identification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics.

Santamaría E, Mora MI, Potel C, Fernández-Irigoyen J, Carro-Roldán E, Hernández-Alcoceba R, Prieto J, Epstein AL, Corrales FJ.

Mol Cell Proteomics. 2009 Apr;8(4):805-15. doi: 10.1074/mcp.M800202-MCP200. Epub 2008 Dec 19.

44.

Mass spectrometric characterization of mitochondrial complex I NDUFA10 variants.

Muñoz J, Fernández-Irigoyen J, Santamaría E, Parbel A, Obeso J, Corrales FJ.

Proteomics. 2008 May;8(9):1898-908. doi: 10.1002/pmic.200701085.

45.

Redox regulation of methylthioadenosine phosphorylase in liver cells: molecular mechanism and functional implications.

Fernández-Irigoyen J, Santamaría M, Sánchez-Quiles V, Latasa MU, Santamaría E, Muñoz J, Sánchez Del Pino MM, Valero ML, Prieto J, Avila MA, Corrales FJ.

Biochem J. 2008 Apr 15;411(2):457-65. doi: 10.1042/BJ20071569.

46.

Proteomic analysis of liver diseases: molecular mechanisms and biomarker discovery.

Santamaría E, Muñoz J, Fernández-Irigoyen J, Sesma L, Odriozola L, Corrales FJ.

Mini Rev Med Chem. 2008 Jan;8(1):1-9. Review.

47.

Toward the discovery of new biomarkers of hepatocellular carcinoma by proteomics.

Santamaría E, Muñoz J, Fernández-Irigoyen J, Prìeto J, Corrales FJ.

Liver Int. 2007 Mar;27(2):163-73. Review.

48.

Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases.

Santamaría E, Muñoz J, Fernandez-Irigoyen J, Sesma L, Mora MI, Berasain C, Lu SC, Mato JM, Prieto J, Avila MA, Corrales FJ.

J Proteome Res. 2006 Apr;5(4):944-53.

49.

Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis.

Fernández-Irigoyen J, Santamaría E, Sesma L, Muñoz J, Riezu JI, Caballería J, Lu SC, Prieto J, Mato JM, Avila MA, Corrales FJ.

Proteomics. 2005 Dec;5(18):4964-72.

PMID:
16252306
50.

Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma.

Berasain C, Hevia H, Fernández-Irigoyen J, Larrea E, Caballería J, Mato JM, Prieto J, Corrales FJ, García-Trevijano ER, Avila MA.

Biochim Biophys Acta. 2004 Nov 5;1690(3):276-84.

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