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Items: 1 to 50 of 134

1.

Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis.

Price NL, Miguel V, Ding W, Singh AK, Malik S, Rotllan N, Moshnikova A, Toczek J, Zeiss C, Sadeghi MM, Arias N, Baldán Á, Andreev OA, Rodríguez-Puyol D, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C, Lamas S.

JCI Insight. 2019 Oct 15. pii: 131102. doi: 10.1172/jci.insight.131102. [Epub ahead of print]

2.

Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.

Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M.

Nat Metab. 2019 Sep;1(9):912-926. doi: 10.1038/s42255-019-0102-3. Epub 2019 Aug 26.

PMID:
31572976
3.

MiR-7 impairs insulin signaling and regulates Aβ levels through posttranscriptional regulation of the IRS-2, INSR, IDE and LXR pathway.

Fernández-de Frutos M, Galán-Chilet I, Goedeke L, Kim B, Pardo-Marqués V, Pérez-García A, Herrero JI, Fernández-Hernando C, Kim J, Ramírez CM.

Mol Cell Biol. 2019 Sep 9. pii: MCB.00170-19. doi: 10.1128/MCB.00170-19. [Epub ahead of print]

PMID:
31501273
4.

Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes.

Kunkemoeller B, Bancroft T, Xing H, Morris AH, Luciano AK, Wu J, Fernandez-Hernando C, Kyriakides TR.

Diabetes. 2019 Oct;68(10):2016-2023. doi: 10.2337/db18-1001. Epub 2019 Aug 7.

PMID:
31391172
5.

ANGPTL4 in Metabolic and Cardiovascular Disease.

Aryal B, Price NL, Suarez Y, Fernández-Hernando C.

Trends Mol Med. 2019 Aug;25(8):723-734. doi: 10.1016/j.molmed.2019.05.010. Epub 2019 Jun 21. Review.

PMID:
31235370
6.

Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation.

Ramírez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, Tellides G, Swirski FK, Lee WL, Schwartz MA, Sessa WC, Fernández-Hernando C.

Circulation. 2019 Jul 16;140(3):225-239. doi: 10.1161/CIRCULATIONAHA.118.038571. Epub 2019 Jun 3.

PMID:
31154825
7.

Specific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque Development.

Price NL, Rotllan N, Zhang X, Canfrán-Duque A, Nottoli T, Suarez Y, Fernández-Hernando C.

Circ Res. 2019 Mar 15;124(6):874-880. doi: 10.1161/CIRCRESAHA.118.314415.

PMID:
30707082
8.

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK.

Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30.

9.

Inhibition of profibrotic microRNA-21 affects platelets and their releasate.

Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M.

JCI Insight. 2018 Nov 2;3(21). pii: 123335. doi: 10.1172/jci.insight.123335.

10.

Endothelial Transcytosis of Lipoproteins in Atherosclerosis.

Zhang X, Sessa WC, Fernández-Hernando C.

Front Cardiovasc Med. 2018 Sep 25;5:130. doi: 10.3389/fcvm.2018.00130. eCollection 2018. Review.

11.

Lacteal junction zippering protects against diet-induced obesity.

Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Fernández-Hernando C, Shulman GI, Sessa WC, Eichmann A.

Science. 2018 Aug 10;361(6402):599-603. doi: 10.1126/science.aap9331.

12.

Non-coding RNAs in lipid metabolism.

Zhang X, Price NL, Fernández-Hernando C.

Vascul Pharmacol. 2019 Mar;114:93-102. doi: 10.1016/j.vph.2018.06.011. Epub 2018 Jun 19. Review.

PMID:
29929012
13.

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells.

Misra A, Feng Z, Chandran RR, Kabir I, Rotllan N, Aryal B, Sheikh AQ, Ding L, Qin L, Fernández-Hernando C, Tellides G, Greif DM.

Nat Commun. 2018 May 25;9(1):2073. doi: 10.1038/s41467-018-04447-7.

14.

Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis.

Singh AK, Aryal B, Chaube B, Rotllan N, Varela L, Horvath TL, Suárez Y, Fernández-Hernando C.

Mol Metab. 2018 May;11:59-69. doi: 10.1016/j.molmet.2018.03.011. Epub 2018 Mar 29.

15.

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis.

Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C.

JCI Insight. 2018 Mar 22;3(6). pii: 97918. doi: 10.1172/jci.insight.97918.

16.

MicroRNA 199a-5p Attenuates Retrograde Transport and Protects against Toxin-Induced Inhibition of Protein Biosynthesis.

Aranda JF, Rathjen S, Johannes L, Fernández-Hernando C.

Mol Cell Biol. 2018 May 15;38(11). pii: e00548-17. doi: 10.1128/MCB.00548-17. Print 2018 Jun 1.

17.

MicroRNAs in endothelial cell homeostasis and vascular disease.

Fernández-Hernando C, Suárez Y.

Curr Opin Hematol. 2018 May;25(3):227-236. doi: 10.1097/MOH.0000000000000424. Review.

18.

Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.

Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfrán-Duque A, Diaz-Ruiz A, Araldi E, Baldán Á, Camporez JP, Suárez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernández-Hernando C.

Cell Rep. 2018 Feb 20;22(8):2133-2145. doi: 10.1016/j.celrep.2018.01.074.

19.

Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance.

Lawan A, Min K, Zhang L, Canfran-Duque A, Jurczak MJ, Camporez JPG, Nie Y, Gavin TP, Shulman GI, Fernandez-Hernando C, Bennett AM.

Diabetes. 2018 Apr;67(4):624-635. doi: 10.2337/db17-0826. Epub 2018 Jan 9.

20.

Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins.

Singh AK, Aryal B, Zhang X, Fan Y, Price NL, Suárez Y, Fernández-Hernando C.

Semin Cell Dev Biol. 2018 Sep;81:129-140. doi: 10.1016/j.semcdb.2017.11.026. Epub 2017 Dec 6. Review.

21.

Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis.

Price NL, Rotllan N, Canfrán-Duque A, Zhang X, Pati P, Arias N, Moen J, Mayr M, Ford DA, Baldán Á, Suárez Y, Fernández-Hernando C.

Cell Rep. 2017 Oct 31;21(5):1317-1330. doi: 10.1016/j.celrep.2017.10.023.

22.

Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE.

Cell Transplant. 2017 Aug;26(8):1365-1379. doi: 10.1177/0963689717720282.

23.

Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis.

Canfrán-Duque A, Rotllan N, Zhang X, Fernández-Fuertes M, Ramírez-Hidalgo C, Araldi E, Daimiel L, Busto R, Fernández-Hernando C, Suárez Y.

EMBO Mol Med. 2017 Sep;9(9):1244-1262. doi: 10.15252/emmm.201607492.

24.

Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages.

Araldi E, Fernández-Fuertes M, Canfrán-Duque A, Tang W, Cline GW, Madrigal-Matute J, Pober JS, Lasunción MA, Wu D, Fernández-Hernando C, Suárez Y.

Cell Rep. 2017 Jun 27;19(13):2743-2755. doi: 10.1016/j.celrep.2017.05.093.

25.

The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress.

Miguel V, Cui JY, Daimiel L, Espinosa-Díez C, Fernández-Hernando C, Kavanagh TJ, Lamas S.

Antioxid Redox Signal. 2018 Mar 20;28(9):773-796. doi: 10.1089/ars.2017.7175. Epub 2017 Jun 30. Review.

26.

Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity.

Kim JD, Toda C, Ramírez CM, Fernández-Hernando C, Diano S.

Diabetes. 2017 Aug;66(8):2102-2111. doi: 10.2337/db16-1558. Epub 2017 May 26.

27.

MiR-33 regulation of stretch-induced intimal hyperplasia in vein grafts.

Zhang X, Fernández-Hernando C.

Cardiovasc Res. 2017 Apr 1;113(5):434-436. doi: 10.1093/cvr/cvx038. No abstract available.

28.

MicroRNAs and lipid metabolism.

Aryal B, Singh AK, Rotllan N, Price N, Fernández-Hernando C.

Curr Opin Lipidol. 2017 Jun;28(3):273-280. doi: 10.1097/MOL.0000000000000420. Review.

29.

miR-33 Regulation of Adaptive Fibrotic Response in Cardiac Remodeling.

Zhang X, Fernández-Hernando C.

Circ Res. 2017 Mar 3;120(5):753-755. doi: 10.1161/CIRCRESAHA.117.310575. No abstract available.

30.

Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes.

Willeit P, Skroblin P, Moschen AR, Yin X, Kaudewitz D, Zampetaki A, Barwari T, Whitehead M, Ramírez CM, Goedeke L, Rotllan N, Bonora E, Hughes AD, Santer P, Fernández-Hernando C, Tilg H, Willeit J, Kiechl S, Mayr M.

Diabetes. 2017 Feb;66(2):347-357. doi: 10.2337/db16-0731. Epub 2016 Nov 29.

31.

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells.

Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC.

Nat Commun. 2016 Nov 21;7:13516. doi: 10.1038/ncomms13516.

32.

Truths and controversies concerning the role of miRNAs in atherosclerosis and lipid metabolism.

Baldán Á, Fernández-Hernando C.

Curr Opin Lipidol. 2016 Dec;27(6):623-629. Review.

33.

ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.

Aryal B, Rotllan N, Araldi E, Ramírez CM, He S, Chousterman BG, Fenn AM, Wanschel A, Madrigal-Matute J, Warrier N, Martín-Ventura JL, Swirski FK, Suárez Y, Fernández-Hernando C.

Nat Commun. 2016 Jul 27;7:12313. doi: 10.1038/ncomms12313.

34.

Preface to: "microRNAs in lipid/energy metabolism and cardiometabolic disease".

Suárez Y, Fernández-Hernando C.

Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2039-2040. doi: 10.1016/j.bbalip.2016.07.001. Epub 2016 Jul 7. No abstract available.

PMID:
27396679
35.

Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice.

Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC.

EMBO Mol Med. 2016 Jun 1;8(6):643-53. doi: 10.15252/emmm.201506031. Print 2016 Jun.

36.

Age-associated vascular inflammation promotes monocytosis during atherogenesis.

Du W, Wong C, Song Y, Shen H, Mori D, Rotllan N, Price N, Dobrian AD, Meng H, Kleinstein SH, Fernandez-Hernando C, Goldstein DR.

Aging Cell. 2016 Aug;15(4):766-77. doi: 10.1111/acel.12488. Epub 2016 May 2.

37.

Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease?

Willeit P, Skroblin P, Kiechl S, Fernández-Hernando C, Mayr M.

Eur Heart J. 2016 Nov 14;37(43):3260-3266. Epub 2016 Apr 20. Review.

38.

Micro-RNAs and High-Density Lipoprotein Metabolism.

Canfrán-Duque A, Lin CS, Goedeke L, Suárez Y, Fernández-Hernando C.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1076-84. doi: 10.1161/ATVBAHA.116.307028. Epub 2016 Apr 14. Review.

39.

miRNA regulation of LDL-cholesterol metabolism.

Goedeke L, Wagschal A, Fernández-Hernando C, Näär AM.

Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2047-2052. doi: 10.1016/j.bbalip.2016.03.007. Epub 2016 Mar 9. Review.

40.

miRNA regulation of white and brown adipose tissue differentiation and function.

Price NL, Fernández-Hernando C.

Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2104-2110. doi: 10.1016/j.bbalip.2016.02.010. Epub 2016 Feb 16. Review.

41.

SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation.

Price NL, Holtrup B, Kwei SL, Wabitsch M, Rodeheffer M, Bianchini L, Suárez Y, Fernández-Hernando C.

Mol Cell Biol. 2016 Feb 1;36(7):1180-93. doi: 10.1128/MCB.00745-15.

42.

microRNAs in lipoprotein metabolism and cardiometabolic disorders.

Rotllan N, Price N, Pati P, Goedeke L, Fernández-Hernando C.

Atherosclerosis. 2016 Mar;246:352-60. doi: 10.1016/j.atherosclerosis.2016.01.025. Epub 2016 Jan 18. Review.

43.

Smooth Muscle Hypoxia-Inducible Factor 1α Links Intravascular Pressure and Atherosclerosis--Brief Report.

Liu D, Lei L, Desir M, Huang Y, Cleman J, Jiang W, Fernandez-Hernando C, Di Lorenzo A, Sessa WC, Giordano FJ.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):442-5. doi: 10.1161/ATVBAHA.115.306861. Epub 2016 Jan 21.

PMID:
26800562
44.

microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain.

Kim J, Yoon H, Horie T, Burchett JM, Restivo JL, Rotllan N, Ramírez CM, Verghese PB, Ihara M, Hoe HS, Esau C, Fernández-Hernando C, Holtzman DM, Cirrito JR, Ono K, Kim J.

J Neurosci. 2015 Nov 4;35(44):14717-26. doi: 10.1523/JNEUROSCI.2053-15.2015.

45.

miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice.

Goedeke L, Rotllan N, Ramírez CM, Aranda JF, Canfrán-Duque A, Araldi E, Fernández-Hernando A, Langhi C, de Cabo R, Baldán Á, Suárez Y, Fernández-Hernando C.

Atherosclerosis. 2015 Dec;243(2):499-509. doi: 10.1016/j.atherosclerosis.2015.09.033.

46.

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis.

Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, Vrbanac V, Lu YC, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fernández-Hernando C, Kaplan LM, Bernards A, Gerszten RE, Näär AM.

Nat Med. 2015 Nov;21(11):1290-7. doi: 10.1038/nm.3980. Epub 2015 Oct 26.

47.

Akt-mediated foxo1 inhibition is required for liver regeneration.

Pauta M, Rotllan N, Fernández-Hernando A, Langhi C, Ribera J, Lu M, Boix L, Bruix J, Jimenez W, Suárez Y, Ford DA, Baldán A, Birnbaum MJ, Morales-Ruiz M, Fernández-Hernando C.

Hepatology. 2016 May;63(5):1660-74. doi: 10.1002/hep.28286. Epub 2015 Dec 18.

48.

VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis.

Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernández-Fuertes M, Sahraei M, Quiles Del Rey M, van Solingen C, Yu J, Fernández-Hernando C, Sessa WC, Suárez Y.

Circ Res. 2016 Jan 8;118(1):38-47. doi: 10.1161/CIRCRESAHA.115.307408. Epub 2015 Oct 15.

49.

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.

Goedeke L, Rotllan N, Canfrán-Duque A, Aranda JF, Ramírez CM, Araldi E, Lin CS, Anderson NN, Wagschal A, de Cabo R, Horton JD, Lasunción MA, Näär AM, Suárez Y, Fernández-Hernando C.

Nat Med. 2015 Nov;21(11):1280-9. doi: 10.1038/nm.3949. Epub 2015 Oct 5.

50.

Dietary lipids modulate the expression of miR-107, a miRNA that regulates the circadian system.

Daimiel-Ruiz L, Klett-Mingo M, Konstantinidou V, Micó V, Aranda JF, García B, Martínez-Botas J, Dávalos A, Fernández-Hernando C, Ordovás JM.

Mol Nutr Food Res. 2015 Sep;59(9):1865-78. doi: 10.1002/mnfr.201570094.

PMID:
26387852

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