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Items: 1 to 50 of 58

1.

Functional coupling of GABAA/B receptors and the channel TRPV4 mediates rapid progesterone signaling in the oviduct.

Jung C, Fernández-Dueñas V, Plata C, Garcia-Elias A, Ciruela F, Fernández-Fernández JM, Valverde MA.

Sci Signal. 2018 Aug 14;11(543). pii: eaam6558. doi: 10.1126/scisignal.aam6558.

PMID:
30108184
2.

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation.

Morató X, Luján R, Gonçalves N, Watanabe M, Altafaj X, Carvalho AL, Fernández-Dueñas V, Cunha RA, Ciruela F.

Hum Mol Genet. 2018 Jul 16. doi: 10.1093/hmg/ddy264. [Epub ahead of print]

PMID:
30010864
3.

Effects of the Dopamine Stabilizer, Pridopidine, on Basal and Phencyclidine-Induced Locomotion: Role of Dopamine D2 and Sigma-1 Receptors.

Sahlholm K, Valle-Leon M, Taura J, Fernandez-Duenas V, Ciruela F.

CNS Neurol Disord Drug Targets. 2018;17(7):522-527. doi: 10.2174/1871527317666180627103337.

PMID:
29952269
4.

Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist.

Taura J, Nolen EG, Cabré G, Hernando J, Squarcialupi L, López-Cano M, Jacobson KA, Fernández-Dueñas V, Ciruela F.

J Control Release. 2018 Aug 10;283:135-142. doi: 10.1016/j.jconrel.2018.05.033. Epub 2018 May 31.

PMID:
29859955
5.

Pridopidine Reverses Phencyclidine-Induced Memory Impairment.

Sahlholm K, Valle-León M, Fernández-Dueñas V, Ciruela F.

Front Pharmacol. 2018 Apr 10;9:338. doi: 10.3389/fphar.2018.00338. eCollection 2018.

6.

Adenosine A2A-dopamine D2 receptor heteromers operate striatal function: impact on Parkinson's disease pharmacotherapeutics.

Fernandez-Duenas V, Ferré S, Ciruela F.

Neural Regen Res. 2018 Feb;13(2):241-243. doi: 10.4103/1673-5374.226388. No abstract available.

7.

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

Font J, López-Cano M, Notartomaso S, Scarselli P, Di Prieto P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F.

Elife. 2018 Jan 8;7. pii: e34752. doi: 10.7554/eLife.34752. No abstract available.

8.

Adenosine A1-A2A Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease.

Fernández-Dueñas V, Pérez-Arévalo A, Altafaj X, Ferré S, Ciruela F.

Front Neurosci. 2017 Nov 22;11:652. doi: 10.3389/fnins.2017.00652. eCollection 2017. No abstract available.

9.

Behavioral control by striatal adenosine A2A -dopamine D2 receptor heteromers.

Taura J, Valle-León M, Sahlholm K, Watanabe M, Van Craenenbroeck K, Fernández-Dueñas V, Ferré S, Ciruela F.

Genes Brain Behav. 2018 Apr;17(4):e12432. doi: 10.1111/gbb.12432. Epub 2017 Nov 17.

PMID:
29053217
10.

Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder.

Massari CM, López-Cano M, Núñez F, Fernández-Dueñas V, Tasca CI, Ciruela F.

Front Pharmacol. 2017 Oct 4;8:700. doi: 10.3389/fphar.2017.00700. eCollection 2017.

11.

The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo.

Morató X, Luján R, López-Cano M, Gandía J, Stagljar I, Watanabe M, Cunha RA, Fernández-Dueñas V, Ciruela F.

Sci Rep. 2017 Aug 25;7(1):9452. doi: 10.1038/s41598-017-10147-x.

12.

Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression.

Sahlholm K, Gómez-Soler M, Valle-León M, López-Cano M, Taura JJ, Ciruela F, Fernández-Dueñas V.

Mol Neurobiol. 2018 Jun;55(6):4952-4958. doi: 10.1007/s12035-017-0696-y. Epub 2017 Aug 5.

PMID:
28779351
13.

Rett-like Severe Encephalopathy Caused by a De Novo GRIN2B Mutation Is Attenuated by D-serine Dietary Supplement.

Soto D, Olivella M, Grau C, Armstrong J, Alcon C, Gasull X, Gómez de Salazar M, Gratacòs-Batlle E, Ramos-Vicente D, Fernández-Dueñas V, Ciruela F, Bayés À, Sindreu C, López-Sala A, García-Cazorla À, Altafaj X.

Biol Psychiatry. 2018 Jan 15;83(2):160-172. doi: 10.1016/j.biopsych.2017.05.028. Epub 2017 Jun 16. Retraction in: Biol Psychiatry. 2018 Apr 15;83(8):715.

PMID:
28734458
14.

Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia.

Oliveira PA, Dalton JAR, López-Cano M, Ricarte A, Morató X, Matheus FC, Cunha AS, Müller CE, Takahashi RN, Fernández-Dueñas V, Giraldo J, Prediger RD, Ciruela F.

Sci Rep. 2017 May 12;7(1):1857. doi: 10.1038/s41598-017-02037-z.

15.

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

Font J, López-Cano M, Notartomaso S, Scarselli P, Di Pietro P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F.

Elife. 2017 Apr 11;6. pii: e23545. doi: 10.7554/eLife.23545. Erratum in: Elife. 2018 Jan 08;7:.

16.

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.

Fernández-Dueñas V, Azuaje J, Morató X, Cordobilla B, Domingo JC, Sotelo E, Ciruela F.

Molecules. 2017 Feb 27;22(3). pii: E366. doi: 10.3390/molecules22030366.

17.

Exploring Drug-Receptor Interaction Kinetics: Lessons from a Sigma-1 Receptor Transmembrane Biosensor.

Fernández-Dueñas V, Burgueño J, Ciruela F.

Front Pharmacol. 2017 Jan 17;8:4. doi: 10.3389/fphar.2017.00004. eCollection 2017. No abstract available.

18.

Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology.

Andrés-Benito P, Fernández-Dueñas V, Carmona M, Escobar LA, Torrejón-Escribano B, Aso E, Ciruela F, Ferrer I.

Neuropathol Appl Neurobiol. 2017 Aug;43(5):373-392. doi: 10.1111/nan.12386. Epub 2017 Apr 19.

PMID:
28117912
19.

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.

Rial D, Morató X, Real JI, Gonçalves FQ, Stagljar I, Pereira FC, Fernández-Dueñas V, Cunha RA, Ciruela F.

Neurosci Lett. 2017 Jan 18;638:162-166. doi: 10.1016/j.neulet.2016.12.040. Epub 2016 Dec 19.

PMID:
28007645
20.

Investigation of LRRC8-Mediated Volume-Regulated Anion Currents in Xenopus Oocytes.

Gaitán-Peñas H, Gradogna A, Laparra-Cuervo L, Solsona C, Fernández-Dueñas V, Barrallo-Gimeno A, Ciruela F, Lakadamyali M, Pusch M, Estévez R.

Biophys J. 2016 Oct 4;111(7):1429-1443. doi: 10.1016/j.bpj.2016.08.030.

21.

The Guanine-Based Purinergic System: The Tale of An Orphan Neuromodulation.

Di Liberto V, Mudò G, Garozzo R, Frinchi M, Fernandez-Dueñas V, Di Iorio P, Ciccarelli R, Caciagli F, Condorelli DF, Ciruela F, Belluardo N.

Front Pharmacol. 2016 Jun 17;7:158. doi: 10.3389/fphar.2016.00158. eCollection 2016. Review.

22.

Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells.

Soto-Cerrato V, Manuel-Manresa P, Hernando E, Calabuig-Fariñas S, Martínez-Romero A, Fernández-Dueñas V, Sahlholm K, Knöpfel T, García-Valverde M, Rodilla AM, Jantus-Lewintre E, Farràs R, Ciruela F, Pérez-Tomás R, Quesada R.

J Am Chem Soc. 2015 Dec 23;137(50):15892-8. doi: 10.1021/jacs.5b09970. Epub 2015 Dec 17.

PMID:
26632983
23.

Visualizing G Protein-Coupled Receptor-Receptor Interactions in Brain Using Proximity Ligation In Situ Assay.

Taura J, Fernández-Dueñas V, Ciruela F.

Curr Protoc Cell Biol. 2015 Jun 1;67:17.17.1-16. doi: 10.1002/0471143030.cb1717s67.

PMID:
26061241
24.

Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands.

Ciruela F, Fernández-Dueñas V, Jacobson KA.

Neuropharmacology. 2015 Nov;98:58-67. doi: 10.1016/j.neuropharm.2015.04.001. Epub 2015 Apr 16. Review.

25.

Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.

Gandía J, Morató X, Stagljar I, Fernández-Dueñas V, Ciruela F.

Behav Brain Res. 2015 Jul 15;288:103-6. doi: 10.1016/j.bbr.2015.04.001. Epub 2015 Apr 9.

PMID:
25862943
26.

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system.

Lopes JP, Morató X, Souza C, Pinhal C, Machado NJ, Canas PM, Silva HB, Stagljar I, Gandía J, Fernández-Dueñas V, Luján R, Cunha RA, Ciruela F.

J Neurochem. 2015 Jul;134(1):135-46. doi: 10.1111/jnc.13109. Epub 2015 Apr 21.

27.

GPCR oligomerization analysis by means of BRET and dFRAP.

Ciruela F, Fernández-Dueñas V.

Methods Mol Biol. 2015;1272:133-41. doi: 10.1007/978-1-4939-2336-6_10.

PMID:
25563182
28.

Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats.

Fernández-Dueñas V, Taura JJ, Cottet M, Gómez-Soler M, López-Cano M, Ledent C, Watanabe M, Trinquet E, Pin JP, Luján R, Durroux T, Ciruela F.

Dis Model Mech. 2015 Jan;8(1):57-63. doi: 10.1242/dmm.018143. Epub 2014 Nov 14.

29.

Coassembly and coupling of SK2 channels and mGlu5 receptors.

García-Negredo G, Soto D, Llorente J, Morató X, Galenkamp KM, Gómez-Soler M, Fernández-Dueñas V, Watanabe M, Adelman JP, Shigemoto R, Fukazawa Y, Luján R, Ciruela F.

J Neurosci. 2014 Oct 29;34(44):14793-802. doi: 10.1523/JNEUROSCI.2038-14.2014.

30.

Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism.

Fernández-Dueñas V, Gómez-Soler M, López-Cano M, Taura JJ, Ledent C, Watanabe M, Jacobson KA, Vilardaga JP, Ciruela F.

ACS Chem Biol. 2014 Nov 21;9(11):2496-501. doi: 10.1021/cb5005383. Epub 2014 Oct 2.

31.

Photomodulation of G protein-coupled adenosine receptors by a novel light-switchable ligand.

Bahamonde MI, Taura J, Paoletta S, Gakh AA, Chakraborty S, Hernando J, Fernández-Dueñas V, Jacobson KA, Gorostiza P, Ciruela F.

Bioconjug Chem. 2014 Oct 15;25(10):1847-54. doi: 10.1021/bc5003373. Epub 2014 Oct 2.

32.

Deciphering G protein-coupled receptor biology with fluorescence-based methods.

Ciruela F, Vallano A, Cuffí ML, Carbonell L, Sánchez S, Arnau JM, Tasca C, Fernández-Dueñas V, Gómez-Soler M.

Curr Pharm Biotechnol. 2014;15(10):962-70. Review.

PMID:
25213309
33.

Portraying G protein-coupled receptors with fluorescent ligands.

Ciruela F, Jacobson KA, Fernández-Dueñas V.

ACS Chem Biol. 2014 Sep 19;9(9):1918-28. doi: 10.1021/cb5004042. Epub 2014 Jul 28. Review.

34.

Striatal adenosine A2A receptor expression is controlled by S-adenosyl-L-methionine-mediated methylation.

Villar-Menéndez I, Nuñez F, Díaz-Sánchez S, Albasanz JL, Taura J, Fernández-Dueñas V, Ferrer I, Martín M, Ciruela F, Barrachina M.

Purinergic Signal. 2014 Sep;10(3):523-8. doi: 10.1007/s11302-014-9417-4. Epub 2014 Jun 19.

35.

Predicting the antinociceptive efficacy of σ(1) receptor ligands by a novel receptor fluorescence resonance energy transfer (FRET) based biosensor.

Gómez-Soler M, Fernández-Dueñas V, Portillo-Salido E, Pérez P, Zamanillo D, Vela JM, Burgueño J, Ciruela F.

J Med Chem. 2014 Jan 9;57(1):238-42. doi: 10.1021/jm401529t. Epub 2013 Dec 20.

PMID:
24354313
36.

Targeting striatal metabotropic glutamate receptor type 5 in Parkinson's disease: bridging molecular studies and clinical trials.

Vallano A, Fernandez-Duenas V, Garcia-Negredo G, Quijada MA, Simon CP, Cuffí ML, Carbonell L, Sanchez S, Arnau JM, Ciruela F.

CNS Neurol Disord Drug Targets. 2013 Dec;12(8):1128-42. Review.

PMID:
24040811
37.

Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework.

Fernández-Dueñas V, Gómez-Soler M, Morató X, Núñez F, Das A, Kumar TS, Jaumà S, Jacobson KA, Ciruela F.

Neurochem Int. 2013 Jul;63(1):42-6. doi: 10.1016/j.neuint.2013.04.006. Epub 2013 Apr 23.

38.

The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain.

Gandía J, Fernández-Dueñas V, Morató X, Caltabiano G, González-Muñiz R, Pardo L, Stagljar I, Ciruela F.

J Neurochem. 2013 May;125(3):362-72. doi: 10.1111/jnc.12196. Epub 2013 Mar 3.

39.

Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R.

Fernández-Dueñas V, Gómez-Soler M, Jacobson KA, Kumar ST, Fuxe K, Borroto-Escuela DO, Ciruela F.

J Neurochem. 2012 Nov;123(3):373-84. doi: 10.1111/j.1471-4159.2012.07956.x. Epub 2012 Sep 28.

40.

Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression.

Canela L, Selga E, García-Martínez JM, Amaral OB, Fernández-Dueñas V, Alberch J, Canela EI, Franco R, Noé V, Lluís C, Ciudad CJ, Ciruela F.

Gene. 2012 Oct 25;508(2):199-205. doi: 10.1016/j.gene.2012.07.074. Epub 2012 Aug 7.

PMID:
22892378
41.

Fluorescence resonance energy transfer-based technologies in the study of protein-protein interactions at the cell surface.

Fernández-Dueñas V, Llorente J, Gandía J, Borroto-Escuela DO, Agnati LF, Tasca CI, Fuxe K, Ciruela F.

Methods. 2012 Aug;57(4):467-72. doi: 10.1016/j.ymeth.2012.05.007. Epub 2012 Jun 6. Review.

PMID:
22683304
42.

G protein-coupled receptor oligomerization and brain integration: focus on adenosinergic transmission.

Ciruela F, Fernández-Dueñas V, Llorente J, Borroto-Escuela D, Cuffí ML, Carbonell L, Sánchez S, Agnati LF, Fuxe K, Tasca CI.

Brain Res. 2012 Oct 2;1476:86-95. doi: 10.1016/j.brainres.2012.04.056. Epub 2012 May 7. Review.

PMID:
22575562
43.

Synergistic interaction between fentanyl and a tramadol: paracetamol combination on the inhibition of nociception in mice.

Fernández-Dueñas V, Poveda R, Sánchez S, Ciruela F.

J Pharmacol Sci. 2012;118(2):299-302. Epub 2012 Feb 3.

44.

An update on adenosine A2A receptors as drug target in Parkinson's disease.

Vallano A, Fernandez-Duenas V, Pedros C, Arnau JM, Ciruela F.

CNS Neurol Disord Drug Targets. 2011 Sep 1;10(6):659-69. Review.

PMID:
21838670
45.

Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts.

López-Hernández T, Sirisi S, Capdevila-Nortes X, Montolio M, Fernández-Dueñas V, Scheper GC, van der Knaap MS, Casquero P, Ciruela F, Ferrer I, Nunes V, Estévez R.

Hum Mol Genet. 2011 Aug 15;20(16):3266-77. doi: 10.1093/hmg/ddr238. Epub 2011 May 30.

PMID:
21624973
46.

Caffeine improves attention deficit in neonatal 6-OHDA lesioned rats, an animal model of attention deficit hyperactivity disorder (ADHD).

Caballero M, Núñez F, Ahern S, Cuffí ML, Carbonell L, Sánchez S, Fernández-Dueñas V, Ciruela F.

Neurosci Lett. 2011 Apr 20;494(1):44-8. doi: 10.1016/j.neulet.2011.02.050. Epub 2011 Mar 6.

PMID:
21362462
47.

Adenosine receptor containing oligomers: their role in the control of dopamine and glutamate neurotransmission in the brain.

Ciruela F, Gómez-Soler M, Guidolin D, Borroto-Escuela DO, Agnati LF, Fuxe K, Fernández-Dueñas V.

Biochim Biophys Acta. 2011 May;1808(5):1245-55. doi: 10.1016/j.bbamem.2011.02.007. Epub 2011 Feb 18. Review.

48.

Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain.

Fernández-Dueñas V, Poveda R, Fernández A, Sánchez S, Planas E, Ciruela F.

Pharmacol Biochem Behav. 2011 May;98(3):331-6. doi: 10.1016/j.pbb.2011.01.023. Epub 2011 Feb 4.

PMID:
21296105
49.

Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits.

Ciruela F, Fernández-Dueñas V, Sahlholm K, Fernández-Alacid L, Nicolau JC, Watanabe M, Luján R.

Eur J Neurosci. 2010 Oct;32(8):1265-77. doi: 10.1111/j.1460-9568.2010.07356.x. Epub 2010 Sep 16.

PMID:
20846323
50.

G protein-coupled receptor oligomerization for what?

Ciruela F, Vallano A, Arnau JM, Sánchez S, Borroto-Escuela DO, Agnati LF, Fuxe K, Fernández-Dueñas V.

J Recept Signal Transduct Res. 2010 Oct;30(5):322-30. doi: 10.3109/10799893.2010.508166.

PMID:
20718634

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