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Items: 1 to 50 of 64

1.

Mechanisms of Blockade of the Muscle-Type Nicotinic Receptor by Benzocaine, a Permanently Uncharged Local Anesthetic.

Cobo R, Nikolaeva-Koleva M, Alberola-Die A, Fernández-Ballester G, González-Ros JM, Ivorra I, Morales A.

Neuroscience. 2019 May 31. pii: S0306-4522(19)30373-2. doi: 10.1016/j.neuroscience.2019.05.043. [Epub ahead of print]

PMID:
31158437
2.

In Silico Approaches for TRP Channel Modulation.

Nikolaeva Koleva M, Fernandez-Ballester G.

Methods Mol Biol. 2019;1987:187-206. doi: 10.1007/978-1-4939-9446-5_12.

PMID:
31028681
3.

The calmodulin-binding tetraleucine motif of KCNE4 is responsible for association with Kv1.3.

Solé L, Roig SR, Sastre D, Vallejo-Gracia A, Serrano-Albarrás A, Ferrer-Montiel A, Fernández-Ballester G, Tamkun MM, Felipe A.

FASEB J. 2019 Jul;33(7):8263-8279. doi: 10.1096/fj.201801164RR. Epub 2019 Apr 10.

PMID:
30969795
4.

Mechanisms Underlying the Strong Inhibition of Muscle-Type Nicotinic Receptors by Tetracaine.

Cobo R, Nikolaeva M, Alberola-Die A, Fernández-Ballester G, González-Ros JM, Ivorra I, Morales A.

Front Mol Neurosci. 2018 Aug 8;11:193. doi: 10.3389/fnmol.2018.00193. eCollection 2018.

5.

Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists.

de la Torre-Martínez R, Bonache MA, Llabrés-Campaner PJ, Balsera B, Fernández-Carvajal A, Fernández-Ballester G, Ferrer-Montiel A, Pérez de Vega MJ, González-Muñiz R.

Sci Rep. 2017 Sep 7;7(1):10766. doi: 10.1038/s41598-017-10913-x.

6.

Muscle-Type Nicotinic Receptor Modulation by 2,6-Dimethylaniline, a Molecule Resembling the Hydrophobic Moiety of Lidocaine.

Alberola-Die A, Fernández-Ballester G, González-Ros JM, Ivorra I, Morales A.

Front Mol Neurosci. 2016 Nov 24;9:127. eCollection 2016.

7.

Muscle-Type Nicotinic Receptor Blockade by Diethylamine, the Hydrophilic Moiety of Lidocaine.

Alberola-Die A, Fernández-Ballester G, González-Ros JM, Ivorra I, Morales A.

Front Mol Neurosci. 2016 Feb 15;9:12. doi: 10.3389/fnmol.2016.00012. eCollection 2016.

8.

In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols.

Encinar JA, Fernández-Ballester G, Galiano-Ibarra V, Micol V.

Drug Des Devel Ther. 2015 Nov 4;9:5877-95. doi: 10.2147/DDDT.S93449. eCollection 2015.

9.

Molecular Binding Mechanism of TtgR Repressor to Antibiotics and Antimicrobials.

Fernandez-Escamilla AM, Fernandez-Ballester G, Morel B, Casares-Atienza S, Ramos JL.

PLoS One. 2015 Sep 30;10(9):e0138469. doi: 10.1371/journal.pone.0138469. eCollection 2015.

10.

Competing Lipid-Protein and Protein-Protein Interactions Determine Clustering and Gating Patterns in the Potassium Channel from Streptomyces lividans (KcsA).

Molina ML, Giudici AM, Poveda JA, Fernández-Ballester G, Montoya E, Renart ML, Fernández AM, Encinar JA, Riquelme G, Morales A, González-Ros JM.

J Biol Chem. 2015 Oct 16;290(42):25745-55. doi: 10.1074/jbc.M115.669598. Epub 2015 Sep 2.

11.

Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain.

Caires R, Luis E, Taberner FJ, Fernandez-Ballester G, Ferrer-Montiel A, Balazs EA, Gomis A, Belmonte C, de la Peña E.

Nat Commun. 2015 Aug 27;6:8095. doi: 10.1038/ncomms9095.

12.

The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating.

Gregorio-Teruel L, Valente P, Liu B, Fernández-Ballester G, Qin F, Ferrer-Montiel A.

Biophys J. 2015 Aug 4;109(3):529-41. doi: 10.1016/j.bpj.2015.06.039.

13.

TRP channels interaction with lipids and its implications in disease.

Taberner FJ, Fernández-Ballester G, Fernández-Carvajal A, Ferrer-Montiel A.

Biochim Biophys Acta. 2015 Sep;1848(9):1818-27. doi: 10.1016/j.bbamem.2015.03.022. Epub 2015 Mar 30. Review.

14.

The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.

Taberner FJ, López-Córdoba A, Fernández-Ballester G, Korchev Y, Ferrer-Montiel A.

J Biol Chem. 2014 Oct 10;289(41):28579-94. doi: 10.1074/jbc.M114.577478. Epub 2014 Aug 25.

15.

Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation.

Gregorio-Teruel L, Valente P, González-Ros JM, Fernández-Ballester G, Ferrer-Montiel A.

J Gen Physiol. 2014 Mar;143(3):361-75. doi: 10.1085/jgp.201311070.

16.

Novel BRAFI599Ins Mutation Identified in a Follicular Variant of a Papillary Thyroid Carcinoma: A Molecular Modeling Approach.

Cañadas-Garre M, Fernandez-Escamilla AM, Fernandez-Ballester G, Becerra-Massare P, García-Calvente C, Ramos JL, Llamas-Elvira JM.

Endocr Pract. 2014 May;20(5):e75-9. doi: 10.4158/EP13465.CR.

PMID:
24449679
17.

Lipid modulation of ion channels through specific binding sites.

Poveda JA, Giudici AM, Renart ML, Molina ML, Montoya E, Fernández-Carvajal A, Fernández-Ballester G, Encinar JA, González-Ros JM.

Biochim Biophys Acta. 2014 Jun;1838(6):1560-7. doi: 10.1016/j.bbamem.2013.10.023. Epub 2013 Nov 8. Review.

18.

A non-canonical di-acidic signal at the C-terminus of Kv1.3 determines anterograde trafficking and surface expression.

Martínez-Mármol R, Pérez-Verdaguer M, Roig SR, Vallejo-Gracia A, Gotsi P, Serrano-Albarrás A, Bahamonde MI, Ferrer-Montiel A, Fernández-Ballester G, Comes N, Felipe A.

J Cell Sci. 2013 Dec 15;126(Pt 24):5681-91. doi: 10.1242/jcs.134825. Epub 2013 Oct 21.

19.

Targeting protein-protein interactions to rescue Δf508-cftr: a novel corrector approach to treat cystic fibrosis.

Devesa I, Fernández-Ballester G, Ferrer-Montiel A.

EMBO Mol Med. 2013 Oct;5(10):1462-4. doi: 10.1002/emmm.201303301. Epub 2013 Aug 27. No abstract available.

20.

Advances in modulating thermosensory TRP channels.

Ferrer-Montiel A, Fernández-Carvajal A, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Messeguer A, González-Muñiz R.

Expert Opin Ther Pat. 2012 Sep;22(9):999-1017. doi: 10.1517/13543776.2012.711320. Epub 2012 Jul 27. Review.

PMID:
22835143
21.

Mutation of Ser-50 and Cys-66 in Snapin modulates protein structure and stability.

Navarro A, Encinar JA, López-Méndez B, Aguado-Llera D, Prieto J, Gómez J, Martínez-Cruz LA, Millet O, González-Ros JM, Fernández-Ballester G, Neira JL, Ferrer-Montiel A.

Biochemistry. 2012 Apr 24;51(16):3470-84. doi: 10.1021/bi201574t. Epub 2012 Apr 11.

PMID:
22471585
22.

Role of the transient receptor potential vanilloid 1 in inflammation and sepsis.

Devesa I, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Ferrer-Montiel A, Fernández-Carvajal A.

J Inflamm Res. 2011;4:67-81. doi: 10.2147/JIR.S12978. Epub 2011 May 24.

23.

Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway.

Goswami C, Kuhn J, Dina OA, Fernández-Ballester G, Levine JD, Ferrer-Montiel A, Hucho T.

J Neurochem. 2011 Jun;117(6):995-1008. doi: 10.1111/j.1471-4159.2011.07270.x. Epub 2011 May 13.

24.

Membrane-tethered peptides patterned after the TRP domain (TRPducins) selectively inhibit TRPV1 channel activity.

Valente P, Fernández-Carvajal A, Camprubí-Robles M, Gomis A, Quirce S, Viana F, Fernández-Ballester G, González-Ros JM, Belmonte C, Planells-Cases R, Ferrer-Montiel A.

FASEB J. 2011 May;25(5):1628-40. doi: 10.1096/fj.10-174433. Epub 2011 Feb 9.

PMID:
21307333
25.

Ionic channels as targets for drug design: a review on computational methods.

Fernández-Ballester G, Fernández-Carvajal A, González-Ros JM, Ferrer-Montiel A.

Pharmaceutics. 2011 Dec 9;3(4):932-53. doi: 10.3390/pharmaceutics3040932.

26.

New strategies to develop novel pain therapies: addressing thermoreceptors from different points of view.

Fernández-Carvajal A, Fernández-Ballester G, Devesa I, González-Ros JM, Ferrer-Montiel A.

Pharmaceuticals (Basel). 2011 Dec 27;5(1):16-48. doi: 10.3390/ph5010016.

27.

Occupancy of nonannular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein.

Triano I, Barrera FN, Renart ML, Molina ML, Fernández-Ballester G, Poveda JA, Fernández AM, Encinar JA, Ferrer-Montiel AV, Otzen D, González-Ros JM.

Biochemistry. 2010 Jun 29;49(25):5397-404. doi: 10.1021/bi1003712.

PMID:
20481584
28.

Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.

Malkia A, Pertusa M, Fernández-Ballester G, Ferrer-Montiel A, Viana F.

Mol Pain. 2009 Nov 3;5:62. doi: 10.1186/1744-8069-5-62.

29.

ADAN: a database for prediction of protein-protein interaction of modular domains mediated by linear motifs.

Encinar JA, Fernandez-Ballester G, Sánchez IE, Hurtado-Gomez E, Stricher F, Beltrao P, Serrano L.

Bioinformatics. 2009 Sep 15;25(18):2418-24. doi: 10.1093/bioinformatics/btp424. Epub 2009 Jul 14.

PMID:
19602529
30.

Structure-based prediction of the Saccharomyces cerevisiae SH3-ligand interactions.

Fernandez-Ballester G, Beltrao P, Gonzalez JM, Song YH, Wilmanns M, Valencia A, Serrano L.

J Mol Biol. 2009 May 15;388(4):902-16. doi: 10.1016/j.jmb.2009.03.038. Epub 2009 Mar 24.

PMID:
19324052
31.

Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions.

Liew CW, Vockel M, Glassmeier G, Brandner JM, Fernandez-Ballester GJ, Schwarz JR, Schulz S, Buck F, Serrano L, Richter D, Kreienkamp HJ.

FEBS Lett. 2009 Jan 5;583(1):49-54. doi: 10.1016/j.febslet.2008.11.048. Epub 2008 Dec 9.

32.

Molecular modeling of the full-length human TRPV1 channel in closed and desensitized states.

Fernández-Ballester G, Ferrer-Montiel A.

J Membr Biol. 2008 Jun;223(3):161-72. doi: 10.1007/s00232-008-9123-7. Epub 2008 Sep 14.

PMID:
18791833
33.

Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I.

Valente P, García-Sanz N, Gomis A, Fernández-Carvajal A, Fernández-Ballester G, Viana F, Belmonte C, Ferrer-Montiel A.

FASEB J. 2008 Sep;22(9):3298-309. doi: 10.1096/fj.08-107425. Epub 2008 Jun 16.

34.

A synthetic hexapeptide (Argireline) with antiwrinkle activity.

Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A.

Int J Cosmet Sci. 2002 Oct;24(5):303-10. doi: 10.1046/j.1467-2494.2002.00153.x.

PMID:
18498523
35.

N-type inactivation of the potassium channel KcsA by the Shaker B "ball" peptide: mapping the inactivating peptide-binding epitope.

Molina ML, Barrera FN, Encinar JA, Renart ML, Fernández AM, Poveda JA, Santoro J, Bruix M, Gavilanes F, Fernández-Ballester G, Neira JL, González-Ros JM.

J Biol Chem. 2008 Jun 27;283(26):18076-85. doi: 10.1074/jbc.M710132200. Epub 2008 Apr 22.

36.

A role of the transient receptor potential domain of vanilloid receptor I in channel gating.

García-Sanz N, Valente P, Gomis A, Fernández-Carvajal A, Fernández-Ballester G, Viana F, Belmonte C, Ferrer-Montiel A.

J Neurosci. 2007 Oct 24;27(43):11641-50.

37.

High frequency of germline succinate dehydrogenase mutations in sporadic cervical paragangliomas in northern Spain: mitochondrial succinate dehydrogenase structure-function relationships and clinical-pathological correlations.

Lima J, Feijão T, Ferreira da Silva A, Pereira-Castro I, Fernandez-Ballester G, Máximo V, Herrero A, Serrano L, Sobrinho-Simões M, Garcia-Rostan G.

J Clin Endocrinol Metab. 2007 Dec;92(12):4853-64. Epub 2007 Sep 11.

PMID:
17848412
38.

Dynamics of tryptophan in the histidine-containing phosphocarrier protein of Streptomyces coelicolor: evidence of multistate equilibrium unfolding.

Poveda JA, Fernández-Ballester G, Prieto M, Neira JL.

Biochemistry. 2007 Jun 19;46(24):7252-60. Epub 2007 May 22.

PMID:
17516658
39.

Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2.

Kölsch V, Seher T, Fernandez-Ballester GJ, Serrano L, Leptin M.

Science. 2007 Jan 19;315(5810):384-6.

40.

Prediction of protein-protein interaction based on structure.

Fernandez-Ballester G, Serrano L.

Methods Mol Biol. 2006;340:207-34. Review.

PMID:
16957339
41.

Computer modelling in combination with in vitro studies reveals similar binding affinities of Drosophila Crumbs for the PDZ domains of Stardust and DmPar-6.

Kempkens O, Médina E, Fernandez-Ballester G, Ozüyaman S, Le Bivic A, Serrano L, Knust E.

Eur J Cell Biol. 2006 Aug;85(8):753-67. Epub 2006 May 11.

PMID:
16697075
42.

New approaches to high-throughput structure characterization of SH3 complexes: the example of Myosin-3 and Myosin-5 SH3 domains from S. cerevisiae.

Musi V, Birdsall B, Fernandez-Ballester G, Guerrini R, Salvatori S, Serrano L, Pastore A.

Protein Sci. 2006 Apr;15(4):795-807.

43.

Biophysical characterization of the enzyme I of the Streptomyces coelicolor phosphoenolpyruvate:sugar phosphotransferase system.

Hurtado-Gómez E, Fernández-Ballester G, Nothaft H, Gómez J, Titgemeyer F, Neira JL.

Biophys J. 2006 Jun 15;90(12):4592-604. Epub 2006 Mar 31.

44.

Molecular compatibility of the channel gate and the N terminus of S5 segment for voltage-gated channel activity.

Caprini M, Fava M, Valente P, Fernandez-Ballester G, Rapisarda C, Ferroni S, Ferrer-Montiel A.

J Biol Chem. 2005 May 6;280(18):18253-64. Epub 2005 Mar 4.

45.

Modulation of botulinum neurotoxin A catalytic domain stability by tyrosine phosphorylation.

Ibañez C, Blanes-Mira C, Fernández-Ballester G, Planells-Cases R, Ferrer-Montiel A.

FEBS Lett. 2004 Dec 3;578(1-2):121-7.

46.

Influence of C-terminal protein domains and protein-lipid interactions on tetramerization and stability of the potassium channel KcsA.

Molina ML, Encinar JA, Barrera FN, Fernández-Ballester G, Riquelme G, González-Ros JM.

Biochemistry. 2004 Nov 30;43(47):14924-31.

PMID:
15554699
47.

Stabilization of TRAIL, an all-beta-sheet multimeric protein, using computational redesign.

van der Sloot AM, Mullally MM, Fernandez-Ballester G, Serrano L, Quax WJ.

Protein Eng Des Sel. 2004 Sep;17(9):673-80. Epub 2004 Oct 14.

PMID:
15486023
48.

Identification of a tetramerization domain in the C terminus of the vanilloid receptor.

García-Sanz N, Fernández-Carvajal A, Morenilla-Palao C, Planells-Cases R, Fajardo-Sánchez E, Fernández-Ballester G, Ferrer-Montiel A.

J Neurosci. 2004 Jun 9;24(23):5307-14.

49.

Molecular architecture of the vanilloid receptor. Insights for drug design.

Ferrer-Montiel A, García-Martínez C, Morenilla-Palao C, García-Sanz N, Fernández-Carvajal A, Fernández-Ballester G, Planells-Cases R.

Eur J Biochem. 2004 May;271(10):1820-6. Review.

50.

Small peptides patterned after the N-terminus domain of SNAP25 inhibit SNARE complex assembly and regulated exocytosis.

Blanes-Mira C, Merino JM, Valera E, Fernández-Ballester G, Gutiérrez LM, Viniegra S, Pérez-Payá E, Ferrer-Montiel A.

J Neurochem. 2004 Jan;88(1):124-35.

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