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Items: 1 to 50 of 128

1.

Natural history and cell-of-origin of TCF3-ZNF384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL.

Bueno C, Tejedor JR, Bashford-Rogers R, González-Silva L, Valdés-Mas R, Agraz-Doblas A, Díaz de la Guardia R, Ribera J, Zamora L, Bilhou-Nabera C, Abermil N, Guermouche H, Gouache E, Leverger G, Fraga MF, Fernández AF, Ballerini P, Varela I, Menendez P.

Blood. 2019 Jun 20. pii: blood.2019000893. doi: 10.1182/blood.2019000893. [Epub ahead of print] No abstract available.

PMID:
31221673
2.

Epigenetic deregulation of protocadherin PCDHGC3 in pheochromocytoma/paragangliomas associated with SDHB mutations.

Bernardo-Castiñeira C, Valdés N, Celada L, San José Martinez A, Sáenz-de-Snata-María I, Bayón GF, Fernández AF, Sierra MI, Fraga MF, Astudillo A, Jiménez-Fonseca P, Rial JC, Hevia MÁ, Turienzo E, Bernardo C, Forga L, Tena I, Molina-Garrido MJ, Cacho L, Villabona C, Serrano T, Scola B, Chirivella I, Olmo MD, Menéndez CL, Navarro E, Tous M, Vallejo A, Athimulam S, Bancos I, Suarez C, Chiara MD.

J Clin Endocrinol Metab. 2019 Jun 19. pii: jc.2018-01471. doi: 10.1210/jc.2018-01471. [Epub ahead of print]

PMID:
31216007
3.

Epigenetic downregulation of TET3 reduces genome-wide 5hmC levels and promotes glioblastoma tumorigenesis.

Carella A, Tejedor JR, García MG, Urdinguio RG, Bayón GF, Sierra M, López V, García-Toraño E, Santamarina-Ojeda P, Pérez RF, Bigot T, Mangas C, Corte-Torres MD, Sáenz-de-Santa-María I, Mollejo M, Meléndez B, Astudillo A, Chiara MD, Fernández AF, Fraga MF.

Int J Cancer. 2019 Jun 18. doi: 10.1002/ijc.32520. [Epub ahead of print]

PMID:
31211412
4.

Epigenetics in cancer therapy and nanomedicine.

Roberti A, Valdes AF, Torrecillas R, Fraga MF, Fernandez AF.

Clin Epigenetics. 2019 May 16;11(1):81. doi: 10.1186/s13148-019-0675-4. Review.

5.

Corrigendum: H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells.

Fernández AF, Bayón GF, Urdinguio RG, Toraño EG, García MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, García-Castro J, Delgado-Calle J, Pérez-Campo FM, Riancho JA, Bueno C, Menéndez P, Mentink A, Mareschi K, Claire F, Fagnani C, Medda E, Toccaceli V, Brescianini S, Moran S, Esteller M, Stolzing A, de Boer J, Nisticò L, Stazi MA, Fraga MF.

Genome Res. 2019 Apr;29(4):710.2. doi: 10.1101/gr.249417.119. No abstract available.

6.

Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment.

Urdinguio RG, Lopez V, Bayón GF, Diaz de la Guardia R, Sierra MI, García-Toraño E, Perez RF, García MG, Carella A, Pruneda PC, Prieto C, Dmitrijeva M, Santamarina P, Belmonte T, Mangas C, Diaconu E, Ferrero C, Tejedor JR, Fernandez-Morera JL, Bravo C, Bueno C, Sanjuan-Pla A, Rodriguez RM, Suarez-Alvarez B, López-Larrea C, Bernal T, Colado E, Balbín M, García-Suarez O, Chiara MD, Sáenz-de-Santa-María I, Rodríguez F, Pando-Sandoval A, Rodrigo L, Santos L, Salas A, Vallejo-Díaz J, C Carrera A, Rico D, Hernández-López I, Vayá A, Ricart JM, Seto E, Sima-Teruel N, Vaquero A, Valledor L, Cañal MJ, Pisano D, Graña-Castro O, Thomas T, Voss AK, Menéndez P, Villar-Garea A, Deutzmann R, Fernandez AF, Fraga MF.

Nucleic Acids Res. 2019 Jun 4;47(10):5016-5037. doi: 10.1093/nar/gkz195.

7.

Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes.

Pérez RF, Santamarina P, Tejedor JR, Urdinguio RG, Álvarez-Pitti J, Redon P, Fernández AF, Fraga MF, Lurbe E.

J Transl Med. 2019 Jan 9;17(1):15. doi: 10.1186/s12967-018-1751-9.

8.

Alzheimer's disease DNA methylome of pyramidal layers in frontal cortex: laser-assisted microdissection study.

Hernández HG, Sandoval-Hernández AG, Garrido-Gil P, Labandeira-Garcia JL, Zelaya MV, Bayon GF, Fernández AF, Fraga MF, Arboleda G, Arboleda H.

Epigenomics. 2018 Nov;10(11):1365-1382. doi: 10.2217/epi-2017-0160. Epub 2018 Oct 16.

PMID:
30324800
9.

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.

Fernández-Ramos D, Fernández-Tussy P, Lopitz-Otsoa F, Gutiérrez-de-Juan V, Navasa N, Barbier-Torres L, Zubiete-Franco I, Simón J, Fernández AF, Arbelaiz A, Aransay AM, Lavín JL, Beraza N, Perugorria MJ, Banales JM, Villa E, Fraga MF, Anguita J, Avila MA, Berasain C, Iruzibieta P, Crespo J, Lu SC, Varela-Rey M, Mato JM, Delgado TC, Martínez-Chantar ML.

Cell Death Dis. 2018 Sep 20;9(10):958. doi: 10.1038/s41419-018-1014-y.

10.

Area dependent behavior of bathocuproine (BCP) as cathode interfacial layers in organic photovoltaic cells.

Patil BR, Ahmadpour M, Sherafatipour G, Qamar T, Fernández AF, Zojer K, Rubahn HG, Madsen M.

Sci Rep. 2018 Aug 22;8(1):12608. doi: 10.1038/s41598-018-30826-7.

11.

Epigenetic prediction of response to anti-PD-1 treatment in non-small-cell lung cancer: a multicentre, retrospective analysis.

Duruisseaux M, Martínez-Cardús A, Calleja-Cervantes ME, Moran S, Castro de Moura M, Davalos V, Piñeyro D, Sanchez-Cespedes M, Girard N, Brevet M, Giroux-Leprieur E, Dumenil C, Pradotto M, Bironzo P, Capelletto E, Novello S, Cortot A, Copin MC, Karachaliou N, Gonzalez-Cao M, Peralta S, Montuenga LM, Gil-Bazo I, Baraibar I, Lozano MD, Varela M, Ruffinelli JC, Palmero R, Nadal E, Moran T, Perez L, Ramos I, Xiao Q, Fernandez AF, Fraga MF, Gut M, Gut I, Teixidó C, Vilariño N, Prat A, Reguart N, Benito A, Garrido P, Barragan I, Emile JF, Rosell R, Brambilla E, Esteller M.

Lancet Respir Med. 2018 Oct;6(10):771-781. doi: 10.1016/S2213-2600(18)30284-4. Epub 2018 Aug 9.

12.

Author Correction: Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.

Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B.

Nature. 2018 Sep;561(7723):E30. doi: 10.1038/s41586-018-0270-4.

PMID:
29921925
13.

Epigenetic dysregulation of TET2 in human glioblastoma.

García MG, Carella A, Urdinguio RG, Bayón GF, Lopez V, Tejedor JR, Sierra MI, García-Toraño E, Santamarina P, Perez RF, Mangas C, Astudillo A, Corte-Torres MD, Sáenz-de-Santa-María I, Chiara MD, Fernández AF, Fraga MF.

Oncotarget. 2018 May 25;9(40):25922-25934. doi: 10.18632/oncotarget.25406. eCollection 2018 May 25.

14.

Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma.

Fernandez AF, Bayón GF, Sierra MI, Urdinguio RG, Toraño EG, García MG, Carella A, López V, Santamarina P, Pérez RF, Belmonte T, Tejedor JR, Cobo I, Menendez P, Mangas C, Ferrero C, Rodrigo L, Astudillo A, Ortea I, Cueto Díaz S, Rodríguez-Gonzalez P, García Alonso JI, Mollejo M, Meléndez B, Domínguez G, Bonilla F, Fraga MF.

Hum Mol Genet. 2018 Sep 1;27(17):3046-3059. doi: 10.1093/hmg/ddy214.

PMID:
29878202
15.

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.

Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B.

Nature. 2018 Jun;558(7708):136-140. doi: 10.1038/s41586-018-0162-7. Epub 2018 May 30. Erratum in: Nature. 2018 Sep;561(7723):E30.

16.

Epigenome-wide analysis reveals specific DNA hypermethylation of T cells during human hematopoietic differentiation.

Tejedor JR, Bueno C, Cobo I, Bayón GF, Prieto C, Mangas C, Pérez RF, Santamarina P, Urdinguio RG, Menéndez P, Fraga MF, Fernández AF.

Epigenomics. 2018 Jul;10(7):903-923. doi: 10.2217/epi-2017-0163. Epub 2018 Apr 5.

PMID:
29620943
17.

Increased autophagy blocks HER2-mediated breast tumorigenesis.

Vega-Rubín-de-Celis S, Zou Z, Fernández ÁF, Ci B, Kim M, Xiao G, Xie Y, Levine B.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4176-4181. doi: 10.1073/pnas.1717800115. Epub 2018 Apr 2.

18.

Distinct chromatin signatures of DNA hypomethylation in aging and cancer.

Pérez RF, Tejedor JR, Bayón GF, Fernández AF, Fraga MF.

Aging Cell. 2018 Jun;17(3):e12744. doi: 10.1111/acel.12744. Epub 2018 Mar 5.

19.

What to do when Heller's myotomy fails? Pneumatic dilatation, laparoscopic remyotomy or peroral endoscopic myotomy: A systematic review.

Fernandez-Ananin S, Fernández AF, Balagué C, Sacoto D, Targarona EM.

J Minim Access Surg. 2018 Jul-Sep;14(3):177-184. doi: 10.4103/jmas.JMAS_94_17. Review.

20.

Autophagy and Proteases: Basic Study of the Autophagic Flux by Western Blot.

Fernández ÁF.

Methods Mol Biol. 2018;1731:73-81. doi: 10.1007/978-1-4939-7595-2_8.

PMID:
29318545
21.

Quantification of Global DNA Methylation Levels by Mass Spectrometry.

Fernandez AF, Valledor L, Vallejo F, Cañal MJ, Fraga MF.

Methods Mol Biol. 2018;1708:49-58. doi: 10.1007/978-1-4939-7481-8_3.

PMID:
29224138
22.

SDHC Promoter Methylation, a Novel Pathogenic Mechanism in Parasympathetic Paragangliomas.

Bernardo-Castiñeira C, Valdés N, Sierra MI, Sáenz-de-Santa-María I, Bayón GF, Perez RF, Fernández AF, Fraga MF, Astudillo A, Menéndez R, Fernández B, Del Olmo M, Suarez C, Chiara MD.

J Clin Endocrinol Metab. 2018 Jan 1;103(1):295-305. doi: 10.1210/jc.2017-01702.

PMID:
29126304
23.

DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes.

Sierra MI, Rubio L, Bayón GF, Cobo I, Menendez P, Morales P, Mangas C, Urdinguio RG, Lopez V, Valdes A, Vales G, Marcos R, Torrecillas R, Fernández AF, Fraga MF.

Nanotoxicology. 2017 Sep;11(7):857-870. doi: 10.1080/17435390.2017.1371350. Epub 2017 Sep 13.

PMID:
28901819
24.

Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens.

Fernández ÁF, Bárcena C, Martínez-García GG, Tamargo-Gómez I, Suárez MF, Pietrocola F, Castoldi F, Esteban L, Sierra-Filardi E, Boya P, López-Otín C, Kroemer G, Mariño G.

Cell Death Dis. 2017 Aug 3;8(8):e2970. doi: 10.1038/cddis.2017.373.

25.

Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the "safe harbor" AAVS1 locus.

Castaño J, Bueno C, Jiménez-Delgado S, Roca-Ho H, Fraga MF, Fernandez AF, Nakanishi M, Torres-Ruiz R, Rodríguez-Perales S, Menéndez P.

Stem Cell Res. 2017 May;21:137-140. doi: 10.1016/j.scr.2017.04.011. Epub 2017 Apr 22.

26.

The role of 5-hydroxymethylcytosine in development, aging and age-related diseases.

López V, Fernández AF, Fraga MF.

Ageing Res Rev. 2017 Aug;37:28-38. doi: 10.1016/j.arr.2017.05.002. Epub 2017 May 10. Review.

PMID:
28499883
27.

Phenotypic characteristics of aged CD4+ CD28null T lymphocytes are determined by changes in the whole-genome DNA methylation pattern.

Suarez-Álvarez B, Rodríguez RM, Schlangen K, Raneros AB, Márquez-Kisinousky L, Fernández AF, Díaz-Corte C, Aransay AM, López-Larrea C.

Aging Cell. 2017 Apr;16(2):293-303. doi: 10.1111/acel.12552. Epub 2016 Dec 27.

28.

Differential analysis of genome-wide methylation and gene expression in mesenchymal stem cells of patients with fractures and osteoarthritis.

Del Real A, Pérez-Campo FM, Fernández AF, Sañudo C, Ibarbia CG, Pérez-Núñez MI, Criekinge WV, Braspenning M, Alonso MA, Fraga MF, Riancho JA.

Epigenetics. 2017 Feb;12(2):113-122. doi: 10.1080/15592294.2016.1271854. Epub 2016 Dec 16.

29.

The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome.

Sierra MI, Valdés A, Fernández AF, Torrecillas R, Fraga MF.

Int J Nanomedicine. 2016 Nov 25;11:6297-6306. eCollection 2016. Review.

30.

Does Autophagy Mediate Cardiac Myocyte Death During Stress?

Nah J, Fernández ÁF, Kitsis RN, Levine B, Sadoshima J.

Circ Res. 2016 Sep 30;119(8):893-5. doi: 10.1161/CIRCRESAHA.116.309765. Review. No abstract available.

31.

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.

Muñoz-López A, Romero-Moya D, Prieto C, Ramos-Mejía V, Agraz-Doblas A, Varela I, Buschbeck M, Palau A, Carvajal-Vergara X, Giorgetti A, Ford A, Lako M, Granada I, Ruiz-Xivillé N, Rodríguez-Perales S, Torres-Ruíz R, Stam RW, Fuster JL, Fraga MF, Nakanishi M, Cazzaniga G, Bardini M, Cobo I, Bayon GF, Fernandez AF, Bueno C, Menendez P.

Stem Cell Reports. 2016 Oct 11;7(4):602-618. doi: 10.1016/j.stemcr.2016.08.013. Epub 2016 Sep 22.

32.

Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells.

Toraño EG, Bayón GF, Del Real Á, Sierra MI, García MG, Carella A, Belmonte T, Urdinguio RG, Cubillo I, García-Castro J, Delgado-Calle J, Pérez-Campo FM, Riancho JA, Fraga MF, Fernández AF.

J Transl Med. 2016 Jul 8;14(1):207. doi: 10.1186/s12967-016-0966-x.

33.

Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene.

Galera-Monge T, Zurita-Díaz F, González-Páramos C, Moreno-Izquierdo A, Fraga MF, Fernández AF, Garesse R, Gallardo ME.

Stem Cell Res. 2016 May;16(3):766-9. doi: 10.1016/j.scr.2016.04.012. Epub 2016 Apr 18. No abstract available.

34.

Generation of a human iPSC line from a patient with an optic atrophy 'plus' phenotype due to a mutation in the OPA1 gene.

Galera-Monge T, Zurita-Díaz F, Moreno-Izquierdo A, Fraga MF, Fernández AF, Ayuso C, Garesse R, Gallardo ME.

Stem Cell Res. 2016 May;16(3):673-6. doi: 10.1016/j.scr.2016.03.011. Epub 2016 Apr 13.

35.

Generation of a human iPSC line from a patient with a mitochondrial encephalopathy due to mutations in the GFM1 gene.

Zurita-Díaz F, Galera-Monge T, Moreno-Izquierdo A, Fraga MF, Ayuso C, Fernández AF, Garesse R, Gallardo ME.

Stem Cell Res. 2016 Jan;16(1):124-7. doi: 10.1016/j.scr.2015.12.019. Epub 2015 Dec 29.

36.

Generation of a human iPSC line from a patient with a defect of intergenomic communication.

Zurita F, Galera T, González-Páramos C, Moreno-Izquierdo A, Schneiderat P, Fraga MF, Fernández AF, Garesse R, Gallardo ME.

Stem Cell Res. 2016 Jan;16(1):120-3. doi: 10.1016/j.scr.2015.12.016. Epub 2015 Dec 28.

37.

Generation of a human control iPSC line with a European mitochondrial haplogroup U background.

Galera T, Zurita F, González-Páramos C, Moreno-Izquierdo A, Fraga MF, Fernández AF, Garesse R, Gallardo ME.

Stem Cell Res. 2016 Jan;16(1):88-91. doi: 10.1016/j.scr.2015.12.010. Epub 2015 Dec 15.

38.

Generation of a human iPSC line from a patient with Leigh syndrome.

Galera T, Zurita F, González-Páramos C, Moreno-Izquierdo A, Fraga MF, Fernández AF, Garesse R, Gallardo ME.

Stem Cell Res. 2016 Jan;16(1):63-6. doi: 10.1016/j.scr.2015.12.005. Epub 2015 Dec 12.

39.

The Impact of External Factors on the Epigenome: In Utero and over Lifetime.

Toraño EG, García MG, Fernández-Morera JL, Niño-García P, Fernández AF.

Biomed Res Int. 2016;2016:2568635. doi: 10.1155/2016/2568635. Epub 2016 May 18. Review.

40.

Longitudinal study of DNA methylation during the first 5 years of life.

Urdinguio RG, Torró MI, Bayón GF, Álvarez-Pitti J, Fernández AF, Redon P, Fraga MF, Lurbe E.

J Transl Med. 2016 Jun 3;14(1):160. doi: 10.1186/s12967-016-0913-x.

41.

Fanconi Anemia Proteins Function in Mitophagy and Immunity.

Sumpter R Jr, Sirasanagandla S, Fernández ÁF, Wei Y, Dong X, Franco L, Zou Z, Marchal C, Lee MY, Clapp DW, Hanenberg H, Levine B.

Cell. 2016 May 5;165(4):867-81. doi: 10.1016/j.cell.2016.04.006. Epub 2016 Apr 28.

42.

Epigenetics of Aging.

Sierra MI, Fernández AF, Fraga MF.

Curr Genomics. 2015 Dec;16(6):435-40. doi: 10.2174/1389202916666150817203459.

43.

Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2.

Redis RS, Vela LE, Lu W, Ferreira de Oliveira J, Ivan C, Rodriguez-Aguayo C, Adamoski D, Pasculli B, Taguchi A, Chen Y, Fernandez AF, Valledor L, Van Roosbroeck K, Chang S, Shah M, Kinnebrew G, Han L, Atlasi Y, Cheung LH, Huang GY, Monroig P, Ramirez MS, Catela Ivkovic T, Van L, Ling H, Gafà R, Kapitanovic S, Lanza G, Bankson JA, Huang P, Lai SY, Bast RC, Rosenblum MG, Radovich M, Ivan M, Bartholomeusz G, Liang H, Fraga MF, Widger WR, Hanash S, Berindan-Neagoe I, Lopez-Berestein G, Ambrosio ALB, Gomes Dias SM, Calin GA.

Mol Cell. 2016 Feb 18;61(4):640. doi: 10.1016/j.molcel.2016.02.006. Epub 2016 Feb 18. No abstract available.

44.

Oncometabolic Nuclear Reprogramming of Cancer Stemness.

Menendez JA, Corominas-Faja B, Cuyàs E, García MG, Fernández-Arroyo S, Fernández AF, Joven J, Fraga MF, Alarcón T.

Stem Cell Reports. 2016 Mar 8;6(3):273-83. doi: 10.1016/j.stemcr.2015.12.012. Epub 2016 Feb 11.

45.

Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2.

Redis RS, Vela LE, Lu W, Ferreira de Oliveira J, Ivan C, Rodriguez-Aguayo C, Adamoski D, Pasculli B, Taguchi A, Chen Y, Fernandez AF, Valledor L, Van Roosbroeck K, Chang S, Shah M, Kinnebrew G, Han L, Atlasi Y, Cheung LH, Huang GY, Monroig P, Ramirez MS, Catela Ivkovic T, Van L, Ling H, Gafà R, Kapitanovic S, Lanza G, Bankson JA, Huang P, Lai SY, Bast RC, Rosenblum MG, Radovich M, Ivan M, Bartholomeusz G, Liang H, Fraga MF, Widger WR, Hanash S, Berindan-Neagoe I, Lopez-Berestein G, Ambrosio ALB, Gomes Dias SM, Calin GA.

Mol Cell. 2016 Feb 18;61(4):520-534. doi: 10.1016/j.molcel.2016.01.015. Epub 2016 Feb 4. Erratum in: Mol Cell. 2016 Feb 18;61(4):640.

46.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, 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