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Items: 1 to 50 of 361

1.

Demonstrating the value of patient-oriented research in Ontario.

Fergusson D, Monfaredi Z.

CMAJ. 2018 Nov 7;190(Suppl):S53-S54. doi: 10.1503/cmaj.180812. No abstract available.

PMID:
30404857
2.

DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial.

Cook JA, Julious SA, Sones W, Hampson LV, Hewitt C, Berlin JA, Ashby D, Emsley R, Fergusson DA, Walters SJ, Wilson ECF, Maclennan G, Stallard N, Rothwell JC, Bland M, Brown L, Ramsay CR, Cook A, Armstrong D, Altman D, Vale LD.

Trials. 2018 Nov 5;19(1):606. doi: 10.1186/s13063-018-2884-0.

3.
4.

The Effectiveness of Tranexamic Acid at Reducing Blood Loss and Transfusion Requirement for Women Undergoing Myomectomy: A Systematic Review and Meta-analysis.

Fusca L, Perelman I, Fergusson D, Boutet M, Chen I.

J Obstet Gynaecol Can. 2018 Oct 29. pii: S1701-2163(18)30293-7. doi: 10.1016/j.jogc.2018.04.007. [Epub ahead of print] Review.

PMID:
30385210
5.

Physician Survey of Timing of Adjuvant Endocrine Therapy Relative to Radiotherapy in Early Stage Breast Cancer Patients.

McGee SF, Vandermeer L, Mazzarello S, Sienkiewicz M, Stober C, Hutton B, Fergusson D, Hilton J, Caudrelier JM, Blanchette P, Clemons M.

Clin Breast Cancer. 2018 Sep 4. pii: S1526-8209(18)30204-0. doi: 10.1016/j.clbc.2018.08.012. [Epub ahead of print]

PMID:
30318304
6.

Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial - the development of the DELTA2 guidance.

Sones W, Julious SA, Rothwell JC, Ramsay CR, Hampson LV, Emsley R, Walters SJ, Hewitt C, Bland M, Fergusson DA, Berlin JA, Altman D, Vale LD, Cook JA.

Trials. 2018 Oct 10;19(1):542. doi: 10.1186/s13063-018-2887-x.

7.

Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol.

Taljaard M, Weijer C, Grimshaw JM, Ali A, Brehaut JC, Campbell MK, Carroll K, Edwards S, Eldridge S, Forrest CB, Giraudeau B, Goldstein CE, Graham ID, Hemming K, Hey SP, Horn AR, Jairath V, Klassen TP, London AJ, Marlin S, Marshall JC, McIntyre L, McKenzie JE, Nicholls SG, Alison Paprica P, Zwarenstein M, Fergusson DA.

Trials. 2018 Sep 27;19(1):525. doi: 10.1186/s13063-018-2895-x.

8.

Safety and Efficacy of Adult Stem Cell Therapy for Acute Myocardial Infarction and Ischemic Heart Failure (SafeCell Heart): A Systematic Review and Meta-Analysis.

Lalu MM, Mazzarello S, Zlepnig J, Dong YYR, Montroy J, McIntyre L, Devereaux PJ, Stewart DJ, David Mazer C, Barron CC, McIsaac DI, Fergusson DA.

Stem Cells Transl Med. 2018 Sep 26. doi: 10.1002/sctm.18-0120. [Epub ahead of print]

9.

Primary Febrile Neutropenia Prophylaxis for Patients Who Receive FEC-D Chemotherapy for Breast Cancer: A Systematic Review.

Fernandes R, Mazzarello S, Stober C, Ibrahim MFK, Dudani S, Perdrizet K, Majeed H, Vandermeer L, Shorr R, Hutton B, Fergusson D, Gyawali B, Clemons M.

J Glob Oncol. 2018 Sep;(4):1-8. doi: 10.1200/JGO.2016.008540. Epub 2017 Apr 21.

10.

Effect of high dose folic acid supplementation in pregnancy on pre-eclampsia (FACT): double blind, phase III, randomised controlled, international, multicentre trial.

Wen SW, White RR, Rybak N, Gaudet LM, Robson S, Hague W, Simms-Stewart D, Carroli G, Smith G, Fraser WD, Wells G, Davidge ST, Kingdom J, Coyle D, Fergusson D, Corsi DJ, Champagne J, Sabri E, Ramsay T, Mol BWJ, Oudijk MA, Walker MC; FACT Collaborating Group.

BMJ. 2018 Sep 12;362:k3478. doi: 10.1136/bmj.k3478.

11.

Personal goal-setting among women living with breast cancer: protocol for a scoping review.

Chow A, Presseau J, Perelman I, Sikora L, Fergusson D.

Syst Rev. 2018 Aug 28;7(1):132. doi: 10.1186/s13643-018-0794-6.

12.

Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery.

Mazer CD, Whitlock RP, Fergusson DA, Belley-Cote E, Connolly K, Khanykin B, Gregory AJ, de Médicis É, Carrier FM, McGuinness S, Young PJ, Byrne K, Villar JC, Royse A, Grocott HP, Seeberger MD, Mehta C, Lellouche F, Hare GMT, Painter TW, Fremes S, Syed S, Bagshaw SM, Hwang NC, Royse C, Hall J, Dai D, Mistry N, Thorpe K, Verma S, Jüni P, Shehata N; TRICS Investigators and Perioperative Anesthesia Clinical Trials Group.

N Engl J Med. 2018 Sep 27;379(13):1224-1233. doi: 10.1056/NEJMoa1808561. Epub 2018 Aug 26.

PMID:
30146969
13.

FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial.

McIntyre L, Taljaard M, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Menon K, Muscedere J, Cook DJ, Weijer C, Saginur R, Maybee A, Iyengar A, Forster A, Graham ID, Hawken S, McCartney C, Seely AJ, Stiell IG, Thavorn K, Fergusson DA.

BMJ Open. 2018 Aug 23;8(8):e022780. doi: 10.1136/bmjopen-2018-022780.

14.

Comparison of crystalloid resuscitation fluids for treatment of acute brain injury: a clinical and pre-clinical systematic review and network meta-analysis protocol.

Thompson M, McIntyre L, Hutton B, Tran A, Wolfe D, Hutchison J, Fergusson D, Turgeon AF, English SW.

Syst Rev. 2018 Aug 17;7(1):125. doi: 10.1186/s13643-018-0790-x.

15.

Feasibility of using a pragmatic trials model to compare two primary febrile neutropenia prophylaxis regimens (ciprofloxacin versus G-CSF) in patients receiving docetaxel-cyclophosphamide chemotherapy for breast cancer (REaCT-TC).

Clemons M, Mazzarello S, Hilton J, Joy A, Price-Hiller J, Zhu X, Verma S, Kehoe A, Ibrahim MF, Sienkiewicz M, Stober C, Vandermeer L, Hutton B, Mallick R, Fergusson D.

Support Care Cancer. 2018 Aug 11. doi: 10.1007/s00520-018-4408-6. [Epub ahead of print]

PMID:
30099602
16.

The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial.

Tucci M, Lacroix J, Fergusson D, Doctor A, Hébert P, Berg RA, Caro J, Josephson CD, Leteurtre S, Menon K, Schechtman K, Steiner ME, Turgeon AF, Clayton L, Bockelmann T, Spinella PC; Canadian Critical Care Trials Group; Pediatric Critical Care Blood Research Network (BloodNet); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

Trials. 2018 Jul 28;19(1):404. doi: 10.1186/s13063-018-2809-y.

17.

Randomised feasibility trial to compare three standard of care chemotherapy regimens for early stage triple-negative breast cancer (REaCT-TNBC trial).

Hilton J, Stober C, Mazzarello S, Vandermeer L, Fergusson D, Hutton B, Clemons M.

PLoS One. 2018 Jul 24;13(7):e0199297. doi: 10.1371/journal.pone.0199297. eCollection 2018.

18.

Case Mix, Patterns of Care, and Inpatient Outcomes Among Ontario Kidney Transplant Centers: A Population-Based Study.

Tsampalieros A, Knoll GA, Dixon S, English S, Manuel D, Van Walraven C, Taljaard M, Fergusson D.

Can J Kidney Health Dis. 2018 Jul 17;5:2054358117730053. doi: 10.1177/2054358117730053. eCollection 2018.

19.

Radiotherapy with radical cystectomy for bladder cancer: A systematic review and meta-analysis.

Mcalpine K, Fergusson DA, Breau RH, Reynolds LF, Shorr R, Morgan SC, Eapen L, Cagiannos I, Morash C, Lavallée LT.

Can Urol Assoc J. 2018 Oct;12(10):351-360. doi: 10.5489/cuaj.5244. Epub 2018 May 28. Review.

20.

Optimal vascular access strategies for patients receiving chemotherapy for early-stage breast cancer: a systematic review.

Robinson A, Souied O, Bota AB, Levasseur N, Stober C, Hilton J, Kamel D, Hutton B, Vandermeer L, Mazzarello S, Joy AA, Fergusson D, McDiarmid S, McInnes M, Shorr R, Clemons M.

Breast Cancer Res Treat. 2018 Oct;171(3):607-620. doi: 10.1007/s10549-018-4868-x. Epub 2018 Jul 4. Review.

PMID:
29974358
21.

Anemia prevalence and incidence and red blood cell transfusion practices in aneurysmal subarachnoid hemorrhage: results of a multicenter cohort study.

English SW, Chassé M, Turgeon AF, Lauzier F, Griesdale D, Garland A, Fergusson D, Zarychanski R, van Walraven C, Montroy K, Ziegler J, Dupont-Chouinard R, Carignan R, Dhaliwal A, Mallick R, Sinclair J, Boutin A, Pagliarello G, Tinmouth A, McIntyre L; Canadian Critical Care Trials Group.

Crit Care. 2018 Jul 4;22(1):169. doi: 10.1186/s13054-018-2089-7.

22.

Accommodating quality and service improvement research within existing ethical principles.

Goldstein CE, Weijer C, Brehaut JC, Campbell M, Fergusson DA, Grimshaw JM, Hemming K, Horn AR, Taljaard M.

Trials. 2018 Jun 25;19(1):334. doi: 10.1186/s13063-018-2724-2.

23.

Antipsychotics for treatment of delirium in hospitalised non-ICU patients.

Burry L, Mehta S, Perreault MM, Luxenberg JS, Siddiqi N, Hutton B, Fergusson DA, Bell C, Rose L.

Cochrane Database Syst Rev. 2018 Jun 18;6:CD005594. doi: 10.1002/14651858.CD005594.pub3. Review.

PMID:
29920656
24.

Clinical trials evaluating red blood cell transfusion thresholds: An updated systematic review and with additional focus on patients with cardiovascular disease.

Carson JL, Stanworth SJ, Alexander JH, Roubinian N, Fergusson DA, Triulzi DJ, Goodman SG, Rao SV, Doree C, Hebert PC.

Am Heart J. 2018 Jun;200:96-101. doi: 10.1016/j.ahj.2018.04.007. Epub 2018 Apr 7.

PMID:
29898855
25.

The prevalence of patient engagement in published trials: a systematic review.

Fergusson D, Monfaredi Z, Pussegoda K, Garritty C, Lyddiatt A, Shea B, Duffett L, Ghannad M, Montroy J, Hassan Murad M, Pratt M, Rader T, Shorr R, Yazdi F.

Res Involv Engagem. 2018 May 22;4:17. doi: 10.1186/s40900-018-0099-x. eCollection 2018.

26.

Tranexamic Acid versus Placebo to Prevent Blood Transfusion during Radical Cystectomy for Bladder Cancer (TACT): Study Protocol for a Randomized Controlled Trial.

Breau RH, Lavallée LT, Cnossen S, Witiuk K, Cagiannos I, Momoli F, Bryson G, Kanji S, Morash C, Turgeon A, Zarychanski R, Mallick R, Knoll G, Fergusson DA.

Trials. 2018 May 2;19(1):261. doi: 10.1186/s13063-018-2626-3.

27.

Thinking clearly about the FIRST trial: addressing ethical challenges in cluster randomised trials of policy interventions involving health providers.

Horn AR, Weijer C, Hey SP, Brehaut J, Fergusson DA, Goldstein CE, Grimshaw J, Taljaard M.

J Med Ethics. 2018 Sep;44(9):593-598. doi: 10.1136/medethics-2017-104282. Epub 2018 Apr 27.

PMID:
29703860
28.

Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial.

Green RS, Erdogan M, Lacroix J, Hébert PC, Tinmouth AT, Sabri E, Zhang T, Fergusson DA, Turgeon AF; ABLE Investigators and the Canadian Critical Care Trials Group.

Transfusion. 2018 Aug;58(8):1846-1854. doi: 10.1111/trf.14640. Epub 2018 Apr 19.

PMID:
29672869
29.

An Ethical Analysis of the SUPPORT Trial: Addressing Challenges Posed by a Pragmatic Comparative Effectiveness Randomized Controlled Trial.

Horn AR, Weijer C, Grimshaw J, Brehaut J, Fergusson D, Goldstein CE, Taljaard M.

Kennedy Inst Ethics J. 2018;28(1):85-118. doi: 10.1353/ken.2018.0003.

PMID:
29628452
30.

Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials.

Houston BL, Hurrie D, Graham J, Perija B, Rimmer E, Rabbani R, Bernstein CN, Turgeon AF, Fergusson DA, Houston DS, Abou-Setta AM, Zarychanski R.

BMJ Open. 2018 Apr 5;8(4):e019240. doi: 10.1136/bmjopen-2017-019240.

31.

The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis.

Montroy J, Hutton B, Moodley P, Fergusson NA, Cheng W, Tinmouth A, Lavallée LT, Fergusson DA, Breau RH.

Transfus Med Rev. 2018 Feb 19. pii: S0887-7963(17)30151-7. doi: 10.1016/j.tmrv.2018.02.003. [Epub ahead of print] Review.

PMID:
29567052
32.

Ethical issues in pragmatic randomized controlled trials: a review of the recent literature identifies gaps in ethical argumentation.

Goldstein CE, Weijer C, Brehaut JC, Fergusson DA, Grimshaw JM, Horn AR, Taljaard M.

BMC Med Ethics. 2018 Feb 27;19(1):14. doi: 10.1186/s12910-018-0253-x.

33.

Drug discontinuation before contrast procedures and the effect on acute kidney injury and other clinical outcomes: a systematic review protocol.

Hiremath S, Kayibanda JF, Chow BJW, Fergusson D, Knoll GA, Shabana W, Lahey B, McBride O, Davis A, Akbari A.

Syst Rev. 2018 Feb 21;7(1):34. doi: 10.1186/s13643-018-0701-1.

34.

Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis.

Waligora M, Bala MM, Koperny M, Wasylewski MT, Strzebonska K, Jaeschke RR, Wozniak A, Piasecki J, Sliwka A, Mitus JW, Polak M, Nowis D, Fergusson D, Kimmelman J.

PLoS Med. 2018 Feb 20;15(2):e1002505. doi: 10.1371/journal.pmed.1002505. eCollection 2018 Feb.

35.

Hemoglobin thresholds and red blood cell transfusion in adult patients with moderate or severe traumatic brain injuries: A retrospective cohort study.

Boutin A, Moore L, Green RS, Zarychanski R, Erdogan M, Lauzier F, English S, Fergusson DA, Butler M, McIntyre L, Chassé M, Lessard Bonaventure P, Léger C, Desjardins P, Griesdale D, Lacroix J, Turgeon AF.

J Crit Care. 2018 Jun;45:133-139. doi: 10.1016/j.jcrc.2018.01.023. Epub 2018 Jan 31.

PMID:
29459342
36.

Filgrastim use in patients receiving chemotherapy for early-stage breast cancer-a survey of physicians and patients.

Hilton J, Vandermeer L, Sienkiewicz M, Mazzarello S, Hutton B, Stober C, Fergusson D, Blanchette P, Joy AA, Brianne Bota A, Clemons M.

Support Care Cancer. 2018 Jul;26(7):2323-2331. doi: 10.1007/s00520-018-4074-8. Epub 2018 Feb 6.

PMID:
29411131
37.

Problems with precaution: the transfusion medicine experience.

Wilson K, Atkinson KM, Fergusson DA, Brown A, Forster A, Murphy MSQ, Tinmouth AT, Keelan J.

J Risk Res. 2018;2017:1-13. doi: 10.1080/13669877.2017.1351478. Epub 2017 Jul 29.

38.

Risk of Acute Kidney Injury in Patients Randomized to a Restrictive Versus Liberal Approach to Red Blood Cell Transfusion in Cardiac Surgery: A Substudy Protocol of the Transfusion Requirements in Cardiac Surgery III Noninferiority Trial.

Garg AX, Shehata N, McGuinness S, Whitlock R, Fergusson D, Wald R, Parikh C, Bagshaw SM, Khanykin B, Gregory A, Syed S, Hare GMT, Cuerden MS, Thorpe KE, Hall J, Verma S, Roshanov PS, Sontrop JM, Mazer CD.

Can J Kidney Health Dis. 2018 Jan 3;5:2054358117749532. doi: 10.1177/2054358117749532. eCollection 2018.

39.

Current practices in perioperative blood management for patients undergoing liver resection: a survey of surgeons and anesthesiologists.

Bennett S, Ayoub A, Tran A, English S, Tinmouth A, McIsaac DI, Fergusson D, Martel G.

Transfusion. 2018 Mar;58(3):781-787. doi: 10.1111/trf.14465. Epub 2018 Jan 10.

PMID:
29322515
40.

Efficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy in patients with haematological and solid malignancies: protocol for a systematic review and meta-analysis.

Grigor EJM, Fergusson DA, Haggar F, Kekre N, Atkins H, Shorr R, Holt RA, Hutton B, Ramsay T, Seftel M, Jonker D, Daugaard M, Thavorn K, Presseau J, Lalu MM.

BMJ Open. 2017 Dec 29;7(12):e019321. doi: 10.1136/bmjopen-2017-019321. Review.

41.

Transfusion Requirements in Cardiac Surgery III (TRICS III): Study Design of a Randomized Controlled Trial.

Shehata N, Whitlock R, Fergusson DA, Thorpe KE, MacAdams C, Grocott HP, Rubens F, Fremes S, Lellouche F, Bagshaw S, Royse A, Rosseel PM, Hare G, Medicis E, Hudson C, Belley-Cote E, Bainbridge D, Kent B, Shaw A, Byrne K, Syed S, Royse CF, McGuiness S, Hall J, Mazer CD.

J Cardiothorac Vasc Anesth. 2018 Feb;32(1):121-129. doi: 10.1053/j.jvca.2017.10.036. Epub 2017 Nov 3.

PMID:
29273477
42.

Center Variation and the Effect of Center and Provider Characteristics on Clinical Outcomes in Kidney Transplantation: A Systematic Review of the Evidence.

Tsampalieros A, Knoll GA, Fergusson N, Bennett A, Taljaard M, Fergusson D.

Can J Kidney Health Dis. 2017 Oct 19;4:2054358117735523. doi: 10.1177/2054358117735523. eCollection 2017.

43.

Study protocol for a phase II dose evaluation randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study).

McNally D, Amrein K, O'Hearn K, Fergusson D, Geier P, Henderson M, Khamessan A, Lawson ML, McIntyre L, Redpath S, Weiler HA, Menon K; Canadian Critical Care Trials Group.

Pilot Feasibility Stud. 2017 Dec 8;3:70. doi: 10.1186/s40814-017-0214-z. eCollection 2017.

44.

A multi-center pragmatic, randomized, feasibility trial comparing standard of care schedules of filgrastim administration for primary febrile neutropenia prophylaxis in early-stage breast cancer.

Ibrahim MFK, Hilton J, Mazzarello S, Fergusson D, Hutton B, Robinson A, Califaretti N, Hsu T, Gertler S, Mates M, Stober C, Vandermeer L, Mallick R, Clemons M.

Breast Cancer Res Treat. 2018 Apr;168(2):371-379. doi: 10.1007/s10549-017-4604-y. Epub 2017 Dec 6.

PMID:
29214415
45.

Red blood cell transfusion in adult palliative care: a systematic review.

Chin-Yee N, Taylor J, Rourke K, Faig D, Davis A, Fergusson D, Saidenberg E.

Transfusion. 2018 Jan;58(1):233-241. doi: 10.1111/trf.14413. Epub 2017 Dec 1. Review.

PMID:
29194669
46.

Vitamin D deficiency in critically ill children: a systematic review and meta-analysis.

McNally JD, Nama N, O'Hearn K, Sampson M, Amrein K, Iliriani K, McIntyre L, Fergusson D, Menon K.

Crit Care. 2017 Nov 23;21(1):287. doi: 10.1186/s13054-017-1875-y. Review.

47.

Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery.

Mazer CD, Whitlock RP, Fergusson DA, Hall J, Belley-Cote E, Connolly K, Khanykin B, Gregory AJ, de Médicis É, McGuinness S, Royse A, Carrier FM, Young PJ, Villar JC, Grocott HP, Seeberger MD, Fremes S, Lellouche F, Syed S, Byrne K, Bagshaw SM, Hwang NC, Mehta C, Painter TW, Royse C, Verma S, Hare GMT, Cohen A, Thorpe KE, Jüni P, Shehata N; TRICS Investigators and Perioperative Anesthesia Clinical Trials Group.

N Engl J Med. 2017 Nov 30;377(22):2133-2144. doi: 10.1056/NEJMoa1711818. Epub 2017 Nov 12.

48.

The Efficacy of Postoperative Iron Therapy in Improving Clinical and Patient-Centered Outcomes Following Surgery: A Systematic Review and Meta-Analysis.

Perelman I, Winter R, Sikora L, Martel G, Saidenberg E, Fergusson D.

Transfus Med Rev. 2018 Apr;32(2):89-101. doi: 10.1016/j.tmrv.2017.10.002. Epub 2017 Oct 22. Review.

PMID:
29126577
49.

Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol.

Barron CC, Lalu MM, Stewart DJ, Fergusson D, Yang H, Moher D, Liu P, Mazer D, Devereaux PJ, McIntyre L; Canadian Perioperative Anesthesia Clinical Trials Group.

Syst Rev. 2017 Nov 7;6(1):226. doi: 10.1186/s13643-017-0601-9. Review.

50.

Canadian funders and institutions are lagging on reporting results of clinical trials.

Cobey KD, Fergusson D, Moher D.

CMAJ. 2017 Oct 23;189(42):E1302-E1303. doi: 10.1503/cmaj.170840. No abstract available.

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