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Items: 1 to 50 of 174

1.

Evaluating the Clinical Effect of Female Blood Donors of Child-Bearing Age on Maternal and Neonatal Outcomes: A Cohort Study.

Chassé M, Tinmouth A, Goldman M, O'Brien SF, Hawken S, Murphy MSQ, Walker M, Sprague AE, Wilson K, van Walraven C, Fergusson DA.

Transfus Med Rev. 2019 Dec 2. pii: S0887-7963(19)30165-8. doi: 10.1016/j.tmrv.2019.11.007. [Epub ahead of print] Review.

PMID:
31882263
2.

Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol.

Crawshaw J, Presseau J, van Allen Z, Pinheiro Carvalho L, Jordison K, English S, Fergusson DA, Lauzier F, Turgeon AF, Sarti AJ, Martin C, D'Aragon F, Li AH, Knoll G, Ball I, Brehaut J, Burns KEA, Fortin MC, Weiss M, Meade M, Marsolais P, Shemie S, Zaabat S, Dhanani S, Kitto SC, Chassé M; Canadian Donation and Transplantation Research Program and the Canadian Critical Care Trials Group.

BMJ Open. 2019 Dec 23;9(12):e034594. doi: 10.1136/bmjopen-2019-034594.

3.

The ethical challenges raised in the design and conduct of pragmatic trials: an interview study with key stakeholders.

Nicholls SG, Carroll K, Zwarenstein M, Brehaut JC, Weijer C, Hey SP, Goldstein CE, Graham ID, Grimshaw JM, McKenzie JE, Fergusson DA, Taljaard M; Ethics of Pragmatic Trials project.

Trials. 2019 Dec 23;20(1):765. doi: 10.1186/s13063-019-3899-x.

4.

Impact of Anticoagulation on Mortality and Resource Utilization Among Critically Ill Patients With Major Bleeding.

Fernando SM, Mok G, Castellucci LA, Dowlatshahi D, Rochwerg B, McIsaac DI, Carrier M, Wells PS, Bagshaw SM, Fergusson DA, Tanuseputro P, Kyeremanteng K.

Crit Care Med. 2019 Dec 19. doi: 10.1097/CCM.0000000000004206. [Epub ahead of print]

PMID:
31855999
5.

Methods and efficacy of extracellular vesicles derived from mesenchymal stromal cells in animal models of disease: a preclinical systematic review protocol.

Tieu A, Slobodian M, Fergusson DA, Montroy J, Burger D, Stewart DJ, Shorr R, Allan DS, Lalu MM.

Syst Rev. 2019 Dec 12;8(1):322. doi: 10.1186/s13643-019-1242-y.

6.

Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial.

Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF; ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.

JAMA. 2019 Dec 10;322(22):2179-2190. doi: 10.1001/jama.2019.17478.

PMID:
31821429
7.

Mapping the preclinical to clinical evidence and development trajectory of the oncolytic virus talimogene laherparepvec (T-VEC): a systematic review.

Lalu M, Leung GJ, Dong YY, Montroy J, Butler C, Auer RC, Fergusson DA.

BMJ Open. 2019 Dec 2;9(12):e029475. doi: 10.1136/bmjopen-2019-029475.

8.

Risks and benefits of unapproved disease-modifying treatments for neurodegenerative disease.

Feustel AC, MacPherson A, Fergusson DA, Kieburtz K, Kimmelman J.

Neurology. 2020 Jan 7;94(1):e1-e14. doi: 10.1212/WNL.0000000000008699. Epub 2019 Dec 2.

PMID:
31792092
9.

Survey of Canadian intensivists on physician non-referral and family override of deceased organ donation.

Weiss MJ, English SW, D'Aragon F, Lauzier F, Turgeon AF, Dhanani S, McIntyre L, Shemie SD, Knoll G, Fergusson DA, Anthony SJ, Haj-Moustafa A, Hartell D, Mohr J, Chassé M; Canadian Critical Care Trials Group.

Can J Anaesth. 2019 Nov 25. doi: 10.1007/s12630-019-01538-x. [Epub ahead of print]

PMID:
31768789
10.

Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop.

Cook JA, Julious SA, Sones W, Hampson LV, Hewitt C, Berlin JA, Ashby D, Emsley R, Fergusson DA, Walters SJ, Wilson EC, MacLennan G, Stallard N, Rothwell JC, Bland M, Brown L, Ramsay CR, Cook A, Armstrong D, Altman D, Vale LD.

Health Technol Assess. 2019 Oct;23(60):1-88. doi: 10.3310/hta23600.

11.

Risk of major bleeding during extended oral anticoagulation in patients with first unprovoked venous thromboembolism: a systematic review and meta-analysis protocol.

Khan F, Kimpton M, Tritschler T, Le Gal G, Hutton B, Fergusson DA, Rodger MA.

Syst Rev. 2019 Oct 28;8(1):245. doi: 10.1186/s13643-019-1175-5.

12.

Correction to: Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial - the development of the DELTA2 guidance.

Sones W, Julious SA, Rothwell JC, Ramsay CR, Hampson LV, Emsley R, Walters SJ, Hewitt C, Bland M, Fergusson DA, Berlin JA, Altman D, Vale LD, Cook JA.

Trials. 2019 Oct 24;20(1):602. doi: 10.1186/s13063-019-3809-2.

13.

Pharmacological interventions for the treatment of delirium in critically ill adults.

Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NK, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L.

Cochrane Database Syst Rev. 2019 Sep 3;9:CD011749. doi: 10.1002/14651858.CD011749.pub2.

PMID:
31479532
14.

Postoperative shared-care for patients undergoing non-cardiac surgery: a systematic review and meta-analysis.

Mazzarello S, McIsaac DI, Montroy J, Fergusson DA, Yateem D, Devereaux PJ, Lalu MM.

Can J Anaesth. 2019 Sep;66(9):1095-1105. doi: 10.1007/s12630-019-01433-5. Epub 2019 Jul 9.

PMID:
31290119
15.

Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies.

Fergusson DA, Wesch NL, Leung GJ, MacNeil JL, Conic I, Presseau J, Cobey KD, Diallo JS, Auer R, Kimmelman J, Kekre N, El-Sayes N, Krishnan R, Keller BA, Ilkow C, Lalu MM.

Mol Ther Oncolytics. 2019 May 21;14:179-187. doi: 10.1016/j.omto.2019.05.004. eCollection 2019 Sep 27.

16.

Safety of a Restrictive versus Liberal Approach to Red Blood Cell Transfusion on the Outcome of AKI in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial.

Garg AX, Badner N, Bagshaw SM, Cuerden MS, Fergusson DA, Gregory AJ, Hall J, Hare GMT, Khanykin B, McGuinness S, Parikh CR, Roshanov PS, Shehata N, Sontrop JM, Syed S, Tagarakis GI, Thorpe KE, Verma S, Wald R, Whitlock RP, Mazer CD; TRICS Investigators and Perioperative Anesthesia Clinical Trials Group.

J Am Soc Nephrol. 2019 Jul;30(7):1294-1304. doi: 10.1681/ASN.2019010004. Epub 2019 Jun 20.

PMID:
31221679
17.

Guidelines on the intraoperative transfusion of red blood cells: a protocol for systematic review.

Baker L, Park L, Gilbert R, Martel A, Ahn H, Davies A, McIsaac DI, Saidenberg E, Tinmouth A, Fergusson DA, Martel G.

BMJ Open. 2019 Jun 17;9(6):e029684. doi: 10.1136/bmjopen-2019-029684.

18.

Independent Validation of the Hematoma Expansion Prediction Score: A Non-contrast Score Equivalent in Accuracy to the Spot Sign.

Yogendrakumar V, Ramsay T, Fergusson DA, Demchuk AM, Aviv RI, Rodriguez-Luna D, Molina CA, Silva Blas Y, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz G, Srivastava P, Roy J, Kase CS, Bhatia R, Hill MD, Selim M, Dowlatshahi D; PREDICT/Sunnybrook CTA Study Group.

Neurocrit Care. 2019 Aug;31(1):1-8. doi: 10.1007/s12028-019-00740-5.

PMID:
31123995
19.

Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature.

Fergusson DA, Avey MT, Barron CC, Bocock M, Biefer KE, Boet S, Bourque SL, Conic I, Chen K, Dong YY, Fox GM, George RB, Goldenberg NM, Gragasin FS, Harsha P, Hong PJ, James TE, Larrigan SM, MacNeil JL, Manuel CA, Maximos S, Mazer D, Mittal R, McGinn R, Nguyen LH, Patel A, Richebé P, Saha TK, Steinberg BE, Sampson SD, Stewart DJ, Syed S, Vella K, Wesch NL, Lalu MM; Canadian Perioperative Anesthesia Clinical Trials Group.

PLoS One. 2019 May 23;14(5):e0215221. doi: 10.1371/journal.pone.0215221. eCollection 2019. Review.

20.

There is still a place for significance testing in clinical trials.

Cook JA, Fergusson DA, Ford I, Gonen M, Kimmelman J, Korn EL, Begg CB.

Clin Trials. 2019 Jun;16(3):223-224. doi: 10.1177/1740774519846504. Epub 2019 May 9. No abstract available.

PMID:
31068002
21.

Red blood cell transfusion in critically ill patients with traumatic brain injury: an international survey of physicians' attitudes.

Lessard Bonaventure P, Lauzier F, Zarychanski R, Boutin A, Shemilt M, Saxena M, Zolfagari P, Griesdale D, Menon DK, Stanworth S, English S, Chassé M, Fergusson DA, Moore L, Kramer A, Robitaille A, Myburgh J, Cooper J, Hutchinson P, Turgeon AF; Canadian Critical Care Trials Group and the Canadian Traumatic Brain Injury Research Consortium.

Can J Anaesth. 2019 Sep;66(9):1038-1048. doi: 10.1007/s12630-019-01369-w. Epub 2019 Apr 22.

PMID:
31012052
22.

Correction: Interventions to improve resilience in physicians who have completed training: A systematic review.

Lavin Venegas C, Nkangu MN, Duffy MC, Fergusson DA, Spilg EG.

PLoS One. 2019 Mar 28;14(3):e0214782. doi: 10.1371/journal.pone.0214782. eCollection 2019.

23.

Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis.

Lalu MM, Fergusson DA, Cheng W, Avey MT, Corbett D, Dowlatshahi D, Macleod MR, Sena ES, Moher D, Shorr R, McCann SK, Gray LJ, Hill MD, O'Connor A, Thayer K, Haggar F, Dobriyal A, Chung HS, Welton NJ, Hutton B.

F1000Res. 2019 Jan 3;8:11. doi: 10.12688/f1000research.15869.1. eCollection 2019.

24.

Prognostic Value of Glial Fibrillary Acidic Protein in Patients With Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.

Shemilt M, Boutin A, Lauzier F, Zarychanski R, Moore L, McIntyre LA, Nadeau L, Fergusson DA, Mercier E, Archambault P, Lamontagne F, Perron C, Léger C, Turgeon AF.

Crit Care Med. 2019 Jun;47(6):e522-e529. doi: 10.1097/CCM.0000000000003728.

PMID:
30889029
25.

Diagnostic Accuracy Studies.

Chassé M, Fergusson DA.

Semin Nucl Med. 2019 Mar;49(2):87-93. doi: 10.1053/j.semnuclmed.2018.11.005. Epub 2018 Dec 13. Review.

PMID:
30819399
26.

Can authorship bias be detected in meta-analysis?

Abou-Setta AM, Rabbani R, Lix LM, Turgeon AF, Houston BL, Fergusson DA, Zarychanski R.

Can J Anaesth. 2019 Mar;66(3):287-292. doi: 10.1007/s12630-018-01268-6. Epub 2019 Feb 6.

PMID:
30725345
27.

Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients.

Schlosser K, Wang JP, Dos Santos C, Walley KR, Marshall J, Fergusson DA, Winston BW, Granton J, Watpool I, Stewart DJ, McIntyre LA, Mei SHJ; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group.

Crit Care Med. 2019 Jul;47(7):918-925. doi: 10.1097/CCM.0000000000003657.

28.

A Systematic Review of the Impact of Surgical Special Care Units on Patient Outcomes and Health Care Resource Utilization.

Mendis N, Hamilton GM, McIsaac DI, Fergusson DA, Wunsch H, Dubois D, Montroy J, Chassé M, Turgeon AF, McIntyre L, McDonald H, Yang H, Sampson SD, McCartney CJL, Shorr R, Denault A, Lalu MM; Canadian Perioperative Anesthesia Clinical Trials Group (PACT).

Anesth Analg. 2019 Mar;128(3):533-542. doi: 10.1213/ANE.0000000000003942.

PMID:
30676348
29.

Evaluating the predictive capabilities of haematoma expansion scores in patients with acute intracerebral haemorrhage: protocol for a scoping review.

Yogendrakumar V, Moores M, Sikora L, Ramsay T, Fergusson DA, Dowlatshahi D.

BMJ Open. 2019 Jan 21;9(1):e024744. doi: 10.1136/bmjopen-2018-024744.

30.

Interventions to improve resilience in physicians who have completed training: A systematic review.

Venegas CL, Nkangu MN, Duffy MC, Fergusson DA, Spilg EG.

PLoS One. 2019 Jan 17;14(1):e0210512. doi: 10.1371/journal.pone.0210512. eCollection 2019. Erratum in: PLoS One. 2019 Mar 28;14(3):e0214782.

31.

Renal hypothermia during partial nephrectomy for patients with renal tumours: a randomised controlled clinical trial protocol.

Breau RH, Cagiannos I, Knoll G, Morash C, Cnossen S, Lavallée LT, Mallick R, Finelli A, Jewett M, Leibovich BC, Cook J, LeBel L, Kapoor A, Pouliot F, Izawa J, Rendon R, Fergusson DA.

BMJ Open. 2019 Jan 3;9(1):e025662. doi: 10.1136/bmjopen-2018-025662.

32.

DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial.

Cook JA, Julious SA, Sones W, Hampson LV, Hewitt C, Berlin JA, Ashby D, Emsley R, Fergusson DA, Walters SJ, Wilson ECF, MacLennan G, Stallard N, Rothwell JC, Bland M, Brown L, Ramsay CR, Cook A, Armstrong D, Altman D, Vale LD.

BMJ. 2018 Nov 5;363:k3750. doi: 10.1136/bmj.k3750. No abstract available.

33.

Stakeholder views regarding ethical issues in the design and conduct of pragmatic trials: study protocol.

Nicholls SG, Carroll K, Brehaut J, Weijer C, Hey SP, Goldstein CE, Zwarenstein M, Graham ID, McKenzie JE, McIntyre L, Jairath V, Campbell MK, Grimshaw JM, Fergusson DA, Taljaard M.

BMC Med Ethics. 2018 Nov 20;19(1):90. doi: 10.1186/s12910-018-0332-z.

34.

DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial.

Cook JA, Julious SA, Sones W, Hampson LV, Hewitt C, Berlin JA, Ashby D, Emsley R, Fergusson DA, Walters SJ, Wilson ECF, Maclennan G, Stallard N, Rothwell JC, Bland M, Brown L, Ramsay CR, Cook A, Armstrong D, Altman D, Vale LD.

Trials. 2018 Nov 5;19(1):606. doi: 10.1186/s13063-018-2884-0.

35.
36.

The effect of surgery report cards on improving radical prostatectomy quality: the SuRep study protocol.

Breau RH, Kumar RM, Lavallee LT, Cagiannos I, Morash C, Horrigan M, Cnossen S, Mallick R, Stacey D, Fung-Kee-Fung M, Morash R, Smylie J, Witiuk K, Fergusson DA.

BMC Urol. 2018 Oct 19;18(1):89. doi: 10.1186/s12894-018-0403-y.

37.

Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial - the development of the DELTA2 guidance.

Sones W, Julious SA, Rothwell JC, Ramsay CR, Hampson LV, Emsley R, Walters SJ, Hewitt C, Bland M, Fergusson DA, Berlin JA, Altman D, Vale LD, Cook JA.

Trials. 2018 Oct 10;19(1):542. doi: 10.1186/s13063-018-2887-x. Erratum in: Trials. 2019 Oct 24;20(1):602.

38.

Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol.

Taljaard M, Weijer C, Grimshaw JM, Ali A, Brehaut JC, Campbell MK, Carroll K, Edwards S, Eldridge S, Forrest CB, Giraudeau B, Goldstein CE, Graham ID, Hemming K, Hey SP, Horn AR, Jairath V, Klassen TP, London AJ, Marlin S, Marshall JC, McIntyre L, McKenzie JE, Nicholls SG, Alison Paprica P, Zwarenstein M, Fergusson DA.

Trials. 2018 Sep 27;19(1):525. doi: 10.1186/s13063-018-2895-x.

39.

Safety and Efficacy of Adult Stem Cell Therapy for Acute Myocardial Infarction and Ischemic Heart Failure (SafeCell Heart): A Systematic Review and Meta-Analysis.

Lalu MM, Mazzarello S, Zlepnig J, Dong YYR, Montroy J, McIntyre L, Devereaux PJ, Stewart DJ, David Mazer C, Barron CC, McIsaac DI, Fergusson DA.

Stem Cells Transl Med. 2018 Dec;7(12):857-866. doi: 10.1002/sctm.18-0120. Epub 2018 Sep 26.

40.

The Ottawa SAH search algorithms: protocol for a multi- centre validation study of primary subarachnoid hemorrhage prediction models using health administrative data (the SAHepi prediction study protocol).

English SW, McIntyre L, Saigle V, Chassé M, Fergusson DA, Turgeon AF, Lauzier F, Griesdale D, Garland A, Zarychanski R, Algird A, van Walraven C.

BMC Med Res Methodol. 2018 Sep 15;18(1):94. doi: 10.1186/s12874-018-0553-3.

41.

Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery.

Mazer CD, Whitlock RP, Fergusson DA, Belley-Cote E, Connolly K, Khanykin B, Gregory AJ, de Médicis É, Carrier FM, McGuinness S, Young PJ, Byrne K, Villar JC, Royse A, Grocott HP, Seeberger MD, Mehta C, Lellouche F, Hare GMT, Painter TW, Fremes S, Syed S, Bagshaw SM, Hwang NC, Royse C, Hall J, Dai D, Mistry N, Thorpe K, Verma S, Jüni P, Shehata N; TRICS Investigators and Perioperative Anesthesia Clinical Trials Group.

N Engl J Med. 2018 Sep 27;379(13):1224-1233. doi: 10.1056/NEJMoa1808561. Epub 2018 Aug 26.

42.

FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial.

McIntyre L, Taljaard M, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Menon K, Muscedere J, Cook DJ, Weijer C, Saginur R, Maybee A, Iyengar A, Forster A, Graham ID, Hawken S, McCartney C, Seely AJ, Stiell IG, Thavorn K, Fergusson DA.

BMJ Open. 2018 Aug 23;8(8):e022780. doi: 10.1136/bmjopen-2018-022780.

43.

Radiotherapy with radical cystectomy for bladder cancer: A systematic review and meta-analysis.

Mcalpine K, Fergusson DA, Breau RH, Reynolds LF, Shorr R, Morgan SC, Eapen L, Cagiannos I, Morash C, Lavallée LT.

Can Urol Assoc J. 2018 Oct;12(10):351-360. doi: 10.5489/cuaj.5244. Epub 2018 May 28. Review.

44.

Accommodating quality and service improvement research within existing ethical principles.

Goldstein CE, Weijer C, Brehaut JC, Campbell M, Fergusson DA, Grimshaw JM, Hemming K, Horn AR, Taljaard M.

Trials. 2018 Jun 25;19(1):334. doi: 10.1186/s13063-018-2724-2.

45.

Antipsychotics for treatment of delirium in hospitalised non-ICU patients.

Burry L, Mehta S, Perreault MM, Luxenberg JS, Siddiqi N, Hutton B, Fergusson DA, Bell C, Rose L.

Cochrane Database Syst Rev. 2018 Jun 18;6:CD005594. doi: 10.1002/14651858.CD005594.pub3. Review.

46.

Clinical trials evaluating red blood cell transfusion thresholds: An updated systematic review and with additional focus on patients with cardiovascular disease.

Carson JL, Stanworth SJ, Alexander JH, Roubinian N, Fergusson DA, Triulzi DJ, Goodman SG, Rao SV, Doree C, Hebert PC.

Am Heart J. 2018 Jun;200:96-101. doi: 10.1016/j.ahj.2018.04.007. Epub 2018 Apr 7.

PMID:
29898855
47.

Tranexamic Acid versus Placebo to Prevent Blood Transfusion during Radical Cystectomy for Bladder Cancer (TACT): Study Protocol for a Randomized Controlled Trial.

Breau RH, Lavallée LT, Cnossen S, Witiuk K, Cagiannos I, Momoli F, Bryson G, Kanji S, Morash C, Turgeon A, Zarychanski R, Mallick R, Knoll G, Fergusson DA.

Trials. 2018 May 2;19(1):261. doi: 10.1186/s13063-018-2626-3.

48.

Thinking clearly about the FIRST trial: addressing ethical challenges in cluster randomised trials of policy interventions involving health providers.

Horn AR, Weijer C, Hey SP, Brehaut J, Fergusson DA, Goldstein CE, Grimshaw J, Taljaard M.

J Med Ethics. 2018 Sep;44(9):593-598. doi: 10.1136/medethics-2017-104282. Epub 2018 Apr 27.

PMID:
29703860
49.

Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial.

Green RS, Erdogan M, Lacroix J, Hébert PC, Tinmouth AT, Sabri E, Zhang T, Fergusson DA, Turgeon AF; ABLE Investigators and the Canadian Critical Care Trials Group.

Transfusion. 2018 Aug;58(8):1846-1854. doi: 10.1111/trf.14640. Epub 2018 Apr 19.

PMID:
29672869
50.

Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials.

Houston BL, Hurrie D, Graham J, Perija B, Rimmer E, Rabbani R, Bernstein CN, Turgeon AF, Fergusson DA, Houston DS, Abou-Setta AM, Zarychanski R.

BMJ Open. 2018 Apr 5;8(4):e019240. doi: 10.1136/bmjopen-2017-019240.

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