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Proportion of Patients in Phase 1 Oncology Trials Receiving Treatments that are Ultimately Approved.

Zhang SX, Fergusson D, Kimmelman J.

J Natl Cancer Inst. 2020 Apr 1. pii: djaa044. doi: 10.1093/jnci/djaa044. [Epub ahead of print]


Impact of Anticoagulation on Mortality and Resource Utilization Among Critically Ill Patients With Major Bleeding.

Fernando SM, Mok G, Castellucci LA, Dowlatshahi D, Rochwerg B, McIsaac DI, Carrier M, Wells PS, Bagshaw SM, Fergusson DA, Tanuseputro P, Kyeremanteng K.

Crit Care Med. 2020 Apr;48(4):515-524. doi: 10.1097/CCM.0000000000004206.


What are potential barriers and enablers to patient and physician participation in Canadian cell therapy trials for stroke? A stakeholder interview study.

Lalu MM, Foster M, Presseau J, Dowlatshahi D, Castillo G, Cardenas A, Tam W, Zlepnig J, Timpson D, Dong YY, Juneau P, Fergusson DA.

BMJ Open. 2020 Mar 19;10(3):e034354. doi: 10.1136/bmjopen-2019-034354.


Journal impact factor, trial effect size, and methodological quality appear scantly related: a systematic review and meta-analysis.

Saginur M, Fergusson D, Zhang T, Yeates K, Ramsay T, Wells G, Moher D.

Syst Rev. 2020 Mar 9;9(1):53. doi: 10.1186/s13643-020-01305-w.


Diet quality during preconception or pregnancy and gestational weight gain: protocol for a systematic review and meta-analysis.

Yu Y, Hardy I, Sun W, Fergusson DA, Fraser W, Dubois L.

BMJ Open. 2020 Feb 28;10(2):e033130. doi: 10.1136/bmjopen-2019-033130.


Liberal Versus Restrictive Red Blood Cell Transfusion Thresholds in Hematopoietic Cell Transplantation: A Randomized, Open Label, Phase III, Noninferiority Trial.

Tay J, Allan DS, Chatelain E, Coyle D, Elemary M, Fulford A, Petrcich W, Ramsay T, Walker I, Xenocostas A, Tinmouth A, Fergusson D.

J Clin Oncol. 2020 Feb 21:JCO1901836. doi: 10.1200/JCO.19.01836. [Epub ahead of print]


Redefining Hematoma Expansion With the Inclusion of Intraventricular Hemorrhage Growth.

Yogendrakumar V, Ramsay T, Fergusson DA, Demchuk AM, Aviv RI, Rodriguez-Luna D, Molina CA, Silva Y, Dzialowski I, Kobayashi A, Boulanger JM, Gubitz G, Srivastava P, Roy J, Kase CS, Bhatia R, Hill MD, Goldstein JN, Dowlatshahi D; PREDICT/Sunnybrook CTA Study Group.

Stroke. 2020 Apr;51(4):1120-1127. doi: 10.1161/STROKEAHA.119.027451. Epub 2020 Feb 6.


Prolonged versus brief balloon inflation during arterial angioplasty for de novo atherosclerotic disease: a systematic review and meta-analysis.

Rockley M, Jetty P, Radonjic A, Rockley K, Wells G, Fergusson D.

CVIR Endovasc. 2019 Aug 17;2(1):29. doi: 10.1186/s42155-019-0072-2. Review.


A randomized trial comparing vascular access strategies for patients receiving chemotherapy with trastuzumab for early-stage breast cancer.

Clemons M, Stober C, Kehoe A, Bedard D, MacDonald F, Brunet MC, Saunders D, Vandermeer L, Mazzarello S, Awan A, Basulaiman B, Robinson A, Mallick R, Hutton B, Fergusson D.

Support Care Cancer. 2020 Jan 30. doi: 10.1007/s00520-020-05326-y. [Epub ahead of print]


Cell therapy with intravascular administration of mesenchymal stromal cells continues to appear safe: An updated systematic review and meta-analysis.

Thompson M, Mei SHJ, Wolfe D, Champagne J, Fergusson D, Stewart DJ, Sullivan KJ, Doxtator E, Lalu M, English SW, Granton J, Hutton B, Marshall J, Maybee A, Walley KR, Santos CD, Winston B, McIntyre L.

EClinicalMedicine. 2020 Jan 17;19:100249. doi: 10.1016/j.eclinm.2019.100249. eCollection 2020 Feb.


Efficacy and Safety of Tranexamic Acid in Major Non-Cardiac Surgeries at High Risk for Transfusion: A Systematic Review and Meta-Analysis.

Houston BL, Uminski K, Mutter T, Rimmer E, Houston DS, Menard CE, Garland A, Ariano R, Tinmouth A, Abou-Setta AM, Rabbani R, Neilson C, Rochwerg B, Turgeon AF, Falk J, Breau RH, Fergusson DA, Zarychanski R.

Transfus Med Rev. 2020 Jan;34(1):51-62. doi: 10.1016/j.tmrv.2019.10.001. Epub 2019 Oct 23. Review.


A systematic review and meta-analysis of pregabalin preclinical studies.

Federico CA, Mogil JS, Ramsay T, Fergusson DA, Kimmelman J.

Pain. 2020 Apr;161(4):684-693. doi: 10.1097/j.pain.0000000000001749.


Phlebotomy resulting in controlled hypovolaemia to prevent blood loss in major hepatic resections (PRICE-1): a pilot randomized clinical trial for feasibility.

Martel G, Baker L, Wherrett C, Fergusson DA, Saidenberg E, Workneh A, Saeed S, Gadbois K, Jee R, McVicar J, Rao P, Thompson C, Wong P, Abou Khalil J, Bertens KA, Balaa FK.

Br J Surg. 2020 Jan 22. doi: 10.1002/bjs.11463. [Epub ahead of print]


Evaluating Hematoma Expansion Scores in Acute Spontaneous Intracerebral Hemorrhage: A Systematic Scoping Review.

Yogendrakumar V, Moores M, Sikora L, Shamy M, Ramsay T, Fergusson D, Dowlatshahi D.

Stroke. 2020 Apr;51(4):1305-1308. doi: 10.1161/STROKEAHA.119.028574. Epub 2020 Jan 22.


Evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic review.

Best CAE, Quimby AE, Best BAB, Fergusson D, Alsaffar H.

J Otolaryngol Head Neck Surg. 2019 Dec 30;48(1):73. doi: 10.1186/s40463-019-0396-x. Review. Erratum in: J Otolaryngol Head Neck Surg. 2020 Jan 15;49(1):5.


Evaluating the Clinical Effect of Female Blood Donors of Child-Bearing Age on Maternal and Neonatal Outcomes: A Cohort Study.

Chassé M, Tinmouth A, Goldman M, O'Brien SF, Hawken S, Murphy MSQ, Walker M, Sprague AE, Wilson K, van Walraven C, Fergusson DA.

Transfus Med Rev. 2019 Dec 2. pii: S0887-7963(19)30165-8. doi: 10.1016/j.tmrv.2019.11.007. [Epub ahead of print] Review.


Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol.

Crawshaw J, Presseau J, van Allen Z, Pinheiro Carvalho L, Jordison K, English S, Fergusson DA, Lauzier F, Turgeon AF, Sarti AJ, Martin C, D'Aragon F, Li AH, Knoll G, Ball I, Brehaut J, Burns KEA, Fortin MC, Weiss M, Meade M, Marsolais P, Shemie S, Zaabat S, Dhanani S, Kitto SC, Chassé M; Canadian Donation and Transplantation Research Program and the Canadian Critical Care Trials Group.

BMJ Open. 2019 Dec 23;9(12):e034594. doi: 10.1136/bmjopen-2019-034594.


The ethical challenges raised in the design and conduct of pragmatic trials: an interview study with key stakeholders.

Nicholls SG, Carroll K, Zwarenstein M, Brehaut JC, Weijer C, Hey SP, Goldstein CE, Graham ID, Grimshaw JM, McKenzie JE, Fergusson DA, Taljaard M; Ethics of Pragmatic Trials project.

Trials. 2019 Dec 23;20(1):765. doi: 10.1186/s13063-019-3899-x.


Impact of Anticoagulation on Mortality and Resource Utilization Among Critically Ill Patients With Major Bleeding.

Fernando SM, Mok G, Castellucci LA, Dowlatshahi D, Rochwerg B, McIsaac DI, Carrier M, Wells PS, Bagshaw SM, Fergusson DA, Tanuseputro P, Kyeremanteng K.

Crit Care Med. 2019 Dec 19. doi: 10.1097/CCM.0000000000004206. [Epub ahead of print]


Cannabis law and cannabis-related harm.

Boden JM, Fergusson DM.

N Z Med J. 2019 Jan 18;132(1488):7-10.


Methods and efficacy of extracellular vesicles derived from mesenchymal stromal cells in animal models of disease: a preclinical systematic review protocol.

Tieu A, Slobodian M, Fergusson DA, Montroy J, Burger D, Stewart DJ, Shorr R, Allan DS, Lalu MM.

Syst Rev. 2019 Dec 12;8(1):322. doi: 10.1186/s13643-019-1242-y.


Childhood predictors of adult adiposity: findings from a longitudinal study.

McLeod GF, Fergusson DM, Horwood LJ, Boden JM, Carter FA.

N Z Med J. 2019 Dec 13;132(1507):11-21.


Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial.

Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF; ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.

JAMA. 2019 Dec 10;322(22):2179-2190. doi: 10.1001/jama.2019.17478.


Mapping the preclinical to clinical evidence and development trajectory of the oncolytic virus talimogene laherparepvec (T-VEC): a systematic review.

Lalu M, Leung GJ, Dong YY, Montroy J, Butler C, Auer RC, Fergusson DA.

BMJ Open. 2019 Dec 2;9(12):e029475. doi: 10.1136/bmjopen-2019-029475.


Risks and benefits of unapproved disease-modifying treatments for neurodegenerative disease.

Feustel AC, MacPherson A, Fergusson DA, Kieburtz K, Kimmelman J.

Neurology. 2020 Jan 7;94(1):e1-e14. doi: 10.1212/WNL.0000000000008699. Epub 2019 Dec 2.


Survey of Canadian intensivists on physician non-referral and family override of deceased organ donation.

Weiss MJ, English SW, D'Aragon F, Lauzier F, Turgeon AF, Dhanani S, McIntyre L, Shemie SD, Knoll G, Fergusson DA, Anthony SJ, Haj-Moustafa A, Hartell D, Mohr J, Chassé M; Canadian Critical Care Trials Group.

Can J Anaesth. 2020 Mar;67(3):313-323. doi: 10.1007/s12630-019-01538-x. Epub 2019 Nov 25.


Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop.

Cook JA, Julious SA, Sones W, Hampson LV, Hewitt C, Berlin JA, Ashby D, Emsley R, Fergusson DA, Walters SJ, Wilson EC, MacLennan G, Stallard N, Rothwell JC, Bland M, Brown L, Ramsay CR, Cook A, Armstrong D, Altman D, Vale LD.

Health Technol Assess. 2019 Oct;23(60):1-88. doi: 10.3310/hta23600.


Risk of major bleeding during extended oral anticoagulation in patients with first unprovoked venous thromboembolism: a systematic review and meta-analysis protocol.

Khan F, Kimpton M, Tritschler T, Le Gal G, Hutton B, Fergusson DA, Rodger MA.

Syst Rev. 2019 Oct 28;8(1):245. doi: 10.1186/s13643-019-1175-5.


Correction to: Choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial - the development of the DELTA2 guidance.

Sones W, Julious SA, Rothwell JC, Ramsay CR, Hampson LV, Emsley R, Walters SJ, Hewitt C, Bland M, Fergusson DA, Berlin JA, Altman D, Vale LD, Cook JA.

Trials. 2019 Oct 24;20(1):602. doi: 10.1186/s13063-019-3809-2.


The Effect of Transplant Volume and Patient Case Mix on Center Variation in Kidney Transplantation Outcomes.

Tsampalieros A, Fergusson D, Dixon S, English SW, Manuel D, Van Walraven C, Taljaard M, Knoll GA.

Can J Kidney Health Dis. 2019 Sep 20;6:2054358119875462. doi: 10.1177/2054358119875462. eCollection 2019.


Pharmacological interventions for the treatment of delirium in critically ill adults.

Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NK, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L.

Cochrane Database Syst Rev. 2019 Sep 3;9:CD011749. doi: 10.1002/14651858.CD011749.pub2.


A multicentre, randomized pilot trial comparing vascular access strategies for early stage breast cancer patients receiving non-trastuzumab containing chemotherapy.

Robinson A, Stober C, Fergusson D, Kehoe A, Bedard D, MacDonald F, Brunet MC, Saunders D, Mazzarello S, Vandermeer L, Joy AA, Awan A, Basulaiman B, Mallick R, Hutton B, Clemons M; REaCT investigators.

Breast Cancer Res Treat. 2019 Nov;178(2):337-345. doi: 10.1007/s10549-019-05388-5. Epub 2019 Aug 7.


New and expanding ventricular hemorrhage predicts poor outcome in acute intracerebral hemorrhage.

Yogendrakumar V, Ramsay T, Fergusson D, Demchuk AM, Aviv RI, Rodriguez-Luna D, Molina CA, Silva Y, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz G, Srivastava P, Roy J, Kase CS, Bhatia R, Hill MD, Warren AD, Anderson CD, Gurol ME, Greenberg SM, Viswanathan A, Rosand J, Goldstein JN, Dowlatshahi D; the PREDICT/Sunnybrook CTA Study Group.

Neurology. 2019 Aug 27;93(9):e879-e888. doi: 10.1212/WNL.0000000000008007. Epub 2019 Aug 1.


Postoperative shared-care for patients undergoing non-cardiac surgery: a systematic review and meta-analysis.

Mazzarello S, McIsaac DI, Montroy J, Fergusson DA, Yateem D, Devereaux PJ, Lalu MM.

Can J Anaesth. 2019 Sep;66(9):1095-1105. doi: 10.1007/s12630-019-01433-5. Epub 2019 Jul 9.


Cost analysis of using Magee scores as a surrogate of Oncotype DX for adjuvant treatment decisions in women with early breast cancer.

de Lima MAG, Clemons M, Van Katwyk S, Stober C, Robertson SJ, Vandermeer L, Fergusson D, Thavorn K.

J Eval Clin Pract. 2019 Jul 9. doi: 10.1111/jep.13223. [Epub ahead of print]


Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies.

Fergusson DA, Wesch NL, Leung GJ, MacNeil JL, Conic I, Presseau J, Cobey KD, Diallo JS, Auer R, Kimmelman J, Kekre N, El-Sayes N, Krishnan R, Keller BA, Ilkow C, Lalu MM.

Mol Ther Oncolytics. 2019 May 21;14:179-187. doi: 10.1016/j.omto.2019.05.004. eCollection 2019 Sep 27.


Safety of a Restrictive versus Liberal Approach to Red Blood Cell Transfusion on the Outcome of AKI in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial.

Garg AX, Badner N, Bagshaw SM, Cuerden MS, Fergusson DA, Gregory AJ, Hall J, Hare GMT, Khanykin B, McGuinness S, Parikh CR, Roshanov PS, Shehata N, Sontrop JM, Syed S, Tagarakis GI, Thorpe KE, Verma S, Wald R, Whitlock RP, Mazer CD; TRICS Investigators and Perioperative Anesthesia Clinical Trials Group.

J Am Soc Nephrol. 2019 Jul;30(7):1294-1304. doi: 10.1681/ASN.2019010004. Epub 2019 Jun 20.


Guidelines on the intraoperative transfusion of red blood cells: a protocol for systematic review.

Baker L, Park L, Gilbert R, Martel A, Ahn H, Davies A, McIsaac DI, Saidenberg E, Tinmouth A, Fergusson DA, Martel G.

BMJ Open. 2019 Jun 17;9(6):e029684. doi: 10.1136/bmjopen-2019-029684.


Creating a pragmatic trials program for breast cancer patients: Rethinking Clinical Trials (REaCT).

Basulaiman B, Awan AA, Fergusson D, Vandermeer L, Arnaout A, Hilton J, Hutton B, Joy AA, Robinson A, Califaretti N, Stober C, Sienkiewicz M, Thavorn K, Clemons M.

Breast Cancer Res Treat. 2019 Aug;177(1):93-101. doi: 10.1007/s10549-019-05274-0. Epub 2019 May 24. Review.


Independent Validation of the Hematoma Expansion Prediction Score: A Non-contrast Score Equivalent in Accuracy to the Spot Sign.

Yogendrakumar V, Ramsay T, Fergusson DA, Demchuk AM, Aviv RI, Rodriguez-Luna D, Molina CA, Silva Blas Y, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz G, Srivastava P, Roy J, Kase CS, Bhatia R, Hill MD, Selim M, Dowlatshahi D; PREDICT/Sunnybrook CTA Study Group.

Neurocrit Care. 2019 Aug;31(1):1-8. doi: 10.1007/s12028-019-00740-5.


Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature.

Fergusson DA, Avey MT, Barron CC, Bocock M, Biefer KE, Boet S, Bourque SL, Conic I, Chen K, Dong YY, Fox GM, George RB, Goldenberg NM, Gragasin FS, Harsha P, Hong PJ, James TE, Larrigan SM, MacNeil JL, Manuel CA, Maximos S, Mazer D, Mittal R, McGinn R, Nguyen LH, Patel A, Richebé P, Saha TK, Steinberg BE, Sampson SD, Stewart DJ, Syed S, Vella K, Wesch NL, Lalu MM; Canadian Perioperative Anesthesia Clinical Trials Group.

PLoS One. 2019 May 23;14(5):e0215221. doi: 10.1371/journal.pone.0215221. eCollection 2019. Review.


De-escalation of bone-modifying agents in patients with bone metastases from breast cancer: a systematic review and meta-analysis.

Awan AA, Hutton B, Hilton J, Mazzarello S, Van Poznak C, Vandermeer L, Bota B, Stober C, Sienkiewicz M, Fergusson D, Shorr R, Clemons M.

Breast Cancer Res Treat. 2019 Aug;176(3):507-517. doi: 10.1007/s10549-019-05265-1. Epub 2019 May 11.


There is still a place for significance testing in clinical trials.

Cook JA, Fergusson DA, Ford I, Gonen M, Kimmelman J, Korn EL, Begg CB.

Clin Trials. 2019 Jun;16(3):223-224. doi: 10.1177/1740774519846504. Epub 2019 May 9. No abstract available.


Red blood cell transfusion in critically ill patients with traumatic brain injury: an international survey of physicians' attitudes.

Lessard Bonaventure P, Lauzier F, Zarychanski R, Boutin A, Shemilt M, Saxena M, Zolfagari P, Griesdale D, Menon DK, Stanworth S, English S, Chassé M, Fergusson DA, Moore L, Kramer A, Robitaille A, Myburgh J, Cooper J, Hutchinson P, Turgeon AF; Canadian Critical Care Trials Group and the Canadian Traumatic Brain Injury Research Consortium.

Can J Anaesth. 2019 Sep;66(9):1038-1048. doi: 10.1007/s12630-019-01369-w. Epub 2019 Apr 22.


Direct oral anticoagulants in treatment of cerebral venous thrombosis: a systematic review protocol.

Bose G, Graveline J, Yogendrakumar V, Fergusson D, Dowlatshahi D.

Syst Rev. 2019 Apr 18;8(1):99. doi: 10.1186/s13643-019-1022-8.


Influence of adjuvant antibiotics on fistula formation following incision and drainage of anorectal abscesses: a systematic review protocol.

Baker L, Williams L, Winter R, Cahill C, Davis A, Fergusson D.

Syst Rev. 2019 Apr 15;8(1):95. doi: 10.1186/s13643-019-1002-z.


Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.

Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM.

Transfus Med Rev. 2019 Apr;33(2):98-110. doi: 10.1016/j.tmrv.2019.01.005. Epub 2019 Feb 14.


Diagnostic Accuracy of Serum, Synovial, and Tissue Testing for Chronic Periprosthetic Joint Infection After Hip and Knee Replacements: A Systematic Review.

Carli AV, Abdelbary H, Ahmadzai N, Cheng W, Shea B, Hutton B, Sniderman J, Philip Sanders BS, Esmaeilisaraji L, Skidmore B, Gauthier-Kwan OY, Bunting AC, Gauthier P, Crnic A, Logishetty K, Moher D, Fergusson D, Beaulé PE.

J Bone Joint Surg Am. 2019 Apr 3;101(7):635-649. doi: 10.2106/JBJS.18.00632.


Correction: Interventions to improve resilience in physicians who have completed training: A systematic review.

Lavin Venegas C, Nkangu MN, Duffy MC, Fergusson DA, Spilg EG.

PLoS One. 2019 Mar 28;14(3):e0214782. doi: 10.1371/journal.pone.0214782. eCollection 2019.

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