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Analysis of the TTR gene in the investigation of amyloidosis: A 25 year single UK centre experience.

Rowczenio D, Quarta CC, Fontana M, Whelan CJ, Martinez-Naharro A, Trojer H, Baginska A, Ferguson SM, Gilbertson J, Rezk T, Sachchithanantham S, Mahmood S, Manwani R, Sharpley F, Wechalekar AD, Hawkins PN, Gillmore JD, Lachmann HJ.

Hum Mutat. 2018 Oct 17. doi: 10.1002/humu.23669. [Epub ahead of print]


How early media exposure may affect cognitive function: A review of results from observations in humans and experiments in mice.

Christakis DA, Ramirez JSB, Ferguson SM, Ravinder S, Ramirez JM.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):9851-9858. doi: 10.1073/pnas.1711548115. Review.


WDR41 supports lysosomal response to changes in amino acid availability.

Amick J, Tharkeshwar AK, Amaya C, Ferguson SM.

Mol Biol Cell. 2018 Sep 1;29(18):2213-2227. doi: 10.1091/mbc.E17-12-0703. Epub 2018 Jul 11.


GATOR1-dependent recruitment of FLCN-FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids.

Meng J, Ferguson SM.

J Cell Biol. 2018 Aug 6;217(8):2765-2776. doi: 10.1083/jcb.201712177. Epub 2018 May 30.


The complex relationship between TFEB transcription factor phosphorylation and subcellular localization.

Puertollano R, Ferguson SM, Brugarolas J, Ballabio A.

EMBO J. 2018 Jun 1;37(11). pii: e98804. doi: 10.15252/embj.201798804. Epub 2018 May 15. Review.


Neuronal lysosomes.

Ferguson SM.

Neurosci Lett. 2018 Apr 4. pii: S0304-3940(18)30260-X. doi: 10.1016/j.neulet.2018.04.005. [Epub ahead of print] Review.


Organelles in metabolism and stress responses.

Ferguson SM, Henne WM.

Mol Biol Cell. 2018 Mar 15;29(6):691. doi: 10.1091/mbc.E17-11-0679. No abstract available.


Axonal transport and maturation of lysosomes.

Ferguson SM.

Curr Opin Neurobiol. 2018 Aug;51:45-51. doi: 10.1016/j.conb.2018.02.020. Epub 2018 Mar 9. Review.


Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.

Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV Jr.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2849-E2858. doi: 10.1073/pnas.1722344115. Epub 2018 Mar 6.


A lentiviral system for efficient knockdown of proteins in neuronal cultures [version 1; referees: 2 approved].

Ritter B, Ferguson SM, De Camilli P, McPherson PS.

MNI Open Res. 2017;1(2). doi: 10.12688/mniopenres.12766.1. Epub 2017 Dec 5.


Chemogenetic inhibition of direct pathway striatal neurons normalizes pathological, cue-induced reinstatement of drug-seeking in rats.

Yager LM, Garcia AF, Donckels EA, Ferguson SM.

Addict Biol. 2018 Jan 5. doi: 10.1111/adb.12594. [Epub ahead of print]


A Guide to Time Lag and Time Lag Shortening Strategies in Oncology-Based Drug Development.

Uygur B, Duberman J, Ferguson SM.

J Commer Biotechnol. 2017 May;23:75-81. doi: 10.5912/jcb792.


Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology.

Gowrishankar S, Wu Y, Ferguson SM.

J Cell Biol. 2017 Oct 2;216(10):3291-3305. doi: 10.1083/jcb.201612148. Epub 2017 Aug 7.


Chemogenetic inhibition reveals midline thalamic nuclei and thalamo-accumbens projections mediate cocaine-seeking in rats.

Wunsch AM, Yager LM, Donckels EA, Le CT, Neumaier JF, Ferguson SM.

Eur J Neurosci. 2017 Aug;46(3):1850-1862. doi: 10.1111/ejn.13631. Epub 2017 Jul 26.


Beyond Hybrid Licenses-Strategies for Post Patent Expiration Payments in the United States1.

Gattari P, Ferguson SM, Crichton D, Helwig B.

LES Nouv. 2017 Mar;52(1):31-36. No abstract available.


Viral strategies for targeting cortical circuits that control cocaine-taking and cocaine-seeking in rodents.

Garcia AF, Nakata KG, Ferguson SM.

Pharmacol Biochem Behav. 2018 Nov;174:33-41. doi: 10.1016/j.pbb.2017.05.009. Epub 2017 May 25. Review.


B-cell non-Hodgkin lymphoma: Selective vulnerability to PIKFYVE inhibition.

Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, Ferguson SM, Xu T, Rothberg J, Lichenstein H.

Autophagy. 2017 Jun 3;13(6):1082-1083. doi: 10.1080/15548627.2017.1304871. Epub 2017 Mar 28.


C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease.

Amick J, Ferguson SM.

Traffic. 2017 May;18(5):267-276. doi: 10.1111/tra.12477. Epub 2017 Mar 23. Review.


Stress-responsiveness influences baseline glucocorticoid levels: Revisiting the under 3min sampling rule.

Small TW, Bebus SE, Bridge ES, Elderbrock EK, Ferguson SM, Jones BC, Schoech SJ.

Gen Comp Endocrinol. 2017 Jun 1;247:152-165. doi: 10.1016/j.ygcen.2017.01.028. Epub 2017 Feb 9.


Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma.

Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, Ferguson SM, Mandelkern T, Zheng M, Xu T, Rothberg J, Lichenstein H.

Blood. 2017 Mar 30;129(13):1768-1778. doi: 10.1182/blood-2016-09-736892. Epub 2017 Jan 19.


Excessive Sensory Stimulation during Development Alters Neural Plasticity and Vulnerability to Cocaine in Mice.

Ravinder S, Donckels EA, Ramirez JS, Christakis DA, Ramirez JM, Ferguson SM.

eNeuro. 2016 Aug 23;3(4). pii: ENEURO.0199-16.2016. doi: 10.1523/ENEURO.0199-16.2016. eCollection 2016 Jul-Aug.


C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.

Amick J, Roczniak-Ferguson A, Ferguson SM.

Mol Biol Cell. 2016 Oct 15;27(20):3040-3051. Epub 2016 Aug 24.


Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB.

Gray MA, Choy CH, Dayam RM, Ospina-Escobar E, Somerville A, Xiao X, Ferguson SM, Botelho RJ.

Curr Biol. 2016 Aug 8;26(15):1955-1964. doi: 10.1016/j.cub.2016.05.070. Epub 2016 Jul 7.


Lysosomes relax in the cellular suburbs.

Gowrishankar S, Ferguson SM.

J Cell Biol. 2016 Mar 14;212(6):617-9. doi: 10.1083/jcb.201602082.


MEDICINE. Membrane traffic en route to cancer.

Ferguson SM.

Science. 2015 Oct 9;350(6257):162-3. doi: 10.1126/science.aad3575. No abstract available.


Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis.

Fan F, Ji C, Wu Y, Ferguson SM, Tamarina N, Philipson LH, Lou X.

J Clin Invest. 2015 Nov 2;125(11):4026-41. doi: 10.1172/JCI80652. Epub 2015 Sep 28.


Corticostriatal Afferents Modulate Responsiveness to Psychostimulant Drugs and Drug-Associated Stimuli.

Kerstetter KA, Wunsch AM, Nakata KG, Donckels E, Neumaier JF, Ferguson SM.

Neuropsychopharmacology. 2016 Mar;41(4):1128-37. doi: 10.1038/npp.2015.253. Epub 2015 Aug 20.


Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques.

Gowrishankar S, Yuan P, Wu Y, Schrag M, Paradise S, Grutzendler J, De Camilli P, Ferguson SM.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3699-708. doi: 10.1073/pnas.1510329112. Epub 2015 Jun 29.


The ins and outs of the striatum: role in drug addiction.

Yager LM, Garcia AF, Wunsch AM, Ferguson SM.

Neuroscience. 2015 Aug 20;301:529-41. doi: 10.1016/j.neuroscience.2015.06.033. Epub 2015 Jun 23. Review.


Beyond indigestion: emerging roles for lysosome-based signaling in human disease.

Ferguson SM.

Curr Opin Cell Biol. 2015 Aug;35:59-68. doi: 10.1016/ Epub 2015 May 15. Review.


Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes.

Willinger T, Staron M, Ferguson SM, De Camilli P, Flavell RA.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4423-8. doi: 10.1073/pnas.1504279112. Epub 2015 Mar 23.


Using DREADDs to investigate addiction behaviors.

Ferguson SM, Neumaier JF.

Curr Opin Behav Sci. 2015 Apr;2:69-72. Epub 2014 Sep 22.


Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts.

Shin NY, Choi H, Neff L, Wu Y, Saito H, Ferguson SM, De Camilli P, Baron R.

J Cell Biol. 2014 Oct 13;207(1):73-89. doi: 10.1083/jcb.201401137. Epub 2014 Oct 6.


A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.

Wu Y, O'Toole ET, Girard M, Ritter B, Messa M, Liu X, McPherson PS, Ferguson SM, De Camilli P.

Elife. 2014 Jun 24;3:e01621. doi: 10.7554/eLife.01621.


Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling.

Willinger T, Ferguson SM, Pereira JP, De Camilli P, Flavell RA.

J Exp Med. 2014 Apr 7;211(4):685-700. doi: 10.1084/jem.20131343. Epub 2014 Mar 17.


Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis.

Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC.

Development. 2014 Apr;141(7):1465-72. doi: 10.1242/dev.104539. Epub 2014 Mar 5.


Essential function of dynamin in the invasive properties and actin architecture of v-Src induced podosomes/invadosomes.

Destaing O, Ferguson SM, Grichine A, Oddou C, De Camilli P, Albiges-Rizo C, Baron R.

PLoS One. 2013 Dec 9;8(12):e77956. doi: 10.1371/journal.pone.0077956. eCollection 2013.


Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.

Petit CS, Roczniak-Ferguson A, Ferguson SM.

J Cell Biol. 2013 Sep 30;202(7):1107-22. doi: 10.1083/jcb.201307084.


Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors.

Park RJ, Shen H, Liu L, Liu X, Ferguson SM, De Camilli P.

J Cell Sci. 2013 Nov 15;126(Pt 22):5305-12. doi: 10.1242/jcs.138578. Epub 2013 Sep 17.


Commercial considerations for immunoproteomics.

Ferguson SM.

Methods Mol Biol. 2013;1061:361-7. doi: 10.1007/978-1-62703-589-7_22.


Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts.

Armbruster M, Messa M, Ferguson SM, De Camilli P, Ryan TA.

Elife. 2013 Jul 30;2:e00845. doi: 10.7554/eLife.00845.


Direct-pathway striatal neurons regulate the retention of decision-making strategies.

Ferguson SM, Phillips PE, Roth BL, Wess J, Neumaier JF.

J Neurosci. 2013 Jul 10;33(28):11668-76. doi: 10.1523/JNEUROSCI.4783-12.2013.


Partnering with the NIH: Now part of the "Value Proposition" for start-ups.

Ferguson SM.

J Commer Biotechnol. 2012 Apr 1;18(2):60-67.


Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.

Soda K, Balkin DM, Ferguson SM, Paradise S, Milosevic I, Giovedi S, Volpicelli-Daley L, Tian X, Wu Y, Ma H, Son SH, Zheng R, Moeckel G, Cremona O, Holzman LB, De Camilli P, Ishibe S.

J Clin Invest. 2012 Dec;122(12):4401-11. doi: 10.1172/JCI65289. Epub 2012 Nov 26.


Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake.

Ruggiero AM, Wright J, Ferguson SM, Lewis M, Emerson KS, Iwamoto H, Ivy MT, Holmstrand EC, Ennis EA, Weaver CD, Blakely RD.

ACS Chem Neurosci. 2012 Oct 17;3(10):767-81. doi: 10.1021/cn3000718. Epub 2012 Jul 9.


Robust behavioral effects of song playback in the absence of testosterone or corticosterone release.

Rosvall KA, Reichard DG, Ferguson SM, Whittaker DJ, Ketterson ED.

Horm Behav. 2012 Sep;62(4):418-25. doi: 10.1016/j.yhbeh.2012.07.009. Epub 2012 Jul 28.


The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.

Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM.

Sci Signal. 2012 Jun 12;5(228):ra42. doi: 10.1126/scisignal.2002790.


Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.

Sousa LP, Lax I, Shen H, Ferguson SM, De Camilli P, Schlessinger J.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4419-24. doi: 10.1073/pnas.1200164109. Epub 2012 Feb 27.


Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.

Lou X, Fan F, Messa M, Raimondi A, Wu Y, Looger LL, Ferguson SM, De Camilli P.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E515-23. doi: 10.1073/pnas.1121626109. Epub 2012 Jan 30.


Dynamin, a membrane-remodelling GTPase.

Ferguson SM, De Camilli P.

Nat Rev Mol Cell Biol. 2012 Jan 11;13(2):75-88. doi: 10.1038/nrm3266. Review.

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